연구실 : 고려대학교 생명과학관 서관 504호 (Tel. 02-3290-3047)

 

식물약학실험실 : 고려대학교 생명과학관 서관 L508호 (Tel. 02-3290-3511)

Education

 

1993 - 1998   Ph. D. ,Major in Plant Pathology and Natural Product Chemistry,  College of Natural Resources, Korea University, Seoul, Korea.

1991 - 1993    M.S., College of Natural Resources, Korea University, Seoul, Korea.

1987 - 1991    B.S.,  Department of Agricultural Biology, College of Natural Resources, Korea University, Seoul, Korea

 

Professional Experience

• 2011.12-2012.8, Vice Dean, College of Life Sciences and Biotechnology , Korea University, Seoul, Korea

•  

• 2005.9 - present, Associate Professor, College of Life Sciences and Biotechnology, Korea University, Seoul, Korea

   

• 2003.7.-2005.9, Senior Research Scientist, Division of Bio-Drug Discovery, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

   

• 2000.3-2003.7, Research Scientist,Institute for Structural Biology and Drug Discovery, Department of Medicinal Chemistry, Medical College of Virginia, , Virginia, USA,

   

• 1995.2-2000.2, Research Associate, Institute of Natural Resources and Environment, Seoul, Korea                                               

                    

Academic service

2014~                      Editor in Plos One

2008~2010              Editor in Plant Pathology Journal (SCIE)

2008~2011              Editor in Journal of Microbiology and Biotechnology (SCIE)

2007~                      Chairman, Commission of GMO (Genetically Modified Organisms) in the Ministry of Environment, Korea

 

국제학술지

 

Jae-Woo Han, Jeong-Do Kim, Jung-Min Lee, Jong-Hyun Ham, Dongho Lee and Beom-Seok Kim. 2014. Structural elucidation and antimicrobial activity of new phencomycin derivatives isolated from Burkholderia glumae strain 411gr-6. 67(10):721-723

 

Dong Wan Lee, Jin-Sung Hong, Sun-Hyung Kim, Jin Won Kim and Beom Seok Kim. 2014. First report of Pseudomonas lurida causing bacterial leaf spot on Miscanthus sinensis. Journal of Phytopathology 162:195-200

 

Mee Kyung Sang, Hye-Sook Kim, Inn-Shik Myung, Choong-Min Ryu, Beom Seok Kim, Ki Deok Kim. 2013. Chryseobacterium kwangjuense sp. nov., isolatedfrom pepper (Capsicum annuum L.) root. International Journal of Systematic and Evolutionary Microbiology 63: 2835-2840.

 

Nak Hyun Kim, Beom Seok Kim, Byung Kook Hwang. 2013. Pepper arginine decarboxylase is required for polyamine and γ-aminobutyric acid signaling in cell death and defense response. Plant Physiology.162: 2067-2083

 

Jaejung Lee, Joo-Hyun Hong,Jeong-Do Kim,Byoung Jun Ahn, Beom Seok Kim, Gyu-Hyeok Kim, Jae-Jin Kim. 2013. The antioxidant properties of solid-culture extracts of basidiomycetous fungi. Journal of General and Applied Microbiology 59:279-285

 

Hye Yoon Kim, Jeong Do Kim, Jin Sung Hong, Jong Hyun Ham and Beom Seok Kim. 2013. Identification of antifungal niphimycin from Streptomyces sp. KP6107 by screening based on adenylate kinase assay. Journal of Basic Microbiology 53:581-589

 

Eun Young Kim, Jae Woo Han, Jee Yeon Lee, and Beom Seok Kim. 2012. Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus. Folia Microbiol. 57:543-550.

 

Hari S. Karki Bishnu K. Shrestha, Jae Woo Han, Donald E. Groth, Inderjit K. Barphagha, Milton C. Rush, Rebecca A. Melanson, Beom Seok Kim, and Jong Hyun Ham. 2012. Diversities in virulence, antifungal activity, pigmentation and DNA fingerprint among strains of Burkholderia glumae. PLos One 7(9) e45376. doi:10.1371/journal.pone.0045376.

