Division of Food Bioscience & Technology, Korea University.

213, West Building, College of Life Sci.& Biotech.

Education

• · Department of Food Science, Oklahoma State Univ. 1988 - 1992 (Ph.D)


• · Department of Animal science, Korea univ. 1984 - 1986 (M.S)


• · Department of Animal science, Korea univ. 1978 - 1982 (B.S)



• · M.S. Thesis : Studies on the Effect of Heat Treatment on Physico-Chemical Properties of Casein Micelles


• · Ph.D. Thesis : Bacteriocin Produced by Strains of Lactobacillus acidophilus Isolated from Different Animal Species

Professional Experiences

• · 2005. 3 - present Professor, Korea Univ.


• · 2004. 3 - present International Association for Food Protection


• · 2004. 3 - present Visiting Scholar, University of Georgia


• · 2000. 3 - 2005. 2 Associate Professor, Korea Univ.


• · 1998. 3 - 2000. 2 Assistant Professor, Korea Univ.


• · 1997. 3 - present Korean Society of Food Science and Technology


• · 1997. 3 - present Korean Society for Microbiology and Biotechnology


• · 1997. 3 - present Korean Society of Animal and resources


• · 1997. 3 - present Korean Society of Milk Processing Technology


• · 1997. 3 - present Korean Society of Animal and Food Science


• · 1996. 9 - 1998. 2 　Lecturer, Korea Univ.


• · 1993. 8 - 1996. 8 　Senior Research Scientist, Culture Systems, Inc.


• · 1992. 6 - 1993. 5 　Research Associate , Oklahoma State University


• · 1990. 3 - present American Dairy Science Association


• · 1990. 3 - present International Food Technologist


• · 1990. 3 - present American Dairy Science Association


• · 1990. 3 - present International Food Technologist


• · 1990. 3 - present American Society for Microbiology

Societies

• - American Dairy Science Association




• - Institute of Food Technologists




• - American Society for Microbiology




• - Korean Society of Animal Science




• - Korean Association of Milk Processing

Research Interest

• - Antagonism of lactic acid bacteria toward pathogenic and spoilage bacteria.




• - Probiotic culture of lactic acid bacteria in the dairy food and animal feed.




• - Application of microbial enzymes in the dairy food and animal feed.

Teaching Activities

• - Milk and Dairy Food Processing




• - Food Microbiology




• - Food Sanitation




• - Microbes and Health




• - Special Topics in Animal Science




• - Dairy Chemistry

SCI Journals

• 1. J. H. Park, Y Kim, and S. H. Kim . 2012 . Green tea extract (Camellia sinensis) fermeted by Lactobacillus fermentum attenuates alcohol-iduced liver damage. Biosci Biotechnol Biochem. 6(12):2294-300.(2012)


• 2. H.S Yun, Y. Kim, S. Oh, W.M. Jeon, J.F. Frank, S.H.Kim. 2012 Susceptibility of Listeria monocytogenes Biofilm sand Planktonic Cultures to Hydrogen Peroxide in Food Processing Environments. BiosciBiotechnolBiochem .76(11):2008-13.(2012)


• 3. Park S. H., S. Shruti, Y. H. Kim, S. J. Oh, S. H. Kim and M. H. Kim. 2012. Development of sandwich enzyme-linked immunosorbent assay for the detection of Cronobacter muytjensii (formerly called Enterobacter sakazakii). Microbiology and Immunology. 56(7): 472–479 Japan (2012. 06.).


• 4. Lee J. H., J. K. Jeon, S. G. Kim, S. H. Kim , T. Chun, and J. Y. Imm. 2011. Comparative analyses of total phenols, flavonoids, saponins and antioxidant activity in yellow soy beans and mung beans. International Journal of Food Science and Technology. 46(12): 2513-2519 England (2011. 12.).


• 5. Lim J., K. M. Lee, S. H. Kim, Y. Kim, S. H. Kim , W. Park, and S. Park. 2011. YkgM and ZinT proteins are required for maintaining intracellular zinc concentration and producing curli in enterohemorrhagic Escherichia coli (EHEC) O157:H7 under zinc deficient conditions. International Journal of Food Microbiology. 149(2): 159-170 Netherlands (2011. 09.)


• 6. Lee J., H. S. Yun, K. W. Cho, S. Oh, S. H. Kim , T. Chun, B. Kim, and K. Y. Whang. 2011. Evaluation of probiotic characteristics of newly isolated Lactobacillus spp.: Immune modulation and longevity. International Journal of Food Microbiology. 148(2): 80-86 Netherlands (2011. 08.)


• 7. Lee S. J., J. H. Lee, H. H. Lee, S. Lee, S. H. Kim , T. Chun, and J. Y. Imm. 2011. Effect of mung bean ethanol extract on pro-inflammtory cytokines in LPS stimulated macrophages. Food Science and Biotechnology. 20(2): 519-524 South Korea (2011. 04.).


• 8. Oh S., H. Roh, H. J. Ko, S. Kim, K. H. Kim, S. E. Lee, I. S. Chang, S. Kim , and I. G. Choi. 2011. Complete genome sequencing of Lactobacillus acidophilus 30SC, Isolated from Swine Intestine. Journal of Bacteriology. 193(11): 2882-2883 United States (2011. 06.).


• 9. Lee J., Y. Kim, H. S. Yun, J. G. Kim, S. Oh, and S. H. Kim . 2010. Genetic and Proteomic Analysis of Factors Affecting Serum Cholesterol Reduction by Lactobacillus acidophilus A4. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 76(14): 4829–4835 United States (2010. 7.).


• 10. Kim, Y., S. Oh, H.S. Yun, S. Oh and S.H. Kim . 2010. Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells. Letters in Applied Microbiology. 51:123–130 United States (2010. 7.).


• 11. Sung C., B. G. Kim, S. H. Kim , H. S. Joo and P. I. Kim. 2010. Probiotic potential of Staphylococcus hominis MBBL 2-9 as anti-Staphylococcus aureus agent isolated from the vaginal microbiota of a healthy woman. Journal of Applied Microbiology. 108(3): 908-916 UK (2010. 03.).


• 12. Kim, J. G., E. Lee, S. H. Kim , K. Y. Whang, S. Oh, and J. Y. Imm. 2009. Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats. International Dairy Journal. 19(11): 690-695 England (2009. 6.).


• 13. Kim, Y., M. J. Kim, K. S. Han, J. Y. Imm, S. Oh, and S. H. Kim . 2009. Anticancer activity of lactoferrin isolated from caprine colostrums on human cancer cell lines. International Journal of Dairy Technology. 62:277-281 England (2009. 5.)


• 14. Kim, Y., S. Oh, S. Park, and S. H. Kim . 2009. Interactive transcriptome analysis of enterohemorrhagic Escherichia coli (EHEC) O157:H7 and intestinal epithelial HT-29 cells after bacterial attachment. International Journal of Food Microbiology. 131:224-232 Netherlands (2009. 5.)


• 15. Lee, K. M., J. Lim, S. Nam, M. Youn, S. W. Nam, Y. Kim, S. H. Kim , W. Park, and S. Park. 2009. Antipathogenic properties pf green tea polyphenol epigallocatechin gallate at concentration below the MIC against Enterophmorrhagic Escherichia coli O157:H7. Journal of Food Protection. 72(2) 325-331 United States (2009. 2.)


• 16. Kim. Y., S. Oh, and S. H. Kim . 2009. Released exopolysaccharide (r-EPS) produced from probiotic bacteria reduce biofilm formation of enterohemorrhagic Escherichia coli O15:H7. Biochemical and Biophysical Research Communications. 379(2) 324-329 United States (2009. 2.)


• 17. Lim, J., K. M. Lee, S. H. Kim, S. W. Nam, Y. J. Oh, H. S. Yun, W. Jo, S. Oh, S. H. Kim , and S. Park. 2008. Nanoscale characterization of Escherichia coli biofilm formed under laminar flow using atomic force microscopy (AFM) and scanning electron microscopy (SEM). Bull. Korean Chem. Soc. 29(11) 2114-2118 Korea, 2008. 11. 20


• 18. Kim, Y., S. H. Kim , K. Y. Whang, Y, J, Kim, and S. Oh. 2008. Inhibition of Escherichia coli O157:H7 Attachment by interactions Between Lactic acid Bacteria and Intestinal Epithelial Cells. J. Microbiol. Biotechnol. 18(7) 1278-1285 Korea, 2008. 07


• 19. Kim, Y., J. Y. Whang, K. Y. Whang, S. Oh, and S. H. Kim . 2008. Characterization of the cholesterol-reducing activity in a cell-free supernatant of Lactobacillus acidophilus ATCC 43121. Biosci. Biotechnol. Biochem. 72(6) 1483-1490 Japan, 2008. 06


• 20. Kim, Y., J. U. Kim, S. Oh, Y. J. Kim, M. Kim, and S. H. Kim . 2008. Technical Optimization of Culture Conditions for the Production of Exopolysaccharide (EPS) by Lactobacillus rhamnosus ATCC 9595. Food Science and Biotechnology. 17(3) 587-593 South Korea, 2008. 06. 01


• 21. Kho, Y. J., S. C. Kim, B. S. Yoon, J. H. Moon, S. Kwak, G. Park, J. Woo, S. Oh, K. Hong, S. H. Kim , H. G. Kim, S. You, and Y. Choi. 2008. WDNM1 is Associated with Differentiation and Apoptosis of Mammary Epithelial Cells. Animal Biotechnology. 19(2) 89-103 UK, 2008. 04. 01


• 22. Kho, Y. J., S. C. Kim, B. S. Yoon, J. H. Moon, B. Kim, S. Kwak, J. Woo, S. Oh, K. Hong, S. H. Kim , H. Kim, S. K. You, and Y. J. Choi. 2008. Induction of Serum Amyloid A Genes Is Associated with Growth and Apoptosis of HC11 Mammary Epithelial Cells. Biosci. Biotechnol. Biochem. 72(1) 70-81 - Japan, 2008. 01


