뇌의 기능은 아직도 많은 것이 밝혀지지 않은 것이 많은, 신비롭고도 동시에 21세기 생명 과학에서의 중요한 도전의 대상 중에 하나라고 할 수 있다. 뇌의 이러한 복잡한 기능에 중요한 인자로 작용하는 것 중의 대표적인 것이 바로 신경전달물질이라고 할 수 있다. 특정 신경세포에서 만들어져 분비되는 신경전달 물질은 그 수용체를 통하여 여러 가지 신호를 전달하고 또한 다른 신경전달 물질, 혹은 다른 단백질들과의 상호작용을 통하여 결국 고유의 생리적 기능으로 이어진다고 할 수 있다. 이러한 과정에서의 생길 수 있는 여러 가지 생물학적인 문제점은 바로 신경질환으로 이어진다고 할 수 있다. 

 우리가 잘 알고 있는 정신 분열증, 치매, 우울증, 파킨슨 증후군, 스트레스 등의 신경정신 질환은 물론 비만과 같은 대사성 질환 등도 이러한 신경전달 물질들의 비 정상적인 조절에서 비롯된 것이라는 것은 이제 잘 알려진 사실이다. 본 연구실에서는 이렇게 뇌의 기능에 중요한 역할을 하는 신경전달 물질, 신경 펩타이드 등의 분자적, 세포적인 측면에서의 신호전달을 연구하고 또한 동물모델을 이용하여 궁극적으로는 중요한 뇌 질환의 표적을 찾는 연구를 수행하고 있다.

 

Education

- Doctor [1987-1992] : 프랑스 파리 6대학 분자세포약리학 이학박사 
- Master [1985-1987] : 프랑스 파리 6대학 생화학 이학석사 
- Bachelor [1981-1985] : 연세대학교 생화학 이학사

Professional Experiences

• - 2006. 9~현재 : 고려대학교 생명과학대학, 교수 
  - 2003. 9~2006. 8 : 고려대학교 생명과학대학, 부교수 
  - 2002. 3~2003. 9 : 연세대학교 의과대학, 부교수 
  - 1996~2002. 2 : 연세대학교 의과대학, 조교수 
  - 1992~1995 : 프랑스 CNRS 소속분자세포유전학연구소(IGBMC), post-doctoral fellow  

수상경력

- 2002년 제1회 로레알 여성 생명과학상 신진과학자 수상 
- 2006년 제 1기 한국보건산업진흥원-아스트라제네카 신약개발 연구비지원사업 수상 
- 2007년 제 2기 한국보건산업진흥원-아스트라제네카 신약개발 연구비지원사업 수상 
- 2014년 한림원 선도과학자 선정

Major Publication

2023

Kim HJ, Hwang B, Reva M, Lee J, Lee BE, Lee Y, Cho EJ, Jeong M, Lee SE, Myung K, Baik JH, Park JH, Kim JI.

GABAergic-like dopamine synapses in the brain.

Cell Rep . 2023 Oct 31;42(10):113239. doi: 10.1016/j.celrep.2023.113239. Epub 2023 Oct 17. (공동저자)

 

Kim HY, Lee J, Kim HJ, Lee BE, Jeong J, Cho EJ, Jang HJ, Shin KJ, Kim MJ, Chae YC, Lee SE, Myung K, Baik JH, Suh PG, Kim JI.

PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.

Exp Mol Med. 2023 Nov;55(11):2357-2375. doi: 10.1038/s12276-023-01104-y. Epub 2023 Nov 1. (공동저자)

 

2022

Jeong H, Park JY, Lee JH, Baik JH, Kim CY, Cho JY, Driscoll M, Paik YK

Deficiency in RCAT-1 Function Causes Dopamine Metabolism Related Behavioral Disorders in Caenorhabditis elegans.

Int J Mol Sci. 2022 Feb 21;23(4):2393. doi: 10.3390/ijms23042393. (공동저자)

 

2021

Baik JH

Dopaminergic Control of the Feeding Circuit (Review).

Endocrinol Metab (Seoul) . 2021 Apr;36(2):229-239. doi: 10.3803/EnM.2021.979. Epub 2021 Apr 6. (교신저자)

 

2020

Baik JH

Stress and the dopaminergic reward system (Review).

