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고려대학교 교수소개

Knowledge & Innovation

생명과학대학

Home > 생명과학대학 >생명과학부

소개

Prof. 강성만

Tel:02-3290-3949
Fax:927-9028

e-mail: skang@korea.ac.kr

  • About Professor
  • Curriculum vitae
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    인류의 역사는 질병과의 끝없는 투쟁으로 점철되어 왔다. 이러한 노력으로 많은 질병이 퇴치되었으나 현재까지도 많은 질환은 그 발병기전에 대해서 전혀 알려지지 않고 있다. 특히 많은 유전 질환들이 인류에 고통을 주고 있음에도 불구하고 질환의 발병 기전뿐만 아니라 원인 유전자조차도 분명히 밝혀지지 않은 상태이다. 본 연구실은 박사 후 연구원, 박사과정, 석사과정 학생 등 여러 구성원이 여러 유전질환의 원인을 밝히기 위해 함께 노력하고 있으며 그 중에서도 노인에게 가장 흔하게 발병하는 알츠하이머병과 그 외 파킨슨병, polyglutamine 관련 질환인 Spinocerebella Ataxia(SCA), 헌팅톤씨 병 등 퇴행성 뇌 질환의 공통적인 발병기전에 특히 관심을 두고 있다. 본 연구실은 각 퇴행성 뇌 질환의 특징적 단백질 응집체가 세포 사멸을 일으키는 기전을 연구하고 질환의 원인 유전자와 상호 작용하는 유전자를 발굴함으로써 뇌 질환의 발병 기전을 이해하고 궁극적으로 질병의 치료에 근거를 제시하는 것을 목표로 하고 있다.

    퇴행성 뇌질환과 세포 내 단백질 응집체

    파킨슨병 환자에게서 발견되는 inclusion body나 헌팅톤씨병 환자, SCA 환자에게서 발견되는 polyglutamine 응집체도 정상적인 구조를 가지지 못하게 된 단백질이 β-sheet 형태를 이루어 만들어지는데 이러한 응집체들은 세포 밖에 형성되는 아밀로이드플라크를 제외하면 모두 세포 내부에 존재한다고 알려져 있었다. 그러나 알츠하이머병의 경우에도 최근 세포 안에서 세포 사멸을 일으키는 아밀로이드 베타가 발견되면서 플라크 중심이었던 알츠하이머 연구의 패러다임이 급격히 변화하고 있다. 따라서 단백질 응집체를 형성하는 퇴행성 뇌 질환들 사이에는 세포 내 응집체가 Ubiquitin-Proteasome System(UPS)을 저해하고 산화적 스트레스를 일으키는 공통적인 세포 사멸 기작이 존재한다고 본다. 또한 아밀로이드 전구체 단백질(APP), α-Synuclein, Parkin, Huntingtin, Ataxin-1과 같은 질환의 원인 유전자와 상호 작용하는 유전자를 찾아 그 기능을 연구하고 있으며 이러한 노력이 퇴행성 뇌 질환의 발병 기전을 이해하는데 큰 도움을 줄 것으로 생각하고 있다.

    퇴행성 뇌 질환과 세포 사멸 기작

    알츠하이머병은 cortex와 hippocampus, 파킨슨병은 substantia nigra, SCA는 cerebellum 등 퇴화되는 부위는 각각 다르지만 신경 세포 사멸 현상이 나타난다는 것은 공통적인 현상이라고 하겠다. 질환을 유발하는 다양한 자극과 세포 사멸 원인을 제거하는 것이 퇴행성 뇌 질환을 예방하는 한가지 방법이라고 한다면 세포 내부의 네트워크를 조절하여 여러 자극에 의해 일어나는 세포 사멸 자체를 막는 것은 퇴행성 뇌 질환을 정복할 수 있는 방법이라고 할 수 있겠다. 따라서 세포 내부에서 일어나는 caspase-dependent, independent apoptosis에 중요한 역할을 하는 HtrA2/Omi 같은 유전자들의 기능을 연구하고 그 유전자들을 조절할 수 있는 방법을 개발하여 궁극적으로는 질환 치료에 도움이 되고자 한다.

  • Curriculum

    education 

    ● Doctor 1992 Molecular Biology, University of Alabama at Birmingham 
    ● Master 1985 Department of Biological Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST) 
    ● Bachelor 1982 Department of Science Education (Major: Biology) Seoul National University

    professional experience  

    ● 2003-present Professor, School of Life Sciences and Biotechnology Korea University 
    ● 1998-2003 Associate professor, Graduate School of Biotechnology Korea University 
    ● 1997-1998 Assistant professor, Graduate School of Biotechnology Korea University 
    ● 1995-1997 Visiting Associate, National Center for Human Genome Research, National Institutes of Health 
    ● 1992-1995 Postdoctoral Fellowship Research Associate, Institute of Biosciences and Technology, Texas A&M University 
    ● 1985-1988 Researcher, Genetic Engineering Center, Korea Advanced Institute of Science and Technology