• 23. Lee. Y., Y. Kim, S. Yeom, S. H. Kim , S. Park, C. O. Jeon, and W. Park. 2008. The role of DsbA (disulfide bond isomerase) of Escherichia coli O157:H7 in the biofilm formation and virulence. FEMS Microbiology Letters. (278 (2), 213–222) - Netherlands, 2008. 01


• 24. Kim, Y., S. Oh, S. Park, J. B. Seo, and S. H. Kim . 2008. Lactobacillus acidophilus reduces expression of enterohemorrhagic Escherichia coli O157:H7 virulence factors by inhibiting autoinducer-2-like activity. Food Control. 19:1042-1050 – England, 2008. 11


• 25. Kim, S. J., S. Y. Cho, S. H. Kim , O. J. Song, I. S. Shin, D. S. Cha, and H. J. Park. 2008. Effect of microencapsulation on viability and other characteristics in Lactobacillus acidophilus ATCC 43121. LWT-Food Science and Technology. (41(3) 493-500) – Swiss, 2008. 04


• 26. Park, Y. H., J. G. Kim, Y. W. Shin, H. S. Kim, U. J. Kim, T. Chun, S. H. Kim , and K. Y. Whang. 2008. Effects of Lactobacillus acidophilus 43121 and a Mixture of Lactobacillus casei and Bifidobacterium longum on the Serum Cholesterol Level and Fecal Sterol Excretion in Hypercholesterolemia-Induced Pigs. Biosci. Biotechnol. Biochem. 72(2) 595-600– Japan, 2008. 02.


• 27. Han, K. S., Y. Kim, S. H. Kim , and S. Oh. 2007. Characterization and Purification of Acidocin 1B, a Bacteriocin Produced by Lactobacillus acidophilus GP1B. J. Microbial. Biotechnol. 17(5) 774-783 - South Korea, 2007.05


• 28. Park, Y. H., J. G.. Kim, Y. W. Kim, S. H. Kim , and K. Y. Whang. 2007. Effect of Dietary Inclusion of Lactobacillus acidophilus ATCC 43121 on Cholesterol Metabolism in Rats. J. Microbial. Biotechnol. 17(4) 655-662 – South Korea, 2007. 04


• 29. Kim, Y., S. N. Oh, E. Y. Ahn, J. Y. Imm, S. Oh, S. Park, and S. H. Kim . 2007. Proteome Analysis of Virulence Factor Regulated by Autoinducer-2 like Activity in Escherichia coli O157:H7. J. Food Prot. 70(2):300-307.- United States, 2007. 01.


• 30. Kim, P. I., Y. J. Min, Y. H. Chang, S. H. Kim , S. J. Kim, and Y. H. Park. 2007. Probiotic properties of Lactobacillus and Bifidobacterium strains isolated from porcine gastrointestinal tract. Appl. Microbial. Biotechnol. 74:1103-1111.- United States, 2007. 04


• 31. Kang, S. H., J. U. Kim, Y. Kim, K. S. Han, W. J. Lee, J. Y. Imm, S. Oh, D. J. Park, Y. I. Moon, and S. H. Kim . 2007. Changes in the levels of Insulin-like Growth Factors (IGF-I and IGF-II) in Bovine Milk according to the Lactation Period and Parity. Asian-Aust. J. Anim. Sci.. 20(1):119-123 – South Korea, 2007. 01


• 32. Ann, E. Y., Y. Kim, S. Oh, J. Y. Imm, D. J. Park, K. S. Han, and S. H. Kim . 2007. Microencapsulation of Lactobacillus acidophilus ATCC 43121 with prebiotic substrates using a hybridization system. Int. J. Food Sci. and Technol. 42:411-419 – England, 2007. 04


• 33. Kim, Y., Y. Lee, S. H. Kim , J. Yeom, B. S. Kim, S. N. Oh, S. Park, C. O. Jeon, and W. Park. 2006. Role of Periplasmic Antioxidant Enzymes (Superoxide Dismutase and Thiol Peroxidase) of the Shiga Toxin-Producing Escherichia coli O157:H7 in the Formation of Biofilms. Proteomics. 6:6181-6193. - Germany, 2006. 12.


• 34. Oh. S., H. J. Heo, D. J. Park, S. H. Kim , S. J. Lee, and J. Y. Imm. 2006. Effect of Encapsulated Bacteriocin on Acid Production and Growth of Starter Cultures in Yoghurt. Food Sci. Biotechnol. 15(6):902-907 – South Korea, 2006. 12.


• 35. Kim, Y. H., K. S. Han, J. Y. Imm, S. Oh, S. You, S. Park, and S. H. Kim . 2006. Inhibitory effects of Lactobacillus acidophilus lysates on the cytotoxic activity of shiga-like toxin 2 produced from Escherichia coli O157:H7. Lett. Appl. Microbiol. 43:502-507 – England, 2006. 11.


• 36. Kim, J. U., Y. Kim, K. S. Han, S. Oh, K. Y. Whang, J. N. Kim, and S. H. Kim . 2006. Function of Cell-Bound and Released Exopolysaccharides Produced by Lactobacillus rhamnosus ATCC 9595. J. Microbiol. Biotechnol. 16(6):939-945. – South Korea, 2006. 06.


• 37. Choi, S. S., Y. Kim, K. S. Han, S. You, S. Oh, and S. H. Kim . 2006. Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro. Lett. Appl. Microbiol. 42:452-458. – England, 2006. 05.


• 38. Kang, S. H., J. U. Kim, J. Y. Imm, S. Oh, and S. H. Kim . 2006. The Effects of Dairy Processes and Storage on Insulin-Like Growth Factor-I (IGF-I) Content in Milk and in Model IGF-I–Fortified Dairy Products. J. Dairy. Sci. 89:402-409. – United States, 2006. 02.


• 39. Oh, S., S. H. Kim , Y. Ko, J. H. Sim, K. S. Kim, S. H. Lee, S. Park, and Y. J. Kim. 2006. Effect of bacteriocin produced by Lactococcus sp. HY449 on skin-inflammatory bacteria. Food Chem. Toxicol. 44:552-559. – England, 2006. 04.


• 40. Imm, J. Y., J. G. Kim, J. U. Kim, S. O. Park, S. Oh, Y. J. Kim, H. N. Chun, H. K. Jung, S. You, K. Y. Whang, and S. H. Kim . 2005. Microbial and Nutritional Quality of Extended Shelf Life (ESL) Milk. Food Sci. Biotechnol. 14(6):752-757. – South Korea, 2005. 12.


• 41. Han, K. S., Y. Kim, S. Choi, S. Oh, S. Park, S. H. Kim , and K. Y. Whang. 2005. Rapid identification of Lactobacillus acidophilus by restriction analysis of the 16S-23S rRNA intergenic spacer region and flanking 23S rRNA gene. Biotechnol. Lett. 27:1183-1188. – Netherlands, 2005. 08.


• 42. Park, D. J., S. Oh, K. H. Ku, C. Mok, S. H. Kim , and J. Y. Imm. 2005. Characteristics of yogurt-like products prepared from the combination of skim milk and soy milk containing saccharified-rice solution. Int. J. Food Sci. Nutr. 56(1):23-34. – England, 2005. 02.


• 43. Kim, Y. H., K. S. Han, S. Oh, S. You, and S. H. Kim . 2005. Optimization of technical conditions for the transformation of Lactobacillus acidophilus strains by electroporation. J. Appl. Microbiol. 99:167-174. – England, 2005. 07.


• 44. Imm, J. Y., E. J. Oh, K. S. Han, S. Oh, Y. W. Park, and S. H. Kim . 2003. Functionality and Physico-Chemical Characteristics of Bovine and Caprine Mozzarella Cheeses During Refrigerated Storage. J. Dairy. Sci. 86:2790-2798. – United States, 2003. 09.


• 45. Rheem, S. S., S. Oh, K. S. Han, J. Y. Imm, and S. H. Kim . 2002. New Response Surface Approach to Optimize Medium Composition for Production of Bacteriocin by Lactobacillus acidophilus ATCC 4356. J. Microbiol. Biotechnol. 12(3):449-456– South Korea, 2002. 06.


• 46. Oh, S., R. W. Worobo, B. C. Kim, S. S. Rheem, and S. H. Kim . 2000. Detection of the cholera toxin-binding activity of κ-casein macropeptide and optimization of its production by the response surface methodology. Biosci. Biotechnol. Biochem. 64(3):516-522.


• 47. Oh, S., S. H. Kim , and R. W. Worobo. 2000. Characterization and purification of a bacteriocin produced by a potential probiotic culture, Lactobacillus acidophilus 30SC. J. Dairy Sci. 83;2747-2752.


• 48. Noh, D. O., S. H. Kim , and S. E. Gilliland. 1997. Incorporation of cholesterol into the cellular membrane of Lactobacillus acidophilus ATCC 43121. J. Dairy Sci. 80(12):3107-3113.


