• HOME
  • 로그인
QUICK MENU

고려대학교 교수소개

Knowledge & Innovation

생명과학대학

Home > 생명과학대학 >생명과학부

소개

Prof. 백자현

Tel:02-3290-3455
Fax:02-927-9028

  • About Professor
  • Curriculum Vitea
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile

     뇌의 기능은 아직도 많은 것이 밝혀지지 않은 것이 많은, 신비롭고도 동시에 21세기 생명 과학에서의 중요한 도전의 대상 중에 하나라고 할 수 있다. 뇌의 이러한 복잡한 기능에 중요한 인자로 작용하는 것 중의 대표적인 것이 바로 신경전달물질이라고 할 수 있다. 특정 신경세포에서 만들어져 분비되는 신경전달 물질은 그 수용체를 통하여 여러 가지 신호를 전달하고 또한 다른 신경전달 물질, 혹은 다른 단백질들과의 상호작용을 통하여 결국 고유의 생리적 기능으로 이어진다고 할 수 있다. 이러한 과정에서의 생길 수 있는 여러 가지 생물학적인 문제점은 바로 신경질환으로 이어진다고 할 수 있다.

     우리가 잘 알고 있는 정신 분열증, 치매, 우울증, 파킨슨 증후군, 스트레스 등의 신경정신 질환은 물론 비만과 같은 대사성 질환 등도 이러한 신경전달 물질들의 비 정상적인 조절에서 비롯된 것이라는 것은 이제 잘 알려진 사실이다. 본 연구실에서는 이렇게 뇌의 기능에 중요한 역할을 하는 신경전달 물질, 신경 펩타이드 등의 분자적, 세포적인 측면에서의 신호전달을 연구하고 또한 동물모델을 이용하여 궁극적으로는 중요한 뇌 질환의 표적을 찾는 연구를 수행하고 있다.

  • Curriculum

    education 

    - Doctor [1987-1992] : 프랑스 파리 6대학 분자세포약리학 이학박사
    - Master [1985-1987] : 프랑스 파리 6대학 생화학 이학석사
    - Bachelor [1981-1985] : 연세대학교 생화학 이학사

    professional experience  

    - 2006. 9~현재 : 고려대학교 생명과학대학, 교수
    - 2003. 9~2006. 8 : 고려대학교 생명과학대학, 부교수
    - 2002. 3~2003. 9 : 연세대학교 의과대학, 부교수
    - 1996~2002. 2 : 연세대학교 의과대학, 조교수
    - 1992~1995 : 프랑스 CNRS 소속분자세포유전학연구소(IGBMC), post-doctoral fellow  

    수상경력 

    - 2002년 제1회 로레알 여성 생명과학상 신진과학자 수상
     - 2006년 제 1기 한국보건산업진흥원-아스트라제네카 신약개발 연구비지원사업 수상
     - 2007년 제 2기 한국보건산업진흥원-아스트라제네카 신약개발 연구비지원사업 수상
     - 2014년 한림원 선도과학자 선정

  • Publications

    Major Publication

    2015 
    Yoon YR, Baik JH 
    Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake. 
    Endocrinol Metab (Seoul) 2015, 30(4):576-83. doi: 10.3803/EnM.2015.30.4.576 (교신저자 KCI IF : 0.11) 

    Yoon DH, Yoon S, Kim D, Kim H, Baik JH 
    Regulation of dopamine D2 receptor-mediated extracellular signal-regulated kinase signaling and spine formation by GABAA receptors in hippocampal neurons. 
    Neuroscience Letters 2015, 586: 24-30, doi: 10.1016/j.neulet. 2014.12.010 (교신저자 SCI IF : 2.026) 

    2014 
    Song SS, Kang BJ, Wen L, Lee HJ, Sim HR, Kim TH, Yoon S, Yoon BJ, Augustine GJ and Baik JH 
    Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization.
    Frontiers in Behavioral Neuroscience 2014, 8: 1-11, doi: 10.3389/fnbeh.2014.00336 (교신저자 SCI IF : 4.758) 

    2013 
    Baik JH 
    Dopamine signaling in food addiction: role of dopamine D2 receptors (Review).
    BMB Reports 2013, 46(11):519-526 (교신저자 SCI IF : 1.634) 

    Kim M, Kim W, Baik JH and Yoon BJ 
    Different locomotors ensitization responses to repeated cocaine injections are associated with differential phosphorylation of GluA1 in the dorsomedial striatum of adult rats. 
    Behavioural Brain Research 2013, 257:71-6, doi:10.1016/j.bbr.2013.09.038. (공동저자 SCI IF : 3.327) 

