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홍정호

Prof. 홍정호

Tel:  02-3290-3427

Tel:  02-3290-3629

E-mail: jh_hong@korea.ac.kr

  • About Professor
  • Curriculum Vitae
  • Publication
  • Research
  • Teaching
  • Lab Members

  • Profile

    홍정호 교수 Jeong-Ho Hong

    하나과학관 A동 213호(Office) 220호(Lab)

    Tel. 3290-3427(Office) 3290-3629(Lab)

    E-mail. jh_hong@korea.ac.kr

  • Curriculum Vitae

    Education
    • 1992.3.1~1997.8.31 Ph.D. in Pharmacy, Seoul National University, Korea
    • 1990.3.1~1992.2.28 M.S. in Pharmacy, Seoul National University, Korea
    • 1986.3.1~1990.2.28 B.S. in Manufacturing Pharmacy, Seoul National University, Korea
    Career
    • 2006.9.1~present Professor in Department of Life Sciences, Korea University, Korea
    • 2001.3.1~2006.8.31 Post-doctoral fellow in Center for Cancer Research, Massachusetts Institute of Technology, USA
    • 1999.11.22~2001.2.28 Post-doctoral fellow in Dana-Farber Cancer Institute, Harvard Medical School, USA
    • 1999.3.26~1999.11.21 Visiting Scientist in Johns Hopkins University School of Medicine, USA

    • 1997.9.1~1999.8.31 Post-doctoral fellow in Samsung Biomedical Research Institute, Korea
    • 1995.10.1~1996.9.30 Visiting Scientist in the Institute for Virus Research, Kyoto University, Japan

  • Publication

    2023

    Hwang JH, Heo W, Park JI, Kim KM, Oh HT, Yoo GD, Park J, Shin S, Do Y, Jeong MG, Hwang ES, Hong JH. Endothelial TAZ inhibits capillarization of liver sinusoidal endothelium and damage-induced liver fibrosis via nitric oxide production. Theranostics. 2023 Jul 16;13(12):4182-4196. doi: 10.7150/thno.83714. PMID: 37554269; PMCID: PMC10405847.

     

    2022

    TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A

    Hwang, J. H., Kim, K. M., Oh, H. T., Yoo, G. D., Jeong, M. G., Lee, H., Park, J. Jeong, K., Kim, Y. K., Ko, Y. G., Hwane, E. S., Hong, J. H., 2022 Feb 5, In : Nature Commun.;13(1);653. doi:10.1038/s41467-022-28247-2

     

    CD133-Src-TAZ signaling stimulates ductal firosis following DDC diet-induced liver injury

    Oh, H. T., Heo, W., Yoo, G. D., Kim, K. M., Hwang, J. H. Hwang, E. S., Ko, J. S., Ko, Y. G, Hong, J. H.

    2022 Dec, J Cell Physiol. 237(12);4504-4516. doi: 10.1002/jcp.30899. Epub 2022 Oct 17.

     

    2020

     

    Transcriptional coactivator with PDZ-binding motif stimulates epidermal regeneration via induction of amphiregulin expression after ultraviolet damage

     

    Kim, K. M., Oh, H. T., Yoo, G. D., Hwang, J. H., Oh, A., Hwang, E. S. & Hong, J. H., 2020 Mar 26, In : Biochemical and biophysical research communications. 524, 1, p. 242-248 7 p.
     
    Transmission and regulation of biochemical stimulus via a nanoshell directly adsorbed on the cell membrane to enhance chondrogenic differentiation of mesenchymal stem cell
    Han, U., Hwang, J. H., Lee, J. M., Kim, H., Jung, H. S., Hong, J. H. & Hong, J., 2020 Jan 1, In : Biotechnology and Bioengineering. 117, 1, p. 184-193 10 p.

     

    2019

     

    TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

    Hwang JH, Kim AR, Kim KM, Park JI, Oh HT, Moon SA, Byun MR, Jeong H, Kim HK, Michael B. Yaffe, Hwang ES & Hong JH

    Nature Commun. 2019;10(1):421. doi: 10.1038/s41467-019-08287-x

     

    Artificial cellular nano-environment composed of collagen-based nanofilm promotes osteogenic differentiation of mesenchymal stem cells.

