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고려대학교 교수소개

Knowledge & Innovation

생명과학대학

Home > 생명과학대학 >생명공학부

소개

Prof. 송권화

Tel: 02-3290-3012 (Lab: 3881)

E-mail: ghsong@korea.ac.kr

  • About Professor
  • Curriculum vitae
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile

    생명과학대학 생명공학부 생명과학대학 서관 310호 (Lab: 330호)

  • Curriculum

    Education 
      
     Ph.D. Texas A&M University, USA (Co-Advisors: Drs. Fuller W. Bazer & Thomas E. Spencer)   
     
     
     
    Professional Experiences  
      
    2014-present  Associate Professor, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea     
     
           
     
    2013-2014  Assistant Professor, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea     
     
          
     
    2009-2013  WCU Assistant Professor, WCU (World Class University) Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea     
     
          
    2007-2009  Postdoctoral Research Associate, Center for Animal Biotechnology and Genomics, Texas A&M University, USA        
     
     
     
     
    Professional Activities in Academic Associations          
     
    2014-present: Member, Grant Evaluation Committee, National Research Foundation of Korea    
     
    2015-present: Member, Associate Editor, Korean Society of Animal Science and Technology    
     
    2010-present: Member, Editorial Boards, Korean Society of Animal Reproduction    
     
    2009-present: Member, Editorial Boards, Korean Society of Poultry Science    
     
    2009-present: Member, Korean Society of Developmental Biology    
     
    2009-present: Member, Korean Society of Reproductive Medicine    
     
    2009-present: Member, Worlds Poultry Science Association    
     
    2014-present: Chairman, Treasure Committee, Korean Society of Poultry Science    
     
    2011-2013: Chairman, International Cooperation Committee, Korean Society of Poultry Science    
     
    2011-2013: Secretary, South Korean Branch of World's Poultry Science Association    
     
    2003-2008: Member, Texas Forum on Reproductive Science    
     
    2003-present: Member, Society for the Study of Reproduction    
     
        
     
     
    Organizing Committee Member for International Conference         
        
    “  Nutrition and Physical Activity in Aging, Obesity, and Cancer ”  (2012)     
     
    “  Biomodulation Symposium ”  (2011)         
     
    “  The 4th Special Biomodulation Symposium ”  (2011)     
     
    “  Germ Cell, Stem Cell and Reproductive Biology ”  (2009)     
     
          
     
    Honors & Awards        
     
    Best Grant Evaluator Award in Basic Research Program, National Research Foundation of Korea (2015)   
     
    Young Investigator for the Next Generation, Seoul National University (2012)    
     
    Dr. A.M.  “  Tony ”  Sorensen, Jr. Achievement Award, Texas A&M University (2007)     
     
    Outstanding Oral Presentation in the Texas Forum on Reproductive Sciences (2006)    
     
    The 2nd-placewinner in Trainee Research Competition, Society for the Study of Reproduction, 39th Annual Meeting (2006)    
     
    USDA-NRI Travel Fellow, Society for the Study of Reproduction, 39th Annual Meeting (2006)    
     
    Graduate Research and Presentation Grant Recipient, Texas A&M University (2005)
     

     

  • Publication

    [2016]      
     

    Lim W, Jeong M, Bazer FW, Song G*. Coumestrol Inhibits Proliferation and Migration of Prostate Cancer Cells by Regulating AKT, ERK1/2 and JNK MAPK Cell Signaling Cascades. Journal of Cellular Physiology. 2016 (in press) *corresponding author

     

     

     

     

    Lim W, Song G*. Inhibitory Effects of Delphinidin on Proliferation of Ovarian Cancer Cells via PI3K/AKT and ERK1/2 MAPK Signal Transduction. Oncology Letters. 2016 (in press) *corresponding author

     

     

     

     

    Lim W, Bae H, Song G*. Differential Expression of Apolipoprotein D in Male Reproductive System of Rats by High-Fat Diet. Andrology. 2016 (in press) *corresponding author

     

     

     

     

    Lim W, Yang C, Bazer FW, Song G*. Induction of Apoptosis in Human Choriocarcinoma JEG-3 Cells by Chrysophanol through Regulation of Excessive Oxidative Stress and Activation of the AKT and ERK1/2 Pathways. Journal of Cellular Physiology. 2016 (in press) *corresponding author

     

     

     

     

    Lim W, Song G*. Characteristics, Tissue-Specific Expression and Hormonal Regulation of Expression of Tyrosine Aminotransferase in the Avian Female Reproductive Tract. Domestic Animal Endocrinology. 2016 (in press) *corresponding author

     

     

     

     

    Lim W, Song G*. Stimulatory Effects of Coumestrol on Embryonic and Fetal Development through AKT and ERK1/2 MAPK Signal Transduction. Journal of Cellular Physiology. 2016 (in press) *corresponding author

     

     

     

     

    Lim W, Park S, Bazer FW, Song G*. Apigenin Reduces Survival of Choriocarcinoma Cells by Inducing Apoptosis via the PI3K/AKT and ERK1/2 MAPK Pathways. Journal of Cellular Physiology. 2016 (in press) *corresponding author