  • Publication

    120.  Goo HG, Rhim H, Kang S.  Pathogenic Role of Serine Protease HtrA2/Omi in Neurodegenerative Diseases.  Curr Protein Pept Sci    2016 Mar 10. [Epub ahead of print]
     
    119.  Nam MK, Han JH, Jang JY, Yun SE, Kim GY, Kang S, Rhim H.(2015)  A novel link between the conformations, exposure of specific epitopes, and subcellular localization of α-synuclein.  Biochim Biophys Acta  1850(12):2497-505
     
    118. Kang AR, Park SH, Lee S, Choi DY, Kim KP, Song HK, Hong S, Kang S. (2015) A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation. Biochim Biophys Acta 1854(5):356-364
     
    117. Goo HG, Rhim H, Kang S. (2014) HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis. Exp Cell Res 328(2):456-65
     
    116. Lee ES, Lee HJ, Lee YJ, Jeong JH, Kang S, Lim YB.(2014) Chemical chaperones reduce ionizing radiation-induced endoplasmic reticulum stress and cell death in IEC-6 cells. Biochem Biophys Res Commun 450(2):1005-9
     
    115. Choi KA, Hwang I, Park HS, Oh SI, Kang S, Hong S.(2014) Stem cell therapy and cellular engineering for treatment of neuronal dysfunction in Huntington's disease. Biotechnol J 9(7):882-94
     
    114. Kim EJ, Lee YJ, Kang S, Lim YB.(2014) Ionizing radiation activates PERK/eIF2α/ATF4 signaling via ER stress-independent pathway in human vascular endothelial cells. Int J Radiat Biol 90(4):306-12
     
    113. Hwang I, Park JH, Park HS, Choi KA, Seol KC, Oh SI, Kang S, Hong S. (2013). Neural stem cells inhibit melanin production by activation of Wnt inhibitors.  J Dermato Sci 72(3), 274-83
     
    112. Bae Y, Jung SH, Kim GY, Rhim H, Kang S (2013). Hip2 ubiquitin-conjugating enzyme overcomes radiation-induced G2/M arrest. BBA - Molecular Cell Research 1833(12), 2911-21
     
    111. Kim EJ, Jeong JH, Bae S, Kang S, Kim CH, Lim YB(2013). mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung
    cancer cells harboring an EGFR activating mutation by inducing autophagy. J Cell Biochem,114(6):1248-56.
     
    110. Kim Y, Park JH, Jang JY, Rhim H, Kang S(2013). Characterization and Hsp104-induced artificial clearance of familial ALS-related SOD1 aggregates. Biochem Biophys Res Commun, 434(3):521-6.           
     
    109. Goo HG, Jung MK, Han SS, Rhim H, Kang S(2013). HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA. Biochim Biophys Acta, 1833(8):1866-75            
     
    108. Kim GY, Kim HY, Kim HT, Moon JM, Kim CH, Kang S, Rhim H.(2012). HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8. Mol Cell Biol, 32(21):4482-92            SCI 2012. 11
     
    107. Seongman Kang and Sunghoi Hong (2011). Prediction of personalized drugs  based on genetic variations provided by DNA sequencing technologies. Genes &  Genomes 33, 591-603  SCIE 2011. 12
     
    106. Lee S, An S, Kang TH, Kim KH, Chang NH, Kang S, Kwak CK, Park HS.  (2011). Comparison of mesenchymal-like stem/progenitor cells derived  from supernumerary teeth with stem cells from human exfoliated deciduous teeth Regen. Med. 6,
    689-699       SCIE 2011. 11
     
    105. Lee S, Kim J, Park TJ, Shin Y, Lee SY, Han YM, Kang S, Park HS.  (2011). The effects of the physical properties of culture
    substrates on the  growth and differentiation of human embryonic stem cells. Biomaterials 32,  8816-8829               SCI 2011. 12
     
    104. Choi KJ, Lee JH, Kim KS, Kang S, Lee YS, Bae S (2011). Identification of  ELAVL4 as a modulator of radiation sensitivity in A549 non-small cell lung  cancer cells. Oncol Rep 26, 55-63  SCI 2011. 07
     
    103. Lee SB, Kim HJ, Shin J, Kang ST, Kang S, Yoo YD (2011). Bcl-XL prevents  serum depreivation-induced oxidative strss mediated by Romo1. Oncol Rep 25,  1337-1342 SCI 2011 . 05
     
    102. Choi D., and Kang S. (2011). Identification and characterization of RNF2   response elements in human adult cells. Mol. Cells.  SCI, 2011.03
     
    101. Cho K, Cho S, Lee SO, Oh C, Kang K, Ryoo J, Lee S, Kang S, Ahn K (2011).  Redox-regulated peptide transfer from the transporter associated with   antigen processing to MHC class I molecules by protein disulfide    isomerase. Antioxid Redox Signal in press  SCI, 2011.02
     
    100. Lee JH, Choi KJ, Seo WD, Jang SY, Kim M, Lee BW, Kim JY, Kang S, Park  KH, Lee YS, Bae S (2011). Enhancement of radiation
    sensitivity in lung   cancer cells by celastrol is mediated by inhibition of Hsp90. Int J Mol Med   27, 441-6  SCI, 2011.03
     