 

Ju Yeon Song, Hyun A Kim, Ji-Seoung Kim, Seon-Young Kim, Haeyoung Jeong, Sung Gyun Kang, Byung Kwon Kim, Soon-Kyeong Kwon, Choong Hoon Lee, Dong Su Yu, Beom Seok Kim, Sun-Hyung Kim, Suk Yoon Kwon, and Jihyun F. Kim. 2012. Genome sequence of the plant growth-promoting rhizobacterium Bacillus sp. strain JS. Journal of Bacteriology 194:3760-3761

 

Jaejung Lee, Nayoon Huh, Joo Hyun Hong, Beom Seok Kim, Gyu-Hyeok Kim and Jae-Jin Kim. 2012. The antagonistic properties of Trichoderma spp. inhabiting woods for potential biological control of wood-damaging fungi. Holzforschung 66:883-887.

 

Jae Woo Han, Eun Young Kim, Jung Min Lee, Yun Sung Kim, Eunjung Bang, Beom Seok Kim. 2012. Site-directed modification of the adenylation domain of the fusaricidin nonribosomal peptide synthetase for enhanced production of fusaricidin analogs. Biotechnol Lett. 34:1327–1334.

 

Chae Woo Lima, Jung-Hyun Kim, Woonhee Baek, Beom Seok Kim, Sung Chul Lee. 2012. Functional roles of the protein phosphatase 2C, AtAIP1, in abscisic acid signaling and sugar tolerance in Arabidopsis. Plant Science 187:83-88.

 

Jeong Do Kim, Jae Woo Han, In Cheon Hwang, Dongho Lee and Beom Seok Kim 2012. Identification and biocontrol efficacy of Streptomyces miharaensis producing filipin III against Fusarium wilt. Journal of Basic Microbiology 2012, 52, 150–159.

 

Jeong Do Kim, Jae Woo Han, Sung Chul Lee, Dongho Lee, In Cheon Hwang, and Beom Seok Kim. 2011. Disease Control Effect of Strevertenes Produced by Streptomyces psammoticus against Tomato Fusarium Wilt. Journal of Agricultural and Food Chemistry 59:1893-1899.

 

Sarita Paudel, Hei Chan Lee, Beom Seok Kim, Jae Kyung Sohng. 2011. Enhancement of pradimicin production in Actinomadura hibisca P157-2 by metabolic engineering. Microbiological Research 167:32– 39.

 

Je Won Park, Sung Ryeol Park, Ah Reum Han, Yeon Hee Ban, Young Ji Yoo, Eunji Kim, Beom Seok Kim, Jae Kyung Sohng, Yeo

 

Joon Yoon. 2011. Characterization and identification of pradimicin analogs from Actinomadura hibisca using liquid chromatography–tandem mass spectrometry. Journal of Chromatography A, 1218: 2284–2291

 

Mee Kyung Sang, Jeong Do Kim, Beom Seok Kim, Ki Deok Kim 2011. Root treatment with Rhizobactria antagonistic to Phytophthora Blight affects anthracnose occurrence, ripening, and yield of pepper fruit in the plastic house and field. Phytopathology 101(6):666-678.

 

Lee, Jung-Sook, Keun Chul Lee, Kwang Kyu Kim, In Cheon Hwang, Cheol Jang, Nam Gyu Kim, Woon Hyung Yeo, Beom Seok Kim, Yong Man Yu, and Jong Seog Ahn. 2009. Acinetobacter antiviralis sp. nov., from tobacco plant roots. J. Microbiol. Biotechnol. 19(3):250-256.

 

Gupta S, Lakshmanan V, Beom Seok Kim, Fecik R, Reynolds KA. 2008. Generation of novel pikromycin antibiotic products through mutasynthesis. Chembiochem. 9(10):1609-1616.

Cheol Nam Park, Jung Min Lee, Dongho Lee, Beom Seok Kim. 2008. Antifungal activity of valinomycin, a peptide antibiotic produced by Streptomyces sp strain M10 antagonistic to Botrytis cinerea. Journal of Microbiology and Biotechnology 18(5):1017-7825

 

Yun Sung Kim, Hyeong Min Kim, Cheol Chang, In Cheon Hwang, Hyuncheol Oh, Jong Seog Ahn, Ki Deok Kim, Byung Kook Hwang, Beom Seok Kim. 2007 Biological evaluation of neopeptins isolated from a Streptomyces strain. Pest Management Science 63(12):1208-1214.

 

Beom Seok Kim and Byung Kook Hwang 2007. Microbial fungicides in the control of plant disease. Journal of Phytopathology, 155:641-653.

