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고려대학교 교수소개

Knowledge & Innovation

생명과학대학

Home > 생명과학대학 >생명과학부

소개

Prof. 장효일

Tel:02-3290-3421

Fax: 02-3290-3421

e-mail: hichang@korea.ac.kr

  • About Professor
  • Curriculum vitae
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile

    ▶ Education ◀


    Ph.D. 
        1987 Biochemistry North carolina state University, U.S.A

     

    Master 
       ● 1978 Food sciences and Technology, Korea University, Seoul, Korea. 
       ● 1983 Wright State Univ., U.S.A

     

    Bachelor 
       ● 1974 Food Sciences and Technology, Korea University, Seoul, Korea.

     

     

    ▶ Professional Experiences ◀ 

     

    1996 ~ present Professor, Graduate School of Biotechnology, Korea University.
    2005.2 ~ present Director of Business Incubation Agency.
    2005.1 ~ 2005.12 Chairman of Executive committee, The Korea Society for Microbiology and Biotechnology.
    2002.9 ~ 2003.8 Visiting Professor, Arizona State University, U.S.A
    2000.1 ~ 2000.12 Secretary of General Affairs, The Korea Society for Microbiology and Biotechnology.
    1997 ~ 1999 Associate Dean of Academic Affairs Division of Life Science, Korea University.
    1995 ~ 1996 Visiting Professor. University of Washington, U.S.A
    1990 ~ 1992 Chairman, Department of Genetic engineering, Korea University.
    1994 ~ 1995 Chairman, Department of Genetic engineering, Korea University.
    1990 ~ 1995 Assciate Professor, Department of Genetic Engineering, Korea Univerisity
    1988 ~ 1990 Assciate Professor, Department of Genetic Engineering, Korea Univerisity
    1987 ~ 1988 Research Associate Institute of Biotechnology, Korea University
    1974 ~ 1976 Artillery Mattalion Intelligence Officer, R.O.T.C. Lieutenant, Republic of Korean Army

     

  • Curriculum

     

     

  • Publication

     
    발표논문
     
    1. Young-Duck Lee,  Hyo-Ihl Chang and Jong-Hyun Park
        “Detection, antibiotic susceptibility and biofilm formation of Cronobacter ssp.  from various products in Korea"
         Food Control  24, 225-230 (2012)
     
     2. Young-Duck Lee,  Hyo-Ihl Chang and Jong-Hyun Park
        “Genomic analysis of the bacteriophage ESP2947-1 Virulent for Cronobacter sakazakii  
         Arch.Virol.  157, 199-202 (2012)
     
     3. Hye Young Kim, Bo Hyun Yoon, and Hyo Ihl Chang
        "Site-Specific Recombination by the Integrase MJ1 on Mammalian Cell" 
         Korea J. Microbiol. Biotech. 39 (4) (2011)  
     
     4. Sun-Joong Kim, Young Sam Park, Hyun-Dong Paik, and Hyo Ihl Chang
        “Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers”
         Brit.J. Nutr. 106, 1792-1801 (2011)  
     
     5. Kim, Sun-Joong; Lee, Hyun Ju; Kim, Bum-Soo; Lee, Dongho; Lee, Sung-Joon; Yoo, Sang-Ho; Chang, Hyo ihl      
        "Anti-ulcer activity of anthocyanins from Rubus coreanus via association with  regulation of the activity of matrix 
         metalloproteinase-2"
         J.Agric.Food Chem. 59, 11786-11793 (2011)   
     
     6. Young-Duck Lee,  Hyo-Ihl Chang and Jong-Hyun Park
        “Genomic sequence Analysis of Virulent Cronobacter sakazakii Phage ES-2 Isolated from Swine Feces”
         Arch.Virol.  156, 2105-2118 (2011)  
                                      
     7. Bo Hyun Yoon and Hyo-Ihl Chang
        “Complete Genomic Sequence of the Lactobacillus temperate phage LF1”
         Arch.Virol.  156, 1919-1912 (2011) 
     