• 49. Kim, S. H. , K. P. Lim, and H. S. Kim. 1997. Differences in the hydrolysis of lactose and other substarates by β-D-galactosidase from Kluyveromyces lactis. J. Dairy Sci. 80:2264-2269

National Journals

• 1. S. J. Oh, C. H. Chai, S. H. Kim , Y. J. Kim, H. S. Kim, R.W. Worobo. 2012 . Comparison of Acid and Bile Tolerances, Cholesterol Assimilation, and CLA Production in Probiotic Lactobacillus acidophilus Strains. KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES (32, 409):409-413 (2012)


• 2. J. H. An, J. M. Park, J. G. Gu, S. J. Yoon, J. S. Lee, J. M. Kim, S. H. Kim , R. J. Kim, J. W. Park, S. O. Song, S. H. Wee and J. M. Kim. 2012 . A Study of Establishment and Exploitation of Bio-markers for Determination of Shelf-life of Eggs and Egg Products. Korean J. Food Sci. Ani. Resour. Vol. 32, No. 3, pp. 354~363(2012)


• 3. Oh. H. W., G. H. Jeun, J. Lee, T. H. Chun, and S. H. Kim . 2012. Probiotics Inhibit Lipopolysaccharide-Induced Interleukin-8 Secretion from Intestinal Epithelial Cells. Kor. J. Food Sci. Ani. 32(4): 434-440
• 4. Oh. S. J., C. H. Chai, S. H. Kim , Y. J. Kim, H. S. Kim, and R. W. Worobo. 2012. Comparison of Acid and Bile Tolerances, Cholesterol Assimilation, and CLA Production in Probiotic Lactobacillus acidophilus Strains. Kor. J. Food Sci. Ani. 32(4): 409-413
• 5. Cho S. A., K. S. Kim, J. R. Do, S. H. Kim , and S. D. Lim. 2010. Physiological characteristics and immunomodulating activity of Streptococcus macedonicus LC743 Isolated from Raw Milk. Kor. J. Food Sci. Ani. Resour. 30(6): 957-965


• 6. Kim, Y. H., S. O. Park, K. S. Han, S. Oh, S, S. K. You, and S. H. Kim . 2004. Adhesion Ability and Inhibition of Enterhemorrhagic E. coli O157:H7 Adhesion to Intestinal Epithelial Cells in Lactobacillus acidophilus. Kor. J. Food Sci. Ani. Resour. 24(1):86-91.


• 7. Han, K. S., W. M. Jeon, Y. H. Kim, and S. H. Kim . 2003. Purification, Bacteriolytic Action and Plasmid Isolation of Acidocin 4A Produced by Lactobacillus acidophilus GP4A. Kor. J. Dairy Technol. Sci. 21(2):114-119.


• 8. Park, D. J., E. Y. An, J. S. Kim, J. Y. Imm, K. S. Han, S. J. Oh, and S. H. Kim . 2002. Dry enteric coating process of lactic acid bacteria by hybridization system. Kor. J. Food Sci. Technol. 34(5):856-861.


• 9. Han, K. S., J. Y. Imm, S. J. Oh, W. M. Jeon, and S. H. Kim . 2002. Bacteriocin produced by lactobacillus acidophilus ATCC 4356: characterization and purification. Food Sci. Biotechnol. 11(5):531-536.
• 10. Han, K. S., S. J. Oh, W. M. Jeon, J. Y. Imm, S. S. Rheem, and S. H. Kim . 2002. Development of bacteriocin preparations from lactic acid bacteria against salmonella using an experimental design for mixtures. Kor. J. Dairy Technol. Sci. 20(1):1-8.


• 11. Joo, K. S., S. J. Oh, K. S. Han, W. M. Jeon, and S. H. Kim . 2002. Characterization and inhibitory activity on Staphylococcus aureus of a bacteriocin produced by Lactobacillis plantarum KU107. Kor. J. Food Sci. Ani. Resour. 22(1):81-86.


• 12. Han, K. S., S. J. Oh, Y. I. Moon, and S. H. Kim . 2002. Antimicrobial effects of a bacteriocin mixture from lactic acid bacteria against foodborne pathogens. Kor. J. Food Sci. Ani. Resour. 22(2):164-171.


• 13. Kim, S. H . 2002. Using of probiotics, prebiotics, and synbiotics. Kor. J. Health Promot Dis Prev. 2(1):193-197


• 14. Kang, S. H., J. W. Kim, J. Y. Imm, K. S. Han, S. J. Oh, and S. H. Kim . 2001. Estimation of insulin like growth factor-Ⅰconcentration in raw milk and milk whey by various milk heat treatment. Kor. J. Dairy Technol. Sci. 19(2):98-102.


• 15. Kang, S. H., K. S. Han, J. Y. Imm, and S. H. Kim . 2001. A study on the dairy information system and effective dairy extension service system. Kor. J. Dairy Technol. Sci. 19(1):22-29.


• 16. Rheem, D. H., W. M. Jeon, K. S. Han, B. C. Kim, K. Y. Hwang, and S. H. Kim . 2000. Fractionation and Physicochemical Characteristics of Caprine Casein by DEAE-Cellulose. Kor. J. Dairy Techno. 18(1):1-8.


• 17. Han, K. S., K. S. Joo, and S. H. Kim , 1999. Characteristics and purification of bacteriocin produced by Lactobacillus acidophilus GP4A. Kor. J. Dairy Techno. 17(1):1-10.


• 18. Kim, Y. C., H. K. Jeong, S. H. Kim , I. L. Moon, and B. C. Kim. 1998. The properties of bifidobacteria isolated from Korean. Kor. J. Dairy Sci. 20(3):191-204.


• 19. Kim, Y. C., J. O. Yang, S. H. Kim , and B. C. Kim. 1998. Effects of oral administration of Bifidobacterium longum A2 isolated from Korean. Kor. J. Dairy Sci. 20(3):205-216.


• 20. Oh, S. J., S. H. Kim , S. K. Kim, Y. J. Baek, and K. H. Cho. 1997. Angiotensin Ⅰ-converting enzyme inhibitory activity of the κ-casein fragments hydrolysated by chymosin, pepsin, and trypsin. Kor J. Food Sci. Technol. 29(6):1316-1318.


• 21. Han, K. S., C. H. Yeom, S. H. Kim , and Y. K. Kim. 1997. Molecular composition and fractionation of colostral casein with advancing lactation. Kor. J. Dairy Sci. 19(1):49-58.


• 22. Oh, S. J., S. H. Kim , W. M. Jeon, B. C. Kim, and Y. K. Kim. 1997. Glycomacropeptide hydrolysed from bovine κ-casein; Ⅰ. The fractionation of glycomacropeptide. Kor. J. Food Sci. Ani. Resour. 17(1):51-57.


• 23. Oh, S. J., S. H. Kim , D. J. Park, B. C. Kim, and Y. K. Kim. 1997. Cholera toxin-binding activity from κ-casein hydrolysate. Kor. J. Food Sci. Ani. Resour. 17(1):45-50.


• 24. Kim, S. H. , Y. K. Kim, and S. E. Gilliland. 1997. Screening and partial purification of bacteriocins by strains of Lactobacillus acidophilus isolated from human origins. Kor. J. Dairy Sci. 15(1):21-26.


• 25. Kim, S. H. , and S. E. Gilliland. 1997. Incorporation of assimilated cholesterol into cellular membrane of Lactobacillus acidophilus. Kor. J. Food Sci. Ani. Resour. 17(1):12-16.


• 26. Yoo, S. A., W. M. Jeon, M. S. Rhee, S. H. Kim , and Y. K. Kim. 1996. Effects of various factors in farm management on raw milk quality. Kor. J. Dairy Sci. 18(4):229-236.


• 27. Kang, S. H., S. H. Kim , Y. K. Kim, and B. C. Kim. 1996. Polyacrylamide gel electrophoresis of purified bovine κ-casein fractions hydrolysed by chymosin. Kor. J. Food Sci. Ani. Resour. 16(2):220-223.


• 28. Lim, K. P., H. S. Kim, S. H. Kim , and Y. K. Kim. 1996. The opposite effect divalent metal ions on lactose and ONPG hydrolytic activities of β-galactosidase from Kluyveromyces lactis. Kor. J. Dairy Sci. 18(4):281-288.

International meeting

• 1. Lee I. A., J. Lee, and S. H. Kim . 2012. Selection and Characterization of the Hypocholesterolemic and Immunomodulatory Effect of Lactic Acid Bacteria. 2012 112th General Meeting of the American Society for Microbiology. (San Francisco, U. S. A.) 1984 (2012. 6. 16-19)


• 2. Park J. H., Y. J. An, J. Lee and S. H. Kim . 2011. Effects of Fermented Products with Lactobacillus on Alcohol Metabolizing Enzyme Activities. 2011 6th Asian Conference on Lactic Acid Bacteria. (Sapporo, Japan) P-AM 15-63 (2011. 9. 8-10)


• 3. Joung J. Y., J. Lee, and S. H. Kim . 2011. Effect of Lactic acid bacteria on the Reduction of Skatole. 2011 IFT Annual Meeting and Food Expo. (New Orleans, U.S.A.) 198-23 (2011. 6. 11-14)


• 4. Choi S. H., H. S. Yun, and S. H. Kim . 2011. Enterohemorrhagic Escherichia coli biofilms are inhibited by 3-methylindole. 2011 IFT Annual Meeting and Food Expo. (New Orleans, U.S.A.) 198-02 (2011. 6. 11-14)


• 5. Jeun, G. H., H. S. Yun, J. Lee, T. H. Chun, and S. H. Kim . 2009. Reduction of synbiotics on interleukin 8 production in human intestinal epithelial cell. 2009 International Meeting of the Federation of Korean Microbiological Societies. (Seoul) (I007) (2009. 10. 22-23)


• 6. Yoo, M. Y., H. S. Yun, J. Lee, and S. H. Kim . 2009. Skatole reduction ability of lactic acid bacteria. 2009 International Meeting of the Federation of Korean Microbiological Societies. (Seoul) (I006) (2009. 10. 22-23)


• 7. Lee, J., H. S. Yun, Y. Kim, and S. H. Kim . 2009. Inhibitory effects of exopolysaccharide (EPS) produced from Lactobacillus acidophilus on biofilm formationof Listeria monocytogenes. The 5th Asian Conference on Lactic Acid Bacteria: Microbes in Disease Prevention & Treatment (Singapore)(P63) (2009. 7. 1-3).
• 8. Jeun, G. H., H. S. Yun, J. Lee, T. H. Chun, S. H. Kim . 2009. Reduction of interleukin 8 production in human intestinal epithelial cell by the probiotic strains of Lactobacillus. The 5th Asian Conference on Lactic Acid Bacteria: Microbes in Disease Prevention & Treatment (Singapore)(P28) (2009. 7. 1-3).


• 9. Yun, H. S., Y. Kim, J. Lee, S. Oh, and S. H. Kim . 2009. Proteome-Based Studies for inhibition of Biofilm Formation of Listeria monocytogenes by -Casein Glycomacropeptide. 2009. ASM 109th General Meeting. (Philadelphia, U.S.A)(D-088) (2009. 5. 17-21).