 

Cheol Nam Park, Dong-Ho Lee, Young-Soo Hong, Jong Seog Ahn, and Beom Seok Kim 2007. Antifungal activity of salaceyin A against Colletotrichum orbiculare and Phytophthora capsici. Journal of Basic Microbiology 47:332-339.

 

Byung Chul Kim, Jung Min Lee, Jong Seog Ahn, and Beom Seok Kim 2007. Cloning, sequencing, and characterization of the pradimicin biosynthetic gene cluster of Actinomadura hibisca P157-2. Journal of Microbiology and Biotechnology, 17:830-839.

 

B.S. Kim, S.Y. Kim, J. Park, W. Park, K.Y. Hwang, Y.J. Yoon, W.K. Oh, B.Y. Kim, J.S. Ahn 2007. Sequence-based screening for self-sufficient P450 monooxygenase from a metagenome library. Journal of Applied Microbiology, 102:1392-1400.

 

D. Kim, J.S. Lee, Y.K. Park, J.F. Kim, H. Jeong, T.-K. Oh, B.S. Kim and C.H. Lee 2007. Biosynthesis of antibiotic prodiginines in the marine bacterium Hahella chejuensis KCTC 2396. Jouranl of Applied Microbiology, 102:937-944.

 

Nahyun Kim, Jin Chul Shin, Woncheol Kim, Bang Yeon Hwang, Beom Seok Kim, Young-Soo Hong, and Dongho Lee 2006. Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi. Journal of Antibiotics 59(12): 797-800.

 

Kim, Dockyu , Yon Kyoung Park , Jong Suk Lee , Jihyun F. Kim , Haeyoung Jeong , Beom Seok Kim, and Choong Hwan Lee. 2006. Analysis of a prodigiosin biosynthetic gene cluster from the marine bacterium Hahella chejuensis KCTC 2396. J. Microbiol. Biotechnol. 16(12):1912-1918

 

Young Hoon Kim, Yunho Lee, Saehun Kim, Jinki Yeom, Sujin Yeom, Beom Seok Kim, Sangnam Oh, Sungsu Park, Che Ok Jeon, Woojun Park 2006. The role of periplasmic antioxidant enzymes (superoxide dismutase and thiol peroxidase) of the Shiga toxin-producing Escherichia coli O157:H7 in the formation of biofilms. Proteomics 6: 6181-6193.

 

Lee SK, Park JW, Kim JW, Jung WS, Park SR, Choi CY, Kim ES, Kim BS, Ahn JS, Sherman DH, Yoon YJ. 2006. Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae. J. Nat. Prod.  69(5):847-849. 

 

Park HJ, Lee JY, Hwang IS, Yun BS, Kim BS, Hwang BK. 2006. Isolation and antifungal and antioomycete activities of staurosporine from Streptomyces roseoflavus strain LS-A24. J. Agric. Food. Chem. 54(8):3041-3046.

 

Na M, Yang S, He L, Oh H, Kim BS, Oh WK, Kim BY, Ahn JS. 2006. Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata. Planta Medica 72(3):261-3. 

 

Hyo Jin Kim, In Sun Hwang, Beom Seok Kim and Byung Kook Hwang 2006. Isolation and in vitro and in vivo antifungal activity of phenylacetic acid produced by Micromonospora aurantiaca strain JK-1. Plant Pathol. J. 22(1):75-89.

 

Sang Kil Lee, Young Shin Ryu, Jay Sung Joong Hong, Devi B. Basnet, Won Seok Jung, Cha Yong Choi, Hei Chan Lee, Jae Kyung Sohng, Keun Garp Ryu, Byung Gee Kim, Beom Seok Kim, Jong Seog Ahn, David H. Sherman, and Yeo Joon Yoon. 2005. Structural diversification of macrolactones by substrate-flexible cytochrome P450 monooxygenases.  Adv. Synt. Biocatalysis 347:1369-1378

 

Bo Yeon Kim, Kyung A.Kim, Osong Kwon, Sun Ok Kim, Min Soo Kim, Beom Seok Kim, Won Keun Oh, Gun Do Kim, Mira Jung and Jong Seog Ahn, 2005. NF-kB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation. Carcinogenesis 26(8):1395—1403.

 

Won Keun Oh, Bo Yeon Kim, Hyuncheol Oh, Beom Seok Kim, Jong Seog Ahn 2005. Phospholipase Cγ1 inhibitory activities of prenylated flavonoids isolated from Erythrina senegalensis. Planta Medica 71: 780-782.