     

     

     

     

    Lim W, Song G*. Naringenin-Induced Migration of Embrynoic Trophectoderm Cells is Mediated via PI3K/AKT and ERK1/2 MAPK Signaling Cascades. Molecular and Cellular Endocrinology. 2016;15;428:28-37 *corresponding author

     

     

     

     

    Jeong W, Seo H, Sung Y, Ka H, Song G*, Kim J. Lysophosphatidic Acid (LPA) Receptor 3-Mediated LPA Signal Transduction Pathways: A Possible Relationship with Early Development of Peri-Implantation Porcine Conceptus. Biology of Reproduction. 2016;94(5):104

     

     

     

     

    Lim W, Jeong W, Song G*. Delphinidin suppresses proliferation and migration of human ovarian clear cell carcinoma cells through blocking AKT and ERK1/2 MAPK signaling pathways. Molecular and Cellular Endocrinology. 2016; 15;422:172-81 *corresponding author

     

     

     

     

    Yang C, Lim W, Bae H, Song G*. Aquaporin 3 is regulated by estrogen in the chicken oviduct and it is involved in progression of epithelial cell-derived ovarian carcinomas. Domestic Animal Endocrinology. 2016; 55; 97-106 *corresponding author

     

     

     

     

    Lim W, Jeong W, Song G*. Coumestrol suppresses proliferation of ES2 human epithelial ovarian cancer cells. Journal of Endocrinoloy. 2016; 228(3):149-60 *corresponding author

     

     

     

     

    Jeong W, Jung S, Bazer FW, Song G*, Kim J. Epidermal growth factor: Porcine uterine luminal epithelial cell migratory signal during the peri-implantation period of pregnancy. Molecular and Cellular Endocrinology. 2016; 15;420:66-74 *co-corresponding author

     

     

     

     

    Jeong W, Bazer FW, Song G*, Kim J. Expression of hypoxia-inducible factor-1 by trophectoderm cells in response to hypoxia and epidermal growth factor. Biochemical and Biophysical Research Communications. 2016; 8;469(2):176-82 *co-corresponding author

     

     

     

     

    Jeong W, Lee J, Bazer FW, Song G*, Kim J. Fibroblast growth factor 4-induced migration of porcine trophectoderm cells is mediated via the AKT cell signaling pathway. Molecular and Cellular Endocrinology. 2016; 5;419:208-16 *co-corresponding author

     

     

     

     

    Jeong W, Kim J, Bazer FW, Song G*, Kim J. Stimulatory effects of interleukin-1 beta on development of porcine uterine epithelial cell are mediated by activation of the ERK1/2 MAPK cell signaling cascade. Molecular and Cellular Endocrinology. 2016; 5;419:225-34 *co-corresponding author

     

    [2015]      

     
    Jeong W, Song G*, Kim J. Mitogen activated protein kinase pathway-dependent effects of platelet-derived growth factor on migration of trophectoderm cells. Biochemical and Biophysical Research Communications. 2015; 7;463(4):575-81 *co-corresponding author   
     
     
     
     
    Lim W, Bae SM, Jo G, Bazer FW, Choi Y, Song G*. Prostaglandin D2 Synthase Related to Estrogen in the Female Reproductive Tract. Biochemical and Biophysical Research Communications. 2015; 2;456(1):355-60 *corresponding author     
     
         
     
    Lim W, Bae H, Sohn JY, Jeong W, Kim SH, Song G*. Dietary Cholesterol Affects Expression of Prostatic Acid Phosphatase in Reproductive Organs of Male Rats. Biochemical and Biophysical Research Communications. 2015;2;456(1):421-7 *corresponding author     
     
         
     
    Jeong J, Bae H, Lim W, Bazer FW, Song G*. Diethylstilbestrol Regulates Expression of Avian Apolipoprotein D during Regression and Recrudescence of the Oviduct and Epithelial-Derived Ovarian Carcinogenesis. Domestic Animal Endocrinology. 2015; 2;52:82-89 *corresponding author    
     
         
     
    Lee JY, Lim W, Jo G, Bazer FW, Song G*. Estrogen Regulation of Phosphoserine Phosphatase during Regression and Recrudescence of Female Reproductive Organs. General and Comparative Endocrinology. 2015;1;214:40-6 *corresponding author     
     
         
     
    Lim W, Song G*. Novel Genes and Hormonal Regulation for Gonadal Development during Embryogenesis in Chickens. General and Comparative Endocrinology. 2015;15;211:20-7 *corresponding author     
     
         
     
    Lim W, Song G*.  Differential Expression of Vitelline Membrane Outer Layer Protein 1: Hormonal Regulation of Expression in the Oviduct and in Ovarian Carcinomas from Laying Hens. Molecular and Cellular Endocrinology.  2015;5;399:250-8  *corresponding author   
       
         
     
    [2014]    
     
    Bae H, Lim W, Bae SM, Bazer FW, Choi Y, Song G*. Avian Prostatic Acid Phosphatase: Estrogen Regulation in the Oviduct and Epithelial Cell-Derived Ovarian Carcinomas. Biology of Reproduction. 2014;91(1):3 *corresponding author     
     