• 10. Lee, J., Y. Kim, H. S. Yun, J. G. Kim, K. Y. Hwang, S. Oh, and S. H. Kim . 2008. Genetic Analysis of Factors Affecting Serum Cholesterol Reduction by Lactobacillus acidophilus A4. 9th Symposium on Lactic Acid Bacteria. Egmond aan Zee (The Netherlands) (C031) (2008. 8. 31-9. 4)


• 11. Yun, H. S., Y. Kim, J. Lee, S. Oh, and S. H. Kim . 2008. Inhibition Effects of Exopolysaccharide (EPS) Produced from Lactobacillus acidophilus on Biofilm Formation of Listeria monocytogenes Scott A. 9th Symposium on Lactic Acid Bacteria. Egmond aan Zee (The Netherlands) (C028) (2008. 8. 31-9. 4)


• 12. Yun, H. S., Y. Kim, J. Lee, S. Oh, and S. H. Kim . 2008. Proteome-Based Studies for inhibition of Biofilm Formation of Listeria monocytogenes by -Casein Glycomacropeptide. 2008 International Association for Food Protection. Columbus, Ohio (U. S. A.) (P4-46) (2008.8.3.-8.6)


• 13. Yun, H. S., Y. Kim, J. Lee, J. Y. Imm, S. Oh, and S. H. Kim . 2008. Effects of hydrogen peroxide on the survival of Listeria monocytogenes cultured in biofilm and planktonic modes. 2008 IFT Annual Meeting and Food Expo. (New Orleans, U.S. A.) 052-25 (2008.6.28-7.1)


• 14. Im, H. J., S. K. Kang, S. H. Kim , and H. J. Park.2008. Preparation and Characterization of Fucosphere Containing Bacteriocin Produced by Lactobacillus acidophilus 30SC for Anti-Helicobacter pylori Therapy. 2008 Annual Meeting of Korean Society of Food Science and Technology. (P13-026) (2008. 06. 18-20, Kimdaejung Convention Center, Gwangju, Korea)


• 15. Nam, G. W., H. L. Choi, M. R. Lee, H. S. Yun., S. H. Kim , J. K. Oh, D. J. Park, and W. J. Lee. 2008. Formation and Structural Properties of Beta-Lactoglobulin Nano-Particles. 2008 Annual Meeting of Korean Society of Food Science and Technology. (P14-031) (2008. 06. 18-20, Kimdaejung Convention Center, Gwangju, Korea)


• 16. Kang, S. K., H. S. Yun, J. Lee, G. Jeun, M. Yoo, Y. J. Choi, Y. Kim, S. Oh, and S. H. Kim . 2008. Detection on Growth Inhibition of Helicobacter pylori by Probiotic Strains Using in vitro Techniques. 2008. 2008 Annual Meeting of Korean Society of Food Science and Technology. (P12-021) (2008. 06. 18-20, Kimdaejung Convention Center, Gwangju, Korea)


• 17. Kang, S., Y. Kim, H. S. Yun, S. H. Kim , and S. Oh. 2008. Released Exopolysaccharide (r-EPS) Produced from Lactobacillus acidophilus Reduce Biofilm Formation of Enterohemorrahgic Escherichia coli. American Society for Microbiology (108th General Meeting.) (P-014) (2008. 06. 01-05, Boston convention & exhibition center. Boston, MA)


• 18. Yoon, M., K. M. Lee, S. Nam, Shumi Wahhisa, S. W. Nam, Y. Kim, S. H. Kim , W. Park, H. Kang, and S. Park. 2007. OmpR is required to adapt to high osmolarity and acidic condition in the intestine of Caenorhabditis elegans. 2007 International Meeting of the Federation of Korean Microbiological Societies. Hotel-Seoul KyoYuk MunHwa HoeKwan. (F023) (2007.10.11-10.12)


• 19. Lim, J., S. H. Kim, Y. Yang, Y. Kim, H. S. Yun, K. M. Lee, S. H. Kim , and S. Park. 2007. Optical monitoring of biofilm under laminar flow conditions with scanning electron microscopy. 2007 International Meeting of the Federation of Korean Microbiological Societies. Hotel-Seoul KyoYuk MunHwa HoeKwan. (H007) (2007.10.11-10.12)


• 20. K. M. Lee, J. Lim, S. Nam, J. R. Park, M. Yoon, Shumi Wahhida, S. H. Kim , W. Park, S. Oh, J. W. Yoon, and S. Park. 2007. Effects of subinhibitory concentration of epigallocatechin gallate on expression of quorum sensing-controlled virulence genes and shiga toxin genes in enterohemorrhagic Escherichia coli O157:H7. International Meeting of the Federation of Korean Microbiological Societies. Hotel-Seoul KyoYuk MunHwa HoeKwan. (J011) (2007.10.11-10.12)


• 21. Lee, Y., Y. Kim, S. Yeom, S. H. Kim , and W. Park. 2007. The role of DsbA (disulfide bond isomerase) of Escherichia coli O157:H7 in the biofilm formation and virulence. ISME (International Symposium on Microbial Ecology) Asia 2007. (Matsuyama, Japan) ISME-16 (2007.9.15-9.17)


• 22. Kim, Y., Y. Cho, S. H. Kim , and S. Oh. 2007. Transcriptome analysis of interactive communication between Enterohemorrhagic Escherichia coli (EHEC) O157:H7 and intestinal epithelial HT-29 cells. ASM Conferences (Cell-cell communication in bacteria). (Austin, Texas) 12A (2007.10.7-10.10)


• 23. Kim, Y., Y. Lee, S. Oh, W. Park, S. Park, and S. H. Kim . 2007. The global regulation of dsbA (disulfide bond isomerase) controlled by autoinducer-2 like activity of in the virulence of enterohemorrhagic Escherichia coli O157:H7. ASM Conferences (Cell-cell communication in bacteria). (Austin, Texas) 42A (2007.10.7-10.10)


• 24. Kang, S., Y. Kim, J. Oh, S. H. Kim , I. Cho, and S. Oh. 2007. Effects of probiotic bacteria inhibiting autoinducer-2 like activity on bacteria community in vitro and in vivo intestinal models. ASM Conferences (Cell-cell communication in bacteria). (Austin, Texas) 44A (2007.10.7-10.10)


• 25. Lee, J., Y. Kim, H. S. Yun, J. Y. Imm, S. Oh, and S. H. Kim . 2007. Proteome analysis of cholesterol reduction factors in Lactobcillus acidophilus A4. IFT Annual Meeting and Food Expo. (Chicago, U.S. A.) 058-32 (2007.7.28-8.1)


• 26. Yun, H. S., Y. Kim, J. Lee, S. H. Kim , and S. Oh. 2007. Characterization of Listeria monocytogenes biofilm formation in different conditions. IFT Annual Meeting and Food Expo. (Chicago, U.S. A.) 098-25 (2007.7.28-8.1)


• 27. Yun, H. S., Y. Kim, Y. Lee, W. Park, S. Park, S. Oh, and S. H. Kim . 2007. Inhibitory effects of expolysacchride (EPS) produced from Lactobacillus acidophilus on the biofilm formation of shiga toxin-producing Escherichia coli O157:H7. 2007 International Association for Food Protection. Florida (U. S. A.) (P5-66) (2007.7.8.-7.11)


• 28. Kim, S. E., Y. Kim, S. Oh, H. S. Yun, J. Lee, and S. H. Kim . 2007. Anti-inflammatory activity of probiotic lactobacilli for modulation of the intestinal inflammation. 2007 International Symposium & Annual Meeting – The Korean Society for Microbiology and Biotechnology. Seoul (COEX), Korea. (H-1) (2007.6.28-6.29)


• 29. Lee, Y., Y. Kim, S. Yeom, S. H. Kim , and W. Park. 2007. The role of DsbA (disulfide bond isomerase) of Escherichia coli O157:H7 in the biofilm formation and virulence. 2007 International Symposium & Annual Meeting – The Korean Society for Microbiology and Biotechnology. Seoul (COEX), Korea. (E-11) (2007.6.28-6.29)


• 30. Kang, S. K., S. E. Kim, J. Lee, J. W. Shin, H. S. Yun, S. Oh, Y. Kim, M. K. Kee, and S. H. Kim . 2007. Quantitative and qualitative studies of lactic acid bacteria in (bacterial community of) Kimchi. 74th Social obligation of food science and technology. Busan (Bexco), Korea. (P12-103) (2007.6.20-6.22)


• 31. Lee, Y., Y. Kim, S. Yeom, S. H. Kim , and W. Park. 2007. The role of DsbA (disulfide bond isomerase) of Escherichia coli O157:H7 in the biofilm formation and virulence. 2007 International Meeting of the Microbiological Society of Korea. Bokwang Phoenix Park, PyeongChang, Korea (F026) (2007.5.10-5.11)


• 32. Lee, Y., Y. Kim, S. H. Kim , and W. Park. 2006. The role of periplasmic antioxidant enzymes (superoxide dismutase and thiol peroxidase) of the shiga toxin-producing Escherichia coli O157:H7 in the formation of biofilms. 2006 International Meeting of the Microbiological Society of Korea. EXCO, Daegu, Korea. (F023) (2006.5.3-5.4)


• 33. Kim, M. J., Y. Kim, H. S. Yun, E. Lee, S. Oh, J. Y. Imm, and S. H. Kim . 2006. Effects of lactoferrin isolated from goat colostrum on cancer cell proliferation, 7thAAAP Animal Science Congress. Busan, Korea. (PPN-037)


• 34. Kim, J. U., Y. Kim, H. S. Yun, E. Lee, S. Oh, J. Y. Imm, and S. H. Kim . 2006. The optimization of culture conditions for the production of expolysaccharide (EPS) by Lactobacillus rhamnosus ATCC 9595. 7thAAAP Animal Science Congress. Busan, Korea. (PPN-036) (Oral presentation and poster) (2006.9.18.-9.22)