Exp Mol Med . 2020 Dec;52(12):1879-1890. doi: 10.1038/s12276-020-00532-4. (교신저자)

 

Na K, Kim M, Kim CY, Lim JS, Cho JY, Shin H, Lee HJ, Kang BJ, Han DH, Kim H, Baik JH, Swiatek-de Lange M, Karl J, Paik YK.

Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth.

J Proteome Res . 2020 Dec 4;19(12):4867-4883. doi: 10.1021/acs.jproteome.0c00787. (공동저자)

 

Lee Y, Han NE, Kim W, Kim JG, Lee IB, Choi SJ, Chun H, Seo M,, Lee CJ, Koh HY,, Kim JH, Baik JH, Bear MF, Choi SY, Yoon BJ.

Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice.

Mol Cells. 2020 Jan 14. doi: 10.14348/molcells.2019.0279. (공동저자)

 

2019

Chae DK, Park J, Cho M, Ban E, Jang M, Yoo YS, Kim EE, Baik JH, Song EJ.

MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-β receptor I ubiquitination.

Mol Oncol. 2019 Dec;13(12):2663-2678. doi: 10.1002/1878-0261.12581. Epub 2019 Nov 8. (공동저자)

 

Kang DS, Kim IS, Baik JH, Kim D, Cocco L, Suh PG.

The function of PLCγ1 in developing mouse mDA system.

Adv Biol Regul. 2019 Sep 19:100654. doi: 10.1016/j.jbior.2019.100654. (공동저자)

 

Jeong H, Shin S, Lee JS, Lee SH, Baik JH, Lim S, Kim YK.

Pan-HDAC inhibitors promote tau aggregation by increasing the level of acetylated TAU.

Int J Mol Sci. 2019 Sep 1;20(17). pii: E4283. doi: 10.3390/ijms20174283. (공동저자)

 

2018

Kim B, Yoon S, Nakajima R, Lee HJ, LIM HJ, Lee YK, Choi JS, Yoon BJ, Augustine G, Baik JH

Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior.

Proc Natl Acad Sci USA 2018, 115(45):E10730-E10739. doi: 10.1073/pnas.1811664115. (교신저자)

 

Yoon YR, Lee TG, Choi MH, Shin SW, Ko YK, Rhyu IJ, Kim DH, Seong JK and Baik JH

Glucose-Regulated Protein 78 binds to and regulates the Melanocortin-4 receptor.

Experimental & Molecular Medicine 2018, 12;50(9):120 (교신저자)

 

Choi MH, Na JE, Yoon YR, Rhyu IJ, Ko YK and Baik JH

Hypomyelination and cognitive impairment in mice lacking CD133 (Prominin-1)

Biochemical and Biophysical Research Communications 2018, 205(3);291-298 (2018). doi: 10.1016/j.bbrc.2018.05.072.  (교신저자)

 

2017

Choi MH, Na JE, Yoon YR, Lee HJ, Yoon S, Rhyu IJ and Baik JH

Role of Dopamine D2 Receptor in Stress-Induced Myelin Loss.

Scientific Reports 2017, 14;7(1):11654. doi: 10.1038/s41598-017-10173-9.  (교신저자)

 

Chae DK, Ban E, Yoo YS, Kim EE, Baik JH, Song EJ

MIR-27a regulates the TGF-β signaling pathway by targeting SMAD2 and SMAD4 in lung cancer.

Molecular Carcinogenesis 2017, 56(8):1992-1998. doi: 10.1002/mc.22655. Epub 2017 Apr 13.  (공동저자)

 

Kang BJ, Song SS, Wen L, Hong KP, Augustine GJ, Baik JH

Effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization.

European Journal of Neuroscience 2017, 46(4):2056-2066. doi: 10.1111/ejn.13648. Epub 2017 Aug 9.  (교신저자)

 

Park J, Park Y, Ryu I, Choi MH, Lee HJ, Oh N, Kim K, Kim KM, Choe J, Lee C, Baik HJ, Kim YK

Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex.