         
     
    Jo G, Lim W, Bae SM, Bazer FW, Song G*. Avian SERPINB12 Expression in the Avian Oviduct is regulated by Estrogen and Up-regulated in Epithelial Cell-Derived Ovarian Carcinomas of Laying Hens.  PLoS ONE.  2014;14;9(7):e99792  *corresponding author    
     
         
     
    Bae SM, Lim W, Jeong W, Kim J, Bazer FW, Song G*. Expression and Regulation of Avian Cathepsin L in the Oviduct During Molting. General and Comparative Endocrinology. 2014;204:88-94 *corresponding author    
     
         
     
    Lim W, Song G*. Pivotal Roles for Hormonally Regulated Expression of the HEP21 Gene in the Reproductive Tract of Chickens for Oviduct Development and in Ovarian Carcinogenesis. Domestic Animal Endocrinology. 2014;48:136-44 *corresponding author    
     
         
     
    Lim W, Song G*. Identification of Novel Regulatory Genes in Development of the Avian Reproductive Tracts. PLoS ONE. 2014; 24;9(4):e96175 *corresponding author     
     
         
     
    Jeong W*, Song G*, Bazer FW, Kim J. Insulin-Like Growth Factor I Induces Proliferation and Migration of Porcine Trophectoderm Cells through Multiple Cell Signaling Pathways, Including Protooncogenic Protein Kinase 1 and Mitogen-Activated Protein Kinase. Molecular and Cellular Endocrinology. 2014;25;384(1-2):175-84 *co-first author     
     
         
     
    Jeong W, Kim J, Bazer FW, Song G*. Stimulatory Effect of Vascular Endothelial Growth Factor on Proliferation and Migration of Porcine Trophectoderm Cells and Their Regulation by the Phosphatidylinositol-3-Kinase-AKT and Mitogen-Activated Protein Kinase Cell Signaling Pathways. Biology of Reproduction. 2014;6;90(3):50 *corresponding author     
     
         
     
    Jeong W, Kim J, Bazer FW, Song G*. Proliferation-Stimulating Effect of Colony Stimulating Factor 2 on Porcine Trophectoderm Cells is Mediated by Activation of Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase. PLoS ONE. 2014;10;9(2):e88731 *corresponding author     
     
         
     
    Bae SM, Lim W, Jeong W, Lee JY, Kim J, Han JY, Bazer FW, Song G*. Hormonal Regulation of Beta-Catenin during Development of the Avian Oviduct and its Expression in Epithelial Cell-Derived Ovarian Carcinogenesis. Molecular and Cellular Endocrinology.  2014;25;382(1):46-54   *corresponding author   
           
           
     
      [2013]     
     
    Jeong W, Lim W, Ahn SE, Lim CH, Lee JY, Bae SM, Kim J, Bazer FW, Song G*. Recrudescence Mechanisms and Gene Expression Profile of the Reproductive Tracts from Chickens during the Molting Period. PLoS ONE.  2013;1;8(10):e76784  *corresponding author    
     
          
     
    Bae SM, Lim W, Jeong W, Lee JY, Kim J, Bazer FW, Song G*. Sex-specific Expression of CTNNB1 in the Gonadal Morphogenesis of the Chicken. Reproductive Biology and Endocrinoloyg.  2013;11;11:89  *corresponding author    
     
          
     
    Im-Aram A, Farrand L, Bae SM, Song G, Song YS, Han JY, Tsang BK. The mTORC2 Component Rictor Contributes to Cisplatin Resistance in Human Ovarian Cancer Cells. PLoS ONE.  2013;23;8(9):e75455      
     
          
     
    Jeong W, Kim J, Bazer FW, Song G*.Epidermal Growth Factor Stimulates Proliferation and Migration of Porcine Trophectoderm Cells Through Protooncogenic Protein Kinase 1 and Extracellular-Signal-Regulated Kinases 1/2 Mitogen-Activated Protein Kinase Signal Transduction Cascades During Early Pregnancy. Molecular and Cellular Endocrinology.  2013;5;381(1-2):302-11  *corresponding author    
     
          
     
    Lim CH, Lim W, Jeong W, Lee JY, Bae SM, Kim J, Han JY, Bazer FW, Song G*. Avian WNT4 in the Female Reproductive Tracts: Potential Role of Oviduct Development and Ovarian Carcinogenesis. PLoS ONE. 2013 Jul 2;8(7):e65935 *corresponding author    
     
          
     
    Rengaraj D, Park TS, Lee SI, Lee BR, Han BK, Song G, Han JY. Regulation of Glucose Phosphate Isomerase by the 3'UTR-Specific miRNAs miR-302b and miR-17-5p in Chicken Primordial Germ Cells. Biology of Reproduction. 2013;15;89(2):33    
     
          
     
    Lee JY, Jeong W, Lim W, Lim CH, Bae SM, Kim J, Bazer FW, Song G*. Hypermethylation and Post-transcriptional Regulation of DNA Methyltransferases in the Ovarian Carcinomas of the Laying Hen. PLoS ONE. 2013; 17;8(4):e61658 *corresponding author    
     