• 35. S. H. Kim , J. Y. Whang, Y. Kim and S. Oh. 2006. Characterization of cholesterol reduction factors from probiotics using two-dimensional gel electrophoresis. The 20th International ICFMH Symposium. Bologna, Italy. (Microorganism and functional foods (C)) (Oral presentation) (2006.8.29-9.2)


• 36. Lee, E., Y. Kim, H. S. Yun, S. You, J. Y. Imm, S. Oh, and S. H. Kim . 2006. Effects of fermented milk by Lactobacillus casei ATCC 393 on the osteoblasts and adipocytes differentiation. 2006. IFT Annual Meeting and Food Expo. Orlando, USA. 078C-18. (2006.6.24.-6.28)


• 37. Yun, H. S., Y. Kim, E. Lee, J. Y. Imm, S. Oh, and S. H. Kim . 2006. Inhibitory activity of glycomarcropeptide that is isolated from k-casein on the biofilm formation of Listeria monocytogenes. IFT Annual Meeting and Food Expo. Orlando, USA. 054B-27. (2006.6.24.-6.28)


• 38. Lee, Y., Y. Kim, S. H. Kim , J. Yeom, and W. Park. 2006. The role of periplasmic antioxidant enzymes (superoxide dismutase and thiol peroxidase) of the shiga toxin-producing Escherichia coli O157:H7 in the formation of biofilms. Annual Meeting and International Symposium of the Kor. Soc. Microbiol. Biotech. Busan (Bexco), Korea. E-45. (2006.6.18.-6.20)


• 39. Lee, E., Y. Kim, J. G. Kim, H. S. Yun, S. C. Kim, J. Y. Imm, K. Y. Whang, S. Oh, and S. H. Kim . 2005. Effects of whey protein concentrate hydrolysates and fermented-milk by Lactobacillus casei ATCC 393 in ovariectomized rat models. 2005 International symposium and Annual Meetings of the KFN. Gangwon-do. Korea P10-160


• 40. Kim, S. H. . 2005. Inhibitory effects of Lactobacillus acidophilus on the virulence of Escherichia coli O157:H7. 2005 International symposium and Annual Meetings of the KFN. Gangwon-do. Korea S3-3 (Oral presentation, 2005.10.19-21)


• 41. Lee, E., Y. Kim, H. S. Yun, J. Y. Imm, S. Oh, and S. H. Kim . 2005. Effects of milk-fermented products of lactic acid bacteria on the proliferation of MC3T3-E1 osteroblastic cells. . 2005 International Meeting of the Federation of Korean Microbiological Societies. Seoul, Korea E-019


• 42. Yun, H. S., Y. Kim, E. Lee, Y. M. Choi, S. Oh, and S. H. Kim . 2005. Tolerances of heat or acid stress adapted Listeria monocytogenes in biofilm against hydrogen peroxide. 2005 International Meeting of the Federation of Korean Microbiological Societies. Seoul, Korea E-018


• 43. Kim, Y. H., S. Oh, Y. I. Moon, and S. H. Kim . 2005. Inhibitory effects of quorum sensing signal by stains of Lactobacillus on initial adhesion of E. coli O157:H7. 8th Symposium of Lactic Acid Bacteria. Egmond aan Zee, Netherlands H-067


• 44. Kim, Y. H., S. Oh, Y. I. Moon, and S. H. Kim . 2005. Effects of Lactobacillus acidophilus on the human colon cancer cell (HT-29) by proteome analysis. 8th Symposium of Lactic Acid Bacteria. Egmond aan Zee, Netherlands H-061


• 45. Kim, Y. H., S. Oh, and S. H. Kim . 2005. Comparative study of protein profiles of Escherichia coli O157:H7.cultivated in biofilm and planktonic growth mode. 2005 KMB Annual meeting & International symposium. Seoul, Korea H-2.


• 46. Yun, H. S., Y. H. Kim, S. Oh, and S. H. Kim . 2005. Comparative Study of Listeria monocytogenes for the Susceptibility of Hydrogen Peroxide during Biofilm Formation. 2005 KoSFoST Annual meeting. Seoul, Korea P10-30.


• 47. Kim, Y. H., S. Oh, and S. H. Kim . 2005. Effects of Quorum sensing (QS) Molecules on Attachment and Protein Expression of Escherichia coli O157:H7. 2005 KoSFoST Annual meeting. Seoul, Korea P10-29.


• 48. Yun, H. S., Y. H. Kim, J. U. Kim, S. S. Choi, K. S. Han, S. Oh, and S. H. Kim . 2004. Evaluation of Methods for Screening of Probiotics Isolated from Korean Infant Feces. 2004 International Symposium on FUSION TECHNOLOGY. Gangwon-do, Korea P6-107 (Yongpyung resort, Korea. 2004.6.23-6.25)


• 49. Choi, S. S., Y. H. Kim, K. S. Han, S. You, S. Oh, and S. H. Kim . 2004. The Anticancer Activity of Lactic Acid Bacteria in Human Cancer Cell Lines. 2004 International Symposium on FUSION TECHNOLOGY. Gangwon-do, Korea P6-105. (Yongpyung resort, Korea. 2004.6.23-6.25)


• 50. . Kim, J. U., K. S. Han, and S. H. Kim . 2004. Characteristics of Two Types of Exopolysaccharides Produced by Lactobacillus rhamnosus RW-9595M. 2004 International Symposium on FUSION TECHNOLOGY. Gangwon-do, Korea P6-102. (Yongpyung resort, Korea. 2004.6.23-6.25)


• 51. Kim, Y. H., K. S. Han, S. Oh, S. K. You, and S. H. Kim . 2004. Influence of Up-regulation MUC2 by Lactobacillus spp. on Adherence of Escherichia coli O157:H7. 91st annual meeting IAFP 2004. P067. (Phoenix, Arizona. 2004.8.8-8.11)


• 52. Park, S. O., S. Oh, and S. H. Kim . 2003. Screening of Microbial Urease Inhibitions on Controlling Ammonia in Manure Slurry. 2003 International Meeting of the Federation of Korean Microbiological Societies. F4029. (Yonsei Univ., Korea. 2003.10.24-10.25)


• 53. Kim, Y. H., K. S. Han, S. Oh, S. K. You, and S. H. Kim . 2003. Inhibition of cytotoxic activity of Escherichia coli O157:H7 shiga-like toxin by strains of Lactobacillus. IFT’s International Food Safety and Quality Conference and Expo. (Florida, USA. 2003.11.5-11.7)


• 54. Kim, Y. H., K. S. Han, S. J. Oh, S. K. You, and S. H. Kim . 2003. The optimal electro-transformation conditions for the strains of Lactobacillus acidophilus. IFT annual meeting. 14A-27. (Chicago, USA. 2003.7.12-7.16)


• 55. Kim, Y. H., S. O. Park, K. S. Han, S. J. Oh, S. K. You, and S. H. Kim . 2003. Inhibition of Adherence and Cytotoxic Activity of Enterohaemorrhagic E. coli O157:H7 by the Strains of Lactobacillus acidophilus.2003 Annual meeting and symposium of The Korean society for Microbiology and Biotechnology. P8-3. (Muju, Korea. 2003.6.24-6.26)


• 56. Kang, S. H., J. W. Kim, J. Y. Imm, S. J. Oh, and S. H. Kim . 2003. The Storage Stability of IGF-I Fortified Dairy Products and Its Improvement by Micro-encapsulation. J. Dairy. Sci. 86:Suppl.1, T234. (Phoenix, Arizona. 2003.6.22-6.26)


• 57. An, E. Y., S. J. Oh, and S. H. Kim . 2003. Selection of Prebiotics for Lactobacillus acidophilus ATCC 43121 as Synbiotics. J. Dairy. Sci. 86:Suppl.1. W262 (Phoenix, Arizona. 2003.6.22-6.26)


• 58. Park, Y. H., K. M. Lee, K. G. Kim, Y. W. Shin, H. S. Kim, S. H. Kim , and K. Y. Hwang. 2002. Studies on the blood cholesterol lowering effect of specific lactic acid bacteria in growing pigs. J. Anim. Sci. 80:Suppl. 1, 156. (Quebec city, Canada. 2002.07.21-07.25)


• 59. Kang, S. H., J. W. Kim, J. Y. Imm, S. J. Oh, and S. H. Kim . 2002. The change of insulin-like growth factor-1 (IGF-1) in bovine milk during lactation period. J. Dairy. Sci. 85:Suppl.1, 627 . (Quebec city, Canada. 2002.07.21-07.25)


• 60. Kang, S. H., J. W. Kim, J. Y. Imm, S. J. Oh, and S. H. Kim . 2002. Effect of dairy process on insulin-like growth factor-1(IGF-1) content and its concentration in several commercial dairy products. J. Dairy. Sci. 85:Suppl.1, 239. . (Quebec city, Canada. 2002.07.21-07.25)


• 61. Han, K. S., Y. H. Kim, S. K. You, and S. H. Kim . 2002. Electroporation and genetic organization of bacteriocin-encoding plasmid in Lactobacillus acidophilus GP1B. 9th International Symposium on the Genetics of Industrial Microorganisms. P10-07. (Gyeongju, Korea, 2003.07.01-07.05)


• 62. Kim, S. H . 2001. Potential application of prebiotics and probiotics. Kor. Soc. Food Sci. Nutr. SⅣ-4, p178.


• 63. Imm, J. Y., S. J. Oh, J. S. Kim, and S. H. Kim . 2001. Control of acidification of yogurt by microencapsulated bacteriocin. J. Dairy Sci. 84. suppl. 1: 382.


• 64. Oh, E. J., J. Y. Imm, K. S. Han, and S. H. Kim . 2001. Changes in functionality of mozarella cheese produced from bovine and caprine milk during refrigerated storage. J. Dairy Sci. 84. suppl. 1: 307.