    99. Lee S, Hong S,, Kim S., and Kang S. (2011). Ataxin-1 occupies the promoter  region of E-cadherin in vivo and activates CtBP2-
    repressed promoter. BBA -  Molecular Cell Research in press     SCI,2011.02
     
    98. Choi D, Goo HG, Yoo J, Kang S. (2011). Identification of RNF2-responding  loci in long-range chromatin interactions using the novel     4C-ChIP-Cloning technology.  J Biotechnol 151, 312-318    SCI, 2011.02
     
    97. Lee PY, Bae KH, Jeong DG, Chi SW, Moon JH, Kang S, Cho S, Lee SC, Park  BC, Park SG. (2011). The S-nitrosylation of glyceraldehyde-3-phosphate   dehydrogenase 2 is reduced by interaction with glutathione peroxidase 3  in  Saccharomyces cerevisiae. Mol Cells, SCI 2011, 03
     
    96. S Kang and S Hong. (2010). SUMO-1 interacts with mutant ataxin-1 and   colocalizes to its aggregates in  Purkinje cells of SCA1 transgenic mice. Arch  Ita Biol, 148, 351-363  SCI 2010, 12
     
    95. Yoonhee Bae, Dongwon Choi, Hyangshuk, Rhim, Seongman Kang. (2010).  Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin  proteasome pathway. FEBS Letters, 584, 4505-4510      SCI 2010, 11
     
    94. Bae Y, Kho CW, Lee SY, Rhim H, Kang, S. (2010). Hip2 interacts with and  destabilizes Smac/DIABLO . Biochem Biophys Res Commun, 397, 718-723
     
    93. Jang J, Hong SH, Choi D, Choi KS, Kang S, Kim IH. (2010). Overexpression of  Newcastle disease virus (NDV) V protein enhances NDV production kinetics in  chicken embryo fibroblasts. Appl Microbiol Biotechnol 85, 1509-1520 SCI 2009.
     
    92. Hye-Min Park, Goo-Young Kim, Min-Kyung Nam, Geun-Hye Seong, Chul Han,  Kwang Chul  Chung, Seongman Kang, Hyangshuk Rhim (2009). The serine  protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin  ligase activity.. Biochem Biophys Res Commun, 387, 537-542  SCI 2009, 08
     
    91. Seongman Kang, Sunghoi Hong (2009). Molecular Pathogenesis of   Spinocerebellar Ataxia Type 1 Disease. Mol. Cells. 27, 621-627 SCI 2009. 6
     
    90. Eun Jin Yoon, Hyo-Jin Park, Goo-Young Kim1, Hyungmin Cho, Jung-Ha Choi,  Hye-Yoon Park, Ja-Young Jang, Hyangshuk Rhim1*, Seongman Kang*(2009).  Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic   activity of SOD1:
    implications for the pathogenesis of ALS. Exp. Mol. Med. 41,  611-617 SCI 2009. 9
     
    89. Park HJ, Kim SS, Kang S, Rhim H. (2009). Intracellular Abeta and C99   aggregates induce mitochondria-dependent cell death in human neuroglioma H4  cells through recruitment of the 20S proteasome subunits. Brain Res. 1273, 1-8.  SCI 2009. 6
     
    88. Ryoo SW, Shin S, Shim MS, Park YS, Lew WJ, Park SN, Park YK, Kang S  (2008). Spread of nontuberculous mycobacteria from 1993 to 2006 in Koreans.. J  Clin Lab Anal. 22(6), 415-20. SCI 2008. 11
     
    87. Sun-Joo Lee, Dongwon Choi, Hyangshuk Rhim, Hyo-Jung Choo,   Young-Gyu Ko, Chul Guen Kim, Seongman Kang (2008). PHB2 interacts with  RNF2 and represses CP2c-stimulated transcription. Mol Cell Biochem, 319, 69-77  SCI 2008. 12
     
    86. Lee PY, Bae KH, Kho CW, Kang S, Lee DH, Cho S, Lee SC, and Park SG  (2008). Interactome analysis of yeast glutathione  peroxidase3. J. Microbiol.  Biotechnol, 18, 1364-1367, SCIE 2008. 08
     
    85. Han, Chul, Min-Kyung Nam, Hyo-Jin Park, Young-Mo Seong, Seongman  Kang, and Hyangshuk Rhim (2008). Tunicamycin-induced ER stress   upregulatesthe expression of mitochondrial HtrA2 and promotes apoptosis   through the cytosolic release of HtrA2. J. Microbiol. Biotechnol, 18, 1197-1202,  SCIE 2008. 06
     
    84. Lee S, Hong S, Kang S (2008). The ubiquitin-conjugating enzyme UbcH6   regulates the transcriptional repression activity of the SCA1 gene product   ataxin-1. Biochem Biophys Res Commun, 372, 735-740, SCI 2008. 08
     
    83. Hong S, Lee S, Cho SG, Kang S (2008). UbcH6 interacts with and   ubiquitinates the SCA gene product ataxin-1. Biochem Biophys Res   Commun, 371, 56-260, SCI 2008. 06
     
