Young Sik Lee

       College of Life Sciences & Biotechnology
       316, West building of LifeScience, Anam-dong Seongbuk-Gu, Seoul, 136-713 Korea
       Email : ys-lee@korea.ac.kr
       Phone : 02-3290-3018
      


   Education
        2000 Ph.D. Korea University, South Korea
        1996 M.S. Korea University, South Korea
        1994 B.S. Korea University, South Korea


   Professional Experiences
        2013.09 - Present Professor, College of Life Sciences and Biotechnology, Korea University, South Korea
        2008.09 - 2013.08 Associate professor, College of Life Sciences and Biotechnology, Korea University, South Korea
        2006.03 - 2008.08 Assistant professor, College of Life Sciences and Biotechnology, Korea University, South Korea
        2001.01- 2006.02 Postdoctoral fellow, Northwestern University, USA

  RNA interference (RNAi) is a biological phenomenon controlling the expression of complementary genes by creating RNAs of 21-23 nucleotides in length, such as small interfering RNA (siRNA) and microRNA (miRNA) in eukaryotes. These small regulatory RNAs play important roles in various biological processes, including animal development, genomic stability, and virus resistance, and are also closely linked to human diseases.

 

  RNAi has also been applied in various fields including the treatment and diagnosis of human diseases. Understanding the formation and action mechanisms of small RNAs as well as their in vivo functions is indispensable, considering the biological importance and applicability of RNAi. Our lab is using various models to study the mechanisms and applications of RNAi and is also conducting in-depth research on the biological functions of individual small RNAs.

 

 

[2023]

DK Na, DH Lim, JS Hong, HM Lee, DH Cho, MS Yu, Bilal Shaker, Jun Ren, Bomi Lee, JG Song, Yuna Oh, KG Lee, KS Oh, MY Lee, MS Choi, HS Choi, YH Kim, Jennifer M. Bui, KS Lee, HW Kim, YS Lee*, and Jörg Gsponer*

A multi-layered network expansion model identifies Akt1 as common modulator of neurodegenertaion.

Molecular Systems Biology 19, e11801 (*Corresponding authors)

 

 

[2020]

 

 

 

 

 

[2019]

 

 

Lim DH, Lee SJ, Han JY, Choi MS, Hong JS, Lee YS* (2019)
MicroRNA miR-252 targets mbt to control the developmental growth of Drosophila.

Insect Molecular Biology 28, 444-454 (*Corresponding author)

[2018]

 

Lim DH, Lee SJ, Han JY, Choi MS, Hong JS, Seong YM, Kwon YS, Lee YS* (2018)
Ecdysone-responsive microRNA-252-5p controls the cell cycle by targeting Abi in Drosophila.
The FASEB Journal 32, 4519-4533 (*Corresponding author)



[2017]

Hong JS, Lee DH, Yook YW, Na DK, Jang YJ, Kim JH, Lee YS* (2017)
MicroRNA signatures associated with thioacetamide-induced liver fibrosis in mice.
Bioscience, Biotechnology, and Biochemistry 81, 1348-1355 (*Corresponding author)



[2016]

Han JH, Bae JB, Choi CY, Choi SP, Kang HS, Jo EK, Park JS, Lee YS, Moon HS, Park CG, Lee MS, Chun TH (2016)
Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice.
Autophagy 12, 2326-2343

Nam MH, Son WR, Lee YS, Lee KW (2016)
Glycolaldehyde-derived advanced glycation end products (glycol-AGEs)-induced vascular smooth muscle cell dysfunction is regulated by the AGES-receptor (RAGE) axis in endothelium.
Cell Communication & Adhesion 7, 1-12

​Du EJ, Ahn TJ, Kwon IM, Lee JH, Park JH, Park SH, Kang TM, Cho HN, Kim TJ, Kim HW, Jun YS, Lee HJ, Lee YS, Kwon JY, Kang KJ (2016)
TrpA1 regulates defecation of food-borne pathogens under the control of the Duox pathway.
PLOS Genetics 12, e1005773

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[2015]