• 65. Kim, S. H. , J. Y. Imm, K. S. Han, S. S. Rheem, and S. J. Oh. 2001. Optimization of medium compositions for the production of bacteriocin of Lactobacillus acidophilus ATCC 4356 by response surface methodology. NIZO Dairy Conf. Food Microbes 2001. P102.


• 66. Sim, J. H., K. S. Han, S. J. Oh, and S. H. Kim . 2001. Effect of spray drying conditions on antimicrobial activity of bacteriocin produced by Lactobacillus plantarum K4. Proc. 11th World Congr. Food Sci. Technol. P06-45. p182.


• 67. Oh, S. J., R. W. Worobo, and S. H. Kim . 2000. Characterization and purification of acidocin 30SC produced by Lactobacillus acidophilus 30SC. Proc. Pre-Congr. Internet Conf. 11th World Congr. Food Sci. Technol. 278-280.


• 68. Oh, S. J., R. W. Worobo, and S. H. Kim . 2000. Purification and characterization of a bacteriocin produced by Lactococcus sp. CU216. Proc. Pre-Congr. Internet Conf. 11th World Congr. Food Sci. Technol. 275-277.


• 69. Oh, S. J., R. W. Worobo, and S. H. Kim . 2000. Lactobacillus acidophilus 30SC: Human isolate for potential use as a probiotic strain. Proc. Pre-Congr. Internet Conf. 11th World Congr. Food Sci. Technol.270-274.


• 70. Oh, S. J., C. H. Chai, S. H. Kim , R. H. Liu, H. S. Kim, and R. W. Worobo. 2000. Comparative study of Lactobacillus acidophilus strains for probiotic characteristics. J. Dairy Sci. 83, Suppl. 1:91.


• 71. Oh, S. J., S. H. Kim , J. Churey, and R. W. Worobo. 2000. Purification and partial amino acid sequence of a acidocin 30SC, a bacteriocin produced by Lactobacillus acidophilus 30SC. J. Dairy Sci. 83, Suppl. 1:91.


• 72. Kim, S. H. , S. J. Oh, and R. W. Worobo. 1999. Characterization and partial purification of a bacteriocin produced by Lactobacillus acdiophilus 30SC isolated from human feces. IFT Ann. Meeting. 37D-8.


• 73. Oh, S., R. worobo, B. C. Kim, S. H. Kim , and S. S. Rheem. 1998. Detection of cholera-toxin-binding activity of glycomacropeptide from bovine κ-casein and optimization of its production by use of response surface methodology. J. Dairy Sci. 81, Suppl. 1:18


• 74. Han, K. S. and S. H. Kim . 1998. Characterization of the bacteriocin production by Lactobacillus acidophilus 4356. Proc. vol. II. 8th World Conf. Animal Prod. OP2-4


• 75. Lim, D. H., K. S. Han, W. M. Jeon, S. H. Kim , and B. C. Kim. 1998. Fractionation of caprine casein by DEAE-cellulose column chromatography. Proc. vol. II. 8th World Conf. Animal Prod. PP2-16.


• 76. Kim, S. H. 1996. Production of bacteriocin by strains of Lactobacillus acdiophilus from different animal origins. Proc. 43th Korean Dairy Technol. Symposium. p30-34.

Domestic meeting

• 1. Lee S. H., J. Lee, and S. H. Kim . 2012. Anti-inflammatory Effects of Mung Bean Extract on DSS Induced Colitis Model. 2012 KoSFoST Annual Meeting. Daejeon, Korea P11-010.


• 2. Oh H. W., J. Lee, and S. H. Kim . 2012. Characterization and Purification of a Bacteriocin Produced by a Potential Probiotic Culture, Lactobacillus gasseri SF. 2012 KoSFoST Annual Meeting. Daejeon, Korea P12-007.
• 3. Joung, J. Y., J. Lee, and S. H. Kim . 2011. Effect of Lactic acid bacteria on Reducing Skatole for Boar Taint. 2011 43th KOSFA


• 4. Lee, S., and S. H. Kim . 2010. Anticancer Effect of Fermented Mung Bean Products by Lactic Acid Bacteria. 2010 42th KOSFA (P-221)


• 5. Kim, Y., H. Yun, S. Oh, S. Park and S. H. Kim . 2006. Inhibition of cell extracts from Lactobacillus acidophillus in the attachment and biofilm formation of Escherichia coli O157:H7, 2006 38th KOSFA (P-319).


• 6. Yun, H. S., Y. H. Kim, S. Oh, and S. H. Kim . 2005. Effect of Hydrogen Peroxide on Survival of Listeria monocytogenes Grown in Biofilm and Planktonic Mode. 6th Annual Congress of KSAST. (PF2504)


• 7. Lee, E. S., Y. H. Kim, H. S. Yun, S. Oh, and S. H. Kim . 2005. Rapid Screening of Probiotic Characterisitcs of Lactic acid bacteria using In vitro Methods. 6th Annual Congress of KSAST. (PF25056)


• 8. Han, K. S., Y. H. Kim, S. J. Oh, S. K. You, and S. H. Kim . 2003. Inhibitory Action and Electrotransformation of Plasmid-linked Determinant of Acidocin 4A Produced from Lactobacillus acidophilus GP4A. Proc. Annual Congress for Kor. J. Food Sci. Technol. (P6-84).


• 9. Kang, S. H., J. U. Kim, S. J. Oh, J. Y. Imm, and S. H. Kim . 2003. The availability of recombinant IGF-Ⅰduring lactic acid bacteria fermentation. Proc. Annual Congress for Kor. J. Food Sci. Technol. (P6-17)


• 10. Kim, J. U., S. H. Kang, K. S. Han, J. Y. Imm, and S. H. Kim . 2002. Change of insulin like growth factor-Ⅱ contents according to environmental factors and heat treatment. Proc. Annual Congress for Kor. J. Food Sci. Technol. (P7-52. p307.)


• 11. Kim, Y. H., and K. S. Han, S. J. Oh, S. K. You, and S. H. Kim . 2002. Use of Green Fluorescent Protein (GFP) as a Reporter Gene in Lactobacillus acidophilus ATCC 43121. Annual meeting and symposium of The Korean society for Microbiology and Biotechnology. (P820).


• 12. Kim, S. H . 2002. Nutritional value of dairy and meat foods. Proc. Annual Congress for Kor. Anim. Sci. p45-52.


• 13. Kang, S. H., J. U. Kim, J. Y. Imm, K. S. Han, S. J. Oh, and S. H. Kim . 2001. Change of insulin like growth factor-Ⅰconcentration in raw milk and milk whey by various milk heat treatment. Proc. Annual Congress for Kor. J. Food Sci. Ani. Resour.( P-213. p134.)


• 14. Kim, Y. H, K. S. Han, and S. H. Kim . 2001. Rapid identification by restriction enzyme fragment length polymorphism (RFLP) and nucleotide sequencing of 16S-23S rRNA intergenic spacer region and its flanking 23S rRNA gene in L. acidophilus. Proc. Annual Congress for Kor. J. Food Sci. Technol. (P6-62. p196.)


• 15. Kang, S. H., J. U. Kim, J. Y. Imm, K. S. Han, and S. H. Kim . 2001. Change of insulin like growth factor (IGF)-Ⅰcontent in colostrum whey and analysis of binding pattern of IGF-Ⅰbinding protein complexes. Proc. Annual Congress for Kor. Anim. Sci. (PC21192. p68.)


• 16. Chai, C. H., K. S. Han, and S. H. Kim . 2001. Selection of cholesterol lowering probiotics in Lactobacillus acidophilus. Annual meeting for Kor. J. Food Sci. Ani. Resour. (P-104. p68.)


• 17. Han, K. S., S. J. Oh, W. M. Jeon, J. Y. Imm, S. S. Rheem, and S. H. Kim . 2000. Development of bacteriocin preparations from lactic acid bacteria against Salmonella using an experimental design for mixtures. Annual meeting for Kor. J. Food Sci. Ani. Resour. (P-118. p104.)


• 18. Kim, J. S., D. J. Park, S. J. Kim, and S. H. Kim . Micro-encapsulation of bacteriocin by hybridization system. Annual meeting for Kor. J. Food Sci. Ani. Resour. (P-119. p105)


• 19. Han, K. S., K. S. Joo, and S. H. Kim . 2000. Inhibitory activity of bacteriocin produced by Lactobacillus plantarum against staphylococcus aureus. Annual meeting for Kor. J. Food Sci. Technol. (P6-36. p361.)


• 20. Oh, S. J., S. H. Kim , and R. W. Worobo. 2000. Purification and characterization of a bacteriocin produced by Lactococcus sp. CU216. Annual meeting for Kor. J. Food Sci. Technol. (P6-34. p360.)


• 21. Oh, S. J., S. H. Kim , and R. W. Worobo. 2000. Inhibitory activity of Lactococcin CU216 against Alicyclobacillus strains. Annual meeting for Kor. J. Food Sci. Technol. (P6-35. p361.)


• 22. Oh, S. J., S. H. Kim , and R. W. Worobo. 2000. Inhibition of Listeria strains by a bacteriocin produced by Leuconostoc sp. W65 isolated from vaccum packed-beef. Annual meeting for Kor. J. Food Sci. Technol. (P6-40. p363.)


• 23. Oh, S. J., K. S. Han, S. H. Kim , and R. W. Worobo. 2000. Characterization and purification of a acidocin 30SC produced by Lactobacillus acidophilus 30SC. Annual meeting for Kor. J. Food Sci. Technol. (P6-33. p360.)


• 24. Oh, S. J., C. H. Chai, S. H. Kim , and R. W. Worobo. 2000. Lactobacillus acidophilus 30SC: Human isolate for potential use as a probiotics strains. Annual meeting for Kor. J. Food Sci. Technol. (P6-32. p359.)


• 25. Han, K. S., K. S. Joo, and S. H. Kim . Antimicrobial effects of a bacteriocin from lactic acid bacteria in sausage storing. Proc. 8th annual congress for Kor. Anim. Sci. (P-99233. p207.)


