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Prof. 김익영


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  • Curriculum

    준비 중입니다.

  • Publication

    ▣ 2016                     


    68. Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonović M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. J Biol Chem. 291 . (2016) 24036-24040


    67. Min-Goo Lee, Seong-In Jeong, Kyung-Phill Ko, Soon-Ki Park, Byung-Kyu Ryu, Ick Young Kim , Jeong-Kook Kim, and Sung-Gil Chi. RASSF1A directly antagonizes RhoA activity through the assembly of a Smurf1-mediated destruction complex to supress tumorigenesis. Cancer Res. 76 . (2016) 1847-1859      

    66. Yeong Ha Jeon Kwan Young Ko Jea Hwang Lee Ki Jun Park Jun Ki Jang Ick Young Kim . Identification of a redox-modulatory interaction between selenoprotein W and 14-3-3 protein. Biochim. Biophys. Acta. 1863 . (2016) 10-18




    65. Jea Hwang Lee, Ki Jun Park, Jun Ki Jang, Yeong Ha Jeon, Kwan Young Ko, Joon Hyun Kwon, Seung-Rock Lee, and Ick Young Kim , Selenoprotein S-dependent selenoprotein K binding to p97(VCP) is essential for endoplasmic reticulum-associated degradation. J Biol Chem. 290 . (2015) 29941-29952


    64. Young Ok Baik, Seuk Keun Choi, Remigio M. Olveda, Roberto A. Espos, Antonio D. Ligsay, May B. Montellano, Jong sung Yeam, Jae seung Yang, Ju Yeon Park, Deok Ryun Kim, Sachin N. Desai, Ajit Pal Singh, Ick Young Kim , Chan Wha Kim, Sue-nie Park. A randomized, non-inferiority trial comparing two bivalent killed, whole cell, oral cholera vaccines(Euvichol vs Shanchol) in the Philippines. J vaccine. (2015) 


    ▣ 2014 

    63. Young Ok Baik, Seuk Keun Choi, Jae Woo Kim, Jae Seung yang, Ick Young Kim , Chan Hwa Kim, and Jang Hee Hong. Safety and immunogenicity assessment of an oral cholera vaccine through phase 1 clinical trial in Korea. J Korean Med Sci 29 . (2014) 494-501



    62. Yeong Ha Jeon, Yong Hwan Park, Jea Hwang Lee, Jeong-Ho Hong,  Ick Young Kim . Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein. Biochim. Biophys. Acta.  1843 . (2014) 1356-1364  



    61. Jea Hwang Lee, Joon Hyun Kwon, Yeong Ha Jeon, Kwan young Ko, Seung Rok Lee, and Ick Young Kim. Pro178 and Pro183 of selenoprotein S are essentail residues for interaction with p97(VCP) during endoplasmic reticulum-associated degradation. J. Biol. Chem  289 . (2014) 13758-13768



    ▣ 2013


    60 . Yeong Ha Jeon, Yong Hwan Park, Joon Hyun Kwon, Jea Hwang Lee,  Ick Young Kim . (2013) Hindrance of 14-3-3 from Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W.  Biochim. Biophys. Acta. 1833 . 2135-2142  


    ▣ 2012


    59. Yong Hwan Park, Yeong Ha Jeon, Ick Young Kim  (2012) Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B. Biochim. Biophys. Acta.  1823 . 2217-2226


    58. Joon Hyun Kwon, Jea Hwang Lee, Ki Soon Kim, Youn Wook Chung and Ick Young Kim (2012) Regulation of Cytosolic Phospholipase A2 Phosphorylation by Proteolytic Cleavage of Annexin A1 in Activated Mast Cells. 

    J. Immunology. 188 . 5665-5673


    ▣ 2011


    57. Chung YW, Kim HK, Kim IY , Yim MB, Chock PB (2011) Dual Function of Protein Kinase C in 12-O- 
    tetradecanoylphorbol-13-acetate (TPA)-induced MnSOD Expression: Activation of CREB and FOXO3a by PKC- 
    {alpha} Phosphorylation and by PKC-Mediated Inactivation of Akt, Respectively. J. Biol. Chem. 