Nature Communications 2017, 7;8:15730. doi: 10.1038/ncomms15730.  (공동저자)

 

2016

Chae DK, Ban E, Yoo YS, Baik JH, Song EJ

Evoluation of inhibition of miRNA expression induced by anti-miRNA oligonucleotides.

Analytical and Bioanalytical Chemistry 2016, 408(18):4829-33  (공동저자) 

 

2015 
Yoon YR, Baik JH 
Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake. 
Endocrinol Metab (Seoul) 2015, 30(4):576-83. doi: 10.3803/EnM.2015.30.4.576 (교신저자) 

Yoon DH, Yoon S, Kim D, Kim H, Baik JH 
Regulation of dopamine D2 receptor-mediated extracellular signal-regulated kinase signaling and spine formation by GABAA receptors in hippocampal neurons. 
Neuroscience Letters 2015, 586: 24-30, doi: 10.1016/j.neulet. 2014.12.010 (교신저자) 

2014 
Song SS, Kang BJ, Wen L, Lee HJ, Sim HR, Kim TH, Yoon S, Yoon BJ, Augustine GJ and Baik JH 
Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization.
Frontiers in Behavioral Neuroscience 2014, 8: 1-11, doi: 10.3389/fnbeh.2014.00336 (교신저자)

2013 
Baik JH 
Dopamine signaling in food addiction: role of dopamine D2 receptors (Review).
BMB Reports 2013, 46(11):519-526 (교신저자)

Kim M, Kim W, Baik JH and Yoon BJ 
Different locomotors ensitization responses to repeated cocaine injections are associated with differential phosphorylation of GluA1 in the dorsomedial striatum of adult rats. 
Behavioural Brain Research 2013, 257:71-6, doi:10.1016/j.bbr.2013.09.038. (공동저자)

Baik JH 
Dopamine Signaling in reward-related behaviors (Review). 
Frontiers in Neural Circuits 2013, 7:152, doi:10.3389/fncir.2013.00152. (교신저자)

Yoon S and Baik JH 
Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation. 
Journal of Biological Chemistry 2013, 288(40):28435-46 (교신저자)

Jung ES, Lee HJ, Sim HR and Baik JH
Cocaine-induced behavioral sensitization in mice: effects of microinjection of dopamine d2 receptor antagonist into the nucleus accumbens.
Experimental Neurobiology 2013, 22(3):224-31 (교신저자)

Han J, Kim YL, Lee KW, Her NG, Ha TK, Yoon S, Jeong SI, Lee JH, Kang MJ, Lee MG, Ryu BK, Baik JH and Chi SG 
ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21WAF1. 
Cell Death and Differentiation 2013, doi: 10.1038/cdd.2013.33. (공동저자)

Kim YS, Jung S, Park BG, Ko MK, Jang H-S, Choi K, Baik JH, Lee J, Lee JK, Pae AN, Cho YS and Min SJ 
Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction.
European Journal of Medicinal Chemistry 2013, 62:71-83 (공동저자)

Sim HR, Choi TY, Lee HJ, Kang E, Yoon S, Han PL, Choi SY and Baik JH 
Role of Dopamine D2 Receptors in Plasticity of Stress-Induced Addictive Behaviors. 
Nature Communications 2013, 4:1579, doi:10.1038/ncomms2598 (교신저자)

Kim JW, Ahn HS, Baik JH and Yoon BJ 
Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice. 
Journal of Psychopharmacology 2013, 27: 171-180 (공동저자) 

2012 
Kang JA, Lee K, Lee KM, Cho S, Seo J, Hur EM, Park CS, Baik JH, Choi SY 
Desipramine inhibits histamine H1 receptor-induced Ca2+ signaling in rat hypothalamic cells.
PLoS One 2012, 7(4): e36185. (공동저자)

2011 
Yoon S, Choi MH, Chang MS, Baik JH 
Wnt5a-Dopamine D2 Receptor Interactions Regulate Dopamine Neuron Development via Extracellular Signal-regulated Kinase (ERK) Activation. 
Journal of Biological Chemistry 2011, 286(18): 15641-15651 (교신저자)