     8. Bo Hyun Yoon, Se Hwan Jang and Hyo-Ihl Chang
        “Sequence analysis of the Lactobacillus temperate phage Sha1"
         Arch.Virol.  156, 1681-1684 (2011)                                   
     
     9. Jun Heong Jang, Sun-Joong Kim, Bo Hyun Yoon, Jee-Hoon Ryu, Man Bock Gu, and Hyo Ihl Chang
        “Detection of Alicyclobacillus Species in Fruit Juice Using a Random Genomic DNA Microarray Chip”
         Journal of Food Protection. 74, 933-938 (2011)                        
     
     10. Young-Duck Lee,  Hyo-Ihl Chang and Jong-Hyun Park
         “Genomic sequence of temperate phage TEM126 isolated from wild type S. aureus”
          Arch.Virol.  156, 717-720 (2011) 
     
     11. Young-Duck Lee,  Hyo Ihl Chang and Jong-Hyun Park
         “Complete nucleotide sequence of Virulent Cronobacter sakazakii Phage ESSI-2 Isolated from Swine Feces”
          Arch.Virol.  156, 721-724 (2011) 
     
     12. Jin Yong Lee, Byoung Chan Kim, Kwan Jong Chang, Joo-Myung Ahn, Jee-Hoon Ryu, Hyo-Ihl Chang, 
          and Man Bock Gu
         “A Subtractively Optimized DNA Microarray Using Non-sequenced Genomic Probe for the Detection of Food-
          Borne Pathogens”
          Appl Biochem. Biotechnol.  164, 183-193 (2011) 
     
     13. Se Hwan Jang,  Bo Hyun Yoon, and Hyo Ihl Chang
         “Complete nucleotide sequence of the temperate bacteriophage LBR48, a new member of the family Myoviridae”
          Arch.Virol.  393, 314-318 (2011) 
     
    14. J. Bang, L.R. Beuchat, M.B. Gu, H.I. Chang and J.H. Ryu
         “Identification of Yersinia enterocolitica using a random genomic DNA microarray chip”
          Letters in Applied Microbiology 51,665-670 (2010) 
     
     15. Eun-Kyung Lee, Na-Kyoung Lee, Si-Kyung Lee, Hyo-Ihl Chang, and Hyun-Dong Paik
         “Screening of Immunostimulatory Probiotic Lactic Acid Bacteria from Chicken Feces as Animal Probiotics”
          Korean J. Food Sci. Ani. Resour. Vol.30, No.4, pp. 634-640 (2010) 
     
     16. Lee,Young-Duck, Tae-Wha Ryu, Hyo-Ihl Chang, and Jong-Hyun Park
         “Identification and Classification of Cronobacter spp. Isolated from Powdered Food in Korea”
          J. Microbiol. Biotechnol., 20(4), 757-762 (2010) 
     
     17. Se Hwan Jang, Mi Hee Hwang, and Hyo-Ihl Chang
         “Complete genomic sequence of ΦMH1, a Leuconostoc temperate phage”
          Arch. Virol. 155, 1883-1885 (2010) 
     
     18. Kihong Lim and Hyo-Ihl Chang 
         “Elevated O-linked N-acetylglucosamine correlates with reduced Sp1 cooperative DNA binding with its
          collaborating factors in vivo”
          Biosci. Biotechnol. Biochem.,  74, 1668-1672 (2010)
     
     19. Kihong Lim and Hyo-Ihl Chang  
         "O-GlcNAc inhibits interaction between Sp1 and sterol regulatory element binding protein 2" 
          Biochem. Biophys. Res. Commun.  393, 314-318 (2010)
     
     20. Kihong Lim and Hyo-Ihl Chang
         "OGlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1"
          FEBS Letters. 583, 512-520 (2009) 
     
     21. Kihong Lim and Hyo-Ihl Chang
         "O-GlcNAcylaton of Sp1 interrupts Sp1 interation with NF-Y"
          Biochemical and Biophysical Research Communications. 380,569-574 (2009)
     
