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고려대학교 교수소개

Knowledge & Innovation

생명과학대학

Home > 생명과학대학 >생명공학부

소개

Prof. 황광연

Tel: 02-3290-3009(Lab : 3512) 

Fax: 923-3229

E-mail: chahong@korea.ac.kr

  • About Professor
  • Curriculum vitae
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile

    구조 단백질체학 연구실 (Lab. of Structural Proteomics)
    생명과학관 서관 516호 (Lab: 522호) - LifeSciences West-Building 516-Ho

  • Curriculum

    Education 
     
    BS.   Department of Chemistry Education, Seoul National University (1985.03 - 1989.02) 
     
    MS.   Department of Chemistry, Seoul National University (1989.03 - 1991.02) 
     
    Ph.D  Department of Chemistry, Seoul National University (1991.03 - 1994.08) 
     
     
     
    Professional Experiences 
     
    Department of Biochemistry, Medical Research Center, University of Alberta, Canada (1995.03 - 1997.04)
     
    Korea Institute of Sciences & Technology, Structural Biology Center (1997.05 - 1998.12) 
     
    LG Chem. Biotech Institute (1999.01 - 2000. 08)
     
    CrystalGenomics, Inc (2000.09 - 2003.08)
     
    Korea Institute of Sciences & Technology, Biomedical Center (2003.09 - 2005.08)
     
    Division of Biotechnology, College of Life Sciences & Biotechnology, Korea University (2005.09 - Current)         
     
     

     

  • Publication

    2014

     

    Kim HS, Cha SY, Jo CH, Han A and Hwang KY* . The crystal structure of arginyl-tRNA synthetase from Homo sapiens FEBS Lett. 2014 in press

     

    Jia Y, Kim JH, Nam B, Kim J, Lee JH, Hwang KY , Lee SJ.The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-α and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells. Bioorg Med Chem Lett . 2014 Apr 13.

     

    Lee EH , Lee K, and Hwang KY* . Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii Acta Crystallogr D Biol Crystallogr. 2014 Apr;70(Pt 4):922-31

     

    Jun HJ, Lee JH, Kim J, Jia Y, Kim KH, Hwang KY , Yun EJ, Do KR, Lee SJ. Aromatic terpenoid linalool is an agonistic ligand for PPARα that reduces plasma triglyceride levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res . 2014 Apr 20.

     

    Lee EH , Kwak G-H, Kim HY and Hwang KY* . Structural analysis of 1-Cys type selenoprotein methionine sulfoxide reductase A Archives of Biochemistry and Biophysics, 2014 Mar 1;545:1-8

     

    2013

     

    Son J, Lee EH, Park M, Kim JH, Kim J, Kim S, Jeon YH and Hwang KY* . Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. Acta Cryst. (2013). D 69 , 2136–2145.

     

    Jia Y, Kim JY, Jun HJ, Kim SJ, Lee JH, Hoang MH, Kim HS, Chang HI, Hwang KY , Um SJ, Lee SJ. Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid. Biochim Biophys Acta. 2013 Apr;1831(4):698-708.

     

    Choi KM, Park GL, Hwang KY , Lee JW, Ahn HJ . Efficient siRNA delivery into tumor cells by p19-YSA fusion protein. Mol Pharm . 2013 Feb 4;10(2):763-73.

     

     

    2012

     

    L MR, Yoo WG, Kim YJ, Kim DW, Cho SH, ee MR, Yoo WG, Kim YJ, Kim DW, Cho SH, Hwang KY , Ju JW, Lee WJ. Molecular characterization of an α-N-acetylgalactosaminidase from Clonorchis sinensis. Parasitol Res. 2012 Nov;111(5):2149-56.

     

    Kwak GH, Hwang KY , Kim HY. Analyses of methionine sulfoxide reductase activities towards free and peptidyl methionine sulfoxides. Arch Biochem Biophys. 2012 Nov 1;527(1):1-5

     

    Hoang MH, Jia Y, Jun HJ, Lee JH, Hwang KY , Choi DW, Um SJ, Lee BY, You SG, Lee SJ. Taurine is a liver X receptor-α ligand and activates transcription of key genes in the reverse cholesterol transport without inducing hepatic lipogenesis. Mol Nutr Food Res. 2012 Jun;56(6):900-11.

