- About Professor
- Curriculum Vitae
- Lab Members
생체 세포의 여러 가지 생명 현상, 즉 세포의 증식과 분화, 대사, 분비, 유전자 발현 등은 세포들 간의 유기적인 정보 교환과 외부 신호에 의한 세포 내에서의 일련의 신호전달 과정을 통해 조절되고 유지된다. 특히, 생체미세환경 내에 존재하는 세포들의 만성적 염증반응에 관련된 신호전달 체계의 불균형은 암과 동맥경화와 같은 비정상적 만성 염증성 질환을 유발한다.
최근에 본 연구실에서 발견한 small leucine zipper protein (sLZIP)과 그 isoform 인 LZIP은 전사인자로써 혈관평활근세포의 이동과 증식을 조절하고, 거품세포 형성에 관여하며, 혈관벽 및 동맥경화반에서 강하게 발현되어 있어 동맥경화의 발병과정에서 중요한 역할을 할 것으로 예상된다. 특히, 전사인자 PPARγ의 전사활성과 MMP 효소들의 발현 및 활성을 조절하여 혈관내 염증성 유도물질들을 분비함으로써 동맥경화를 유도하는 것으로 생각되고 있다. 본 연구실은 sLZIP과 LZIP을 중심으로 동맥경화에 관련된 단백질들의 기능을 분자적 수준에서 이해하고, 이 단백질들을 질병 치료를 위한 target molecule로 제시하여 동맥경화 발병기전 규명과 치료제 개발에 공헌하고자 한다.
안드로겐 수용체 (AR), 에스트로겐 수용체 (ER), 글루코콜티코이드 수용체 (GR) 등의 핵 수용체는 개체의 발생 및 분화, 생식, 염증반응, 항상성 유지 등 개체유지에 중요한 다양한 과정에서 기능을 하며, 이러한 핵 수용체가 관련된 신호전달체계의 이상은 전립선암, 유방암, 대사성 질환 등 많은 질병과 연관되어 있다.
최근 본 연구실은 AR과 ER에 결합하고 전사활성을 조절하여 전립선암과 유방암의 발병과정에서 중요한 기능을 하는 단백질을 발견하였다. 본 연구실은 전립선암 및 유방암 세포에서 이 단백질에 의한 핵 수용체 표적 단백질들의 발현 조절 작용을 규명하고, 형질전환 동물모델을 이용하여 이를 검증함으로써 전립선암 및 유방암 진단/치료를 위한 바이오마커를 개발하려고 한다. 또한, GR과 결합하여 GR의 전사활성을 조절하는 단백질에 의한 당 대사 조절 기전을 규명하여 대사성 질환 관련성 및 분자세포생물학적 치료방법 개발에 대한 표적단백질로서 가능성을 제시하고자 한다.
(1993) Biological Sciences, University of Rhode Island, RI, USA
(1987) Food Science, Korea University, Seoul, Korea
(1985) Food Science, Korea University, Seoul, Korea
▷ Professional Experiences
2009. 3 - present : Professor, Korea University, Seoul, Korea
2005. 3 - 2009. 2 : Associate Professor, Korea University, Seoul, Korea
1999. 12 - 2005. 2 : Assistant Professor, University of Ulsan College of Medicine, Seoul, Korea
1997. 5 - 1999. 11 : Research Fellow, Dana-Farber Cancer Institute/Harvard Medical School, MA, USA
1995. 1 - 1997. 4 : Research Fellow, Harvard Medical School, MA, USA
1994. 1 - 1994. 12 : Post-doc, University of Rhode Island, RI, USA
Jeong J*, Park S*, An HT, Kang M, Ko J. (2017) Small leucine zipper protein functions as a negative regulator of estrogen receptor α in breast cancer. PLoS One. *co-first author
Kang M, Kim J, An HT, Ko J.(2017) Human leucine zipper protein promotes hepatic steatosis via induction of apolipoprotein A-IV. FASEB J.