    82. Lee JH, Shin SH, Kang S, Lee YS, Bae S. (2008). A novel    activation-induced suicidal degradation mechanism for Akt by selenium.   Int J Mol Med. 21(1):91-7 SCI 2008. 01
     
    81. Dongwon Choi, Sun-Joo Lee, Sunghoi Hong, Ik-Hwan Kim, and Seongman  Kang (2008). Prohibitin interacts with RNF2 and regulates E2F1 function via  dual pathways. Oncogene 27, 1716-1725, SCI  2008.03
     
    80. Phil-young Lee, Changwon Ko, Dohee Lee Sunghyun Kang, Seongman  Kang 외 5인 . (2007)  Glutathione Peroxidase3 of  Saccharomyces   cerevisiae suppresses non-enzymatic proteolysis pf glutamine synthetase  in activity-independent manner. Biochem Biophys Res Commun, 362,   405-409, SCI 2007. 10
     
    79. Ryoo SW, Park YK, Park SN, Shim YS, Liew H, Kang S, Bai GH. (2007)  Comparative proteomic analysis of virulent Korean
    ycobacterium   tuberculosis K-strain with other mycobacteria strain following infection of  U-937 macrophage. J Microbiol. 45, 268-271, SCIE 2007. 07
     
    78. Kyung-Mi Choi, Chang-Mo Kang, Eun Sook Cho, Seong Man Kang, Seung  Bum Lee, and Hong-Duck Um (2007). Ionizing radiation-induced   micronucleus  formation is mediated by reactive oxygen species that are  produced in a  manner dependent on mitochondria, Nox1, and JNK.   Oncology Reports, 17, 1189-1194, SCI 2007. 05
     
    77. Hyun-Woo Suh,  Seongman Kang, Ki-Sun Kwon (2007) Curcumin   attenuates glutamate-induced HT22 cell death by suppressing MAP kinase  sinaling. Mol Cell Biochem, 298, 187-194, SCI 2007. 03
     
    76. Hyo-Jin Park, Sang-Soo Kim, Young-Mo Seong, Kyung-Hee Kim, Hui Gwan  Goo, Eun Jin Yoon, Do Sik Min, Seongman Kang (corresponding author),   Hyangshuk Rhim (corresponding author) (2006) Beta-Amyloid Precursor Protein  is a direct cleavage target of HtrA2 serine protease: implications for the   physiological function of HtrA2 in the mitochondria J. Biol. Chem. 281, 34277-87  (SCI) 2006, 11
     
    75. Kho CW Lee PY, Bae KH, Cho S, Lee ZW, Park BC, Kang S, Lee H, and Park  SG (2006) Glutathione peroxidase of Sacharomyces cerevisiae regulates the  activity ofmethionine sulfoxide reductase in a redox state-dependent way.   Biochem Biophys Res Commun, 348, 25-35  (SCI) 2006. 9
     
    74. Jinwook Shin, Boyoun Park, Sungwook Lee, Youngkyun Kim,Bonita J. Biegalke,  Seongman Kang, and Kwangseog Ahn. (2006) A Short Isoform of HCMV US3  Functions as a Dominant Negative Inhibitor of the Full-length Form. Journal of  Virology 80, 5397-5404    (SCI) 2006. 06
     
    73. Choi SY, Kim MJ, Kang CM, Bae S, Cho CK, Soh JW, Kim JH, Kang S,   Chung HY, Lee YS, Lee SJ. (2006) Activation of bak and bax through   C-ABL-PKCdelta -P38MAPK signaling in response to ionizing radiation in  human non-small cell lung cancer. J. Biol. Chem. 281, 7049-7059, (SCI) 2006. 03
     
    72. Kwang-Soo Lee, Hae-Ryong Song, Tae-Joon Cho, Hyon J. Kim, Tae-Mi Lee,  Hyun-Seok Jin, Hyun-Young Park, Seongman Kang, Sung-Chul Jung, Soo  Kyung Koo (2006) Mutational spectrum of type I collagen genes in Korean  patients with osteogenesis imperfecta, Human mutaion 27, 599  (SCI) 2006. 06
     
    71. Min-Kyung Nam, Young-Mo Seong, Hyo-Jin Park, Ju-Youn Choi, Seongman  Kang, Hyangshuk Rhim, (2006) The homotrimeric structure of HtrA2 is   indispensable for executing its serine protease activity. Experimental and   Molecular Medicine 38,  36-43,  (SCI) 2006. 02
     
    70. Min-Kyung Nam1, Hye-Min Park, Ju-Youn Choi, Hyo-Jin Park, Kwang Chul  Chung, Seongman Kang, Hyangshuk Rhim, (2005) The expression patterns of  human parkin in E. coli and mammalian cells Kor J Life Sci 15, 916-922
     
    69. Oh HJ, Lee H, Park JW, Rhee H, Koo SK, Kang S, Jo I, Jung SC. (2005)   Reversal of gene expression profile in the phenylketonuria mouse model  after adeno-associated virus vector-mediated gene therapy. Mol Genet  Metab 86, 124-132,  (SCI)  2005. 12
     