    Baik JH 
    Dopamine Signaling in reward-related behaviors (Review). 
    Frontiers in Neural Circuits 2013, 7:152, doi:10.3389/fncir.2013.00152. (교신저자 SCI IF : 3.333) 

    Yoon S and Baik JH 
    Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation. 
    Journal of Biological Chemistry 2013, 288(40):28435-46 (교신저자 SCI IF : 4.651) 

    Jung ES, Lee HJ, Sim HR and Baik JH
    Cocaine-induced behavioral sensitization in mice: effects of microinjection of dopamine d2 receptor antagonist into the nucleus accumbens.
    Experimental Neurobiology 2013, 22(3):224-31 (교신저자, 국내저널) 

    Han J, Kim YL, Lee KW, Her NG, Ha TK, Yoon S, Jeong SI, Lee JH, Kang MJ, Lee MG, Ryu BK, Baik JH and Chi SG 
    ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21WAF1. 
    Cell Death and Differentiation 2013, doi: 10.1038/cdd.2013.33. (공동저자 SCI IF : 8.371) 

    Kim YS, Jung S, Park BG, Ko MK, Jang H-S, Choi K, Baik JH, Lee J, Lee JK, Pae AN, Cho YS and Min SJ 
    Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction.
    European Journal of Medicinal Chemistry 2013, 62:71-83 (공동저자 SCI IF : 3.499) 

    Sim HR, Choi TY, Lee HJ, Kang E, Yoon S, Han PL, Choi SY and Baik JH 
    Role of Dopamine D2 Receptors in Plasticity of Stress-Induced Addictive Behaviors. 
    Nature Communications 2013, 4:1579, doi:10.1038/ncomms2598 (교신저자 SCI IF : 10.015) 

    Kim JW, Ahn HS, Baik JH and Yoon BJ 
    Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice. 
    J Psychopharmacol. 2013, 27: 171-180 (공동저자 SCI IF : 3.730) 

    2012 
    Kang JA, Lee K, Lee KM, Cho S, Seo J, Hur EM, Park CS, Baik JH, Choi SY 
    Desipramine inhibits histamine H1 receptor-induced Ca2+ signaling in rat hypothalamic cells.
    PLoS One 2012, 7(4): e36185. (공동저자 SCIE IF : 3.730) 

    2011 
    Yoon S, Choi MH, Chang MS, Baik JH 
    Wnt5a-Dopamine D2 Receptor Interactions Regulate Dopamine Neuron Development via Extracellular Signal-regulated Kinase (ERK) Activation. 
    Journal of Biological Chemistry 2011, 286(18): 15641-15651 (교신저자 SCIE IF : 4.651) 

    2010 
    Kim HK, Youn BS, Shin MS, Namkoong C, Park KH, Baik JH, Kim JB, Park JY, Lee K, Kim YB, Kim MS 
    Hypothalamic Angpt14/Fiaf Is a Novel Regulator of Food Intake and Body Weight.
    Diabetes 2010, 59: 2772-2780 (공동저자 SCI IF : 7.895) 

    Park HW, Jung H, Choi KH, Baik JH, Rhim H
    Direct interaction and functional coupling between voltage-gated Ca(V)1.3 Ca(2+) channel and GABA(B) receptor subunit 2. 
    FEBS Lett. 2010, 584(15):3317-3322 (공동저자 SCI IF : 3.582) 

    Yun HM, Baik JH, Kang IS, Jin C, Rhim H 
    Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. 
    Journal of Biological Chemistry 2010, 285(13):10016-10029 (공동저자 SCI IF : 4.651) 

    Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, Kim MS 
    NF-{kappa}B activation in hypothalamic POMC neurons is essential in illness- and leptin-induced anorexia. 
    Journal of Biological Chemistry 2010, 285(13):9706-9715 (공동저자 SCI IF : 4.651) 

    Kim KS, Yoon YR, Lee HJ, Yoon S, Kim S-Y, Shin SW, An JJ, Kim M, Choi SY, Sun W, and Baik JH 
    Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors.
    Journal of Biological Chemistry 2010, 285(12):8905-8917 (교신저자 SCI IF : 4.651) 

    2009 
    Yoon KW, Cho JH, Lee JK, Kang YH, Chae JS, Kim YM, Kim J, Kim EK, Kim SE, Baik JH, Naik U.P., Cho SG, and Choi EJ 
    CIB1 functions as a Ca2+ -sensitive modulator of stress-induced signaling by targeting ASK1. 
    Proc Natl Acad Sci USA 2009, 106(41):17389-94 (공동연구 SCI IF: 9.737) 