Kim BC, Hwang HJ, An HT, Lee H, Park JS, Hong J, Ko J, Kim C, Lee JS, Ko YG.(2016) Antibody neutralization of cell-surface gC1qR/HABP1/SF2-p32 prevents lamellipodia formation and tumorigenesis . Oncotarget
An HT, Yoo S, Ko J.(2016) α-Actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of Snail expression and β-catenin stabilization in cervical cancer. Oncogene.Park S*, Yoo S*, Kim J, An HT, Kang M, Ko J.(2015) 14-3-3β and γ differentially regulate peroxisome proliferator activated receptor γ2 transactivation and hepatic lipid metabolism . Biochim Biophys Acta. *co-first authorCho H, Park OH, Park J, Ryu I, Kim J, Ko J, Kim YK.(2015) Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation. Proc Natl Acad Sci U S A.J Kim, J Ko.(2014) Human sLZIP promotes atherosclerosis via MMP-9 transcription and vascular smooth muscle cell migration . The FASEB JournalJ Kim, J Ko.(2014) A novel PPARc2 modulator sLZIP controls the balance between adipogenesis and osteogenesis during mesenchymal stem cell differentiation . Cell Death & Differentiation.Kim J, Jang SW, Park E, Oh M, Park S, Ko J.(2014) The role of heat shock protein 90 in migration and proliferation of vascular smooth muscle cells in the development of atherosclerosis . J MOL CELL CARDIOL.Park E, Kang H, Kim J, Ko J. (2014) The role of sLZIP in transcriptional regulation of c-Jun and involvement in migration and invasion of cervical cancer cells . CELL PHYSIOL BIOCHEM .Kim Y*, Kim J*, Jang SW, Ko J. (2015) The role of sLZIP in negative regulation of cyclin D3-mediated androgen receptor transactivation and its involvement in prostate cancer . Oncogene. *co-firtst authorAn HT, Kim J, Yoo S, Ko J. (2013) sLZIP negatively regulates skeletal muscle differentiation via interaction with α-actinin-4 . J Biol Chem.Yoon Suk Kim, Jeonghan Kim, Chi A Yi, Jesang Ko, Yong Serk Park, Seung-Jae Lee.(2012) Macromolecular Crowding Enhances Interaction of α-synuclein with Vesicles. Journal of Experimental and Biomedical Sciences.Kang H, Ko J, Jang SW. (2012) The role of annexin A1 in expression of matrix metalloproteinase-9 and invasion of breast cancer cells. Biochem Biophys Res Commun .Kang H, Lee M, Choi KC, Shin DM, Ko J, Jang SW (2012) N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression . J Cell Biochem.Ya ng EJ, Choi E, Ko J, Kim DH, Lee JS, Kim IS. (2012) Differential effect of CCL2 on constitutive neutrophil apoptosis between normal and asthmatic subjects. J Cell Physiol .Sung HJ, Kim J, Kim Y, Jang SW, Ko J. (2012) N-acetyl cysteine suppresses the foam cell formation that is induced by oxidized low density lipoprotein via regulation of gene expression. Mol Biol Rep .Sung HJ, Kim Y, Kang H, Sull JW, Kim YS, Jang SW, Ko J. (2012) Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells. Int J Mol Med .Jang SY, Jang SW, Ko J. (2012) Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration. Cancer Lett .Kang H, Jang SW, Ko J. (2011) Human leucine zipper protein sLZIP induces migration and invasion of cervical cancer cells via expression of matrix metalloproteinase-9. J Biol Chem .Kim Y, Kim H, Jang SW, Ko J. (2011) The role of 14-3-3β in transcriptional activation of estrogen receptor α and its involvement in proliferation of breast cancer cells. Biochem Biophys Res Commun .Kim Y, Kang H, Jang SW, Ko J. (2011) Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression. Cell Physiol Biochem .Jang SY, Jang SW, Ko J. (2011) Celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α. Cancer Lett .Jung-A