2010 
Kim HK, Youn BS, Shin MS, Namkoong C, Park KH, Baik JH, Kim JB, Park JY, Lee K, Kim YB, Kim MS 
Hypothalamic Angpt14/Fiaf Is a Novel Regulator of Food Intake and Body Weight.
Diabetes 2010, 59: 2772-2780 (공동저자)

Park HW, Jung H, Choi KH, Baik JH, Rhim H
Direct interaction and functional coupling between voltage-gated Ca(V)1.3 Ca(2+) channel and GABA(B) receptor subunit 2. 
FEBS Letter 2010, 584(15):3317-3322 (공동저자)

Yun HM, Baik JH, Kang IS, Jin C, Rhim H 
Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. 
Journal of Biological Chemistry 2010, 285(13):10016-10029 (공동저자)

Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, Kim MS 
NF-{kappa}B activation in hypothalamic POMC neurons is essential in illness- and leptin-induced anorexia. 
Journal of Biological Chemistry 2010, 285(13):9706-9715 (공동저자)

Kim KS, Yoon YR, Lee HJ, Yoon S, Kim S-Y, Shin SW, An JJ, Kim M, Choi SY, Sun W, and Baik JH 
Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors.
Journal of Biological Chemistry 2010, 285(12):8905-8917 (교신저자)

2009 
Yoon KW, Cho JH, Lee JK, Kang YH, Chae JS, Kim YM, Kim J, Kim EK, Kim SE, Baik JH, Naik U.P., Cho SG, and Choi EJ 
CIB1 functions as a Ca2+ -sensitive modulator of stress-induced signaling by targeting ASK1. 
Proc Natl Acad Sci USA 2009, 106(41):17389-94 (공동연구)

2008 
Choi J, Ha CM, Choi EJ, Jeong CS, Park JW, Baik JH, Park JY, Costa M.E., Ojeda S.R., Lee BJ
Kinesin Superfamily-Associated Protein 3 Is Preferentially Expressed in Glutamatergic Neurons and Contributes to the Excitatory Control of Female Puberty.
Endocrinology 2008, 149(12):6146-6156 (공동연구)

Kim SY, Lee HJ, Kim YN, Yoon S, Lee JE, Sun W, Choi EJ, Baik JH 
Striatal-Enriched Protein Tyrosine Phosphatase Regulates Dopaminergic Neuronal Development via Extracellular Signal-Regulated Kinase Signaling. 
Experimental Neurology 2008, 214(1):69-77 (교신저자)

Kim DH, Shin SW, Baik JH
Role of third intracellular loop of the melanocortin 4 receptor in the regulation of constitutive activity.
Biochemical and Biophysical Research Communications 2008, 365, 439-445 (교신저자)

2007 
Yang MZ, Mun CH, Choi YJ, Baik JH, Park KA, Lee WT, Lee JE
Agmatine inhibits matrix metalloproteinase-9 via endothelial nitric oxide synthase. 
Neurological Research 2007, 29(7), 749-754, (공동참여)

Kim S, Yun HM, Baik JH, Chung KC, Nah SY, Rhim H
Functional Interaction of neuronal Cav1.3 L-type calcium channel with ryanodine receptor type-2 in the rat hippocampus. 
Journal of biological chemistry 2007, 282(45)32877-32889, (공동참여)

Yun HM, Kim S, Kim HJ, Kostenis E., Kim JI , Seong JY, Baik JH, Rhim H
The novel cellular mechanism of human 5-HT6 receptor through an interaction with fyn.
Journal of biological chemistry 2007, 282(8), 5496-5505, (공동참여)

An JJ, Rhee Y, Kim SH, Kim DM, Han D-H, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT and Lim S-K
Peripheral Effect of α-Melanocyte-stimulating Hormone on Fatty Acid Oxidation in Skeletal Muscle. 
Journal of biological chemistry 2007, 282(5), 2862-2870 (공동참여)

2006 
Kim SJ, Kim SY, Na YS, Lee HJ, Chung KC, Baik JH
α-synuclein enhances dopamine D2 receptor signaling. 
Brain Research 2006, 1124(1), 5-9 (교신저자)