          
     
    Kim J*, Song G*, Wu G, Gao H, Johnson GA, Bazer FW. Arginine, Leucine, and Glutamine Stimulate Proliferation of Porcine Trophectoderm Cells Through MTOR-RPS6K-RPS6-EIF4EBP1 Signal Transduction Pathway. Biology of Reproduction. 2013; 2;88(5):113 *co-first author    
     
          
     
    Lim W, Jeong W, Kim J, Lee JY, Yoshimura Y, Bazer FW, Han JY, Song G*. Expression and Regulation of Beta-Defensin 11 in the Oviduct in Response to Estrogen and in Ovarian Tumors of Chickens. Molecular and Cellular Endocrinology. 2013; 5;366(1):1-8 *corresponding author    
     
          
     
    Jang HJ, Lee MO, Kim TH, Kim S, Kim SK, Song G, Womack JE, Han JY. Biallelic Expression of the L-Arginine:Glycine Amidinotransferase Gene with Different Methylation Status between Male and Female Primordial Germ Cells in Chickens. Poultry Science. 2013;92(3):760-9     
     
        
     
     [2012]  
     
      Kim J*, Song G*, Wu G , Bazer FW. Functional Roles of Fructose. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):E1619-28 *co-first author    
     
    Lee JY, Jeong W, Kim JH, Kim J, Bazer FW, Han JY, Song G*. Distinct Expression Pattern and Post-transcriptional Regulation of Cell Cycle Genes in the Glandular Epithelia of Avian Ovarian Carcinomas. PLoS ONE. 2012;7(12):e51592 *corresponding author    
     
    Lim W, Kim HS, Jeong W, Ahn SE, Kim J, Kim YB, Kim MA, Kim MK, Chung HH, Song YS, Bazer FW, Han JY, Song G*. SERPINB3 in the Chicken Model of Ovarian Cancer: A Prognostic Factor for Platinum Resistance and Survival in Patients with Epithelial Ovarian Cancer. PLoS ONE. 2012;7(11):e49869 *corresponding author    
     
    Jeong W, Kim J, Ahn SE, Lim W, Lee SI, Bazer FW, Han JY, Song G*. Estrogen-mediated ERK1/2 MAPK cell signaling cascades regulate AHCYL1 expression and functional aspects in the chicken oviduct. PLoS ONE. 2012;7(11):e49204 *corresponding author    
     
    Rengaraj D, Lee SI, Yoo M, Kim TH, Song G, Han JY. Expression and Knockdown Analysis of Glucose Phosphate Isomerase in Chicken Primordial Germ Cells. Biol Reprod. 2012 Sep 13;87(3):57    
     
     
    Rengaraj D, Lee BR, Choi JW, Lee SI, Seo HW, Kim TH, Choi HJ, Song G, Han JY. Gene Pathways and Cell Cycle-Related Genes in Cultured Avian Primordial Germ Cells. Poultry Science. 2012; 91(12):3167-3177  
     
    Lim CH, Jeong W, Lim W, Kim J, Song G*, Bazer FW*. Differential Gene Expression of SLC Family of Genes via MicroRNA Regulation in the Chicken Oviduct at Different Stages of the Laying Cycle. Biol Reprod. 2012 Dec 21;87(6):145 *co-corresponding author    
     
    Bazer FW, Kim J, Song G, Ka H, Tekwe CD, Wu G. Select Nutrients, Progesterone, and Interferon Tau Affect Conceptus Metabolism and Development. Ann N Y Acad Sci. 2012;1271:88-96    
     
    Bazer FW, Song G, Kim J, Dunlap K, Satterfield C, Johnson GA, Burghardt RC, Wu G. Uterine Biology and Pregnancy in Pigs and Sheep. Journal of Animal Science and Technology. 2012;16;3(1):23    
     
    Lim W, Jeong W, Kim J, Ka H, Bazer FW, Han JY, Song G*. Differential Expression of Secreted Phosphoprotein 1 in Response to Estradiol-17   
      β   and in Ovarian Tumors in Chickens. Biochemical and Biophysical Research Communications. 2012; 8;422(3):494-500 *corresponding author       
     
    Jeong W, Lim W, Kim J, Ahn SE, Lee HC, Jeong JW, Han JY,  Song G, Bazer FW. Cell    -specific and temporal aspects of gene expression in the chicken oviduct at different stages of the laying cycle. Biol Reprod. 2012; 7;86(6):172  
     
    Jeong W, Kim HS, Kim YB, Kim MA, Lim W, Kim J, Jang HJ, Suh DH, Kim K, Chung HH, Bazer FW, Song YS, Han JY, Song G*. Paradoxical expression of AHCYL1 affecting ovarian carcinogenesis between chickens and women. Exp Biol Med (Maywood). 2012;1;237(7):758-67 *corresponding author    
     
    Lee JY, Jeong W, Lim W, Kim J, Bazer FW, Han JY, Song G*. Chicken Pleiotrophin Gene: Identification and Regulation of Tissue Specific Expression by Estrogen in the Oviduct and Distinct Expression Pattern in the Glandular Epithelia of Ovarian Carcinomas. PLoS ONE. 2012;7(4):e34215 *corresponding author    
     