     22. Kihong Lim and Hyo-Ihl Chang
         "O-GlcNAc inhibits interation between Sp1 and Elf-1"
          Biochemical and Biophysical Research Communications. 380,569-574 (2009) 
     
     23. Kim, Jeong-Hwan, Woobong Choi, Jong-Hwan Lee, Sung-Jong Jeon, Yung-Hyun Choi, Byung-woo Kim,
          Hyo-Ihl Chang, Soo-Wan Nam
         "Astaxanthin Inhibits H2O2-mediated Apoptotic Cell Death in Mouse Neural Progenitor Cells via Modulation
          of P38 and MEK signaling Pathways"
          J. Microbiol. Biotechnol. 19(11), 1355-1363 (2009)
     
    24. B.I. Cho, S.J. You, E.J. Kim, B.K. Ahn, H.D. Paik, C.W. Yun, H.I. Chang, S.W. Kim, C.W. Kang.
        “효모변이균주 유래 β-글루칸과 복합 균종 생균제의 혼합급여가 육계의 생산성 및 장내 균총에 미치는 영향”
         한국 동물자원과학회. 50(1), 89-98 (2008)
     
    25. Park, Young Sam, Sun-Jung Kim, Hyo-Ihl Chang 
        "Isolation of Anthocyanin from Black rice (Heugjinjubyeo) and Screening of its Antioxidant Activities."
         Kor. J. Microbiol. Biotechnol. 36(1) 55-60 (2008)
     
    26. B.K. An, B.L. Cho, S.J. You, H.D. Paik, H.I. Chang, S.W. Kim, C.W. Yun, C.W. Kang
        "Growth Performance and Antibody Response of Broiler Chicks Fed Yest Derived β-Glucan and Single-strain   
         Probiotics"
         Asian-Aust. J. Anim. Sci. 21(7) 1027-1032 (2008)
     
    27. Chun-Ying Li, Hong-De Xu, Bing-Tian Zhao, Hyo-Ihl Chang, Hae-Ik Rhee 
        "Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastriclesions in rats"
         Alcohol. 42, 683-687 (2008)
     
    28. Choi, Seok-Kuen, Young-sam Park, Dong-Kug Choi, Hyo-Ihl Chang 
        "Effects of Astaxanthin on the Production of No and the Expression of COX-2 and iNOS in LPS-Stimulated BV2 
         Microglial Cells"
         J. Microbiol. Biotechnol. 18(12), 1990-1996 (2008)
     
    29. Lee, Na-Kyoung, Cheol-Won Yun, Seung Wook Kim, Hyo-Ihl Chang, Chang-Won Kang 
        "Screening of Lactobacilli Derived from Chicken Feces and Partial Characterization of Lactobacillus acidophilus 
         A12 as Animal Probiotics" 
         J. Microbiol. Biotechnol. 18(2), 338-342 (2008)
     
    30. Cha, Kyung-Il Ki-Hong Lim, Se-Hwan Jang, Sang-yoon Choi, Tae-Hyoung Kim, and Hyo-Ihl Chang 
        "Molecular interactions of a replication initiator protein, RepA, with the origin of Enterococcal plasmid p703/5" 
          J. Microbiol. Biotechnol. 17 (11), 1841-1847 (2007)
     
    31. Na-Kyoung Lee, Ji-Eun Noh, Gui-Hun Choi, Eunjun Park, Hyo-Ihl Chang, Cheol-Won Yun, Seung-Wook Kim,
         Chang-Won Kang, Yoh-Chang Yoon, and Hyun-Dong Paik 
        "Potential Properties of Lactococcus lactis NK34 Isolated from Jeotgal" 
         Food Sci. Biotech. 16(5), 843-847 (2007)
     
    32. Choi, seok-Keun, Jeong-hwan Kim, Young-Sam Park, Young-Jin Kim, and Hyo-Ihl Chang 
        "An Efficient Method for the Extraction of Astaxanthin from the Red yeast Xanthophyllomyces dendrorhous"
         J. Microbiol. Biotechnol. 17(5), 847-852 (2007)
     