     

    Jia Y, Kim JY, Jun HJ, Kim SJ, Lee JH, Hoang MH, Hwang KY , Um SJ, Chang HI, Lee SJ. The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes. Mol Nutr Food Res. 2012 Jun;56(6):878-88.

     

    Han AR, Kim HS, Cho GY, Ki HS, Kim HY, Hwang KY* . Crystallization and preliminary X-ray crystallographic analysis of the methionine sulfoxide reductase A domain of MsrAB from Haemophilus influenzae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 May 1;68(Pt 5):557-9. doi: 10.1107/S1744309112011256.

     

    Lee EH, Cho YW, Hwang KY* . Crystal structure of LeuD from Methanococcus jannaschii. Biochem Biophys Res Commun. 2012 Mar 9;419(2):160-4

     

    Park SH, Chang JE, Hawkes HJ, Kang YH, Hwang KY* . Structural analysis and serological test of arginine periplasmic binding protein 2 from Chlamydophila pneumoniae. Biochem Biophys Res Commun. 2012 Feb 17;418(3):518-24.

     

    Lee MR, Kim YJ, Kim DW, Yoo WG, Cho SH, Hwang KY , Ju JW, Lee WJ. The identification of antigenic proteins: 14-3-3 protein and propionyl-CoA carboxylase in Clonorchis sinensis. Mol Biochem Parasitol. 2012 Mar-Apr;182(1-2):1-6

     

     

    2011

     

    Jia Y, Bhuiyan MJ, Jun HJ, Lee JH, Hoang MH, Lee HJ, Kim N, Lee D, Hwang KY , Hwang BY, Choi DW, Lee SJ. Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism . Bioorg Med Chem Lett . 2011 Oct 1;21(19):5876-80.

     

    Choi SH, Kwon IC, Hwang KY , Kim IS, Ahn HJ.

    Small Heat Shock Protein as a Multifunctional Scaffold: Integrated Tumor Targeting and Caspase Imaging within a Single Cage. Biomacromolecules . 2011 Aug 8;12(8):3099-106.

     

    Lee EH, Kim HS, Kim HY, Jeon YH, Hwang KY* .

    Structural insights into the metal binding properties of hypothetical protein MJ0754 from Methanococcus jannaschii. Proteins . 2011 Jul;79(7):2358-2363.

     

    Lee WH, Sung MW, Kim JH, Kim YK, Han A, Hwang KY* .

    Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum. Biochem Biophys Res Commun. 2011. Mar 18;406(3): 459-463.

     

    Lee KM, Choi WJ, Lee Y, Lee HJ, Zhao LX, Lee HW, Park JG, Kim HO, Hwang KY , Heo YS, Choi S, Jeong LS. X-ray Crystal Structure and Binding Mode Analysis of Human S-Adenosylhomocysteine Hydrolase Complexed with Novel Mechanism-Based Inhibitors, Haloneplanocin A Analogues. J Med Chem . 2011. Feb 24;54(4):930-938.

     

    Kim KH, Ha BH, Kim SJ, Hong SK, Hwang KY , Kim EE.

    Crystal Structures of Enoyl-ACP Reductases I (FabI) and III (FabL) from B. subtilis. J Mol Biol . 2011 Feb 25;406(3):403-15.

     

    Kim MJ, Lee BC, Jeong J, Lee KJ, Hwang KY , Gladyshev VN, Kim HY.

    Tandem use of selenocysteine: adaptation of a selenoprotein glutaredoxin for reduction of selenoprotein methionine sulfoxide reductase. Mol Microbiol . 2010 Dec 14.

     

    2010

     

    Lee YR, Park JH, Hahm SH, Kang LW, Chung JH, Nam KH, Hwang KY , Kwon IC, Han YS. Development of bimolecular fluorescence complementation using Dronpa for visualization of protein-protein interactions in cells. Mol Imaging Biol . 2010 Oct;12(5):468-78.