    Bazer FW, Kim J, Ka H, Johnson GA, Wu G, Song G. Select nutrients in the uterine lumen of sheep and pigs affect conceptus development. J Reprod Dev. 2012;58(2):180-8  
     
    Bazer FW, Song G, Kim J, Erikson DW, Johnson GA, Burghardt RC, Gao H, Satterfield MC, Spencer TE, Wu G. Mechanistic mammalian target of rapamycin (MTOR) cell signaling: Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses. Mol Cell Endocrinol. 2012;6;354(1-2):22-33    
     
    Bazer FW, Song G, Thatcher WW. Roles of conceptus secretory proteins in establishment and maintenance of pregnancy in ruminants. Asian-Aust. J. Anim. Sci. 2012; 25 (1):1-16  
     
    Ahn SE, Jeong W, Kim JH, Lim W, Kim J, Bazer FW, Han JY, Song G*. ERBB receptor feedback inhibitor 1: identification and regulation by estrogen in chickens. Gen Comp Endocrinol. 2012; 175(1):194-205 *corresponding author    
     
    Lim W, Kim JH, Ahn SE, Jeong W, Kim J, Bazer FW, Han JY, Song G*. Avian SERPINB11 gene: A marker for ovarian cancer in chickens. Exp Biol Med (Maywood). 2012;1;237(2):150-9 *corresponding author    
     
    Lim W, Ahn SE, Jeong W, Kim JH, Kim J, Lim CH, Bazer FW, Han JY, Song G*. Tissue Specific Expression and Estrogen Regulation of SERPINB3 in the Chicken Oviduct. Gen Comp Endocrinol. 2012; 175(1):65-73 *corresponding author    
     
     
     
     [2011]    
     
     Bazer FW, Wu G, Johnson GA, Kim J, Song G*. Uterine histotroph and conceptus development: Select nutrients and secreted phosphoprotein 1 affect MTOR cell signaling in ewes. Biol Reprod. 2011;85(6):1094-107 *corresponding author    
     
    Lim W, Jeong W, Kim JH, Lee JY, Kim J, Bazer FW, Han JY, Song G*. Differential expression of alpha 2 macroglobulin in response to diethylstilbestrol and in ovarian carcinomas in chickens. Reprod Biol Endocrinol. 2011;7;9:137 *corresponding author    
     
    Lim W, Kim JH, Ahn SE, Jeong W, Kim J, Bazer FW, Han JY, Song G*. Avian SERPINB11 gene: characteristics, tissue specific expression and regulation of expression by estrogen. Biol Reprod. 2011;85(6):1260-8 *corresponding author    
     
    Lee SI, Lee BR, Hwang YS, Lee HC, Rengaraj D, Song G, Park TS, Han JY. MicroRNA-mediated posttranscriptional regulation is required for maintaining undifferentiated properties of blastoderm and primordial germ cells in chickens. Proc Natl Acad Sci U S A. 2011; 108(26):10426-31  
     
    Song G, Han JY. Avian biomodels for use as pharmaceutical bioreactors and for studying human diseases. Ann N Y Acad Sci. 2011; 1229:69-75    
     
    Jung JG, Park TS, Kim JN, Han BK, Lee SD, Song G, Han JY. Characterization and application of oviductal epithelial cells in vitro in Gallus domesticus. Biol Reprod. 2011; 85(4):798-807    
     
    Choi JW, Suzie E, Rengaraj D, Seo HW, Lim W, Song G, Han JY. Matrix metalloproteinase 3 is a stromal marker for chicken ovarian cancer. Oncology Letters. 2011;2(6):1047-1051    
     
    Jung JG, Lim W, Park TS, Kim JN, Han BK, Song G, Han JY. Structural and histological characterization of oviductal magnum and lectin-binding patterns in Gallus domesticus. Reprod Biol Endocrinol. 2011; 9:62  
     
    Choi JH, Kim GA, Park JH, Song G, Park JW, Kim DY, Lim JM. Generation of viable embryos and embryonic stem cell-like cells from cultured primary follicles in mice. Biol Reprod. 2011; 85(4):744-54    
     
    Song G, Seo HW, Choi JW, Rengaraj D, Kim TM, Lee BR, Kim YM, Yun TW, Jeong JW, Han JY. Discovery of candidate genes and pathways regulating oviduct development in chickens. Biol Reprod. 2011; 85(2):306-14  
     
    Dunlap K, Filant J, Hayashi K, Rucker EB, Song G, Deng JM, Behringer R, DeMayo FJ, Lydon J, Jeong JW, Spencer TE. Postnatal deletion of Wnt7a inhibits uterine gland morphogenesis and compromises adult fertility in mice. Biol Reprod. 2011; 85(2):386-96    
     
    Rengaraj D, Lee BR, Park KJ, Lee SI, Kang KS, Choi JW, Kang SJ, Song G, Han JY. The distribution of neuron-specific gene family member 1 in brain and germ cells: Implications for the regulation of germ-line development by brain. Dev Dyn. 2011;240(4):850-61    
     