    Hwang JH, Han U, Yang M, Choi Y, Choi J, Lee JM ... Hong JH.

    Acta Biomater. 2018. doi: 10.1016/j.actbio.2018.12.044

     

    TAZ stimulates liver regeneration through interleukin-6-induced hepatocyte proliferation and inhibition of cell death after liver injury

    Kim AR, Park JI, Oh HT, Kim KM, Hwang JH, Jeong MG, Kim EH, Hwang ES& Hong JH

    FASEB Journal. 2019. doi:10.1096/fj.201801256RR

     

    2017

     

    SRC activates TAZ for intestinal tumorigenesis and regeneration.

    Byun MR, Hwang JH, Kim AR, Kim KM, Park JI, Oh HT, Hwane ES & Hong JH.

    Cancer Lett. 2017;410:32-40. doi: 10.1016/j.canlet.2017.09.003

     

    Nanotopological plate stimulates osteogenic differentiation through TAZ activation.

    Hwang JH, Lee DH, Byun MR, Kim AR, Kim KM, Park JI, ... Hong JH.

    Sci Rep. 2017;7(1):3632. doi: 10.1038/s41598-017-03815-5

     

    (-)-Epigallocatechin-3-gallate stimulates myogenic differentiation through TAZ activation.

    Kim AR, Kim KM, Byun MR, Hwang JH, Park JI, Oh HT, ... Hong JH.

    Biochem Biophys Res Commun. 2017;486(2):378-84. doi: 10.1016/j.bbrc.2017.03.049

     

    Catechins activate muscle stem cells by Myf5 induction and stimulate muscle regeneration.

    Kim AR, Kim KM, Byun MR, Hwang JH, Park JI, Oh HT, ... Hong JH.

    Biochem Biophys Res Commun. 2017;489(2):142-8. doi: 10.1016/j.bbrc.2017.05.114

     

    2016

     

    Tunable Crosslinked Cell-Derived Extracellular Matrix Guides Cell Fate.

    Subbiah R, Hwang MP, Du P, Suhaeri M, Hwang JH, Hong JH & Park K.

    Macromol Biosci. 2016;16(11):1723-34. doi: 10.1002/mabi.201600280

     

    2015


    • Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation.
    • Hwang JH, Byun MR, Kim AR, Kim KM, Cho HJ, Lee YH, Kim J, Jeong MG, Hwang ES, Hong JH.
    • PLoS One. 2015 Aug 11;10(8):e0135519. doi: 10.1371/journal.pone.0135519. eCollection 2015.

    2014


    • Novel TAZ modulators enhance myogenic differentiation and muscle regeneration.
    • Park GH, Jeong H, Jeong MG, Jang EJ, Bae MA, Lee YL, Kim NJ, Hong JH, Hwang ES.
    • Br J Pharmacol. 2014 Sep;171(17):4051-61. doi: 10.1111/bph.12755.

    • Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein.
    • Jeon YH, Park YH, Lee JH, Hong JH, Kim IY.
    • Biochim Biophys Acta. 2014 Jul;1843(7):1356-64. doi: 10.1016/j.bbamcr.2014.04.002. Epub 2014 Apr 12.

    • Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation.
    • Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH.
    • Cell Death Differ. 2014 Jun;21(6):854-63. doi: 10.1038/cdd.2014.8. Epub 2014 Feb 7.

    • Shear stress induced by an interstitial level of slow flow increases the osteogenic differentiation of mesenchymal stem cells through TAZ activation.
    • Kim KM, Choi YJ, Hwang JH, Kim AR, Cho HJ, Hwang ES, Park JY, Lee SH, Hong JH.
    • PLoS One. 2014 Mar 21;9(3):e92427. doi: 10.1371/journal.pone.0092427. eCollection 2014.