    33. Kim, Young-Hwan, Seong Woo Kang, Jong Ho Lee, Hyo-Ihl Chang, Cheol-Won Yun, Hyun-Dong Paik, 
         Chang-Won Kang, and Seung Wook Kim 
        "High Cell Density Fermentation of Saccharomyces cerevisiae JUL3 in Fed-batch Culture for the Production
         of B-glucan."
         J. Ind. Eng. Chem., Vol. 13, No.1 (2007) 153-158
     
    34. Lee, Young-Duck, Bo-Youn Moon, Jong-Hyun Park, Hyo-Ihl Chang, and Wang-June Kim
        "Expression of Enterotoxin Gene in Staphylococcus aureus isolates based on mRNA Analysis"
         J. Microbiol. Biotechnol.17(3), 461-467 (2007)
     
    35. Park, Mi-Ok, Ki-Hong Lim, Tae-Hyung Kim, and Hyo-Ihl Chang
        "Characterization of site-specific recombination by the integrase MJ1 from enterococcal bacteriophage ΦFC1"
         J. Microbiol. Biotechnol. 17(2), 342-347 (2007)
     
    36. Cha, S.H., Lim, J.S., Yoon, C.S., Koh, J.H., Chang, H.I., and Kim, S.W.
        “Production of mycelia and exo-biopolymer from molasses by cordceps sinensis 16 in rubmerged culture”,
         Bioresource Technol., 98, 165-168 (2007).
     
    37. Lim, Ki-Hong and Hyo-Ihl Chang,
        "O-linked N-acetyl glucosamine suppressor thermal aggregation on sp1"
         FEBS Letters 580, 4645-4652 (2006)
     
    38. Kim, Young-Hwan, Seong-Woo Kang, Jong-Ho Lee, Hyo-Ihl Chang, Cheol-Won Yun, Hyun-Dong Paik,
         Chang-won Kang, and Seung-Wook Kim.
        "Optimization of Medium Components for Cell Mass Production of Saccharomyces cerevisiae JUL3 using
         Response Surface Methodology.
         Korean J. Biotechnol. Bioeng. Vol. 21, no. 6, 479-483 (2006)
     
    39. Park, Young-Sung, Jae-hyoung Kim, Hyo-Ihl Chang, Ha-Chin Sung, and Cheol-Won Yun,
        “Cellular iron utilization is regulated by putative sideroporter Fgsit 1 not by free iron transporter in Fusarium
         graminearum”,
         Biochem. Biophys. Res. Commun. 345, 1634-1642 (2006).
     
    40. Lee, NK, KIM, HW Chang, HI Yun, CW Kim, SW Kang, CW and Paik, HD, 
        “Probiotic properties of Lactobacillus plantarum NK181 isolated from Jeotagal, a Korean fermented food”,
         Food Sci. Biotechnol. 15, 227-231, (2006).
     
    41. Park YS, Choi, ID Kang, CM Ham, MS Kim, JH Kim, TH Yun, SH Lee, YW Chang, HI Sung, HC and Yun, CW,   
        “Functional identification of high-affinity iron permeases from Fusarium graminearum”,
         Fungal. Genet. Biol. 43, 273-282, (2006).
     
    42. Ha, CH, Lim, KH Jang, SH Yun, CW Paw, HD Kim, SW Kang, CW and Chang, HI,
        “Immine-enhancing alkali-soluble glucans produced by wild-type and mutant Saccharomyces cerevisiae”,
         J. Microbiol. Biotechnol. 16, 576-583, (2006).
     
    43. Cha, SH, Kim, JC Lim, JS Yoon, CS Koh, JH Chang, HI Kim, SW,
         “Morphological characteristics of Cordyceps sinensis 16 and production of mycelia and exo-biopolymer from
          molasses in submerged culture”,
          J. Ind. Eng. Chem. 12, 115-120, (2006).
     
    44. Kim, JH, Chang, HI,
        “High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using chemical and light  
         induction”,
         J. Microbiol. Biotechnol., 16, 381-385, (2006).
     