 

Han YM, Oh H, Na M, Kim BS, Oh WK, Kim BY, Jeong DG, Ryu SE, Sok DE, Ahn JS 2005. PTP1B Inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza. Biol.Pharm.Bull. 28(9):1795-7.

 

Youn-Chul Kim, Hyuncheol Oh, Beom Seok Kim, Tai-Hyun Kang, Eun-Kyung Ko, Yu Mi Han, Bo Yeon Kim, Jong Seog Ahn. 2005. In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia. Planta Medica 71-87-89.

 

Sang Joon Mo, Beom Seok Kim, Kevin A. Reynolds. 2005. Production of branched chain novel alkylprodiginines in Streptomyces coelicolor by replacement of the 3-ketoacyl ACP synthase III & II enzymes. Chemistry & Biology. 12:191-200.

 

Beom Seok Kim, Hyuncheol Oh, Sun Young Kim, Jeong Ah Park, Yeo Joon Yoon, Sang Kil Lee, Bo Yeon Kim and Jong Seog Ahn. 2005 Identification and antibacterial activity of a new oleandomycin derivative from Streptomyces antibioticus  Journal of Antibiotics . 58(3):196-201.

 

Won Keun Oh, Hyuncheol Oh, Bo Yeon Kim, Beom Seok Kim, and Jong Seog Ahn 2004. CRM-51006, a new phospholipase C (PLC) inhibitor, produced by unidentified fungal strain MT51005. Journal of Antibiotics 57(12):808-811

 

Oh H., Bae, E.Y., Beom Seok Kim, et al. 2004. A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme. Planta Medica 70(9):869-870

 

Beom Seok Kim, David H. Sherman, and Kevin A. Reynolds. 2004. An efficient method fo creation and functional analysis of libraries of hybrid type I polyketide synthases. Protein Engineering 17(3) 277-284. Oxford Press

 

Hyuncheol Oh, Beom Seok Kim, Eun Youn Bae, Min Soo Kim, Hyang Burm Lee, Chang-Jin Kim, and Jong Seog Ahn. 2004. Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232. J. Antibiotics 57(8):528-531.

 

Beom Seok Kim and Byung Kook Hwang. 2003. Biofungicides from microbial metabolites. In Handbook of Fungal Biotechnology, D.K. Arora (Ed),. Marcel & Decker, New York. ISBN:0-8247-4018-1

 

Nadaraj Palaniappan, Beom Seok Kim, Yasuyo Sekiyama, Hiroyuki Osada, and Kevin A. Reynolds, 2003. Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster. Journal of Biological Chemistry 278(37):25552-25557.

 

Beom Seok Kim, T. Ashton Cropp, Brian J. Beck, David H. Sherman, and Kevin A. Reynolds_2002. Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. Journal of Biological Chemistry 277(50)48028-48034

 

Beom Seok Kim, T. Ashton Cropp, Galina Florova, Yuko Lindsay, David H. Sherman, and Kevin A. Reynolds. 2002. An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis. Biochemistry 41:10827-10833. American Chemical Society

 

Yoon Y. J. Brian, B., Kim, B. S. Reynolds, K. A., and D. H. Sherman. 2002. Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chemistry & Biology 9:203-214. Elsevier Science

 

Cropp, A. T., Kim, B. S., Beck, B. J., Yoon, Y. J., Sherman, D. H., and Reynolds, K. A. 2002. Recent developments in the production of novel polyketides by combinatorial biosynthesis. Biotechnology and Genetic Engineering Reviews 19:159-172. Intercept Ltd. UK

 

Hwang, B. K. Lim S. W. Kim, B. S. Lee, J. Y., and Moon, S. S. 2001. Isolation and in vivo and in vitro antifungal activity of phenyl acetic acid and sodium phenyl acetate from Streptomyces humidus. J. of Applied and Environmental Microbiology 67:3739-3745. American Society for Microbiology

 

Lee, B. K., Kim, B. S., Chang S. W., and Hwang, B. K. 2001 Aggressiveness to pumpkin cultivars of isolates of Phytophthora capsici from pumpkin and pepper. Plant Disease 497-500. The American Phytopathological Society

 

Beom Seok Kim, Jung Yeop Lee, and Hwang, B. K. 2000. In vivo and in vitro antifungal activity of rhamnolipid B, a glycolipid antibiotic, against Phytophthora capsici and Colletotrichum orbiculare. Pest Management Science 56:1029-1053. Society of Chemical Industry, UK.