    Song G, Fleming JGW, Kim J, Spencer TE, Bazer FW. Pregnancy and interferon tau regulate N-myc interactor in the ovine uterus. Domest Anim Endocrinol. 2011;40(2):87-97    
     
    Song G, Fleming JGW, Kim J, Spencer TE, Bazer FW. Pregnancy and interferon tau regulate DDX58 and PLSCR1 in the ovine uterus during the peri-implantation period. Reproduction. 2011;141(1):127-38    
     
    Seo HW, Rengaraj D, Choi JW, Park KJ, Song G, Han JY. The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model. Oncol Rep. 2011;25(1):49-56  
     
     
     
     [2010]    
     
     Seo HW, Rengaraj D, Choi JW, Ahn SE, Song YS, Song G, Han JY. Claudin 10 is a glandular epithelial marker in the chicken model as human epithelial ovarian cancer. Int J Gynecol Cancer. 2010;20(9):1465-73    
     
    Park KJ, Kang SJ, Kim TM, Lee YM, Lee HC, Song G, Han JY. Gamma-irradiation depletes endogenous germ cells and increases donor cell distribution in chimeric chickens. In Vitro Cell Dev Biol Anim. 2010;46(10):828-33    
     
    Choi JW, Kim S, Kim TM, Kim YM, Seo HW, Park TS, Jeong JW, Song G, Han JY. Basic fibroblast growth factor activates MEK/ERK cell signaling pathway and stimulates the proliferation of chicken primordial germ cells. PLoS ONE. 2010; 5 (9): e12968    
     
    Seo HW, Kim TM, Choi JW, Han BK, Song G, Han JY. Evaluation of combinatorial cis-regulatory elements for stable gene expression in chicken cells. BMC Biotechnol. 2010; 10:69    
     
    Ahn SE, Choi JW, Rengaraj D, Seo HW, Lim W, Han JY, Song G*. Increased  expression of cysteine cathepsins in ovarian tissue from chickens with ovarian cancer. Reprod Biol Endocrinol. 2010; 8:100 *corresponding author    
     
    Song G, Park TS, Kim TM, Han JY. Avian biotechnology: insights from germ cell-mediated transgenic system. The Journal of Poultry Science. 2010; 47(3):197-207  
     
    Choi JW, Kim JK, Seo HW, Cho BW, Song G, Han JY. Molecular cloning and comparative analysis of immunoglobulin heavy chain genes from Phasianus colchicus, Meleagris gallopavo, and Coturnix japonica. Vet Immunol Immunopathol. 2010; 136:248-56    
     
    Kwon SC, Kwon SC, Choi JW, Jang HJ, Shin SS, Lee SK, Park TS, Choi IY, Lee GS, Song G, Han JY. Production of biofunctional recombinant human interleukin 1 receptor antagonist (rhIL1RN) from transgenic quail egg white. Biol Reprod. 2010; 82(6):1057-64    
     
    Song G, Bailey DW, Dunlap KA, Burghardt RC, Spencer TE, Bazer FW, Johnson GA. Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae. Biol Reprod. 2010; 82(5):854-64    
     
    Lee SI Kim JK, Park HJ, Jang HJ, Lee HC, Min T, Song G, Han JY. Molecular cloning and characterization of the germ cell-related nuclear orphan receptor in chickens. Mol Reprod Dev. 2010; 77(3):273-84    
     
    Forde N, Spencer TE, Bazer FW, Song G, Roche JF, Lonergan P. Effect of pregnancy and progesterone concentration on expression of genes encoding for transporters or secreted proteins in the bovine endometrium. Physiological Genomics. 2010; 41:53-62    
     
     
     
     [2009]    
     
     Satterfield MC, Song G, Kochan KJ, Riggs PK, Simmons RM, Elsik CG, Adelson DL, Bazer FW, Zhou H, Spencer TE. Discovery of candidate genes in the ovine endometrium regulating blastocyst development. Physiol Genomics. 2009; 39:85-99    
     
    Song G, Satterfield MC, Kim J, Bazer FW, Spencer TE. Progesterone and interferon tau regulate LIFR and IL6ST in the ovine uterus during early pregnancy. Reproduction. 2009; 137:553-565    
     
    Fleming JA, Song G, Choi Y, Bazer FW, Spencer TE. Interferon regulatory factor 6 (IRF6) is expressed in the ovine uterus and functions as a transcriptional activator. Mol Cell Endocrinol. 2009; 299:252-260    
     
    Song G, Dunlap KA, Kim J, Bailey DW, Spencer TE, Burghardt RC, Graham FW, Johnson GA, Bazer FW. Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estrogen. Endocrinology. 2009; 150:936-945    
     
     
     
     [2008]    
     
     Satterfield MC, Song G, Hayashi K, Bazer FW, Spencer TE. Progesterone regulation of the endometrial WNT system in the ovine uterus. Reprod Fertil Dev. 2008;20:935-46    
     
    Satterfield MC, Hayashi K, Song G, Black SG, Bazer FW, Spencer TE. Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus. Biol Reprod 2008;79:1226-36  
     