    2008 
    Choi J, Ha CM, Choi EJ, Jeong CS, Park JW, Baik JH, Park JY, Costa M.E., Ojeda S.R., Lee BJ
    Kinesin Superfamily-Associated Protein 3 Is Preferentially Expressed in Glutamatergic Neurons and Contributes to the Excitatory Control of Female Puberty.
    Endocrinology 2008, 149(12):6146-6156 (공동연구 SCI IF: 4.717) 

    Kim SY, Lee HJ, Kim YN, Yoon S, Lee JE, Sun W, Choi EJ, Baik JH 
    Striatal-Enriched Protein Tyrosine Phosphatase Regulates Dopaminergic Neuronal Development via Extracellular Signal-Regulated Kinase Signaling. 
    Experimental Neurology 2008, 214(1):69-77 (교신저자 SCI IF: 4.645) 

    Kim DH, Shin SW, Baik JH
    Role of third intracellular loop of the melanocortin 4 receptor in the regulation of constitutive activity.
    Biochem. Biophys. Res. Commun. 2008, 365, 439-445 (교신저자 SCI IF 2.406) 

    2007 
    Yang MZ, Mun CH, Choi YJ, Baik JH, Park KA, Lee WT, Lee JE
    Agmatine inhibits matrix metalloproteinase-9 via endothelial nitric oxide synthase. 
    Neurological Research 2007, 29(7), 749-754, (공동참여 SCI IF 1.182) 

    Kim S, Yun HM, Baik JH, Chung KC, Nah SY, Rhim H
    Functional Interaction of neuronal Cav1.3 L-type calcium channel with ryanodine receptor type-2 in the rat hippocampus. 
    The journal of biological chemistry 2007, 282(45)32877-32889, (공동참여 SCI IF. 4.651) 

    Yun HM, Kim S, Kim HJ, Kostenis E., Kim JI , Seong JY, Baik JH, Rhim H
    The novel cellular mechanism of human 5-HT6 receptor through an interaction with fyn.
    The journal of biological chemistry 2007, 282(8), 5496-5505, (공동참여 SCI IF. 4.651) 

    An JJ, Rhee Y, Kim SH, Kim DM, Han D-H, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT and Lim S-K
    Peripheral Effect of α-Melanocyte-stimulating Hormone on Fatty Acid Oxidation in Skeletal Muscle. 
    The journal of biological chemistry 2007, 282(5), 2862-2870 (공동참여 SCI IF. 4.651) 

    2006 
    Kim SJ, Kim SY, Na YS, Lee HJ, Chung KC, Baik JH
    α-synuclein enhances dopamine D2 receptor signaling. 
    Brain Research 2006, 1124(1), 5-9 (교신저자 SCI IF. 2.879) 

    Kim HS, Song M, Yumkham S, Choi JH, Lee T, Kwon J, Lee SJ, Kim JI, Lee KW, Han PL, Shin SW, Baik JH, Kim YS, Ryu SH, Suh PG.
    Identification of a new functional target of haloperidol metabolite:implications for a receptor-independent role of FBPA(3-(4-fluorobenzoyl) propionic acid. 
    Journal of Neurochemistry 2006, 99 (2), 458-469 (공동참여 SCI IF. 3.973) 

    An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT, Lim SK
    Peripheral effect of alpha-melanocyte stimulating hormone on fatty acid oxidation in skeletal muscle. 
    Journal of Biological Chemistry 2006, 282(5): 862-2870 (공동참여 SCI IF. 4.651) 

    Kim SY, Choi KC, Chang MS, Kim MH, Kim SY, Na YS, Lee JE, Jin BK, Lee BH, Baik JH
    The Dopamine D2 Receptor Regulates the Development of Dopaminergic Neurons via ERK and Nurr1 Activation. 
    Journal of Neuroscience 2006, 26(17): 4567-4576 (교신저자 SCI IF. 6.908) 

    2005 
    Cho MK, Li SZ, Lim SK, Baik JH, Lee CJ, Lee W
    Structures and Functions of the Potent Cyclic and Linear Melanocortin Analogues. 
    Journal of Structural Biology 2005, 150:300-318 (공동참여 SCI IF. 3.496) 