Kim HS, Song M, Yumkham S, Choi JH, Lee T, Kwon J, Lee SJ, Kim JI, Lee KW, Han PL, Shin SW, Baik JH, Kim YS, Ryu SH, Suh PG.
Identification of a new functional target of haloperidol metabolite:implications for a receptor-independent role of FBPA(3-(4-fluorobenzoyl) propionic acid. 
Journal of Neurochemistry 2006, 99 (2), 458-469 (공동참여)

An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT, Lim SK
Peripheral effect of alpha-melanocyte stimulating hormone on fatty acid oxidation in skeletal muscle. 
Journal of Biological Chemistry 2006, 282(5): 862-2870 (공동참여)

Kim SY, Choi KC, Chang MS, Kim MH, Kim SY, Na YS, Lee JE, Jin BK, Lee BH, Baik JH
The Dopamine D2 Receptor Regulates the Development of Dopaminergic Neurons via ERK and Nurr1 Activation. 
Journal of Neuroscience 2006, 26(17): 4567-4576 (교신저자)

2005 
Cho MK, Li SZ, Lim SK, Baik JH, Lee CJ, Lee W
Structures and Functions of the Potent Cyclic and Linear Melanocortin Analogues. 
Journal of Structural Biology 2005, 150:300-318 (공동참여)

Kim RY, Shin SW, Kim BJ, Lee W, Baik JH
Dynamic Regulation of Hypothalamic Neuropeptide Gene Expression and Food Intake by Melanocortin Analogues and Reversal with Melanocortin-4 receptor antagonist. 
Biochemical and Biophysical Research Communications 2005, 329:1178-1185 (교신저자)

2004 
Jin YJ, Li SZ, Zhao ZS, An JJ, Kim RY, Kim YM, Baik JH and Lim SK
The stimulating effect of cerulenin on CPT-1 activity through the sympathetic nervous system activation surpasses its peripheral effects. 
Endocrinology 2004, 145:3197-3204 (공동참여)

An JJ, Bae MH, Cho SR, Lee SH, Choi SH, Lee BH, Shin HS, Kim YN, Park KW, Borrelli E. and Baik JH
Altered GABAergic Neurotransmission In Mice Lacking Dopamine D2 Receptors. 
Molecular and Cellular Neuroscience 2004, 25: 732-740 (교신저자)

Kim SJ, Kim MY, Lee EJ, Ahn YS and Baik JH
Distinct Regulation of Internalization and MAPK Activation By Two Isoforms of Dopamine D2 Receptor.
Molecular Endocrinology 2004, 18:640-652 (교신저자)

2003 
Cho MK, Kim SS, Lee MR, Shin J, Lee J, Lim SK, Baik JH, Yoon CJ, Shin I, Lee W
NMR studies on turn mimetic analogs derived from melanocyte-stimulating hormones. 
Journal of Biochemistry and Molecular Biology 2003, 36: 552-557. (공동참여)

Lee KH, Chung HS, Kim HS, Oh SH, Ha MK, Baik JH, Lee S, Bang D
Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behcet's disease. 
Arthritis and Rheumatism 2003, 48: 2025-2035. (공동참여)

An JJ, Cho SR, Jeong DW, Park KW, Ahn YS and Baik JH
Anti-proliferative effects and cell death mediated by two isoforms of dopamine D2 receptors in pituitary tumor cells.
Molecular and Cellular Endocrinology 2003, 206:49-62 (교신저자)

Kim KH, Min YK, Baik JH, Lau LF, Chaqour B, Chung KC
Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor.
Journal of Biological Chemistry 2003, 278: 13847-13854 (공동참여)

2002 
Kim CS, Lee SH, Kim RY, Kim BJ, Li SZ, Lee IH, Lee EJ, Lim SK, Bae YS, Lee W and Baik JH
Identification of domains directing specificity of coupling to G-proteins for the melanocortin MC3 and MC4 receptors. 
Journal of Biological Chemistry 2002, 277: 31310-31317 (교신저자)

2001 
Lim SK, Li SZ, Lee CH, Yoon CJ, Baik JH and Lee W
Minimization of MC1R selectivity by modification of core structure of α-MSH-ND.
Chemistry and Biology 2001, 8: 857-870 (공동참여)