    Song G, Kim J, Satterfield MC, Bazer FW, Spencer TE. Gastrin-releasing peptide (GRP) in the ovine uterus: regulation by interferon tau and progesterone. Biol Reprod 2008; 79:376-386    
     
    Kim J, Song G, Gao H, Farmer JL, Satterfield MC, Burghardt RC, Wu G, Johnson GA, Spencer TE, Bazer FW. Insulin-like growth factor II activates phosphatidylinositol 3-kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell signaling pathways, and stimulates migration of ovine trophectoderm cells. Endocrinology. 2008;149:3085-94  
       
         
     
    Song G, Kim J, Bazer FW, Spencer TE. Progesterone and interferon tau regulate hypoxia-inducible factors (HIFs) in the endometrium of the ovine uterus. Endocrinology 2008; 149:1926-1934    
     
     
     
     [2007]    
     
    Song G, Bazer FW, Spencer TE. Differential expression of cathepsins and cystatin C in ovine uteroplacental tissues. Placenta 2007; 28:1091-1098    
     
    Song G, Bazer FW, Spencer TE. Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Reproduction 2007; 133:285-295    
     
     
     
     [2006]    
     
    Song G, Spencer TE, Bazer FW. Progesterone and interferon tau regulate cystatin C (CST3) in the endometrium. Endocrinology 2006; 147:3478-3483    
     
    Song G, Wagner GF, Bazer FW, Spencer TE. Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormones. Biol Reprod 2006; 74:913-922    
     
     
     
     [2005]    
     
    Song G, Spencer TE, Bazer FW. Cathepsins in the ovine uterus: regulation by pregnancy, progesterone and interferon tau. Endocrinology 2005; 146:4825-4833    
     
     
     
     [Book Chapter]    
     
    Bazer FW, JohnsonGA, Song G, Wu G. Pregnancy recognition signaling, fetal-placental development and prenatal fetal programming. Encyclopedia of Life Support Systems (EOLSS). 2012 
     

     

  • Research

    여성 생식기관은 난자를 생성하고 성호르몬을 분비하는 난소, 수정이 이루어지며 수정란의 이동 통로가 되는 난관, 배아의 착상 및 태아가 성장하는 자궁 등의 중심기관으로 이루어져 있습니다. 분자발생공학 연구실은 여성 생식기관의 발달 기전 규명, 여성 생식 관련 질환의 예방 및 치료, 착상 및 임신 유지를 위한 유용 물질 발굴 등을 목표로 여성 생식 전반에 걸쳐 다양한 주제의 연구를 수행하고 있습니다. 이에 여성 생식기관의 발달 및 질환에 대한 생리학적, 유전학적, 분자내분비학적 신호 전달체계의 규명을 위해 세포수준의 연구를 비롯하여 돼지, 닭, 마우스 등의 다양한 동물모델을 이용한 연구를 수행하고 있습니다. 특히, 포유동물 초기 배 또는 기관형성시기에 유전공학 및 세포공학적 기술을 이용한 유전자도입 또는 적중을 통하여 포유동물의 생식기관 발달과정의 원리를 파악하고, 그 과정에서 관여하는 유전자의 기능 및 세포 신호전달 체계를 연구하는 발생유전학 분야의 연구를 진행하고 있습니다. 이와 더불어 주로 폐경기 여성에게 발생하는 악성종양인 상피성 난소암을 비롯한 다양한 부인암종의 발병 기전을 규명하고, 이를 표적할 수 있는 식물성화합물 (phytochemical)의 발굴에 힘쓰고 있습니다. 뿐만 아니라 자궁내막증, 자궁근종, 자궁선근증 등 여성에게서 흔하게 발생하는 다양한 양성 자궁질환의 진단, 예방 및 치료를 목적으로 발병 메커니즘 규명 및 바이오마커 발굴에 관한 생식의학 연구를 수행하고 있습니다.

     

     

    1. 임신초기 배아의 발달 및 분화에 관련된 중요 유전자 발굴 및 기능분석 연구

     

    자궁은 초기배아 및 착상 후 배의 발달과 분화를 위해 다양한 물질들을 분비하는데 현재까지 다양한 인자들이 분비됨이 밝혀졌으나 아직 그 기능이 완전히 이해되지 않고 있습니다. 따라서 현재까지 알려진 자궁 내 인자들 이외에 착상과 태반형성에 관여하는 새로운 인자들의 발굴과 그들의 기능에 관한 연구를 통해 임신율 향상 및 효과적인 임신 유지를 도모하고 이를 통해 난임 및 조기 유산에 대한 문제 해결을 위한 기초적 연구를 수행하고 있습니다. 이를 위해 분자발생공학 연구실에서는 사람과 높은 유전체 서열의 유사성을 지닌 돼지모델을 사용하여 착상 효율 증진 및 조기 유산율 저하를 방지하는 생리학적, 분자유전학적, 내분비학적, 후생유전학적 조절기전을 연구하고 있습니다. 또한 포유류의 경우 착상기간 동안 모체에서 공급되는 영양분이 태아의 발달과 성장뿐 아니라 초기 임신유지에 매우 중요하다고 알려져 있기 때문에, 초기 임신돈의 자궁에서 추출한 영양외배엽 (trophectoderm) 세포를 이용한 세포 발달 및 증식 효과를 나타내는 인자를 규명하는 연구를 수행하고 있습니다. 뿐만 아니라 사람의 임신 초기 태반으로 발달하는 영양막 (trophoblast) 세포를 이용하여 자궁내막으로의 침투성, 신혈관생성, 태아-모체 면역기전 조절 등 다각적인 연구를 수행, 사람의 태반 발달기전에 관한 연구를 진행하고 있습니다.