    • (-)-Epicatechin gallate (ECG) stimulates osteoblast differentiation via Runt-related transcription factor 2 (RUNX2) and transcriptional coactivator with PDZ-binding motif (TAZ)-mediated transcriptional activation.
    • Byun MR, Sung MK, Kim AR, Lee CH, Jang EJ, Jeong MG, Noh M, Hwang ES, Hong JH.
    • J Biol Chem. 2014 Apr 4;289(14):9926-35. doi: 10.1074/jbc.M113.522870. Epub 2014 Feb 10.

    • FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression.
    • Byun MR, Kim AR, Hwang JH, Kim KM, Hwang ES, Hong JH.
    • Bone. 2014 Jan;58:72-80. doi: 10.1016/j.bone.2013.09.024. Epub 2013 Oct 11.

    • YAP and TAZ regulate skin wound healing.
    • Lee MJ, Ran Byun M, Furutani-Seiki M, Hong JH, Jung HS.
    • J Invest Dermatol. 2014 Feb;134(2):518-25. doi: 10.1038/jid.2013.339. Epub 2013 Aug 9.

    2013


    • Phorbaketal A inhibits adipogenic differentiation through the suppression of PPARγ-mediated gene transcription by TAZ.
    • Byun MR, Lee CH, Hwang JH, Kim AR, Moon SA, Sung MK, Roh JR, Hwang ES, Hong JH.
    • Eur J Pharmacol. 2013 Oct 15;718(1-3):181-7. doi: 10.1016/j.ejphar.2013.08.035. Epub 2013 Sep 12.

    • Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet.
    • Jang EJ, Park HR, Hong JH, Hwang ES.
    • J Immunol. 2013 Jun 1;190(11):5764-70. doi: 10.4049/jimmunol.1203403. Epub 2013 Apr 24.

    2012


    • TAZ suppresses NFAT5 activity through tyrosine phosphorylation.
    • Jang EJ, Jeong H, Han KH, Kwon HM, Hong JH, Hwang ES.
    • Mol Cell Biol. 2012 Dec;32(24):4925-32. doi: 10.1128/MCB.00392-12. Epub 2012 Oct 8.

    • Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation.
    • Byun MR, Kim AR, Hwang JH, Sung MK, Lee YK, Hwang BS, Rho JR, Hwang ES, Hong JH.
    • FEBS Lett. 2012 Apr 24;586(8):1086-92. doi: 10.1016/j.febslet.2012.03.008. Epub 2012 Mar 13.

    • Idesolide inhibits the adipogenic differentiation of mesenchymal cells through the suppression of nitric oxide production.
    • Hwang JH, Moon SA, Lee CH, Byun MR, Kim AR, Sung MK, Park HJ, Hwang ES, Sung SH, Hong JH.
    • Eur J Pharmacol. 2012 Jun 15;685(1-3):218-23. doi: 10.1016/j.ejphar.2012.04.018. Epub 2012 Apr 20.

    • TAZ is required for the osteogenic and anti-adipogenic activities of kaempferol.
    • Byun MR, Jeong H, Bae SJ, Kim AR, Hwang ES, Hong JH.
    • Bone. 2012 Jan;50(1):364-72. doi: 10.1016/j.bone.2011.10.035. Epub 2011 Nov 12.

    2011


    • Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells.
    • Lee K, Won HY, Bae MA, Hong JH, Hwang ES.
    • Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9548-53. doi: 10.1073/pnas.1012645108. Epub 2011 May 18.
    • Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation.
    • Rho JR, Hwang BS, Joung S, Byun MR, Hong JH, Lee HY.
    • Org Lett. 2011 Mar 4;13(5):884-7. doi: 10.1021/ol1029386. Epub 2011 Jan 27.

    • Hesperedin promotes MyoD-induced myogenic differentiation in vitro and in vivo.
    • Jeong H, Lee JY, Jang EJ, Lee EH, Bae MA, Hong JH, Hwang ES.
    • Br J Pharmacol. 2011 Jun;163(3):598-608. doi: 10.1111/j.1476-5381.2011.01243.x.

    2010


    • Suppression of adipocyte differentiation by 15-methoxypinusolidic acid through inhibition of PPARγ activity.
    • Lee YS, Sung SH, Hong JH, Hwang ES.
    • Arch Pharm Res. 2010 Jul;33(7):1035-41. doi: 10.1007/s12272-010-0709-0. Epub 2010 Jul 27.