     

    Nam KH,Park SH, Lee WH, Hwang KY* Biochemical and structural analysis of hormone-sensitive lipase homolog EstE7: Insight into the stabilized dimerization of HSL-homolog proteins

    Bull.Kor.Chem.Soc. 2010 31(9). 2627-2632.

     

    Priyadarshi A, Roy A, Kim KS, Kim EE, Hwang KY* Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol. Biochem Biophys Res Commun . 2010 Apr 9;394(3):515-21.

     

    Kawai F, Clarke TB, Roper DI, Han GJ, Hwang KY , Unzai S, Obayashi E, Park SY, Tame JR.

    Crystal Structures of Penicillin-Binding Proteins 4 and 5 from Haemophilus influenzae.

    J Mol Biol. 2010 Feb 26;396(3):634-645.

     

    Priyadarshi A, Kim EE, Hwang KY*

    Structural insights into S. aureus Enoyl-ACP Reductase (FabI), in complex with NADP and Triclosan. Proteins. 2010 . Feb 1;78(2):480-6.

     

    Nam KH, Lee WH, Rhee KH, Hwang KY* .

    Structural characterization of bifunctional glucanase-xylanase CelM2 reveals the metal effect and substrate-binding moiety. Biochem Biophys Res Commun. 2010. Jan 22;391(4):1726-30.

     

    Nam KH, Sung MW, Hwang KY*

    Structural insight into the substrate recognitnion properties of beta-glucosidase.

    Biochem Biophys Res Commun. 2010. Jan 1;391(1):1131-5.

     

    Nam KH, Xu Y, Piao S, Priyadarshi A, Lee EH, Kim HY, Jeon YH, Ha NC, Hwang KY*

    Crystal structure of bacterioferritin from R. sphaeroides.

    Biochem Biophys Res Commun. 2010. Jan 1;391(1):990-4.

     

     

    2009

     

    Nam KH, Kim SJ, Priyadarshi A, Kim HS, Hwang KY* The crystal structure of an HSL-homolog EstE5 complex with PMSF reveals a unique configuration that inhibits the nucleophile Ser144 in catalytic triads.

    Biochem Biophys Res Commun. 2009 Nov 13;389(2):247-50.

     

    Priyadarshi A, Kim EE, Hwang KY* Structural and functional analysis of Vitamin K2 synthesis protein MenD.

    Biochem Biophys Res Commun. 2009 Oct 30;388(4):748-51. Epub 2009 Aug 22.

     

    Lee EH, Nam KH. Hwang KY* Cloning, purification and preliminary X-ray crystallographic analysis of a hypothetical protein, MJ0754, from Methanococcus jannaschii DSM 2661.

    Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10):1065-7.

     

    Priyadarshi A, Lee EH, Sung MW, Nam KH, Lee WH, Kim EE, Hwang KY* Structural insights into the alanine racemase from Enterococcus faecalis.

    Biochim Biophys Acta. 2009 Jul;1794(7):1030-40

     

    Park SH, Kwon SJ, Lee SJ, Kim YC, Hwang KY , Kang YH, Lee KJ.

    Identification of Immunogenic Antigen Candidate for Chlamydophila pneumoniae Diagnosis.

    J Proteome Res . 2009. Jun;8(6):2933-43.

     

    Xu Y, Sim SH, Nam KH, Jin XL, Kim HM, Hwang KY , Lee K, Ha NC.

    Crystal structure of the periplasmic region of MacB, a noncanonic ABC transporter.

    Biochemistry . 2009. Jun 16;48(23):5218-25.

     

    Kim YK, Shin YJ, Lee WH, Kim HY, Hwang KY*

    Structural and Kinetic Analysis of an MsrA-MsrB Fusion Protein from Streptococcus pneumoniae.

    Mol Microbiol. 2009. May;72(3) 699-709.

     

    Nam KH, Kim SJ, Hwang KY* Crystal structure of CelM2, a bifunctional glucanase-xylanase protein from a metagenome library. Biochem Biophys Res Commun. 2009 May 29;383(2):183-6.

     

    Nam KH, Kim KH, Kim EE, Hwang KY* Crystal structure of an EfPDF complex with Met-Ala-Ser based on crystallographic packing. Biochem Biophys Res Commun. 2009 Apr 17;381(4):630-3.