Kim JM, Lim KS, Hong JS, Kang JH, Lee YS, Hong KC (2015)
A polymorphism in the porcine miR-208b is associated with microRNA biogenesis and expressions of SOX-6 and MYH7 with effects on muscle fibre characteristics and meat quality.
Animal Genetics 46, 73-77

Hong JS, Kim NH, Choi CY, Lee JS, Na DK, Chun TH, Lee YS* (2015)
Changes in cellular microRNA expression induced by porcine circovirus type 2-encoded proteins.
Veterinary Research 46, 39 (*Corresponding author) 

Lim JH, Kim DJ, Lee DE, Han JY, Chung JH, Ahn HK, Lee SW, Lim DH, Lee YS, Park SY, Ryu HM (2015)
Genome-wide microRNA expression profiling in placentas of fetuses with Down syndrome.
Placenta 36, 322-328



[2014]

Bae JB, Lee SJ, Park CG, Lee YS, Chun TH (2014)
Trafficking of LAG-3 to the surface on activated T cells via its cytoplasmic domain and protein kinase C signaling.
Journal of Immunology 193, 3101-3112

Seong YM, Lim DH, Kim Augustine, Lee YS, Song HS, Kwon YS (2014) 
Global identification of target recognition and cleavage by the microprocessor in human ES cells.
Nucleic Acids Research  42, 12806-12821

Lim DH , Oh CT, Han SJ* , Lee YS* (2014) 
Methods for studying the biological consequences of endo-siRNA deficiency in Drosophila melanogaster.
Methods in Molecular Biology 1173, 51-58 ( *Corresponding authors)

Joo JY, Ko HY, Lee JH, Lim DH, Kim EY, Cho SJ, Hong KS, Ko JJ, Lee SM, Lee YS, Choi YS, Lee KA, Kim SH (2014) 
Microinjection free delivery of miRNA inhibitor into zygotes. 
Scientific Reports 4, 5417

Ko HY, Lee YS*, Kim SH* (2014)
Bioluminescence Reporter Gene-Based Detection of MicroRNAs. 
Methods in Molecular Biology 1098, 85-95 (*Corresponding authors)



[2013] 

Lim DH, Lee LH, Oh CT, Kim NH, Hwang SW, Han SJ and Lee YS* (2013)
Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs. 
Journal of Cellular Biochemistry 114, 418-427 (*Corresponding author)

Lee JS, Kim JM, Lim KS, Hong JS, Hong KC, and Lee YS* (2013) 
Effects of polymorphisms in the porcine microRNA MIR206/ MIR133B cluster on muscle fiber and meat quality traits.    
Animal Genetics 44, 101-106 (*Corresponding author)



[2012] 

Hong JS, Noh SH, Lee JS, Kim JM, Hong KC, and Lee YS* (2012) 
Effects of polymorphisms in the porcine microRNA miR-1 locus on muscle fiber type composition and miR-1 expression.   
Gene 506, 211-216 (*Corresponding author)

Lim DH, Han JY, Kim JR, Lee YS*, and Kim HY* ( 2012)
Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila.   
Biochemical and Biophysical Research Communications 419, 20-26 (*Corresponding authors) 

Kwak GH, Lim DH, Han JY, Lee YS*, and Kim HY* (2012) 
Methionine sulfoxide reductase B3 protects from endoplasmic reticulum stress in Drosophila and in mammalian cells.   
Biochemical and Biophysical Research Communications 420, 130-135 (*Corresponding authors) 

Lee JS, Kim JM, Hong JS, Lim KS, Hong KC, Lee YS* (2012) 
Effects of polymorphisms in the 3 untranslated region of the porcine PPARGC1A gene on muscle fiber characteristics and meat quality traits.   
Molecular Biology Reports .39, 3943-3950 (*Corresponding author)



[2011] 

Lim DH, Oh CT, Lee RH, Hong JS, Noh SH, Hwang SW, Kim SC, Han SJ, Lee YS* (2011) 
The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis.   
FEBS Letters 585, 3079-3085 (*Corresponding author) 



[2010] 