• 26. Kim, S. H. Prospects of functional milk protein. Annual meeting for Kor. J. Food Sci. Ani. Resour. (P97-120.)


• 27. Kim, Y. C., J. O. Yang, S. H. Kim , Y. I. Moon, and B. C. Kim. 1998. The properties of bifidobacteria isolated from Korean: 2. Effects of oral administration of Bifidobacterium longum A2. Annual meeting for Kor. J. Food Sci. Technol. (P6-61, p181.)


• 28. Kim, Y. C., H. G. Jung, S. H. Kim , Y. I. Moon, and B. C. Kim. 1998. The properties of bifidobacteria isolated from Korean: 1. Requisites and effects of probiotics. Annual meeting for Kor. J. Food Sci. Technol.( P6-60, p180.)


• 29. Oh, S. J., S. S. Rheem, S. H. Kim , B. C. Kim, and Y. K. Kim. 1997. Optimization of glycomacopeptide producion by using response surface methodology. Annual meeting for Kor. J. Food Sci. Technol. (P-179. p187).


• 30. Oh, S. J., S. H. Kim , S. G. Kim, Y. J. Baek, K. H. Cho. 1997. Angiotensin Ⅰ-converting enzyme inhibitory activity of the κ-casein fragments hydrolysated by chymosin, pepsin, and trypsin. Annual meeting for Kor. J. Food Sci. Technol. (P-181. p188.)


• 31. Oh, S. J., S. H. Kim , W. M. Jeon, B. C. Kim, and Y. K. Kim. 1997. Chromatographic isolation of glycomacropeptide from bovine κ-casein. Annual meeting for Kor. J. Food Sci. Technol. (P-182. p188.)


• 32. Oh, S. J., S. H. Kim , D. J. Park, B. C. Kim, and Y. K. Kim. 1997. Cholera toxin binding activity of fractionated glycomacropeptide. Annual meeting for Kor. J. Food Sci. Technol. (P-180. p187)

Patents

• 1. Probiotics having hydrolyzing activity of soy saponin and compositions for hydrolyzing of soy saponin comprising thereof. Pub No. 10-2011-0006797. Pub. Date. 20110124



• 2. Lactobacillus acidophilus KCNU. The Republic of Korea. Pub No. 10-0871904. Pub Date. 2008112



• 3. Optimization of technical conditions for the transformation of Lactobacillus acidophilus strains. Pub No. 0635450. Pub Date. 20061011



• 4. Lactobacillus acidophilus 30SC. Pub No. 0434610. Pub. Date. 20040525



• 5. Method and technology for controlling fermentation in fermented foods. Pub No. 0376769. Pub. Dat

Research Topic

  유산균 은 “GRAS” (Generally Recognized As Safe) 로써 오랜 역사를 두고 발효 유제품을 중심으로 각종 발효식품, 장 류, 주류, 김치, 의약품 및 가축의 사료첨가제 등에 이르기까지 인류생활에 광범위하게 활용되어 오고 있다.

  식품미생물학 실험실은 식품 내 존재하는 미생물에 대한 연구와 이들을 제어하기 위한 연구를 실행하고 있다. 특히 Lactic Acid Bacteria (LAB)가 생성하는 생리활성 물질에 관한 연구에 중점을 두어 실시하고 있으며 이를 식품산업에 접목할 수 있도록 우유 및 유제품에 관련된 연구도 연계하여 진행하고 있다.

  유산균 유래의 생리활성물질은 그 역가가 치료 용의 의약품보다 낮다 하더라도 항상 섭취가 가능하다는 장점이 있다. 또한 화학적 합성물질이 아닌 천연 물질이므로 안전성과 함께 가공식품 내 신속히 적용 가능하다는 점에서 이와 같은 연구는 식품산업을 고부가가치 산업으로 발전시킬 수 있을 것으로 생각되며, 기능성 신제품의 개발 촉진 및 바이오 식품산업의 제품개발 활성화에 기여할 수 있을 것으로 기대한다.

  본 연구실은 mammalian cell culture를 위한 실험실 (식품미생물학 실험실 III, L210호), DNA manipulation 및 각종 Bacteria Culture 등 일반실험을 위한 실험실 (식품미생물학 실험실 I, 223호), 총 2개의 실험실을 분리하여 운영하고 있다. 현재 석/박사 학생들이 열심히 연구에 전념하고 있다 ( 식품미생물학 실험실 II, 214호, 3290-3491 ).

Research Topic

1) 다양한 근원에서 분리한 유산균의 probiotics 특성 연구

  본 연구실은 다양한 근원에서 분리한 유산균주 및 병원성 미생물 균주를 보유하고 있으며, 우유 및 유산균이 생성하는 다양한 생리활성 물질의 정제, 특성 연구 및 대량 생산, 유산균 유래 물질에 의한 여러 가지 기능성을 지닌 신개념 바이오 식품 소재 탐색 관련 연구를 진행하고 있다.

• - 내산성 / 내담즙성
• - Bacteriocin 생성 능력
• - 장상피세포 attachment 능력
• - Prebiotics 이용능력

2) 유산균의 probiotics 로써의 기능성 연구

최근에 유산균의 probiotics 로써 기능성을 입증하기 위한 in vitro 및 in vivo 실험을 다양하게 실시하고 있다.

- 면역조절 작용

Probiotics 균주에서 분획한 물질을 이용하여 염증성 장 질환 (Inflammatory Bowel Disease, IBD) 및 과민성 대장증후군 (Irritable Bowel Syndrome, IBS)과 관련된 면역조절 작용에 대한 연구를 진행하였다. 장 상피세포 모델인 대장 암 세포주 (HT-29 cell line)를 대상으로 세포 수준에서의 면역 조절 효능을 검증했으며, 세포주의 단백질 발현 패턴을 분석, 또한 동물모델 (DSS model)을 통해 숙주의 면역세포 및 anti-inflammatory cytokine의 분비를 살펴보았다. 그리고 유산균이 함유된 드링크 요구르트의 섭취를 통한 과민성대장증상 환자의 다양한 증상완화 평가를 위한 임상실험을 통해 장내균총 변화 및 cytokine, enzyme activity 등을 살펴보았다.

- 골다공증 예방

골다공증은 폐경 후 발생하는 대표적인 Bone Disease로, 조골세포 (osteoblast)와 파골세포 (osteoclast)의 osteocyte 불균형 및 칼슘 섭취, 흡수의 저하로 인해 발생한다. 골다공증 치료제로써 호르몬제 (estrogen), Bisphosphonate 등이 사용되고 있지만, 장기간 복용 시 많은 부작용을 가지는 단점을 가지고 있다. 이러한 단점을 극복하기 위해, Probiotics 균주가 발현하는 단백질 및 유청단백질 (WPC)을 이용하여 osteoblast cell의 분화 및 증식을 향상시키는 작용에 대한 연구를 진행하였고, 골다공증 동물모델(난소적출, OVX model) 을 이용하여 골밀도 및 골강도 향상, micro-CT, 혈청 내 ALT, AST, Creatinine, calcium, BUN, ALP, ACP 등의 변화를 통해 Probiotics 및 WPC의 골다공증 예방 및 치료 효과를 살펴보았다.

- Biofilm 관련 연구

대부분의 미생물이 자연상태, 식품가공공정, 인체 내에서 biofilm 을 형성하고 문제를 발생하는데 이들의 기작을 알아내고 문제를 예방하기 위해 biofilm 생성 시 발생하는 변화를 proteomics 등을 이용하여 연구하였다. Escherichia coli O157:H7 이나 Listeria monocytogenes 의 경우 빈번한 biofilm 의 형성으로 식품가공공정이나 식품의 표면에서 문제를 야기하는데 이를 연구하기 위해 biofilm 이 표면에 생성되는 기작과 probiotics 균주 처리 시 효능에 대해 연구하였다.

- Cholesterol 저감화

높은 cholesterol 수치는 동맥경화의 주요원인으로 현대인의 건강을 위협하는 가장 큰 문제 중 하나이다. 본 실험실에서는 김치와 같은 발효식품에서 분리한 유산균을 이용하여 in vitro 및 in vivo 실험을 통해 cholesterol 수치를 낮추는 Probiotics (생균제)를 개발하고 있다.

- 천연 항균제 (Bacteriocin) 관련 연구

항균작용이 뛰어난 Bacteriocin을 생성하는 유산균주 선발을 통해 천연 항균제 개발을 연구 중에 있다. Staphylococcus aureus, Streptococcus aureus, Listeria monocytogenes, Yersinia, Escherichia coli, Salmonella 등 식품 유래 병원성 미생물에 대한 항균작용의 기작 규명에 대한 연구를 진행하고 있다. 또한 Bacteriocin의 상업적인 생산 수율과 관련하여, Bacteriocin Production과 관련된 외부 인자에 대한 영향 및 Bacteriocin expression, regulation과 관련된 gene profile 연구를 진행하고 있다.

3) 기타 연구

• - 항암 및 항산화 능력 평가
• - 유산균이 생성하는 다당류 Exopolysaccharide (EPS) 생성 능력 평가
• - Toxic compounds inactivation 능력 평가
• - Probiotic culture of lactic acid bacteria in the dairy food and animal feed
• - 산양유에서 분리한 lactoferrin의 항균 및 항암효과
• - 유가공제품내 인슐린 유사 성장촉진인자의 안정화 및 강화기술개발
• - 분체표면 가공기법을 이용한 유산균체의 인스턴트화
• - 복합 유산균 박테리오신의 시너지를 이용한 축산식품의 선도유지 및 저장성 향상에 관한 기술 개발

Project

프로바이오틱스를 균주를 이용한 유단백질의 발효생성물 제조 및 심혈관 기능성 검증

· 농림수산식품부 연구과제, 연구기간 : 2011. 12. - 2014. 12.