    68. Mi Jin Kim, Young A Yoo, Hyung Kim,; Seongman Kang, Yong Kim, Jun Kim,  (2005) Mitochondrial ribosomal protein L41 (MRPL41) mediates serum   starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1.  Biochem and Biophysical Res Comm. 338,1179-1184, (SCI)  2005. 12
     
    67. Sun-Ju Lee, Dongwon Choi,  Hyangshuk Rhim., Seongman Kang. (2005) E3  ubiquitin ligase RNF2 interacts with the S6' proteasomal ATPase subunit  and  increases the ATP hydrolysis activity of S6'. Biochemical J.389,  457-463,  (SCI) 2005. 06
     
    66. Yongjae Park, Sunghoi Hong, Sung-Jo Kim, Soyeon Lee, Dong-Won Choi, and  Seongman Kang (2005) Proteasome Function is Inhibited by    Polyglutamine-Expanded Ataxin-1, the SCA1 Gene Product, Mol Cells, 19, 23-30 (SCI), 2005. 02
     
    65. Moon-Taek Park, Min-Jeong Kim, Young-Hee Kang, Soon-Young Choi,   Jung-A Choi, Chang-Mo Kang, Chul-Koo Cho, Seongman Kang, Sangwoo-Bae,  Yun-Sil Lee, Hee Young Chung, and Su-Jae Lee (2005) Phytosphingosine in  combination with ionizing radiation enhances apoptotic cell death in   radiation-resistant cancer cells through ROS-dependent and -independent AIF  release. Blood, 105, 1724-1733  (SCI), 2005. 02
     
    64. Chang Won Kho, Sung Goo Park, Do Hee Lee, Sayeon Cho, Goo Taeg Oh,  Seongman Kang, Byong Chul Park (2004) Activity of glutathione peroxidase  after two-dimensional gel electrophoresis. Mol Cells, 18, 369-373  (SCI),, 2004. 12
     
    63. Tae-Mi Lee, Sang-Wun Kim, Kwang-Soo Lee, Hyun-Seok Jin, Soo Kyung  Koo, Inho Jo, Seongman Kang, Sung-Chul Jung  (2004) Quantitative analysis of  SMN1 gene and estimation of SMN1 deletion carrier frequency in Korean   population based on real-time PCR. J Kor Med Sci, 19, 870-873  (SCIE), 2004. 12
     
    62. Sung-Weon Ryu, Sang-Chan Park, Mun-Nam Bang, Sung-Sik Han, Young-Kil  Park, Sue-Nie  Park, Young-Soo Shim, Seongman Kang, Gill-Han Bai (2004)  Analysis of the cell lysate proteome of a Korean Mycobacterium tuberculosis  isolate K01 with H37Rv and H37Ra Strains. Journal of Bacteriology and   Virology, 34, 107-112
     
    61. Young-Mo Seong, Ju-Youn Choi, Hyo-Jin Park, Ki-Joong Kim, Sang-Gun Ahn,  Geun-Hye Seong, In-kyung Kim, Seongman Kang (corresponding author),   Hyangshuk Rhim (corresponding author) (2004) Autocatalytic processing of  HtrA2/Omi is essential for induction of caspase-dependent cell death through  antagonizing XIAP J. Biol. Chem., 279, 37588-37596
     
    60. Hyun-Jeong Oh, Eun-Sook Park, Seongman Kang, Inho Jo, Sung-Chul Jung  (2004) Long-term enzymatic and phenotypic correlation in the phenylketonuria  mouse model by adeno-associated virus vector mediated gene transfer. Pediatric  research, 56, 278-284
     
    59. Hyunho Kim, Woocho Jeong, Kwangseok Ahn, Curie Ahn, Seongman Kang  (2004) Siah-1 interacts with the intracellular region of polycystin-1 and affects  its stability via the ubiquitin-proteasome pathway. J. Am Soc Nephrol, 15,   2042-2049
     
    58. Kim H, Bae Y, Chung W, Ahn C, Kang S. (2004) Depletion of PKD1 by an  antisense oligodeoxynucleotide induces premature G1/S phase transition. Eur. J  Human Genet, 12, 433-440
     
    57. Sung-Weon Ryu, Hyun-Ho Kim, Mun-Nam Bang, Young-Kil Park, Sue-Nie  Park, Young-Soo Shim, Seongman Kang, Gill-Han Bai (2004) Trial for Drug  susceptibility testing of Mycobacterium tuberculosis with live and dead cell  differentiation. Tuberculosis and Respiratory Diseases, 56, 261-267
     
    56. Bae Y, Kim H, Chung W, Ahn C, Kang S. (2004) Characterization of   microsatellite markers to diagnose ADPKD. Mol. Cell. Probes 18, 155-159
     
    55. Hyo-Jin Park, Young-Mo Seong, Ju-Youn Choi, Seongman Kang, Hyangshuk  Rhim (2004) Alzheimer’s disease-associated amyloid beta specifically interacts  with the human serine protease HtrA2/Omi. Neuroscience Letters, 357, 63-67
     