    Kim RY, Shin SW, Kim BJ, Lee W, Baik JH
    Dynamic Regulation of Hypothalamic Neuropeptide Gene Expression and Food Intake by Melanocortin Analogues and Reversal with Melanocortin-4 receptor antagonist. 
    Biochemical and Biophysical Research Communications 2005, 329:1178-1185 (교신저자 SCI IF. 2.855) 

    2004 
    Jin YJ, Li SZ, Zhao ZS, An JJ, Kim RY, Kim YM, Baik JH and Lim SK
    The stimulating effect of cerulenin on CPT-1 activity through the sympathetic nervous system activation surpasses its peripheral effects. 
    Endocrinology 2004, 145:3197-3204 (공동참여 SCI IF: 4.717) 

    An JJ, Bae MH, Cho SR, Lee SH, Choi SH, Lee BH, Shin HS, Kim YN, Park KW, Borrelli E. and Baik JH
    Altered GABAergic Neurotransmission In Mice Lacking Dopamine D2 Receptors. 
    Molecular and Cellular Neuroscience 2004, 25: 732-740 (교신저자 SCI IF: 3.837) 

    Kim SJ, Kim MY, Lee EJ, Ahn YS and Baik JH
    Distinct Regulation of Internalization and MAPK Activation By Two Isoforms of Dopamine D2 Receptor.
    Molecular Endocrinology 2004, 18:640-652 (교신저자, SCI IF: 4.746) 

    2003 
    Cho MK, Kim SS, Lee MR, Shin J, Lee J, Lim SK, Baik JH, Yoon CJ, Shin I, Lee W
    NMR studies on turn mimetic analogs derived from melanocyte-stimulating hormones. 
    J Biochem Mol Biol. 2003, 36: 552-557. (공동참여 SCIE IF: 1.465) 

    Lee KH, Chung HS, Kim HS, Oh SH, Ha MK, Baik JH, Lee S, Bang D
    Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behcet's disease. 
    Arthritis and Rheumatism 2003, 48: 2025-2035. (공동참여 SCI IF: 7.751) 

    An JJ, Cho SR, Jeong DW, Park KW, Ahn YS and Baik JH
    Anti-proliferative effects and cell death mediated by two isoforms of dopamine D2 receptors in pituitary tumor cells.
    Molecular and Cellular Endocrinology 2003, 206:49-62 (교신저자 SCI IF: 2.918) 

    Kim KH, Min YK, Baik JH, Lau LF, Chaqour B, Chung KC
    Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor.
    Journal of Biological Chemistry 2003, 278: 13847-13854 (공동참여 SCI IF: 4.651) 

    2002 
    Kim CS, Lee SH, Kim RY, Kim BJ, Li SZ, Lee IH, Lee EJ, Lim SK, Bae YS, Lee W and Baik JH
    Identification of domains directing specificity of coupling to G-proteins for the melanocortin MC3 and MC4 receptors. 
    Journal of Biological Chemistry 2002, 277: 31310-31317 (교신저자, SCI IF: 4.651) 

    2001 
    Lim SK, Li SZ, Lee CH, Yoon CJ, Baik JH and Lee W
    Minimization of MC1R selectivity by modification of core structure of α-MSH-ND.
    Chemistry and Biology 2001, 8: 857-870 (공동참여, SCI IF: 6.157) 

    Lee EJ, Lee SH, Jung JW, Lee W, Kim BJ, Park KW, Lim SK, Yoon CJ and Baik JH
    Differential Regulation of cAMP-Mediated Gene Transcription and ligand selectivity by MC3R and MC4R Melanocortin Receptors.
    European Journal of Biochemistry 2001, 268: 582-591 (교신저자, SCI IF: 4.250) 

    2000 
    Usiello A., Baik JH, RougePont F., Picetti R., Dierich A., LeMeur M., Piazza PV and Borrelli E
    Distinct Functions of the Two Isoforms of D2 Dopamine Receptors.
    Nature 2000, 408: 199-203 (공동 제1저자, SCI IF: 38.597 ) 

    Park KW, Lee EJ, Lee SH, Lee JE, Choi EY, Kim BJ, Hwang RJ, Park KA and Baik JH
    Molecular Cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG. 
    Gene 2000, 257: 45-55 (교신저자, SCI IF: 2.196) 

    1999 
    Li SZ, Lee JH, Lee W, Yoon CJ, Baik JH, Lim SK
    Type I beta-turn conformation is important for biological activity of the melanocyte-stimulating hormone analogues. 
    European Journal of Biochemistry 1999, 265: 430-440 (공동참여, SCI IF: 4.250) 