    45. Kim, JH, Choi, SK Park, YS Yun, CW Cho, WD Chee, KM, and Chang, HI,
        “Effect of culture conditions on astaxanthin formation in red yeast Xanthophyllomyces dendrorhous mutant JH1”
         J. Microbiol. Biotechnol., 16, 438-442, (2006).
     
    46. Ha, CH, Yun, CW Paik, HD Kim, SW Kang, CW Hwang, and HJ Chang, HI,
        “Preparation and analysis of yeast cell wall mannoproteins, immune enhancing materials, from cell wall mutant
         Saccharomyces cerevisiae”,
         J. Microbiol. Biotechnol., 16, 247-255, (2006).
     
    47. Kim, Jeong-Hwan, Young-Sik Kim, Gwan-Gyu Song, Jong-Jae Park, and Hyo-Ihl Chang.
        "Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats.  
         Eur. J. Pharmacol. 514 (1), 53-59 (2005).
     
    48. Lim, Jung Soo, Jung Mo Kim, Jong Chae Kim, Chang Ho Kim, Dae Ryook Yang, Hyo Ihl Chang,
         and Seung Wook Kim,
       “Realationship Between Fractal Dimension and Morphological Features of Cephalosporium acremonium M25
         in a 30-1 Bioreactor Cultire”,
        J. Microbiol. Biotechnol. 15, 971-976, (2005).
     
    49. Kim, JH, Kang, SW Kim, SW and Chang, HI,
        “High-level production of astaxanthin by Xanthophyllomyces denerorhous mutant JH1 using statistical
         experimental designs”, 
         Biosci. Biotechnol. Biochem. 69, 1743-1748, (2005).
     
    50. Kim, Jeong-Hwan, Seok-Keun Choi, Sang-Yun Choi, Han-Kyeom Kim, and Hyo-Ihl Chang.
        "Suppressive Effect of Astaxanthin Isolated from the Xanthophyllomyces dendrorhous Mutant on Ethanol-Induced
         Gastric Mucosal Injury in Rats."
         Biosci. Biotechnol. Biochem. 69(7),1300-1305 (2005)
     
    51. Kim, Jeong-Hwan, Seung-Wook Kim, Cheol- Won Yun, and H. I. Chang.
        "Therapeutic effect of astaxanthin isolated from Xanthophyllomyces dendrorhous mutant against naproxen-
          induced gastric antral ulceration in rats."
         J. Microbiol. Biotechnol. 15(3) 633-639 (2005).
     
    52. Ha, Chang Hoon, Hye Young Kim, Cheol Won Youn, Hyun Dong Paik, Seung Wook Kim, Chang Won Kang
         and Hyo-Ihl Chang.
        "Eye and Skin Irritation Tests for Cell Wall Glucan and Mannoproteins, from Saccharomyces cerevisiae."
         Lab. Anim. Res. 21(3) 281-286 (2005)
     
    53. Kim, Jeong-Hwan, Seok-Keun Choi, Wang-Jin Lim and Hyo-Ihl Chang.
        "Protective Effect of Astaxanthin Produced by Xanthophyllomyces dendrorhous Mutant on Indomethacin-induced
         Gastric Mucosal Injury in Rats."
         J. Microbiol. Biotechnol. 14(5) 996~1003(2004)
     
    54. Kim, Jeong-Hwan, Chan-Wha Kim and Hyo-Ihl Chang. 
       "Screening and Characterization of Red Yeast Xanthophyllomyces dendrorhous Mutants."
        J. Microbiol. Biotechnol. 14(3) 570-575 (2004)
     
    55. Hyun-Jung Chung, Hyo-Ihl Chang and Seung-Taik Lim. 
        "Physical aging of glassy normal and waxy rice starches : Effect of crystallinity on glass transition and
         enthalpy relaxation."
         Carbohyd. Polym. 58, 101-107 (2004)
     
    56. Ki-Hong Lim, Chang-Hoon Ha and Hyo-Ihl Chang.
        "Production of O-GlcNAc modified Recombination Protein in Escherichia coli."
         J. Microbiol. Biotechnol. 12(2) (2002)
     