    54. Young-Mo Seong, Hyo-Jin Park, Geun-Hye Seong, Ju-Youn Choi, Sung-Joo  Kim Yoon, Byung-Re Min, Seongman Kang, and Hyangshuk Rhim (2004)   N-terminal truncation circumvents proteolytic degradation of the human   HtrA2/Omi serine protease in Escherichia coli: Rapid purification of a   proteolytically active HtrA2/Omi. Protein Express. Purif. 33, 200-208
     
    53. Young-Mo Seong, Chul Han, Ju-Youn Choi, Hyo-Jin Park, Geun-Hye Seong,  Min Kyung Nam, Sang-Soo Kim, In-Kyung Kim, Seongman Kang, Hyangshuk  Rhim (2003) High-level expression of human procaspase-9 in E. coli and   purification of its GST-tagged recombinant protein. Kor. J. Microbiol. 39,   216-222
     
    52. Moon-Taek Park, Jung-A Choi, Min-Jeong Kim, Hong-Duck Um,    Sangwoo-Bae, Chang-Mo Kang, Chul-Koo Cho, , Seongman Kang, Hee Young  Chung, Yun-Sil Lee, and Su-Jae Lee (2003) Suppression of extracellular   signal-related kinase and activation of p38 MARK are two critical events   leading to  caspase 8 and mitochondria-mediated cell death in    phytosphingosine-treated human cancer cells. J. Biol. Chem. 278, 50624-50634
     
    51. H-J Park, J-Y Choi, Y-M Sung, C Han, S Kim, S. Kang, H Rhim. (2003)   Antigenicity of the region encoded by exon8 of the human serine protease   HtrA2/Omi, is associated with its protein solubility. Biotechnology Letters.  25:1597-1603
     
    50. Sungjo Kim, Tae-soo Kim, Ick Young Kim, Sunghoi Hong, Hyangshuk Rhim,  Seongman Kang (2003)  Polyglutamine-expanded
    ataxin-1 recruits Cu/Zn  superoxide dismutase into the nucleus of HeLa cells, Biochem and Biophysical  Res Comm, 307:660-665
     
    49. Sungjo Kim, Tae-soo Kim, Sunghoi Hong, Hyangshuk Rhim, Ick Young Kim,  Seongman Kang (2003)  Oxidative stimuli affect polyglutamine aggregation and  cell death in human mutant ataxin-1-expressing cells, Neuroscience Letter,  348:21-24
     
    48. Jung-Hwan Kim, Seongman Kang, Joon Kim, Byung-Yoon Ahn (2003) Hepatitis  B virus core protein stimulates the proteasome-mediated degradation of viral X  protein, Journal of Virology. 77:7166-7173
     
    47. Sunghoi Hong, Sojeong Ka, Sungjo Kim, Yongjae Park, and Seongman Kang  (2003)  p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the  SCA1 gene product, Biochemica Biophysica Acta, 1638:35-42
     
    46. Moon-Taek Park, Jung-A Choi, Chang-Mo Kang, Tae-Hwan Kim, Seongman  Kang, Sujong Kim, Weon-Ik Choi, Chul-Koo Cho, Su-Jae Lee (2003)   Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax  translocation in human cancer cells, Clinical cancer Res. 9:878-885
     
    45. Jong Kuk Park, Young Min Chung, Seongman Kang, Jae-Uk Kim, Yun-Taik  Kim, Hyung Jung Kim, Yeul Hong Kim, Jun Suk Kim,& Young Do Yoo (2002)  c-Myc Exerts a Protective Function through Ornithine Decarboxylase against  Cellular Insults, Mol. Pharmacol., 62:1400-8
     
    44. Choi J-Y, Sung Y-M, Park H, Hur E-H, Lee S-J, Hahn C, Min B-R, Kim I-K,   Kang S, Rhim H. (2002) Rapid purification and analysis of alpha synuclein proteins: C-terminal truncation promotes the conversion of alpha-synuclein into  a protease-sensitive form in E. coli.. Biotechnol. Appl. Biochem 36:33-40
     
    43. Sunghoi Hong, Sung-Jo Kim, Sojeong Ka, Inho Choi and Seongman   Kang (2002) USP7, a ubiquitin-specific protease, interacts with ataxin-1, the  SCA1 gene product, Mol. Cell. Neuroscience 20:298-306
     
    42. Choi J-Y, Sung Y-M, Park H, Hur E-H, Kim J-Y, Choi E Y, Park J, Min  B-R, Kang S, Rhim H. (2001) Slowly-migrating synucein forms are found in  the brains of patients with Parkinson's disease. Kor. J. Genetics 23:393-400
     
    41. Bae Y, Kim H, Namgoong H, Baek M, Lee J, Hwang Y, Hwang Y, Ahn C,  Kang S. (2001) Characterization of microsatellite markers adjacent to AP-4 on  chromosome 16p13.3. Mol. Cell. Probes 15:313-315
     
    40. Lee S-J, Choi J-Y, Sung Y-M, Park H, Rhim H., Kang S. (2001) E3 ligase  activity of RING finger proteins that interact with Hip-2, a human   ubiquitin-conjugating enzyme. FEBS Letters 503:61-64
     