     

    Priyadarshi A, Saleem Y, Nam KH, Kim KS, Park SY, Kim EE, Hwang KY* Structural insights of the MenD from Escherichia coli reveal ThDP affinity. Biochem Biophys Res Commun. 2009 Mar 20;380(4):797-801.

     

    Nam KH, Kim MY, Kim SJ, Priyadarshi A, Kwon ST, Koo BS, Yoon SH, Hwang KY* Structural and functional analysis of a novel hormone-sensitive lipase from a metagenome library.

    Proteins. 2009 Mar;74(4):1036-40.

     

    Nam KH, Kim MY, Kim SJ, Priyadarshi A, Lee WH, Hwang KY* Structural and functional analysis of a novel EstE5 belonging to the subfamily of hormone-sensitive lipase.

    Biochem Biophys Res Commun. 2009 Feb 6;379(2):553-6.

     

    Nam KH, Ham JI, Priyadarshi A, Kim EE, Chung N, Hwang KY* Insight into the antibacterial drug design and architectural mechanism of peptide recognition from the E. faecium peptide deformylase structure. Proteins. 2009 Jan;74(1):261-5.

     

     

    2008

     

    Priyadarshi A, Nam KH, Kim EE, Hwang KY* Crystallization and preliminary X-ray crystallographic analysis of the probable tRNA-modification GTPase (TrmE) from Staphylococcus aureus.

    Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec 1;64(Pt 12):1166-8.

     

    Bong SM, Moon JH, Nam KH, Lee KS, Chi YM, Hwang KY* Structural studies of human brain-type creatine kinase complexed with the ADP-Mg(2+)-NO(3-)-creatine transition-state analogue complex.

    FEBS Lett. 2008 Nov 26;582(28):3959-65.

     

    Nam KH, Kim SJ, Kim MY, Kim JH, Yeo YS, Lee CM, Jun HK, Hwang KY* Crystal structure of engineered beta-glucosidase from a soil metagenome. Proteins. 2008 Nov 15;73(3):788-93.

     

    Kim JH, Sung MW, Lee EH, Nam KH, Hwang KY* Crystallization and preliminary X-ray diffraction analysis of 5,10- methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum DSM 1728.

    J Microbiol Biotechnol. 2008 Feb;18(2):283-6.

     

    Park AK, Shin YJ, Moon JH, Kim YK, Hwang KY , Chi YM.

    Overexpression, purification, and preliminary X-ray crystallographic studies of methionine sulfoxide reductase B from Bacillus subtilis. J Microbiol Biotechnol. 2008 Jan;18(1):59-62.

     

    Priyadarshi A, Lee EH, Sung MW, Kim JH, Ku MJ, Kim EE, Hwang KY* Overexpression, crystallization, and preliminary X-ray crystallographic analysis of the alanine racemase from Enterococcus faecalis v583. J Microbiol Biotechnol. 2008 Jan;18(1):55-8.

     

     

    2007

     

    Ahn WS, Ahn JY, Jung CH, Hwang KY , Kim EE, Kim J, Im H, Kim JO, Yu MH, Lee C.

    Optimization of expression conditions for soluble protein by using a robotic system of multi-culture vessels.

    J Microbiol Biotechnol. 2007 Nov;17(11):1868-74.

     

    Kim YK, Mizutani K, Rhee KH, Nam KH, Lee WH, Lee EH, Kim EE, Park SY, Hwang KY.

    Structural and mutational analysis of tRNA intron-splicing endonuclease from Thermoplasma acidophilum DSM 1728: catalytic mechanism of tRNA intron-splicing endonucleases.

    J Bacteriol. 2007 Nov;189(22):8339-46.

     

    Kim KH, Bong YJ, Park JK, Shin KJ, Hwang KY , Kim EE.

    Structural basis for glutamate racemase inhibition.

    J Mol Biol. 2007 Sep 14;372(2):434-43. Epub 2007 May 10.

     

    Lee WH, Kim YK, Nam KH, Priyadarshi A, Lee EH, Kim EE, Jeon YH, Cheong C, Hwang KY .

    Crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes.

    Proteins. 2007 Sep 1;68(4):1016-9.

     

    Nam KH, Kwon OY, Sugiyama K, Lee WH, Kim YK, Song HK, Kim EE, Park SY, Jeon H, Hwang KY.

    Structural characterization of the photoswitchable fluorescent protein Dronpa-C62S.

    Biochem Biophys Res Commun. 2007 Mar 23;354(4):962-7.

     

     

    2006

     

    Rhee KH, Nam KH, Lee WH, Ko YG, Kim EE, Hwang KY.

    Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-.

    Protein Pept Lett. 2006;13(9):945-9.

     

    Lee KS, Park SM, Rhee KH, Bang WG, Hwang KY , Chi YM.

    Crystal structure of fatty acid-CoA racemase from Mycobacterium tuberculosis H37Rv.

    Proteins. 2006 Aug 15;64(3):817-22.

     

     

    2005

     

    Rhee KH, Lee KS, Priyadarshi A, Kim EE, Hwang KY.

    Crystallization and preliminary X-ray crystallographic studies of fatty acid-CoA racemase from Mycobacterium tuberculosis H37Rv.

    Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt 11):1017-9.

     

    Lee HK, Rhee KH, Kim CW, Hwang KY , Kim EE.

    Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3.

    Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Sep 1;61(Pt 9):831-3.

     

    Ku MJ, Lee WH, Nam KH, Rhee KH, Lee KS, Kim EE, Yu MH, Hwang KY.

    Crystallization and preliminary X-ray crystallographic analysis of the tRNA-specific adenosine deaminase from Streptococcus pyogenes.

    Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt 4):375-7.

     

    Lee KS, Park SM, Hwang KY, Chi YM.

    Crystallization and preliminary X-ray crystallographic studies of glutamate racemase from Lactobacillus fermenti.

    Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Feb 1;61(Pt 2):199-201.

     

     

    2004

     

    Heo YS, Kim SK, Seo CI, Kim YK, Sung BJ, Lee HS, Lee JI, Park SY, Kim JH, Hwang KY , Hyun YL, Jeon YH, Ro S, Cho JM, Lee TG, Yang CH.

    Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

    EMBO J. 2004 Jun 2;23(11):2185-95.

     

     

    2003

     

    Sung BJ+, Hwang KY+ , Jeon YH+, Lee JI, Heo YS, Kim JH, Moon J, Yoon JM, Hyun YL, Kim E, Eum SJ, Park SY, Lee JO, Lee TG, Ro S, Cho JM.

    34: Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. Nature. 2003 Sep 4;425(6953):98-102. (+Co-first)

     

     

    2002

     

    Im H, Woo MS, Hwang KY, Yu MH.

    Interactions causing the kinetic trap in serpin protein folding.

    J Biol Chem. 2002 Nov 29;277(48):46347-54.

     

    Heo YS, Ryu JM, Park SM, Park JH, Lee HC, Hwang KY+, Kim J+.

    Structural basis for inhibition of protein tyrosine phosphatases by Keggin compounds phosphomolybdate and phosphotungstate.

    Exp Mol Med. 2002 Jul 31;34(3):211-23. (+Co-corresponding)

     

    Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY .

    Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. J Biol Chem. 2002 Nov 29;277(48):46651-8.

     

    Chang JH, Kim HC, Hwang KY , Lee JW, Jackson SP, Bell SD, Cho Y.

    Structural basis for the NAD-dependent deacetylase mechanism of Sir2.

    J Biol Chem. 2002 Sep 13;277(37):34489-98.

     

     

    2000

     

    Lee JY, Kim HK, Chang C, Eom SH, Hwang KY , Cho Y, Yu YG, Ryu SE, Kwon ST, Suh SW.

    Crystallization and preliminary x-ray crystallographic analysis of NAD+-dependent DNA ligase from Thermus filiformis. Acta Crystallogr D Biol Crystallogr. 2000 Mar;56(Pt 3):357-8.

     

     

     

    ~1999

     

    Hwang KY , Chung JH, Kim SH, Han YS, Cho Y.