Choi, Jin-Wook Lee, Hyunju Kim, Eun-Young Kim, Ji-Min Seo, Jesang Ko, and Jae-Hong Kim. (2010) Pro-survival of estrogen receptor -negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway. Carcinogenesis.Jeonghan Kim, Yoon Suk Kim, and Jesang Ko. (2010) CKbeta8/CCL23 and its isoform CKbeta8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKCdelta/ERK leading to cell-cycle progression. Cytokine.Jeonghan Kim, Yoon Suk Kim, and Jesang Ko. (2010) CK beta 8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKC delta/NF-kappa B and is involved in inflammatory responses. Life Sci.Yoon Suk Kim, Hyoung Tae An, Jeonghan Kim, and Jesang Ko. (2009 Effects of protein kinase Cdelta and phospholipase C-gamma1 on monocyte chemoattractant protein-1 expression in taxol-induced breast cancer cell death. Int. J. Mol. Med. 24 (6), 853-858.Hyereen Kang, Yoon Suk Kim, and Jesang Ko. (2009) A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor. Mol Endo. 23 (11):1746-1757.Geun Hyang Kim, Keunhee Park, Seon-Yong Yeom, Kyung Jin Lee, Gukhan Kim, Jesang Ko , Dong-Kwon Rhee, Young Hoon Kim, Hye Kyung Lee, Hae Won Kim, Goo Taeg Oh, Ki-Up Lee, Jae W. Lee, and Seung-Whan Kim (2009) Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages. Mol Endo. 23 (7), 966-974.Byong Wook Min, Chang Gun Kim, Jesang Ko, Yoongho Lim, Young Han Lee, and Soon Young Shin. (2008) Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin . Exp. Mol. Med. 40 (6), 699-708.Yoon Suk Kim, Jeonghan Kim, Yoonseo Kim, Young Han Lee, Jae-Hong Kim, Seung-Jae Lee, Soon Young Shin, and Jesang Ko. (2008) The role of calpains in ligand-induced degradation of the glucocorticoid receptor. Biochem. Bioph. Res. Co. 374 (2), 373-377.Ho Joong Sung, Yoon Suk Kim, Hyereen Kang, and Jesang Ko. (2008) Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. Exp. Mol. Med. 40 (3), 332-338.Sang Min Jung, KiBeom Lee, Joung Wook Lee, Hong Namkoong, Hyun Kee Kim, Sanghee Kim, Hae Ri Na, Seon-Ah Ha, Jae-Ryong Kim, Jesang Ko, and Jin Woo Kim. (2008) Both plasma retinol-binding protein and haptoglobin precursor allele 1 in CSF: candidate biomarkers for the progression of normal to mild cognitive impairment to Alzheimer's disease. Neurosci. Lett. 436 (2), 153-157.Sung-Wuk Jang, Yoon Suk Kim, Yoon Rim Kim, Ho Joong Sung, and Jesang Ko. (2007) Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. J. Biol. Chem. 282(15), 11092-11100.Sung-Wuk Jang, Yoon Suk Kim, Young Han Lee, and Jesang Ko. (2007) Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines. J. Cell. Physiol. 211(3), 630-637.Jesang Ko, Chi-Young Yun, Ji-Sook Lee, Joo-Hwan Kim, and In Sik Kim. (2007) p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells. Exp. Mol. Med. 39(2), 129-138.Soon Young Shin, Byeong Hyeok Choi, Jesang Ko, Se Hyun Kim, Yong Sik Kim, and Young Han Lee. (2006) Clozapine, a neuroleptic agent, inhibits Akt by counteracting Ca2+/calmodulin in PTEN-negative U-87MG human glioblastoma cells. Cell. Signal. 18(11), 1876-1886.Jesang Ko, Chi-Young Yun, Ji-Sook Lee, Dong-Hee Kim, Ji Eun Yuk, and In Sik Kim . (2006) Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1. Life Sci. 79(13), 1293-1300.Seung Min Shin, Yeun Jun Chung, Seong Tack Oh, Hae Myung Jeon, Lae Jeong Hwang, Hong Namkoong, Hyun Kee Kim, Goang Won Cho, Soo Young Hur, Tae Eung Kim, Youn Soo Lee, Yong Gyu Park, Jesang Ko, and Jin Woo Kim. (2006) HCCR-1-interacting molecule "deleted in polyposis 1" plays a tumor-suppressor role in colon carcinogenesis. Gastroenterology, 130 (7), 2074-2086.