    57. Hee-Yeon Yang, Young-Woo Kim, and Hyo-Ihl Chang. 
       "Construction of an Integration-proficient vector based on the Site-Specific Recombination Mechanism of
        Enterococcal Template Phage φFC1."
        J. Bacteriol. 184(7) : 1859-1864 (2002)
     
    58. Chang-Hoon Ha, Ki-Hong Lim, Young-Teck Kim, Seung-Taik Lim, Chan-Wha Kim and Hyo-Ihl Chang.
        "Analysis of Alkali Soluble Glucan Producedby Wild Type and Mutants Saccharomyces cerevisiae." 
         Appl. Microbiol. Biotechnol. 58(3) : 370-377 (2002)
     
    59. Do-Youn Lee, In-Hye Ji, Hyo-Ihl Chang, and Chan-Wha Kim. 
        "High-Level TNF-α secretion and Macrophage Activity with Soluble β-glucans from Biosci."
         biotechnol. Biochem. 66(2): 233-238 (2002)
     
    60. Choi Sang-Yun,Hyun-jung Kim,Jung-Ik Yang and Hyo-ihl Chang.
        "Translation Inhibition Factor IF1-Dependent Stimulation of 30S preinitiation Complex Formation :
         Rapid Isolation and fMet-tRNA Binding Activity of IF1."
         J. Microbiol. biotechnol. (2002) 11(6) : 986-993
     
    61. Hyung Soo Park, Byung Hong Kim, Hyo Sik Kim, Hyung Joo Kim, Gwang Tae Kim, Mia Kim, In Seop Chang 
         and Yong Keun Park. and Hyo Ihl Chang 
        "A Novel Electrochemically Active and Fe(Ⅲ)-reducing Bacterium Phylogenetically Related to Clostridium
         butyricum Isolated from a Microbial Fuel Cell."
         Anaerobe 7, 297-30 (2001)
     
    62. Kyung-Im Kim, Kwang-soon Shin, Woo-Jin Jun and Bum-Shik Hong. Dong-Hoon Shin, Hong- Yon Cho
         Hyo-Ihl Chang, Seong Mo Yoo, and Han-Chul Yang.
        "Effect of Polysaccharides extracted from Rhizomes of Curcuma zedoaria on Macrophage Functions."
         Biosci. Biotechnol. Biochem., 65(11), 2369-2377 (2001)
     
    63. Jae-Won Yang, Jun-Seop Shin, Jae-Jeong Lee, Hyo-Ihl Chang and Chan-Wha Kim. 
        "In Vitro Model using Mouse Hepatocytes for Study of Alcohol Stress."
         Biosci. Biotechnol. Biochem. 65(7) : 1528-1533 (2001).
     
    64. Young-Woo Kim, Se-Hwan Jang, Bum-Sik Hong, Wang-Jin Lim, Chan-Wha Kim, Ha-Chin Sung, 
         and Hyo-Ihl Chang.
        "Circular Permutation of the DNA genome of Temperate Bacteriohage ΦFC1 from Enterococcus faecalis KBL703."
         J. Microbiol. Biotechnol. 9(4): 457-463 (1999)
     
    65. Cho, Yu-Ree, Sang-duk Kim, Hyo-Ihl Chang, Ha-Chin Sung, Cherl-Ho Lee, and Chan-Wha Kim. 
        "A Method for the Seperation of Mouse Pancreatic Islets Using Discontinuous Percoll Gradient Centrifugation."
         J. Microbiol. biotechnol. 9(4): 522-524 (1999)
     
    66. Kwon Mee Hyang, Hyo Jang, Hyo-Ihl Chang, Chan-Wha Kim, Ha-Chin Sung, and Han-Churl Yang.  
        "Anticomplementary Properties of polysaccharides Isolated from Fruit Bodies of Mushroom Pleurotus ostreatus."
         J. Microbiol. Biotechnol. 9(4): 450-456 (1999)
     