    56. Hee Eun Yoon, Ki Soon Kim and Ick Young KIm (2011) 14-3-3η inhibits chondrogenic differentiation of ATDC cell.

    Biochemical and Biophysical Research Communications. 406 , 59-63


    ▣ 2010


    55. Noh OJ, Park YH, Chung YW, and Kim IY (2010) Transcriptional regulation of selenoprotein W by MyoD during early 
    skeletal muscle differentiation. J. Biol. Chem. 285 , 40496-40507


    54. Kim KS, Choi HW, Yoon HE, and Kim IY (2010) Reactive oxygen species generated by NADPH oxidase 2 and 4 are 
    required for chondrogenic differentiation. J. Biol. Chem. 285 , 40294-40302


    ▣ 2009

    53. Myoung Sup Shim, Jin Young Kim, Hee Kyoung Jung, Kwang Hee Lee, Xue-Ming Xu, Bradley A. Carlson, Ki Woo Kim, 
    Ick Young Kim , Dolph L. Hatfield and Byeong Jae Lee (2009). Elevation of glutamine level by selenophosphate 
    synthetase 1 knockdown induces megamitochondria formation in Drosophila cells. J. Biol. Chem. 284, 32881-32894


    52. Youn Wook Chung, Daewon Jeong, Ok Jeong Noh, Yong Hwan Park, Soo Im Kang, Min Goo Lee, Tae-Hoon Lee, Moon Bin Yim, and Ick Young Kim (2009). Antioxidative Role of Selenoprotein W in Oxidant-Induced Mouse Embryonic Neuronal Cell Death. Mol. Cells . 27, 609-613.


    ▣ 2008 

    51. Won-Kyu Lee, Sang-Yeop, Woo-Il Kim, Yoon-Hwa Rho, Young-seuk Bae, Cheolju-Lee, Ick Young Kim , Yeon Gyu Yu 
    (2008) Characterization of the InsP6-dependent interaction between CK2 and Nopp140. Biochemical and Biophysical Research Communications . 376 439-444

    50. Soo Im Kang, Hae Woo Choi, Ick Young Kim , (2008) Redox-mediated modification of PLZF by SUMO-1 and ubiquitin. 
    Biochemical and Biophysical Research Communications 369 (4) 1209-1214



    ▣ 2007


    49. Won-Kyu Lee, Hye-Jung Kim, Hye-Ki Min, Un-Beom Kang, Cheolju Lee, Sang-Won Lee, Ick Young Kim , Seoung-Taek Lee, Oh-Seung Kwon, and Yeon Gyu Yu (2007) A comprehensive identification of synaptic vesicle proteins in rat 
    brains by cRPLC/MS-MS and 2DE/MALDI-TOF-MS. Bull. Korean Chem. Soc . 28 , 1449-1509


    48. Krishna Moorthy Vukoti, Won-Kyu Lee, Ho-Jun Kim, Ick Young Kim , Eun Gyeong Yang, Cheolju Lee, and Yeon Gyu Yu (2007) Molecular dissection if the interaction between hBLT2 and the G protein alpha subunits. Bull. Korean Chem. 
     . 28 , 1005-1009


    47. Chae Young Hwang, Ick Young Kim and Ki-Sun Kwon (2007) Cytoplasmic localization and ubiquitination of p21Cip1 by reactive oxygen species. Biochemical and Biophysical Research Communications , 358 (1) , 219-25



    ▣ 2006

    46. Hyunsoo Kim, Ick Young Kim , Soo Young Lee, Daewon Jeong (2006) Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts, FEBS Letters , 580, 5661-5665


    45. Bae, Gun Won, Dae-won Jeong, Hong Jin Kim, Gyun Min Lee, Hongwoo Park, Tae-Boo Choe, Ick Young Kim , and Ik- 
    Hwan Kim (2006) High productivity of t-PA in CHO Cells Using Hypoxia Response Element. J. Micro. Biotech, 16 , 695-703