    Structure-based identification of a novel NTPase from Methanococcus jannaschii.

    Nat Struct Biol. 1999 Jul;6(7):691-6.

     

    Hwang KY , Cho CS, Kim SS, Sung HC, Yu YG, Cho Y.

    Structure and mechanism of glutamate racemase from Aquifex pyrophilus.

    Nat Struct Biol. 1999 May;6(5):422-6.

     

    Kim SY, Hwang KY , Kim SH, Sung HC, Han YS, Cho Y.

    Structural basis for cold adaptation. Sequence, biochemical properties, and crystal structure of malate dehydrogenase from a psychrophile Aquaspirillium arcticum.

    J Biol Chem. 1999 Apr 23;274(17):11761-7.

     

    Bae KW, Baek KW, Cho CS, Hwang KY , Kim HR, Sung HC, Cho Y.

    Expression, purification, characterization and crystallization of flap endonuclease-1 from Methanococcus jannaschii.

    Mol Cells. 1999 Feb 28;9(1):45-8.

     

    Hwang KY, Cho CS, Kim SS, Baek K, Kim SH, Yu YG, Cho Y.

    Crystallization and preliminary x-ray analysis of glutamate racemase from Aquifex pyrophilus, a hyperthermophilic bacterium.

    Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):927-8.

     

    Hwang KY , Baek K, Kim HY, Cho Y.

    The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.

    Nat Struct Biol. 1998 Aug;5(8):707-13.

     

    Lee JY, Min K, Cha H, Shin DH, Hwang KY , Suh SW.

    Rice non-specific lipid transfer protein: the 1.6 A crystal structure in the unliganded state reveals a small hydrophobic cavity.

    J Mol Biol. 1998 Feb 20;276(2):437-48.

     

    Kim KK, Song HK, Shin DH, Hwang KY , Choe S, Yoo OJ, Suh SW.

    Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha/beta hydrolase with broad substrate specificity.

    Structure. 1997 Dec 15;5(12):1571-84.

     

    Hwang KY , Song HK, Chang C, Lee J, Lee SY, Kim KK, Choe S, Sweet RM, Suh SW.

    Crystal structure of thermostable alpha-amylase from Bacillus licheniformis refined at 1.7 A resolution.

    Mol Cells. 1997 Apr 30;7(2):251-8.

     

    Kim KK, Song HK, Shin DH, Hwang KY , Suh SW.

    The crystal structure of a triacylglycerol lipase from Pseudomonas cepacia reveals a highly open conformation in the absence of a bound inhibitor.

    Structure. 1997 Feb 15;5(2):173-85.

     

    Shin DH, Lee JY, Hwang KY , Kim KK, Suh SW.

    High-resolution crystal structure of the non-specific lipid-transfer protein from maize seedlings.

    Structure. 1995 Feb 15;3(2):189-99.

     

    Cheong CG, Eom SH, Chang C, Shin DH, Song HK, Min K, Moon JH, Kim KK, Hwang KY , Suh SW.

    Crystallization, molecular replacement solution, and refinement of tetrameric beta-amylase from sweet potato.

    Proteins. 1995 Feb;21(2):105-17.

     

    Song HK, Hwang KY , Kim KK, Suh SW.

    Crystallization and preliminary X-ray crystallographic study of ribosome-inactivating protein from barley seeds.

    Acta Crystallogr D Biol Crystallogr. 1994 Nov 1;50(Pt 6):910-2.

     

    Shin DH, Hwang KY , Kim KK, Kim S, Sweet RM, Suh SW.

    Crystallization and preliminary X-ray crystallographic analysis of phospholipid transfer protein from maize seedlings.

    Proteins. 1994 May;19(1):80-3.

     

    Song HK, Hwang KY , Kim KK, Suh SW.

    Crystallization and preliminary X-ray crystallographic analysis of chitinase from barley seeds.

    Proteins. 1993 Sep;17(1):107-9.

     

    Kim KK, Hwang KY , Jang WH, Lee H, Yoo OJ, Choi MU, Suh SW.

    Crystallization and preliminary X-ray crystallographic analysis of carboxylesterase from pseudomonas fluorescens.