    Choi EY, Jeong DW, Park KW and Baik JH
    G protein-mediated mitogen-activated- protein (MAP) kinase activation by two dopamine D2 receptors. 
    Biochemical and Biophysical Research Communications 1999, 256: 33-40 (교신저자, SCI IF: 2.406) 

    1998 
    Saiardi A., Samad TA., Picetti R., Bozzi Y., Baik JH and Borrelli E
    The physiological role of dopamine D2 receptors. 
    Advances in Pharmacology 1998, 42: 521-524 (공동참여, IM) 

    1997 
    Saiardi A., Bozzi Y., Baik JH and Borrelli E
    Antiproliferative role of dopamne: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia. 
    Neuron 1997, 19: 115-126 (공동참여, SCI IF: 15.766) 

    Picetti R., Saiardi A., Samed TA., Bozzi Y., Baik JH and Borrelli E
    Dopamine D2 receptors in signal transduction and behavior. 
    Critical Reviews in Neurobiology 1997, 11: 121-142 (공동참여, SCI IF: 5.75) 
    Calabresi P., Saiardi A., Pisani A., Baik JH, Centonze D., Mercuri NB., Bernardi G. and Borrelli E
    Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors. 
    Journal of Neuroscience 1997, 17: 4536-4544 (공동참여, SCI IF:6.908) 

    Seeman P., Guan HC., Nobrega J., Jiwa D., Markstein R., Baik JH, Picetti R., Borrelli E. and Tol HH
    Dopamine D2-like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3H]benzquinoline.
    Synapse 1997, 25: 137-146 (공동참여, SCI IF: 2.31) 

    1996 
    Sastre J., Siegrist S., Bulle F., Asensi M., Baik JH, Pawlak A. and Guellaen G
    High-level Expression of Functional Human γ-Glutamyl Transpeptidase Using the Baculovirus System. Biochemistry and Molecular Biology International. 
    Academic press Australia 1996, 38: 801-811 (공동참여, SCI IF: 0.925) 

    1995 
    Baik JH, Picetti R., Saiardi A., Thiriet G., Dierich A., Depaulis A., LeMeur M. and Borrelli E
    Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. 
    Nature 1995, 377: 424-428 (제1저자: SCI IF: 38.597) 

  • Research

    Research Area

    저희 연구실은 신경전달물질과 호르몬의 수용체를 중심으로 생리적인 기능과 신호전달기전 등을 분자적, 세포적인 측면에서 분석하고 있습니다. 그 중에서도 G protein-coupled receptor family에 속하는 운동기능 및 여러 가지 신경생리기능에 관여하는 도파민의 수용체중 대표적인 그룹인 도파민 D2 수용체와, 중추신경계에서 비만 관련신호전달에 중요한 역할을 하는 멜라노코틴 MC3R/MC4R 수용체에 초점을 맞추어 다음과 같은 연구를 진행하고 있습니다.

    Ongoing Project

    • 약물중독 및 우울증에서의 도파민성 신경전달 시스템의 역할
    • 음식중독 및 섭식장애에서의 도파민성 신경전달 시스템의 역할
    • 광 유전학을 통한 도파민성 신경정신 질환 모델에서의 도파민성 신경회로 규명
    • 도파민성 신경세포 분화에서의 도파민 D2 수용체를 통한 신호전달 기전
    • 뇌의 시상하부에서의 멜라노코틴의 수용체 MC4R을 통한 비만 신호전달 기전 분석

  • Teaching

    Undergraduate

    신경생물학
    시스템 신경과학
    유전학

    Graduate

    신경생물학
    시스템 신경과학 
    세포생물학

  • Lab Members

    • Mi-hyun Choi, PhD Student, cmh0912@hanmail.net 
    • Ye-Lan Yoon, PhD Student, yellayella@hanmail.net 
    • Hyo-Jin Lee, PhD Student, hohosaraly@hanmail.net 
    • Donghoon Kim, Graduate Student, dusdhfkd7@naver.com 
    • Shelly Sooyun Song, Graduate Student, ssong07@gmail.com 
    • Byeong Jun Kang, Graduate student, cethynm@gmail.com 
    • Bokyeong Kim, Graduate student, bobobo90@naver.com 
    • Hee Jeong Lim, Graduate student, lhj3994@naver.com 
    • Ki-Pyo Hong, Graduate student, kpblue3459@gmail.com 
    • Dayoung Yoo, Graduate student, ekdud0637@naver.com 
    • Hayeon Jo, Graduate student, ddolong34@naver.com