    39. Lee S, Yoon J, Park B, Jun Y, Jin ., Sung HA, Kim I-H, Kang S, Choi E-I,  Ahn BY, Ahn K (2000) Structural and functional dissection of human   cytomegalovirus US3 in binding major histocompatibility complex class I   molecules. J. Virology 74:11262-11269
     
    38. Kim H., Namgung H, Kim S,, Ahn C, Kang S (2000) Development of   microsatellite markers for diagnosis of autosomal dominant polycystic kidney  disease. Kor. J Nephrology 19:674-680
     
    37. Choi YS, Lee D-Y, Kim IY, Kang S, Ahn K, Kim HJ, Jeong YH, Chun, Jung  G-T, Park K, and Kim I-H (2000) Ammonia removal using hepatoma cells in  mammalian cell  cultures Biotechnol. Prog 16:760-768
     
    36. Kim, H. and Kang, S.  (2000) Human functional genomics: present and  future.  Genetics Reviews 3:122-138
     
    35. Ryu, S. Park, Y.-K. Bai, G.-H. Kim, S.-J. Park. S.-N. and Kang, S. (2000)  3'UTR  polymorphisms in the NRAMP1 gene are associated with susceptibility  to tuberculosis in Koreans.  Int J Tuberc Lung Dis, 4(6): 577-580
     
    34. Bok K-S, Rhim H, Yoo YD, Choi E, Ahn K, Kim I-H, Kang S (1999)   Expanded polyglutamine tract itself induces cell death in cultured cells. Mol.  Cells 9:398-402
     
    33. Kim H, Jin M, Kim I-Y, Ahn B-Y, Kang S, Choi E, Kim J, KIm I-H, Ahn K  (1999) Analysis of the major histocompatibility complexes classI antigen   presentation machinery in human lung cancer. J Microbiol Biotechnol 9:346-351
     
    32. Rhim H., Choi J.-Y., Sung, Y.-M., Kim, I. K., Kang S.  A new bicistronic fragmentation vector for manupulation and analysis of functional yeast artificial chromosomes (YAC). Kor J Microbiol 35(1): 28-34  (1999)
     
    31. Rhim H., Kim S., Kang S. Intramolecular triplexes in Echerichia coli. Kor J Microbiol 34(4): 231-235  (1998)
     
    30. Rhim H, Bok K-S, Chang M-J, Kim I-K, Park SS, Kang S (1998)   Polyglutamine residues from Machado-Joseph disease gene enhance formation of  aggregates of GST-polyglutamine fusion protein in E. coli. J Microbiol   Biotechnol 8: 663
     
    29. Yoo YD, Kang S, Kang Y-K (1998) Cellular resistance to adriamycin conferred  by enhanced Rb expression is associated with increased MDR1 expression.   Biochem and Biophysical Res Comm 249: 61
     
    28. Kang S, Rosenberg M, Ko VD, Green E, Biesecker LG (1997) Fine   structure and intragenic polymorphisms of the human Gli3 gene.   Human   Genetics, 101: 154
     
    27. Kang S, Allen J, Graham JM Jr, Grebe T, Clericuzio C, Patronas N, Ondrey F,  Green E, Schaffer A, Abbott M, Biesecker LG (1997) Linkage mapping and  phenotypic analysis of autosomal dominant Pallister-Hall syndrome. J Med   Genet 34: 441
     
    26. Kang S, Graham JM Jr, Olney AH, Biesecker LG (1997) GLI3 frameshift   mutations cause autosomal dominant Pallister-Hall syndrome. Nat Genet 15:  266
     
    25. Bacolla A, Gellibolian R, Shimizu M, Amirhaeri S, Kang S, Ohshima K, Larson  JE, Harvey SC, Stollar BD, Wells RD (1997) Flexible DNA: genetically unstable  CTG.CAG and CGG.CCG from human hereditary neuromuscular disease genes.  J Biol Chem 272: 16783
     
    24. Ohshima K, Kang Wells RD (1996) CTG repeats expand preferentially of 10  triplets, J. Biol. Chem. 271: 1853
     
    23. Rosche WA, Jaworski A, Kang S, Kramer SF, Larson JE, Geidroc DP, Wells  RD, Sinden RR (1996) Single strand DNA binding protein enhances the stability  of CTG triplet repeats. J. Bacteriol. 178: 5042
     
    22. Ohshima K, Kang S, Larson JE, Wells RD (1996) TTA.TAA triplet   repeats in plasmids form a non-H bonded structure, J. Biol. Chem. 271: 16784
     
    21. Ohshima K, Kang S, Larson JE, Wells RD (1996) Cloning, characterization and  properties of seven triplet repeat DNA sequences. J. Biol. Chem. 271: 16773
     
    20. Kang S, Ohshima K, Jaworski A, Wells RD (1996) CTG triplet repeats from  human diseases are expanded in E. coli distal to the replication origin as a  single event. J. Mol. Biol. 258: 543
     
    19. Biesecker LG, Kang S, Schaffer AA, Abbott M, Kelley RI, Allen JC, Clericuzio  C, Grebe T, Olney A, Graham JM Jr. (1996) Exclusion of candidate loci and  cholesterol biosynthetic abnormalities in familial Pallister-Hall syndrome. J.  Med. Genet. 33: 947
     