    44. Dae-won Jeong, Il Taeg Cho, Tae Soo Kim, Gun Won Bae, Ik-Hwan Kim and Ick Young Kim (2006) Effects of lactate 
    dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism. 
    Molecular and Cellular Biochemistry, 284 1-8



    ▣ 2005


    43. Youn Wook Chung, Tae Soo Kim, Soo Young Lee, Seoung Hoon Lee, Yongwon Choi, Nacksung Kim, Byung-Moo Min, Dae-Won Jeong, Ick Young Kim (2005) Selenite-induced apoptosis of osteoclasts mediated by the mitochondrial pathway. Toxicology Letters 160 , 143-150


    42. Kyungmi Yang, Jeong Hak Kim, Hae Jong Kim, In-Sung Park, Ick Young Kim and Beom-Seok Yang (2005) Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc 
    signaling complex formation. J. Biol. Chem. 280 , 39058-39066



    ▣ 2004


    41. Youn Wook Chung, Hae Yeun Oh, Ji Yeong Kim, Jae-Hong Kim, and Ick Young Kim (2004) Allergen-induced Proteolytic Cleavage of Annexin-1 and Activation of Cytosolic Phospholipase A2 in the Lungs of a Mouse Model of Asthma. Proteomics 4, 3328-3334

    40. Dae-won Jeong, Eun Hae Kim, Tae Soo Kim, Yoon Wook Chung, Hyun Kim, and Ick Young Kim (2004) Different distributions of selenoprotein W and thioredoxin during postnatal brain development and embryogenesis. Mol. Cells 17  ,156-159


    39. Dae-won Jeong, Tae soo Kim, Il Taeg Cho, and Ick Young Kim (2004) Modification of glycolysis affects cell sensitivity to apoptosis induced by oxidative stress and mediated by mitochondria. Biochem. Biophys. Res. Commun.313 984-991



    ▣ 2003


    38. Soo Im Kang, Woo-Jung Chang,1 Ssang-Goo Cho, and Ick Young Kim (2003) Modification of promyelocytic leukemia zinc finger protein (PLZF) by SUMO-1 conjugation regulates its transcriptional repressor activity. J. Biol. Chem. 278, 51479-51483


    37. Tae-soo Kim, Byung Yup Yun, and Ick Young Kim (2003) Induction of the mitochondrial permeability transition by selenium compounds mediated by oxidation of the protein thiol groups and generation of the superoxide. Biochem. Pharm . 66 , 2301-2311


    36. Sung-Jo Kim, Tae-soo Kim, Sunghoi Hong, Hyangshuk Rhim, Ick Young Kim , Seongman Kang (2003) Oxidative stimuli affect polyglutamine aggregation and cell death in human mutant ataxin-1-expressing cells. Neurosci. Lett. 348,21-24

    35. Sung-Jo Kim, Tae-Soo Kim, I ck Young Kim , Sunghoi Hong, Hyangshuk Rhim, and Seongman Kang (2003) 
    Polyglutamine-expanded ataxin-1 recruits Cu/Zn-superoxide dismutase into the nucleus of HeLa cells. Biochem. 
    Biophys. Res. Commun
     307 , 660-665

    34. Myung Il Chung, Mi Hee Lim, Yun Jeong Lee, Ik Hwan Kim, Ick Young Kim , Jung Hoe Kim, Kern Nee Chang, and Hong Jin Kim (2003) Reduction of ammonia accumulation and improvement of cell viability by expression of urea cycle enzymes in Chinese hamster oveary cells. J. Microbiol. Biotechnol. 13 , 217-224

    33. Kim, Ick Young (2003) Biological function of selenoprotein W: a Glutathione-Dependent Antioxidant. J. Kor. Assoc. 
    Cancer Prevention
     . 8, 30-35(Korean)