    Arch Biochem Biophys. 1993 May;302(2):417-9.

     

    Shin DH, Hwang KY , Kim KK, Lee HR, Lee CS, Chung CH, Suh SW.

    Crystallization and preliminary X-ray crystallographic analysis of the protease inhibitor ecotin.

    J Mol Biol. 1993 Feb 20;229(4):1157-8.

     

    Kim KK, Hwang KY , Choi KD, Kang JH, Yoo OJ, Suh SW.

    Crystallization and preliminary X-ray crystallographic analysis of arylesterase from Pseudomonas fluorescens.

    Proteins. 1993 Feb;15(2):213-5.

     

    Hwang KY , Kim KK, Min K, Eom SH, Yu YG, Kim S, Sweet RM, Suh SW.

    Crystallization and preliminary X-ray crystallographic analysis of probable amylase/protease inhibitor-B from rice seeds.

    J Mol Biol. 1993 Jan 5;229(1):255-7.

     

    Chang C, Kim KK, Hwang KY , Choi MU, Suh SW.

    Crystallization and preliminary X-ray crystallographic analysis of alpha-amylase from Bacillus subtilis.

    J Mol Biol. 1993 Jan 5;229(1):235-8.

     

    Kim KK, Hwang KY, Jeon HS, Kim S, Sweet RM, Yang CH, Suh SW.

    Crystallization and preliminary X-ray crystallographic analysis of lipase from Pseudomonas cepacia.

    J Mol Biol. 1992 Oct 20;227(4):1258-62.

     

  • Research

     

    Lab Profile
     

    Proteomics, the study of protein characteristics and functions, is one of the most exciting and dynamic areas of biological research today, because it offers accessible approaches to a wide spectrum of research fields. Three dimensional structures are key element in understanding biological processes and play a central role in the discovery of new lead drugs. Due to the discovery of functional genomics, many potential drug targets are identified at tremendously fast speed. Our laboratory is focusing on the understanding the molecular mechanism of potential drug targets and nucleotide binding proteins based on the structural information. In addition we would like to extend our research to annotate the unknown proteins using functional proteomics. We would like to identify new potential drug targets using integrative-proteomics technologies.

     

     

    Research Projects

     

    Disease-related Proteins

    Aminoacyl-tRNA Synthetase Family

    Methionin-Sulfoxide-Reductases Family

    DNA/RNA binding Proteins

    Transcription Factors

    Recombinase Family

    Virus-Host interaction Proteins

    Herpesviridae, SFTS

    Malaria Proteins

     

     

    Research Scheme

     

     research scheme

  • Teaching

    준비 중입니다.

  • Lab Members

              

    Research Professor

    Dr. Woo-Chul Lee

    wclee3@korea.ac.kr

    Post-Doc

    Dr. Eun-Hye Lee

    ksmeeteh @hanmail.net

    Ph.D Course

    Eun-Hwa Hwang / @ KBSI

    hwang0131@kbsi.re.kr

    Seung-Kon Hong / @ KIST

    biyah@hanmail.net

    Hyun-Sook Kim

    k970329@hanmail.net

    Ah-Reum Han   / @ NWU

    woohut07@korea.ac.kr

    Chang-Hwa Jo

    bluebird5208@hanmail.net

    Ki-taik Lee

    kitaeque@gmail.com

    Jun-Soo Kim

    fuwa1202@naver.com

    Jong-hyun Son

    tuutoo@naver.com

    Hyun-Tae Kim / @ CGI

    htkim@cgxinc.com

    Min-Hwan Jeong   / @ LG

    mhjunge@daum.net

    MS Course

    June-Hye Moon   / @ CDC

    june_moon@hanmail.net

    Seol-Min Ko

    sulmin2002@nate.com

    So-Young Cha

    asdfjkl116@naver.com

    Seol-Hee Kim

    sulhee@korea.ac.kr  

    Ji-Ae Shin

    shinklove@korea.ac.kr

    Nan-Kyeong Lee / @ SNUH

    81119@snuh.org

    Su-Jin Choi / @ SNUH

    csj6692@hanmail.net