    67. Kiocin Hwang, Dae Won Chung, Jun Won Lee, Ik-Hwan Kim, Hong-Jin Kim,and Ick Young Kim. 
       "Alteration of NAD+/NADH Ratio in CHO Cells by Stable Transfection with Human Cytosolic Glycerol-3-Phosphate
        Dehydrogenase: Resistance to Oxidative Stress."
        Mol. Cells. 9(4): 429-435 (1999)
     
    68. Jun-Seop Shin, Hyo-Ihl Chang, Ha-Chin Sung, and Chan-Wha Kim.
        "The Effect of Fetal Bovine Serum, Epidermal Growth Factor, and Retiboic Acid on Adult Rat Islets Embedded
         in Collagen Gels."
         J. Microbiol. Biotechnol. 9(2):150-156 (1999)
     
    69. Joon-Seok Song, jin-Hwan Park, Chan-Wha Kim, Young,Woo Kim, Wang-Jin Lim, Ick Young Kim, 
         and Hyo Ihl Chang. 
       "Characterization of the replication Region of the Enterococcus Faecalis Plasmid p703/5." 
        J. Microbiol. Biotechnol. 9(1) : 91-97 (1999)
     
    70. Seok-Keun Choi, Sang-Ho Lee and Hyo-Ihl Chang. 
       "Changes of Nuclear glycoproteins in Normal and Simian Virus 40-transformed WI-38 Human Lung Fibroblasts."
        Mol. Cells. 8 (6) : 724-730 (1998)
     
    71. Minjung Kim, Jin-Young Lee, Young-Woo Kim, Ha-Chin Sung and Hyo-Ihl Chang. 
        "Molecular Characterization of the region Encoding Integrative Functions."
          J. Biochem. Mol. Biol. 29(5): 448-454 (1996)
    특허
    국제특허 
      1. 등 록 번 호 : 미국 7,273,757 B2
          등   록   일 : 2007년 9월 25일
          발 명 명 칭 : Recombineant vector containing MJ1 gene and method of site specific integration using the same 
          발   명   인 : 최효숙, 장효일
      2. 등 록 번 호 : 중국 ZL 2005 8 0041683. 4 
          등   록   일 : 2011년 2월 16일
          발 명 명 칭 : Recombineant vector containing MJ1 gene and method of site specific integration using the same
          발   명   인 : 최효숙, 장효일
     
     
     
    국내특허 
     
      1. 등 록 번 호  :  제 10-1091025호
          등   록   일 : 2011년 12월 1일
          발 명 명 칭 : 복분자 추출물을 함유하는 비스테로이드성 항염증제에 의해 유발된 위염 및 위궤양 예방 및 치료용 
                            조성물  
          발   명   인 : 이현주, 김선중, 장효일
       2. 등 록 번 호 : 제 10-0905747호  
          등   록   일 : 2009년 6월 25일
          발 명 명 칭 : Composition for curing NSAIDs-induced gastric antral ulceration comprising anthocyanin 
          발   명   인 : 박영삼, 장효일
       3. 등 록 번 호 : 제 10-0818966호
           등   록   일 : 2008년 03월 27일
           발 명 명 칭 : DNA의 서열 특이적 재조합 방법
           발   명   인 : 김혜영, 장효일
       4. 등 록 번 호 : 제 10-0700910호
           등   록   일 : 2007년 3월 22일
           발 명 명 칭 : 알칼리-용해성 β-글루칸을 생산하는 효모 변이주
           발   명   인 : 하창훈, 강창원, 김승욱, 백현동, 윤철원, 장효일
       5. 등 록 번 호 : 제 10-0777025호
           등   록   일 : 2007년 11월 09일
           발 명 명 칭 : MJ1 유전자를 포함하는 재조합 벡터 및 이를 이용한 부위 특이적 인테그레이션 방법
           발   명   인 : 최효숙, 장효일
       6. 등 록 번 호 : 제 10-0635980호
           등   록   일 : 2006년 10월 12일
           발 명 명 칭 : A method of mass production of astaxanthin by anthophyllomyces dendrorhous mutant JH1 using
                             statistical optimization methods and chemical induction
           발   명   인 : 김정환, 장효일
       7. 등 록 번 호 : 제 10-0635979호
           등   록   일 : 2006년 10월 12일
           발 명 명 칭 : A method of mass production of astaxanthin by Xanthophyllomyces dednrorhous mutant JH1
           발   명   인 : 김정환, 장효일
       8. 등 록 번 호 : 제 10-0614217호
           등   록   일 : 2006년 8월 11일
           발 명 명 칭 : A mutant Strain of Saccaromyces cerevisiae having Enhanced Productivity of Mannoprotein
           발   명   인 : 하창훈, 장효일 
       9. 등 록 번 호 : 제 10-0566897호
           등   록   일 : 2006년 3월 27일
           발 명 명 칭 : A mutant Strain of Xanthophyllomyces dendrorhous Having Enhanced Productivity of Astaxanthin
           발   명   인 : 김정환, 장효일  
       10. 등 록 번 호 : 제 10-0552396호
            등   록   일 : 2006년 2월 8일
            발 명 명 칭 : A composition containing astaxanthin for curing NSAIDs-induced gastric Damage
            발   명   인 : 김정환, 장효일
       11. 등 록 번 호 : 제 10-0449171호
            등   록   일 : 2004년 9월 7일
            발 명 명 칭 : Recombinant vector having MJ1 gene and production method of integrase MJ1 using the same
            발   명   인 : 양희연, 장효일 
  • Research