    ▣ 2002 

    32. 배근원 , 김익영 , 김익환 (2002) 동물세포의 대량배양 중에 유도되는 stress protein 의 발현을 조절하는 전사조절인자 (총설 ) 생물화공 Vol. 16(2) 50-58


    31. Tae-soo Kim, Dae-won Jeong, Byung Yup Yun, and Ick Young Kim (2002) Dysfunction of rat liver mitochondria by selenite: Induction of mitochondrial permeability transition through thiol-oxidation. Biochem. Biophys. Res. Commun .294, 1130-1137


    30. Youn Wook Chung, Dae-won Jeong, Joo Yun Won, Eui-Ju Choi, Yung Hyun Choi, and Ick Young Kim (2002) H 2 O2 -induced AP-1 activation and its effect on p21 WAF1/CIP1 -mediated G2/M arrest in a p53-deficient human lung cancer cell. Biochem. Biophys. Res. Commun . 293 , 1248-1253


    29 . Dae-won Jeong, Min-Hyuk Yoo, Tae Soo Kim, Jae-Hong Kim, and Ick Young Kim (2002) Protection of mice from allergen-induced asthma by selenite: prevention of eosinophil infiltration by inhibition of NF-κB activation. J. Biol. Chem  . 277, 17871-17876

    28. Dae-won Jeong, Tae Soo Kim„, Youn Wook Chung, Byeong Jae Lee, and Ick Young Kim (2002) Selenoprotein W is a glutathione-dependent antioxidant in vivo. FEBS Letters 517 , 225-228


    27. Kim, Ji-Young, Hee-Sae Park, Soo Im Kang„, Eui-Ju Choi, and Ick Young Kim (2002) Redox Regulation of cytosolic glycerol-3-phosphate dehydrogenase: Cys 102 is the target of the redox control and essential for the catalytic activity.Biochim. Biophys. Acta . 1569 , 67-74



    ▣ 2001


    26. Jeong, Dae-won , Tae Soo Kim , Joon Won Lee , Ki Tae Kim„, Hong Jin Kim, Ik-Hwan Kim, and Ick Young Kim .(2001) Blocking of Acidosis-mediated Apoptosis by a Reduction of Lactate Dehydrogenase Activity Through Anti-sense mRNA Expression. Biochem. Biophys. Res. Commun. 289 1141-1149



    ▣ 2000


    25. Choi, Yeon Sook, Doo-Young Lee, Ick Young Kim , Seongman Kang, Kwangseok Ahn, Hong Jin Kim, Yeon Ho Jeong, Gie-Taek Chun, Jung Keug Park, and Ik-Hwan Kim.(2000) Ammonia removal using hepatoma cells in mammalian cell cultures. Biotechnol. Progr . 16(5): 760-768


    24. Park, Hyo-Soon, Ik-Hwan Kim, Ick Young Kim, Ki-Ho Kim, and Hong-Jin Kim (2000) Expression of carbamoyl phosphate synthetase I and ornithine transcarbamoylase genes in Chinese hamster ovary dhfr - cells decreased accumulation of ammonium ion in culture media. J. Biotech . 81 , 129-140


    23. Park, Hee-Sae, Sung-Ho Huh, Youngho Kim, Jaekyung Shim, Seung-Hoon Lee, Il-Seon Park, Yong-Keun Jung, Ick Young Kim , and Eui-Ju Choi (2000) Selenite negatively regulates caspase-3 through a redox mechanism. J. Biol. Chem. 275 , 8487-8491


    22. Kim, Hyun-Soo, Kim, Ick Young , Dieter Soll, and Se Yong Lee (2000) Transfer RNA Identity Change in Anticodon Variants of E. coli tRNA Phe In vivo. Mol. Cells 10, 76-82


    21. Park, Hee-Sae, Eun Park, Mi-Sung Kim, Kwangseog Ahn, Ick Young Kim , and Eui-Ju Choi (2000) Selenium inhibits the C-Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK) through a thiol mechanism. J. Biol. Chem.275 , 2527-2531