▷ Research Area
Chemokines are a family of small secreted proteins involved in homeostatic trafficking of leukocytes and leukocyte influx into sites of injury and inflammation.
Chemokines can regulate multiple aspects of host defense and inflammation, including hematopoiesis, angiogenesis, metastasis, tumor rejection, Th1/Th2 responses, and HIV-1 infection.
Signaling molecules that bind to chemokine receptors should play key roles in regulation of cell migration induced by chemokines.
Recently, we identified LZIP as a CCR1-binding protein. LZIP has been known as a transcription factor in various cell types.
We are now trying to understand the regulatory mechanism of the leukocyte movement by LZIP and roles of LZIP in inflammatory diseases such as atherosclerosis.
Our second project is regarding novel breast cancer-related oncoprotein HCCR-2. We are trying to understand the tumorigenesis mechanism by characterization of HCCR-2-mediated protein network and develop the diagnosis biomarkers for breast cancer.
▷ Ongoing Projects
Understanding of the regulatory mechanism of leukocyte movement by LZIP, characterization of LZIP-mediated signal transduction pathway, and roles of LZIP in inflammatory diseases
• Characterization of the regulatory mechanism of leukocyte migration by LZIP
• Characterization of LZIP-mediated signal transduction pathway
• Characterization of roles of LZIP in atherosclerosis
• Characterization of atherosclerosis development mechanism
• Identification of proteins expressed by LZIP using proteomics and investigation of their cellular functions
Understanding of the tumorigenesis mechanism induced by novel oncoprotein HCCR-2 and identification of biomarkers for breast cancer
• Characterization of HCCR-2-mediated signal transduction pathway
• Characterization of roles of HCCR-2 in breast cancer development
• Establishment of HCCR-2-related protein network
Lab Members▷ PresentMinsoo KangMS/Ph.D Studentlovesadly@korea.ac.krSuhyun KimMS/Ph.D Studentdariakullen@korea.ac.krSungyeon ParkMS/Ph.D Studentsungyeon10@korea.ac.krJaeyeon JungMS Studentjaeyeonie@korea.ac.krSeukun KimMS/Ph.D Studentyuha0607@korea.ac.kr▷ FormerYoon Suk KimProfessor, Yonsei Univ.firstname.lastname@example.orgIn Sik KimAssociate Professor, Eulji Univ.email@example.comSung-Wuk JangAssistant Professor, Univ. of Ulsan College of Medicineswjang@amc.seoul.krHo Joong SungAssistant Professor, Eulji Univ.firstname.lastname@example.orgHyereen KangPost-doc, Univ. of Ulsan College of Medicinefrejya1052@gmail.comGeun Hyang KimPost-doc, Sanford-Burnham Medical Institute, USArlarmsgid@hanmail.netSoon Young JangPost-doc, Korea Univ. College of Medicineagct98@gmail.comYoonseo KimPost-doc, NIH, USAkys2117@hanmail.netHyung Jin KimSamsung Electronics Co.email@example.comSun Kyoung HanSeoul Nat. Univ. Hospitalluvsun@korea.ac.krYunhee HwangDaemyoung Science Co.firstname.lastname@example.orgEunsoo ParkResearcherparkespink@naver.comSodam ParkAmorepacificcookiestar@korea.ac.krMinseok OhSamsung Biologicsdaeguoms@korea.ac.krJeonghan KimPost-doc, NIH, USAblessnow@korea.ac.krJunseok KwakSK Chemicalsjunnseokkwak@gmail.comSoo Ji LeeCelltrion Inc.email@example.comHyoungtae AnPost-doc. Johns Hopkins University School of Medicinekarin0297@korea.ac.krSeungmin YooResearchersmmagi@korea.ac.krJuyeon JeongSamsung Bioepisjjy2789@korea.ac.kr