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고려대학교 교수소개

Knowledge & Innovation

생명과학대학

Home > 생명과학대학 >생명공학부

소개

Prof. 이영식

Tel: 02-3290-3018 

Fax: 02-926-9746

E-mail: ys-lee@korea.ac.kr

  • About Professor
  • Curriculum vitae
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile

    준비 중입니다.

  • Curriculum

    Education

     

    2000 Ph.D. Korea University, South Korea

    1996 M.S. Korea University, South Korea

    1994 B.S. Korea University, South Korea

     

     

     


    Professional Experiences

     

     

    2013.09 - Present Professor, College of Life Sciences and Biotechnology, Korea University, South Korea

    2008.09 - 2013.08 Associate professor, College of Life Sciences and Biotechnology, Korea University, South Korea

    2006.03 - 2008.08 Assistant professor, College of Life Sciences and Biotechnology, Korea University, South Korea

    2001.01- 2006.02 Postdoctoral fellow, Northwestern University, USA 

     

  • Publication

    [2014]       
    Seong YM, Lim DH, Kim Augustine , Lee YS, Song HS, Kwon YS (2014) Global identification of target recognition and cleavage by the microprocessor in human ES cells. Nucleic Acids Research  (In press)
     
    Lim DH , Oh CT, Han SJ* , Lee YS* (2014) Methods for studying the biological consequences of endo-siRNA deficiency in (2014) Methods for studying the biological consequences of endo-siRNA deficiency in Drosophila melanogaster.    Methods in Molecular Biology  (In press) ( *Corresponding authors)
     
    Joo JY, Ko HY, Lee JH, Lim DH, Kim EY, Cho SJ, Hong KS, Ko JJ, Lee SM, Lee YS, Choi YS, Lee KA, Kim SH (2014) Microinjection free delivery of miRNA inhibitor into zygotes. Scientific Reports   (In press)
     
    Ko HY, Lee YS*, Kim SH* (2014) Bioluminescence Reporter Gene-Based Detection of MicroRNAs. Methods in Molecular Biology 1098, 85-95   (*Corresponding authors)
     
    [2013] 
    Lim DH, Lee LH, Oh CT, Kim NH, Hwang SW, Han SJ and Lee YS* (2013) Microarray analysis of Drosophiladicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs.  Journal of Cellular Biochemistry    114, 418-427    (*Corresponding author)
     
    Lee JS , Kim JM, Lim KS, Hong JS, Hong KC, and Lee YS* (2013) Effects of polymorphisms in the porcine microRNA MIR206/ MIR133B cluster on muscle fiber and meat quality traits.    Animal Genetics 44, 101-106 (*Corresponding author)
     
    [2012] 
    Hong JS, Noh SH, Lee JS, Kim JM, Hong KC, and Lee YS* (2012) Effects of polymorphisms in the porcine microRNA miR-1 locus on muscle fiber type composition and miR-1 expression.  Gene  506(1), 211-216   (*Corresponding author)
     
    Lim DH, Han JY, Kim JR, Lee YS*, and Kim HY* ( 2012) Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila.  Biochem. Biophys. Res. Commun. 419(1), 20-26 (*Corresponding authors) 
     
    Kwak GH, Lim DH, Han JY, Lee YS*, and Kim HY* (2012) Methionine sulfoxide reductase B3 protects from endoplasmic reticulum stress in Drosophila and in mammalian cells  Biochem. Biophys. Res. Commun. 420(1), 130-135    (*Corresponding authors) 
     
    Lee JS, Kim JM, Hong JS, Lim KS, Hong KC, Lee YS* (2012) Effects of polymorphisms in the 3 untranslated region of the porcine PPARGC1A gene on muscle fiber characteristics and meat quality traits.Mol. Biol. Rep 39(4), 3943-3950    (*Corresponding author)
     
    [2011] 
    Lim DH, Oh CT, Lee RH, Hong JS, Noh SH, Hwang SW, Kim SC, Han SJ, Lee YS* (2011) The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis.  FEBS Letters   585(19), 3079-3085    (*Corresponding author) 
     
    [2010] 
    Cho IS, Kim J, Seo HY, Lim DH, Hong JS, Park YH, D.C.Park, K.Hong, Whang KY, Lee YS* (2010)Cloning and characterization of microRNAs from porcine skeletal muscle and adipose tissue.   Mol. Biol. Rep.37, 3567-3574    (*Corresponding author)
     
    Kim JM, Lee KT, Lim KS, Park EW, Lee YS, Hong KC   (2010) Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs.  Animal Genetics 41, 642-645
     