    18. Biesecker LG, Abbott M, Allen J, Clericuzio C, Feuillan P, Graham JM Jr, Hall J, Kang S, Olney AH, Lefton D, Neri G, Peters K, Verloes A (1996) Report from the workshop on Pallister-Hall syndrome and related phenotypes. Am J Med Genet 65: 76
     
    17. Kang S, Ohshima K, Shimizu M, Amirhaeri S, Wells RD (1995) Pausing of  DNA synthesis in vitro at specific loci in CTG and CGG triplet repeats from  human hereditary disease genes. J Biol Chem 270: 27014
     
    16. Jaworski A, Rosche WA, Gellibolian R, Kang S, Shimizu M, Bowater RP,   Sinden RR, Wells RD (1995) Mismatch repair in Escherichia coli enhances   instability of (CTG)n triplet repeats from human hereditary diseases. Proc Natl  Acad Sci U S A 92: 11019
     
    15. Kang S, Jaworski A, Ohshima K, Wells RD (1995) Expansion and deletion of  CTG repeats from human disease genes are determined by the direction of  replication in E. coli. Nat Genet 10: 13
     
    14. Chastain PD, Eichler EE, Kang S, Nelson DL, Levene SD, Sinden RR   (1995) Anomalous rapid electrophoretic mobility of DNA containing triplet   repeats associated with human disease genes. Biochemistry 34: 16125
     
    13. Kang S, et al. (1994) Zinc destabilizes DNA Watson-Crick pairs at AGCT. J  Biol Chem 269 9528
     
    12. Wang YH, Amirhaeri S, Kang S, et al (1994) Preferential nucleosome assembly  at DNA triplet repeats from the myotonic dystrophy gene. Science 265: 669
     
    11. Kang S, et al. (1992) Metal ions cause the isomerization of certain   intramolecular triplexes. J Biol Chem 267: 1259
     
    10. Lee HW, Joo J-H, Kang S, et al. (1992) Expression of Human Interleukin-2  from native and synthetic genes in E. coli: no correlation between major codon  bias and high level expression. Biotechnology Letters 14: 653
     
    9. Kang S, et al. (1992) GC-rich flanking tracts decrease the kinetics of   intramolecular DNA triplex formation. J Biol Chem 267: 19435
     
    8. Kang S, et al. (1992)  Central non-Pur.Pyr sequences in oligo(dG.dC) tracts and  metal ions influence the formation of intramolecular DNA triplex isomers. J Biol  Chem 267: 20887
     
    7. Na D-S, et al. (1991) Recombinant human interleukin-2: cloning, expression of  cDNA in E. coli and purification K J BRM 1: 15
     
    6. Park S-K, Sung M-H, Kwon J-B, Song I-S, Kang S, et al. (1991) Recombinant  human lymphotoxin: cloning, expression of cDNA in E. coli and purification K J  BRM 1: 118
     
    5. Joo H-S, Kang S, et al. (1991) Total synthesis and expression in E. coli of a  gene coding for human interleukin-2. Kor J Appl Microbiol Biotechnol 19: 228
     
    4. Huh K-R, Park S, Kang S, et al. (1990) Cloning and expression of human  lipocortin-1 cDNA in E. coli. K Biochem J 23: 459
     
    3. Kang S, et al. (1989) Production of Ser125-interleukin-2 by site directed   mutagenesis. K Biochem J 22: 306
     
    2. Kang S, et al. (1988) Cloning of human interleukin-2 cDNA using   oligonucleotide. K Biochem J 21: 31
     
    1. Kang S, et al. (1988) Overproduction of human interleukin-2 in E. coli. K   Biochem J 21: 38
  • Research

    Research Area

    ● Molecular mechanism of neurodegenerative genetic diseases: polyglutamine diseases, Parkinson disease, and Alzheimer’s disease 
    ● Ubiquitin proteasome system

    Ongoing Project

    ● Studies on the molecular mechanism of polyglutamine neurodegenerative diseases 
    ● Studies on the molecular mechanism of Parkinson's disease 
    ● Studies on the molecular mechanism of Alzheimer’s disease

  • Teaching

    준비 중입니다.

  • Lab Members

    ● 장자영(Jang Jayoung) Ph.D. student yksljjy@hanmail.net
    ● 강아람(Kang A-ram) Ph.D. student khg5701@naver.com
    ● 박주황(Ju-Hwang Park) Ph.D. student pjhch7@korea.ac.kr
    ● Ts. Battur Ph.D. student battur_tserennadmid@yahoo.com
    ● 홍난희(Hong Nan-Hee ) M.S student lovely-lui@hanmail.net
    ● 이요한(Lee Yo Han) M.S student side6530@naver.com
    ● 임진민(Lim Jin-Min) M.S student jmlim6916@hanmail.net
    ● 장해림(Jang Hae Rim) M.S student appy0054@hanmail.net
    ● 진윤정(Jin Yunjung) M.S student totojin91@korea.ac.kr