Lee EJ, Lee SH, Jung JW, Lee W, Kim BJ, Park KW, Lim SK, Yoon CJ and Baik JH
Differential Regulation of cAMP-Mediated Gene Transcription and ligand selectivity by MC3R and MC4R Melanocortin Receptors.
European Journal of Biochemistry 2001, 268: 582-591 (교신저자)

2000 
Usiello A., Baik JH, RougePont F., Picetti R., Dierich A., LeMeur M., Piazza PV and Borrelli E
Distinct Functions of the Two Isoforms of D2 Dopamine Receptors.
Nature 2000, 408: 199-203 (공동 제1저자)

Park KW, Lee EJ, Lee SH, Lee JE, Choi EY, Kim BJ, Hwang RJ, Park KA and Baik JH
Molecular Cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG. 
Gene 2000, 257: 45-55 (교신저자)

1999 
Li SZ, Lee JH, Lee W, Yoon CJ, Baik JH, Lim SK
Type I beta-turn conformation is important for biological activity of the melanocyte-stimulating hormone analogues. 
European Journal of Biochemistry 1999, 265: 430-440 (공동참여)

Choi EY, Jeong DW, Park KW and Baik JH
G protein-mediated mitogen-activated- protein (MAP) kinase activation by two dopamine D2 receptors. 
Biochemical and Biophysical Research Communications 1999, 256: 33-40 (교신저자)

1998 
Saiardi A., Samad TA., Picetti R., Bozzi Y., Baik JH and Borrelli E
The physiological role of dopamine D2 receptors. 
Advances in Pharmacology 1998, 42: 521-524 (공동참여)

1997 
Saiardi A., Bozzi Y., Baik JH and Borrelli E
Antiproliferative role of dopamne: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia. 
Neuron 1997, 19: 115-126 (공동참여)

Picetti R., Saiardi A., Samed TA., Bozzi Y., Baik JH and Borrelli E
Dopamine D2 receptors in signal transduction and behavior. 
Critical Reviews in Neurobiology 1997, 11: 121-142 (공동참여)

Calabresi P., Saiardi A., Pisani A., Baik JH, Centonze D., Mercuri NB., Bernardi G. and Borrelli E
Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors. 
Journal of Neuroscience 1997, 17: 4536-4544 (공동참여)

Seeman P., Guan HC., Nobrega J., Jiwa D., Markstein R., Baik JH, Picetti R., Borrelli E. and Tol HH
Dopamine D2-like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3H]benzquinoline.
Synapse 1997, 25: 137-146 (공동참여)

1996 
Sastre J., Siegrist S., Bulle F., Asensi M., Baik JH, Pawlak A. and Guellaen G
High-level Expression of Functional Human γ-Glutamyl Transpeptidase Using the Baculovirus System. Biochemistry and Molecular Biology International. 
Academic press Australia 1996, 38: 801-811 (공동참여)

1995 
Baik JH, Picetti R., Saiardi A., Thiriet G., Dierich A., Depaulis A., LeMeur M. and Borrelli E
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. 
Nature 1995, 377: 424-428 (제1저자)

Research Area

 

저희 연구실은 신경전달물질과 호르몬의 수용체를 중심으로 생리적인 기능과 신호전달기전 등을 분자적, 세포적인 측면에서 분석하고 있습니다. 그 중에서도 G protein-coupled receptor family에 속하는 운동기능 및 여러 가지 신경생리기능에 관여하는 도파민의 수용체중 대표적인 그룹인 도파민 D2 수용체와, 중추신경계에서 비만 관련신호전달에 중요한 역할을 하는 멜라노코틴 MC3R/MC4R 수용체에 초점을 맞추어 다음과 같은 연구를 진행하고 있습니다.