    ▣ 1999


    20. Kim, Ji Young, Young Soo Chung, Sung Han Ok, Sang Gak Lee, Won Il Chung, Ick Young Kim , and Jeong Sheop Shin (1999) Characterization of the full-length sequences of phospholipase A 2 induced during flower development.Biochim. Biophys. Acta 1489, 389-392


    19. Kim, Tae-Soo, Min-Hyuk Yu, Younwook Chung, Joon Kim, Eui-ju Choi, Hoy-Ihl, Kwangseog Ahn, and Ick Young Kim  (1999) Fetal mouse selenophosphate synthetase 2 (SPS2): Biological activities of mutant forms in Escherichia coli.Mol. Cells 9 , 422-428


    18. Hwang, Kiocin, Dae-Won Jung, Gun-Won Bae, Hong-Jin Kim, Ik-Hwan Kim, Hoy-Ihl Chang, and Ick Young Kim(1999) Alteration of NAD + /NADH ratio in CHO cells by stable transfection with human cytosolic glycerol-3-phosphate dehydrogenase: Resistance to oxidative stress. Mol. Cells 9 , 429-435


    17. Kim, Hyunpyo, Ick Young Kim , Seongman Kang, Ik-Hwan Kim, Byung-Yoon Ahn, and Kwangseog Ahn. (1999) Analysis of the Major Histocompatibility Complex Class I Antigen Presentation Machinery in Human Lung Cancer. J. Microbiol. Biotech. . 9, 346-351


    16. Lee, J.Y., Y.-B. Bae, J.A.Kim, J.M.Song, M.Choe, I.Y.Kim , and J.Kim (1999) Site-directed saturation mutagenesis of yeast Gcn4p at codon 242. J. Microbiol. Biotech. . 9, 122-125


    15. Song, J.-S., J.-H. Park, Y.-W., Kim, W.-J. Lim, I.Y. Kim , and H.-I., Chang (1999) Characterization of the replication region of the Enterococcus faecalis plasmid p703/5. J. Microbio. Biotech 9, 91-97



    ▣ 1997                                                                                                    


    14. Kim, Ick Young and Thressa C. Stadtman (1997) Inhibition of NF-κB DNA binding and nitric oxide induction in human T-cells and lung adenocarcinoma cells by selenite treatment. Proc. Natl. Acad. Sci. U.S.A. 94 , 12904-12907


    13. Kim, Ick Young (1997) Biosynthesis and biological roles of selenocysteine-containing enzyme (Korean) Bioindustry   17, 72-75


    12. Kim, Ick Young , M. Jorge Guimaraes, J. Fernando Bazan, Albert Zlotnik, and Thressa C. Stadtman (1997) Fetal mouse selenophosphate synthetase 2 (SPS2): Characterization of the cysteine mutant from overproduced in a baculovirus-insect cell system. Proc. Natl. Acad. Sci. U.S.A. 94, 418-421



    ▣ 1995


    11. Kim, Ick Young and Thressa C. Stadtman (1995) Selenophosphate synthetase: Detection in extracts of rat tissues by immunoblot assay and partial purification of the enzyme from the archaean Methanococcus vannielii. Proc. Natl. Acad.Sci. U.S.A. 92 , 7710-7713



    ▣ 1994


    10. Kim, Ick Young and Thressa C. Stadtman (1994) Effects of monovalent cations and divalent metal ions onEscherichia coli selenophosphate synthetase activity. Proc. Natl. Acad. Sci. U.S.A. 91 , 7326-7329


    9. Stadtman, T. C., Zsuzsa Veres, and Ick Young Kim (1994) Selenophosphate: Synthesis, properties and role as 
    biological donor. Phosphate in Microorganism:Cellular and Molecular Biology (Ed. A.M. Torriani, S. Siver, and E. 
    Yagil) 109-111

    8. Veres Zsuzsa, Ick Young Kim , Thomas D. Scholz, and Thressa C. Stadtman (1994) Selenophosphate synthetase: enzyme properties and catalytic reaction. J. Biol. Chem. 269 , 10597-10603



    ▣ 1993


    7. Kim, Ick Young , Zsuzsa Veres, and Thressa C. Stadtman (1993) Biochemical analysis of Escherichia coli 
    selenophosphate synthetase mutant: Lysine-20 is essential for catalytic activity and cysteine-17/19 for 8-azido-ATP derivatization. J. Biol. Chem. 268, 27020- 27025.