    [2009] 
    Lee YS*, Sigal Pressman, Arlise P. Andress, Kim Kevin, Jamie L. White, Justin J. Cassidy, Xin Li, Kim Lubell, Lim DH, Cho IS, Kenji Nakahara, Jonathan B. Preall, Priya Bellare, Erik J. Sontheimer, Richard W. Carthew* (2009) Silencing by small RNAs is linked to endosomal trafficking .   Nature Cell Biology 11, 1150 - 1156    (*Corresponding authors) ( Selected as a cover article and highlighted in Nature Cell Biology and Nature Reviews Molecular Cell Biology ) 
     
    [2008] 
    Cho IS, Kim J, Lim DH, Ahn HC, Kim HG, Lee KB, Lee YS* (2008) Improved serum stability and biophysical properties of siRNAs following chemical modifications. Biotechnol. Lett. 30, 1901-1908    (*Corresponding author) 
     
    Kim J, Cho IS, Hong JS, Choi YS, Kim HG, Lee YS* (2008) Identification and charaterization of new microRNAs from pig.   Mammalian Genome 19, 570-580     (*Corresponding author) 
     
    Lim DH, Kim J, Kim SU, Richard W. Carthew, Lee YS* (2008) Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila.   Biochem. Biophys. Res. Commun. 371, 525-530    (*Corresponding author)
     
    [2007] 
    Oh HY, Jin X, Kim JG, Oh Mj, Pian X, Kim JM, Yoon MS, Son CI, Lee YS, Hong KC, Kim H, Choi YJ, Whang KY (2007) Characteristics of primary and immortalized fibroblast cells derived from the miniature and domestic pigs. BMC Cell Biol. 8, 20. 
     
    Lee EH, Song MS, Shin JY, Lee YM, Kim CJ, Lee YS, Kim H, Choi YK (2007) Genetic characterization of avian metapneumovirus subtype C isolated from pheasants in live bird market.   Virus Res. 128, 18-25 
     
    Kim Kevin, Lee YS, Richard W. Carthew (2007) Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes.   RNA 13, 22-29
     
    [2006] 
    Kim Kevin, Lee YS, Dinari Harris, Kenji Nakahara, Richard W. Carthew (2006) The RNAi pathway initiated by Dicer-2 in Drosophila.   Cold Spring Harb. Symp. Quant. Biol. 71, 39-44
     
    [~2005] 
    Lee YS, Kenji Nakahara, John W. Pham, Kevin Kim, Zhengying He, Erik J. Sontheimer, Richard W. Carthew (2004) Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.  Cell 117, 69-81 

    John W. Pham, Janice L. Pellino, Young Sik Lee, Richard W. Carthew, Erik J. Sontheimer (2004) A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila.   Cell 117, 83-94 

    Lee YS, Richard W. Carthew (2003) 
    Making a better RNAi vector for Drosophila : use of intron spacers.   Methods 30, 322-329 
     

     

  • Research

    Research Topic   
     
     ● The Mechanism of RNA Interference (RNAi)  
    1. Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila. 
    2. Silencing by small RNAs is linked to endosomal trafficking  
     
    ● Functional Study of small RNAs (miRNAs, siRNAs)  
     1. Identification and charaterization of new microRNAs from pig.  
    2. Cloning and characterization of microRNAs from porcine skeletal muscle and adipose tissue.  
    3.  The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis  
     
    ● RNAi Applications  
    1. Improved serum stability and biophysical properties of siRNAs following chemical modifications.  
    2. Effects of polymorphisms in the 3 untranslated region of the porcine PPARGC1A gene on muscle fiber characteristics and meat quality traits. 

     

  • Teaching

    준비 중입니다.

  • Lab Members

    Postdoc  임도환

     

    limdh@korea.ac.kr

    (2014~현재)

     

    Ph.D students   

      홍재상

       jsf7205@korea.ac.kr

       (2011~현재)

     

     

     

     

     

     

     

     

     

     

    이승재   

    imsjay@gmail.com

    (2012~현재)

    MS students   

        육예원

        awake_y_u_k@korea.ac.kr

       (2013~현재)

     

        

    윤정필

    slease@naver.com

    (2013~현재)

     

    Undergraduated Student

     

       이서우

    gogo787@nate.com

    (2013~현재)

     

    Alumni

    김동성 학부연구생 2006-2009
    코넬대 박사과정
    김정 석사과정 2007-2009
    미네소타주립대 박사과정
    조익상 석사과정 2007-2009

     

    정은이 석사과정 2008-2010
    동아제약
    노수현 석사과정 2010-2012
    한국유나이티드제약
        이준성

        석사과정 2010-2012

        맥길대 박사과정 

        한지연

        석사과정 2011-2013

        서울대학교 

        김남훈 석사과정 2012-2014