Ongoing Project

• 약물중독 및 우울증에서의 도파민성 신경전달 시스템의 역할 
• 음식중독 및 섭식장애에서의 도파민성 신경전달 시스템의 역할 
• 광 유전학을 통한 도파민성 신경정신 질환 모델에서의 도파민성 신경회로 규명 
• 도파민성 신경세포 분화에서의 도파민 D2 수용체를 통한 신호전달 기전 
• 뇌의 시상하부에서의 멜라노코틴의 수용체 MC4R을 통한 비만 신호전달 기전 분석

 

유전자 조작 쥐 및 광유전학을 이용한 동물 모델 행동 실험

• Wildtype과 D2R knockout 쥐의 강박적 섭식 행동 분석을 위한 Light/Dark box 실험

 

• 광유전학을 이용한 D2R 신경세포의 CeA-BNST 신경회로 특이적 활성 조절을 통한 충동성 조절 실험

 

2018 PNAS 논문 링크

Undergraduate

• 신경생물학 
• 시스템 신경과학 
• 유전학

 

Graduate

• 신경생물학
• 시스템 신경과학 
• 세포생물학

 

PhD. Students

 

Byeong Jun Kang

byjunkang@gmail.com

 

Bokyeong Kim

bobobo90@naver.com

 

 

Min Ji Kim

vitaminzee@naver.com

 

Graduate Students

 

Seoryoung Park

tjfodzz07@naver.com

 

Sion Kim

sion5029@gmail.com

 

Jihee Seo

seoji-@daum.net

 

Former Lab members

 

박사학위 취득

• Dr. Sehyoun Yoon. Ph.D.

Northwestern University, Chicago, USA
(Post-Doc Fellow)

 

• Dr. Mi Hyun Choi. Ph.D.

KIST
(Post-Doc Fellow)

 

• Dr. Ye Ran Yoon. Ph.D.

엑세스바이오파마

 

• Dr. Hye ri Sim. Ph.D.

유한양행 책임연구원

 

• Dr. Sunoh Kim. Ph.D. (KIST 학연 프로그램)

전라남도생물산업진흥재단 책임연구원

 

• Dr. Hyung Mun Yoon. Ph.D. (KIST 학연 프로그램)

경희대학교 치의예과 조교수

 

• Dr. Dong Kyu Chae. Ph.D. (KIST 학연 프로그램)

클리노믹스

 

 

석사학위 취득

• Kyu Seok Kim. M.S

Merck

 

• Eun Young Kang. M.S

메디파인

 

• Sung Jae Kim. M.S

한국 Merck

 

• Seung Woo Shin. M.S

줄기찬 주식회사 연구소

 

• Min Seok Chang. M.S

셀트리온

 

• Ryang Yeo Kim. M.S

로레알 코리아

 

• Tae gul Lee. M.S

방사선 의학연구소

 

• Eun Sol Jung . M.S

에이디엠코리아

 

• Do Hoon Kim. M.S

연세대학교 의과대학 박사과정

 

• Hyo Jin Lee. M.S

바이오 오케스트라

 

• Dong Hoon Yoon. M.S

종근당 바이오

 

• Dae Hee Han. M.S

한국 팜바이오

 

• Hee-Jung Lim. M.S

SK바이오팜

 

• Dong Hoon Kim. M.S

LG 화학

 

• Da-Young Yoo. M.S

제넥신

 

Sungwoon Yoon

 

Chae Eun Kim

 

Yea Jue Kim

 

Post-Doc fellow

• Dr. Sung Yeol Kim. Ph.D.

한국 휴렛팩카드

 

연구원 (연세대학교 의과대학 분자생물학연구실)

• Dr. Dae-Won Jeong, Ph.D.

(전) 연구원

(현) 영남대학교 의과대학 미생물학교실 교수

 

• Dr. Kye Won Park, Ph.D.

(전) 연구원

(현) 성균관대학교 식품생명공학과 교수

 

• Dr. Mi Hyun Bae, Ph.D.

(전) 연구원

(현) IBS 시냅스뇌질환 연구단 박사연구원

 

• Dr. Juanji An, Ph.D.

(전) 연구원

(현) Senior Staff Scientist, The Scripps Research Institute Florida, USA

 

• Dr. Soo Hyun Lee, Ph.D.

(전) 연구원

(현) Principal Investigator, NIMH, USA

 

• Myeong Yoon Kim, M.S

(전) 연구원

(현) 유니메디 대표