    ▣ 1992

    6. Kim, Ick Young , Zsuzsa Veres, and Thressa C. Stadtman (1992) Escherichia coli mutant SELD enzymes: Cysteine 17 residue is essential for selenophosphate formation from ATP and selenide. J. Biol. Chem. , 267 . 19650-19654



    ▣ 1991


    5. Lee, Se Yong , Ick Young Kim, and Inwon Park (1991) Site-specific mutagenesis on the 32-T and 39-T of E.colitRNAPhe gene. Recent Advance in Biochemistry (Ed. S. M. Byun, S. Y. Lee, and C. H. Yang) pp.169-178



    ▣ 1990


    4. Kim, Ick Young and Se Yong Lee (1990) Enzymatic synthesis of unmodified E.coli tRNAPhe. Molecules and Cells , 1. 3-7



    ▣ 1989


    3. Kim, Ick Young and Se Yong Lee (1989) Site-specific mutagenesis on the 32-T and 39-T of E.coli tRNAPhe gene.Kor. J. Microbiol ., 27 . 176-180



    ▣ 1985


    2. Chi, Youn Tae, Ick Young Kim , and Se Yong Lee (1985) Effects of tat - and ssd - mutation on the expression of 
    recombinant trp plasmid and tryptophan production in Klebsiella pneumoniae . Kor. Biochem. J., 18 , 103-107



    ▣ 1984


    1. Chi, Youn Tae, Ick Young Kim , and Se Yong Lee (1984) Cloning and Expression of Escherichia coli K-12 trpL(Δ att) 
     gene in Klebsiella pneumoniae . Kor. J. Microbiol ., 22 , 229-234

  • Research

  • Teaching

    준비 중입니다.

  • Lab Members



    고관영 ( 박사 과정 )
    Study of mechanism about Selenoproteins

    장준기 ( 석박사 통합 과정 )
    Fucntion of Selenoproteins in differentiation of chondrogenesis
    Function of SELENOS in Alzheimer's disease

    진윤정 ( 석박사 통합 과정 )

    Study of mechanism about SELENOP

    함민주 ( 석사 과정 )
    Function of SELENOW in lipid metabolism

    강현우 ( 학부 연구생 )

    Selenoprotein in transdifferentiation of myoblast








    강수임   분당서울대학교병원 선임연구원

    권준현   National Institutes of Health Post-doc

    김기순   National Institutes of Health Post-doc

    김태수   대전 한의학 연구소 차장 ( 선임 연구원 )

    노효주   Yale 변리사 사무소 차장

    박용환   National Institutes of Health Post-doc

    배근원   명문제약 수석연구원

    양경미   이화여대 연구교수

    이원규   국민대학교 연구교수  


    정대원   영남대학교 의과대학 미생물학 교실

    정연욱   연세대학교 의과대학 환경의생물학교실

    황채영   생명공학연구원 , 노화과학연구센터

    이재황   Harvard Medical school ( MGH ) post-doc


    권혜미   일동제약 연구원



    김은정   상지대학교 교수

    김지영   삼양사 연구원

    김한천   The university of Texas MD Andersun cancer center

    박기준   SK 바이오랜드   

    송후근   LG 생명과학연구소 ( 과장 )

    오혜연   태평양 연구원

    원주윤   서울대학교 의과대학 박사과정

    유민혁   National Institutes of Health staff scientist



    윤희은   한미약품 연구원

    이준원   셀트리온 ( 차장 )



    정희경   LG 생명과학연구소 ( 차장 )

    조일택   University of Pennsylvania Post-doc

    최슬기  서울대병원

    최해웅   Duke university phD candidate


    황교신   삼성 SDS