Cho IS, Kim J, Seo HY, Lim DH, Hong JS, Park YH, D.C.Park, K.Hong, Whang KY, Lee YS* (2010) 
Cloning and characterization of microRNAs from porcine skeletal muscle and adipose tissue.   
Molecular Biology Reports 37, 3567-3574 (*Corresponding author) 

Kim JM, Lee KT, Lim KS, Park EW, Lee YS, Hong KC (2010) 
Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs.  
Animal Genetics 41, 642-645 



[2009] 

Lee YS*, Sigal Pressman, Arlise P. Andress, Kim Kevin, Jamie L. White, Justin J. Cassidy, Xin Li, Kim Lubell, Lim DH, Cho IS, Kenji Nakahara, Jonathan B. Preall, Priya Bellare, Erik J. Sontheimer, Richard W. Carthew* (2009) 
Silencing by small RNAs is linked to endosomal trafficking.    
Nature Cell Biology 11, 1150 - 1156 (*Corresponding authors) 
(Selected as a cover article and highlighted in Nature Cell Biology and Nature Reviews Molecular Cell Biology) 



[2008] 

Cho IS, Kim J, Lim DH, Ahn HC, Kim HG, Lee KB, Lee YS* (2008) 
Improved serum stability and biophysical properties of siRNAs following chemical modifications. 
Biotechnology Letters 30, 1901-1908 (*Corresponding author) 

Kim J, Cho IS, Hong JS, Choi YS, Kim HG, Lee YS* (2008) 
Identification and charaterization of new microRNAs from pig.   
Mammalian Genome 19, 570-580 (*Corresponding author) 

Lim DH, Kim J, Kim SU, Richard W. Carthew, Lee YS* (2008) 
Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila.
Biochemical and Biophysical Research Communications 371, 525-530    (*Corresponding author)



[2007] 

Oh HY, Jin X, Kim JG, Oh Mj, Pian X, Kim JM, Yoon MS, Son CI, Lee YS, Hong KC, Kim H, Choi YJ, Whang KY (2007) 
Characteristics of primary and immortalized fibroblast cells derived from the miniature and domestic pigs. 
BMC Cell Biology 8, 20 

Lee EH, Song MS, Shin JY, Lee YM, Kim CJ, Lee YS, Kim H, Choi YK (2007) 
Genetic characterization of avian metapneumovirus subtype C isolated from pheasants in live bird market.  
Virus Research 128, 18-25 

Kevin Kim, Young Sik Lee, Richard W. Carthew (2007) 
Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes.   
RNA 13, 22-29



[2006] 

Kevin Kim, Young Sik Lee, Dinari Harris, Kenji Nakahara, Richard W. Carthew (2006) 
The RNAi pathway initiated by Dicer-2 in Drosophila.   
Cold Spring Harbor Symposia on Quantitative Biology 71, 39-44



[~2005] 

Young Sik Lee, Kenji Nakahara, John W. Pham, Kevin Kim, Zhengying He, Erik J. Sontheimer, Richard W. Carthew (2004) 
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.  
Cell 117, 69-81 

John W. Pham, Janice L. Pellino, Young Sik Lee, Richard W. Carthew, Erik J. Sontheimer (2004) 
A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila.   
Cell 117, 83-94 

Young Sik Lee, Richard W. Carthew (2003) 
Making a better RNAi vector for Drosophila : use of intron spacers.   
Methods 30, 322-329 

Ken-Ichi Takemaru, Shinji Yamaguchi, Young Sik Lee, Yang Zhang, Richard W. Carthew, Randall T. Moon (2003)
Chibby, a nuclear-beta-catenin-associated antagonist of the Wnt/Wingless pathway.   
Nature 422, 905-909

PhD students

 

 

     Open positions for PhD students and postdocs

          

          If you are interested or have any inquiries about the current openings or research,

          please email (yoojaejoon96@gmail.com).

 

     Shipping and Mailing Address

          02841

          Regulatory RNA Biology Lab
          L204, West building of Life Science       
          Korea University
          145, Anam-ro, Seongbuk-Gu, Seoul
          Republic of Korea


       Contact Info

          Email : yoojaejoon96@gmail.com
          Phone : 02-3290-3626