    Research Topic
    본 연구실에서 진행중인 첫 번째 연구는 유전자 치료나 vaccine에 이용되는 vecotr의 개발을 위해 필요한 유전자를 내재 하는 extrachromosomal integration system의 개발이다. 유전자 치료나 생 vaccine에 이용될 vector는 과거 10년 이상 연구해 온 Enterococcus 유래 bacteriophage의 integrase와 그 부착부위인 attP를 이용하며, site-specific integration 기작을 통하여 mammalian cell의 pseudo 부착부위인 pseudo attB로의 integration에 응용된다. 또한 항생제 내성 전이의 주 원인으로 알려져 있는 Enterococcus 내재 plasmid의 replication mechanism을 연구하고 이를 이용하여 내성 전이 차단 system 및 gram positive와 gram negative strain 양쪽에 모두 적용 될 수 있는 shuttle vector system을 개발 중이다.
    본 연구실의 두번째 연구 테마는 기능성 식품 신소재 및 생리활성 물질의 개발 및 기작규명이다. 효모가 생산하는 적색소인 astaxanthin의 고생산 변이주의 개발을 통해 고효율 대량 생산법의 확립, 위염및 위궤양 치료제 개발 및 항암작용의 규명에 초점을 맞추고 있으며, 식물(흑미, 자초, 오미자 등)에서 항산화 물질을 함유한 색소(phytochemical)를 추출 및 정제하여 항산화 작용 규명 및 식품 첨가물로의 개발을 위해 연구중이다. 또한 생리활성을 가진 다당류를 탐색하고, 이 다당류의 항암, immune 강화작용 및 항균 활성 기작을 규명한다. Yeast로 부터 β-glucan과 mannan(manno-protein)을 분리 정제 하여 immune강화 activity를 측정하고 구조 분석 및 새로운 생리활성 물질로의 개발에 역점을 둔다.
    Research Area
    The study of devilopment of novel vectors and strategies for gene therapy.
    The development of mannan (mannoprotein) and β-glucan as a immune stimulation factor or anti-immuns factor from yeast
    The study of anthocyanin as antioxidant activity from black colored rice.
    The study of shikonin as antioxidant activity and anticancer activity from Lithospermum
     
  • Teaching

  • Lab Members

    Ph. D student. 
    Yoon Bo Hyun ( shallop@korea.ac.kr )
     
     
    M.S student  
    An Tae-woo ( gild001@korea.ac.kr )
    Jung hak-jun ( hakjun0706@korea.ac.kr )
    Jung Bo-Ra ( hushviolet04@korea.ac.kr )
     
    B.S student  
    Kim Jee min ( jeeminkim11@korea.ac.kr )