     

     

    2. 여성 생식기관 유래 악성종양 진단, 예방 및 치료에 관한 연구

     

    부인암은 난소암, 자궁경부암, 자궁내막암으로 대표되는 여성에게 발병하는 악성 종양입니다. 특히 난소암은 주기적인 배란으로 인한 난소 상피의 파열 및 이에 따른 유전자 변이로부터 발생하는데, 특이적인 초기 증상과 조기 진단 가능한 바이오마커의 부재로 인해 대다수의 난소암 환자들은 말기에 진단되는 실정입니다. 분자발생공학 연구실에서는 조직학적 특성과 암 전이 경향 등의 유사성에 근거하여 닭을 인간 난소암 모델로 이용, 암세포의 성장, 분화 및 전이와 관련된 유전자들의 발현 및 기능을 연구해왔습니다. 더 나아가, 인간 유래 난소암 세포를 이용해 난소암 예방 및 치료를 위한 세포 수준 연구 및 세포 내 신호전달기전 규명 및 조절에 관한 연구를 수행 중에 있습니다. 특히, 사람의 체내에서 항산화물질 또는 세포 손상을 억제하는 작용을 통해 발암물질 생성을 억제하는 것으로 알려진 식물성화합물이 인간 난소암 세포주에 미치는 영향을 규명하고 그에 대한 신호전달기전을 밝힘으로써 난소암 치료를 위한 후보 생리활성물질을 검증하는 연구를 진행하고 있습니다. 뿐만 아니라, 국내 대학병원 산부인과 연구진과의 협업을 통해 난소암 환자 조직을 제공받아, 한국형 부인암을 조기진단할 수 있는 최적의 바이오마커 개발에 힘쓰고 있습니다. 또한 영양막세포가 비정상적으로 증식하거나 전이하여 발병하는 악성 종양인 융모암 치료에 있어서 다양한 채소 및 과일 유래의 식물추출물의 효과를 규명하며, 치료보조제 및 건강보조제로의 개발 가능성을 열어두고 있습니다. 이러한 여성 생식기관 유래의 암종 이외에도, 남성에게서 발병하는 대표적인 악성 종양인 전립선암에 대해서 종양억제유전자 발현 여부에 따른 다양한 세포주를 확보하여, 구체적인 발병 기전에 대한 연구를 통해 효과적인 치료법 개발을 목표로 하고 있습니다. 또한 다양한 암종의 세포를 마우스 모델에 이식한 후 식물추출물을 주입함으로써 체내 항암 효과를 검증하고, 임상 적용 가능성을 제시하고 있습니다.

     

     

    3. 여성 비뇨생식기 및 임신관련 질환 발병 메커니즘 규명에 관한 연구

     

    대부분의 여성들이 임신기 뿐만 아니라 일생에 걸쳐 크고 작은 비뇨생식기 질환을 겪고 있습니다. 여성 비뇨생식기 질환은 복잡한 내분비학적 조절기전에 의해 영향을 받는 것으로 알려져 있으나 구체적인 발병원인에 대해서는 거의 알려진 바가 없습니다. 특히, 임신 기간을 기준으로 37주 이전에 분만하는 조산은 신생아 기형 및 뇌손상의 가능성을 높이는 것으로 알려져 있으나 그 명확한 원인은 불분명합니다. 조산에 대한 세포치료제 개발을 위해 분자발생공학 연구실은 염증성 사이토카인 중심의 발병 메커니즘에 대한 기초 연구를 수행 중에 있습니다. 이 외에도 폐경기 여성 요실금 개선을 위한 근조직량 조절 관련 유전자 선별 및 분자내분비학, 후생유전학적 기전 분석과 자궁내막증, 자궁근종, 자궁선근증 등 양성의 자궁질환 조기진단 및 치료를 위한 유전학적 연구를 지속적으로 수행 중에 있습니다.  

     

     

  • Teaching

    준비 중입니다.

  • Lab Members


    ph.D course

                                  배효철                              bhc7@korea.ac.kr

     

    MS course

                                 양창원                              ycw117@korea.ac.kr

     

                                 박선우                              sunwoojump@korea.ac.kr

     

                                 함지연                              glorijy76@korea.ac.kr

     

                                 유수민                              tnals6917@korea.ac.kr

     
     

     

    Undergraduate course

                       안이경                             spezielle11@korea.ac.kr

     

                                                    강민경                              gmg729@korea.ac.kr

     

                                  박하현                              pa1301@korea.ac.kr

     

    Alumni