 

Beom Seok Kim, Seok Sik Moon, and Byung Kook Hwang, 2000. Structure elucidation and antifungal activity of an anthracycline antibiotic, daunomycin, isolated from Actinomadura roseola. Journal of Agricultural and Food Chemistry 48(5):1875-1881. American Chemical Society

 

Lim, S. W., Kim, J. D. Kim, B. S., Hwang, B. K. 2000. Isolation and numerical identification of Streptomyces humidus strain S5-55 antagonistic to plant pathogenic fungi. Plant Pathology J. 16(4):189-199

 

Kim, B. S., Lee, J. Y., and Hwang, B. K. 2000. Screening for Antifungal Compounds from Microbial Secondary Metabolites for Control of Plant Diseases. Researches in Natural Resources and Environment. 7:99-134.

 

Lee, J. Y., Kim, B. S, Lim, S. W., Lee, B. K., Kim, C. H., and Hwang, B. K. 1999. Field control of Phytophthora blight of pepper plants with antagonistic rhizobacteria and DL-b-amino-n-butyric acid. Plant Pathology J. 15(4):217-222.

 

Kim, B. S., Hwang, B. K., and Moon, S. S. 1999. Isolation, identification and antifungal activity of a macrolide antibiotic, oligomycin A, produced by Streptomyces libani. Canadian Journal of Botany 77(6): 850-858.

 

Kim, B. S., Hwang, B. K., and Moon, S. S. 1999. Isolation, antifungal activity, and structure elucidation of the glutarimide antibiotic, streptimidone, produced by Micromonospora coerulea. Journal of Agricultural and Food Chemistry 47(8): 3372-3380.

 

Kim, B. S., Lee, J. Y., and Hwang, B. K. 1998. Diversity of actinomycetes antagonistic to pathogenic fungi in cave and sea-mud soils of Korea. Journal of Microbiology 36(2):86-92.

 

 

Research Topic

미생물이 생산하는 미생물 이차 대사산물은 유기합성으로는 만들 수 없는 다양한 생물학적 활성을 지닌 다양한 화학적 구조를 가지고 있기 때문에 천연물을 이용한 살균제의 발견과 개발에 있어 새로운 화합물 구조와 다양한 생리활성 표적을 제공하는 중요한 역할을 하고 있습니다. 이와 더불어 미생물 대사산물은 농업환경에 노출되었을 때 한 달 또는 수일 만에 쉽게 분해되기 때문에 농업환경에서 잔류에 의한 부작용을 최소화함으로 환경 친화적이라는 장점을 가지고 있습니다. 또한 미생물은 대량 배양이 용이하며, 천연물 생산에 관련하는 유전자 연구가 상대적으로 발전되어 있어, 신규 살균제 개발 측면에 있어 다른 천연물 소재보다 유리하다는 점에서 그 중요성이 있습니다.

 

따라서 본 식물약학 연구실(Plant Pharmacology Lab.)에서는 천연물 연구 전략으로서 화학생물학(Chemical biology), 미생물 유전자 분석(Microbial genetic analysis)에 기반한 미생물 이차대사 산물 연구에 중점을 두고 있으며, 핵자기공명분광학(Nuclear magnetic resonance spectroscopy)을 비롯한 다양한 분광학, 분자생물학(Molecular biology)및 생화학(Biochemistry) 등의 다양한 학문을 바탕으로 미생물의 대사산물로부터 유용한 항진균활성 물질을 개발하여 식물 병원균에 방제 효과가 있는 천연 살균제의 개발을 목표로 천연물의 화학적 연구와 미생물 대사산물의 생합성 기구의 공학적 재설계에 관한 연구를 수행하고 있습니다.

 

방선균 유래 생리활성 물질 분리 정제 및 구조연구

 

미생물 유래 생리활성물질의 생합성 경로 및 생화학 공학연구

 

친환경 식물병 방제제 개발의 위한 생리활성 물질의 비독성 메카니즘 연구

LIBT256    식물의학개론

LIBT362    식물약학및실험

LIBT489    식물세균학및실험

LIST203    미생물학Ⅰ

LIST204    미생물학Ⅱ

 

BPH507   화학적식물병방제학

BPH551   살균제특론

BPH568   생리활성천연항균물질

 

내용을 입력해주세요