• - 마이얄 반응 가수분해능을 갖는 균주의 스크리닝 및 프로바이오틱스를 이용한 마이얄반응 가수분해물의 제조
• - 프로바이오틱스를 이용한 마이얄반응 가수분해물의 심혈관계 질환 예방능력 및 혈행개선능력 평가


•    (in vitro 상에서 콜레스테롤 저하 및 항혈전 효과의 검증)
• - 동물모델(mice model)에서 마이얄반응 가수분해물의 기능성 확인

프로바이오틱스 균주의 골다공증 예방 및 완화 효과 검증

· 명가유업 연구과제, 연구 기간 : 2012. 03. - 2013. 02.

• - 조골세포 (osteoblast)의 성장 및 분화를 촉진하는 프로바이오틱스 균주의 선별 및 효과 검증
• - 프로바이오틱스 균주 발효에 의한 우유단백질 분해물의 분별
• - 유단백질 분해물의 조골세포 성장 및 분화에 미치는 효과 검증
• - 골다공증 동물모델 (난소절제 쥐)을 이용한 프로바이오틱스 균주 및 유단백질 분해물의 골밀도 증진 효과 검증

유가공품 및 아이스크림류의 유통기한 설정실험지표 개발 및 권장유통기간 설정

· 국립수의과학검역원 연구과제, 연구기간 : 2011. 04. - 2012. 11.

• - 아이스크림류, 계란 및 알가공품의 특성에 맞는 객관적이고 일관성 있는 유통기한 설정 실험 지표 탐색
• - 아이스크림류, 계란 및 알가공품의 유통기한 실험 지표에 따른 유통기한 설정 시험법 개발
• - 유통기한 설정 시험법의 적용 (가속실험 적용방법 및 유통기한 설정 예측지침을 통한 가속실험 모델 제시)
• - 유통기한에 대한 올바른 정보를 알기 쉽게 제공할 수 있는 소비자단체를 활용한 홍보 매체 개발 및 교육

건강 지향식 발효 특성 적합 균주 선발 연구

· CJ제일제당 연구과제, 연구 기간: 2012. 02. - 2012.08. (과제종료)

• - 과채 시럽의 유산균 발효를 통한 관능, 산도, pH, 생균수의 변화 확인 및 균주 선발
• - 선발된 균주의 안전성 및 내산성, 내담즙성, 장부착 능력 등 프로바이오틱스 특성 확인
• - 과채 시럽의 유산균 발효를 통한 건강 지향식 개발

산육능력향상, 식품안전성확보 및 수정능력 유지가 가능한 웅취 제거기법 개발

· 농림수산식품부 연구과제, 연구기간 : 2008. 12. - 2012. 06. (과제종료)

• - 간세포 내 Androstenone 분해활성물질 발굴
• - 장 내 Skatole 생성 미생물의 제어기술 개발
• - 사료첨가제 생산공정 개발
• - 웅취원인물질 관련 DNA 표지인자 개발

Tagatose의 Synbiotic 기능 검증

· CJ제일제당 연구과제, 연구기간 : 2011. 9. - 2012. 2. (과제종료)

• - Tagatose 이용 능력을 보유한 유용 미생물의 발굴 및 검증
• - Tagatose 이용 균주의 세포 및 단백질 수준의 관련인자 발견 방법 정립
• - 국내 및 국제 표준 기준을 적용한 자체평가기준 확립 후 기준치 이상의 균주 확보

녹두의 신규 항염증 성분과 사포닌 발효수식을 이용한 염증완화 유제품개발

· 농림수산식품부 연구과제, 연구기간 : 2008. 04. - 2011. 04. (과제종료)

• - 녹두 추출물 제조 및 활성성분의 분리 정제
• - 녹두 발효를 위한 균주 검색 및 발효조건 설정
• - 녹두 추출물과 발효물의 세포 내 항염증 활성 측정 및 기전분석
• - 선발된 균주의 녹두추출물을 이용한 복합발효기술 확립

국내 기능성 축산식품의 기능성 물질(성분) 분석기준 확립 및 인증·표시 등 세부관리 기준에 관한 연구

· 농림수산식품부 연구과제, 연구기간 : 2009. 12. - 2010. 12. (과제종료)

• - 기능성 물질(성분)의 효용성과 안전성을 확인(검증)할 수 있는 분석·평가 기술의 정립


• - 기능성 축산식품의 세부관리기준을 마련하기 위한 유형별 기준 및 규격 설정


• - 국내외 축산식품의 기능성 관리현황 파악 및 표방 축산물의 정밀조사

프로바이오틱스 균주와 천연물의 복합 발효 산물을 이용한 염증성 장 질환의 면역조절 식품소재 개발

· 농림수산식품부 연구과제, 연구기간 : 2008. 12. - 2011. 12. (과제종료)

• - 장염증 완화 활성을 가지는 Probiotics 균주 및 천연추출물 탐색
• - 선발된 천연 추출물 활성물질의 분석법 및 QC 방법 확립
• - 선발된 물질의 세포, 단백질 수준 및 동물실험에서의 항염증 효과 검증
• - 선발된 균주와 천연추출물을 이용한 복합발효기술 확립
• - Encapsulation process에 따른 산업적 활용방안 모색

LGG 유산균이 함유된 드링크 요구르트의 기능성 확인

· 매일유업 연구과제, 연구기간 : 2010. 9. - 2011. 2. (과제종료)

• - LGG 유산균이 함유된 드링크 요구르트 투여 전 후의 장내 세균무리 조사
• - LGG 유산균이 함유된 드링크 요구르트 투여 전 후의 혈액 검사
• - LGG 유산균이 함유된 드링크 요구르트의 섭취를 통한 과민성대장증상 환자의 다양한 증상완화 평가

Listeria monocytogenes 가 생성하는 biofilm의 형성 억제를 위한 식품소재 개발

· 보건복지부 연구과제, 연구기간 : 2008. 11. - 2010. 10. (과제종료)

• - 식품 및 유산균 유래 물질로부터의 Listeria monocytogenes 발병력 인자 생성 저감제 스크리닝 시스템 구축


• - 장관세포 및 동물모델을 이용한 저감제의 발병력 저감 효과 평가

국내 기능성 축산식품산업 육성을 위한 관리방안 연구

· 농림수산식품부 연구과제, 연구기간 : 2008. 07. - 2009. 06. (과제종료)

• - 국내외의 건강기능식품제도의 현황 분석
• - 국내외의 기능성 축산물의 관리 분석
• - 국내 기능성 축산물을 위한 관리 방안 모색
• - 국내 기능성 축산물을 위한 새로운 제도의 모색

High-throughput Casenorhabditis elegans-killing assay를 이용한 항생제 대체제의 선발

· 농촌진흥청 연구과제, 연구기간 : 2008. 01. (과제종료)

• - 천연항균활성물질 선발 및 단백질체학과 유전체학을 이용한 항균능력의 기작 규명
• - 병원성 세균의 virulence factors 탐색
• - High-throughput C. elegans-killing assay (Bio-MEMS)
• - 나노 입자를 이용한 장내 delivery 기술 탐색

산양유에서 분리한 lactoferrin의 항균 및 항암효과

• · 산양유에서 다양한 정제기법을 이용한 lactoferrin의 정제
• · 항균 및 항암효과 탐색
• · 우유, 모유의 lactoferrin과의 활력비교

미생물 발효에 의한 우유 단백질 분해물의 분별 및 생체 내.외에서의 골강도 증진효과 검증

· 농림기술개발연구과제, 연구기간 : 2002. 10. - 2005. 10.

• - 단백질 분해효소 생산 미생물의 선별 및 유단백질 분해물의 분별
• - 유단백질 분해물의 생체외에서 조골세포 성장에 미치는 효과 검증
• - 실험동물의 이용한 유단백질 분해물의 골강도 증진효과 검증

천연물 및 미생물 urease inhibitor 개발과 복합화 제제 생산

· 농림기술개발연구과제, 연구기간 : 2002. 10. - 2005. 10.

• - Urease 생성 억제 미생물 균주 개발
• - Microbial urease inhibitor의 activity 검증
• - 선발균주 및 제제 효능의 동물실험 검증

식품에서 유래된 Shiga-like toxin 중화물질의 분리 및 생산

· 보건의료기술연구개발사업, 연구기간 : 2002. 05 - 2004. 04. (과제종료)

• - 천연물 소재로부터 Glycopeptide 제조
• - 당쇄구조의 분석 및 Shiga like toxin과의 결합능력 평가 및 추출, 정제
• - 유산균의 Exopolysaccharide (EPS)의 특성 조사
• - 분획된 EPS와 Shiga like toxin과의 결합작용 비교
• - 선발된 독소중화물질을 in vivo에서의 세포독성을 평가하여 IC50 결정
• - 활성 Glycopeptide의 정제조건 최적화
• - EPS를 생산하는 유산균에 대한 발효공학 및 효소 공학적 방법으로 대량생산 조건의 정립

유가공제품내 인슐린 유사 성장촉진인자의 안정화 및 강화기술개발

· 농림기술개발 연구과제, 연구기간 : 2000. 07 - 2003. 07. (과제종료)

• - 유제품내 IGFs의 강화 방안 탐색
• - IGFs의 생체내 ·외에서의 생리화학적 활성 검증
• - IGFs의 강화 유제품의 안정성 평가

복합생균제 피복기술에 의한 양돈용 사료첨가제 개발

· 농림수산식품부 연구과제, 연구기간 : 2000. 08 – 2003. 07. (과제종료)

• - 기능성 균주와 Prebiotics를 이용한 복합 생균제 개발
• - 분체 복합화 기술 확립
• - 복합생균제의 사료 안정성 및 동물 능력개선효과 검증

복합유산균박테리오신의 시너지를 이용한 축산식품의 선도유지 및 저장성 향상에 관한 기술 개발

· 보건복지부(보건의료기술연구개발사업) 연구과제, 연구기간 : 1997. 5. - 2000. 4. (과제종료)

   분체표면 가공기법을 이용한 유산균체의 인스턴트화

· 산업자원부(산업기반기술개발사업) 연구과제, 연구기간 : 1998. 8. - 1999. 7. (과제종료

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