    • TAZ as a novel enhancer of MyoD-mediated myogenic differentiation.
    • Jeong H, Bae S, An SY, Byun MR, Hwang JH, Yaffe MB, Hong JH, Hwang ES.
    • FASEB J. 2010 Sep;24(9):3310-20. doi: 10.1096/fj.09-151324. Epub 2010 May 13.

    • In vivo tumor suppression activity by T cell-specific T-bet restoration.
    • Lee K, Min HJ, Jang EJ, Hong JH, Hwang ES.
    • Int J Cancer. 2010 Nov 1;127(9):2129-37. doi: 10.1002/ijc.25238.

    • Anti-allergic function and regulatory mechanisms of KR62980 in allergen-induced airway inflammation.
    • Won HY, Min HJ, Ahn JH, Yoo SE, Bae MA, Hong JH, Hwang ES.
    • Biochem Pharmacol. 2010 Mar 15;79(6):888-96. doi: 10.1016/j.bcp.2009.10.023. Epub 2009 Nov 5.

    2009


    • Augmentation of PPARgamma-TAZ interaction contributes to the anti-adipogenic activity of KR62980.
    • Jung H, Lee MS, Jang EJ, Ahn JH, Kang NS, Yoo SE, Bae MA, Hong JH, Hwang ES.
    • Biochem Pharmacol. 2009 Nov 15;78(10):1323-9. doi: 10.1016/j.bcp.2009.07.001. Epub 2009 Jul 8.

    • Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone.
    • Min HJ, Won HY, Kim YC, Sung SH, Byun MR, Hwang JH, Hong JH, Hwang ES.
    • Biochem Biophys Res Commun. 2009 Jul 24;385(2):204-9. doi: 10.1016/j.bbrc.2009.05.039. Epub 2009 May 19.

    • Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells.
    • Min HJ, Nam JW, Yu ES, Hong JH, Seo EK, Hwang ES.
    • Int Immunopharmacol. 2009 Apr;9(4):448-54. doi: 10.1016/j.intimp.2009.01.008. Epub 2009 Feb 7.

    • Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma.
    • Park JW, Min HJ, Sohn JH, Kim JY, Hong JH, Sigrist KS, Glimcher LH, Hwang ES.
    • J Allergy Clin Immunol. 2009 Feb;123(2):479-85. doi: 10.1016/j.jaci.2008.10.035. Epub 2008 Dec 10.

    2008


    • Regulatory mechanisms of IL-2 and IFNgamma suppression by quercetin in T helper cells.
    • Yu ES, Min HJ, An SY, Won HY, Hong JH, Hwang ES.
    • Biochem Pharmacol. 2008 Jul 1;76(1):70-8. doi: 10.1016/j.bcp.2008.03.020. Epub 2008 Apr 6.

    • Isoeleutherin and eleutherinol, naturally occurring selective modulators of Th cell-mediated immune responses.
    • Hong JH, Yu ES, Han AR, Nam JW, Seo EK, Hwang ES.
    • Biochem Biophys Res Commun. 2008 Jun 27;371(2):278-82. doi: 10.1016/j.bbrc.2008.04.060. Epub 2008 Apr 22.

    2007


    • TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.
    • Tian Y, Kolb R, Hong JH, Carroll J, Li D, You J, Bronson R, Yaffe MB, Zhou J, Benjamin T.
    • Mol Cell Biol. 2007 Sep;27(18):6383-95. Epub 2007 Jul 16.

    2006


    • TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation.
    • Hong JH, Yaffe MB.
    • Cell Cycle. 2006 Jan;5(2):176-9. Epub 2006 Jan 16. Review.

    2005


    • IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508.
    • Hwang ES, Hong JH, Glimcher LH.
    • J Exp Med. 2005 Nov 7;202(9):1289-300.
    • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
    • Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB.
    • Science. 2005 Aug 12;309(5737):1074-8.
    • The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members.
    • Mahoney WM Jr, Hong JH, Yaffe MB, Farrance IK.
    • Biochem J. 2005 May 15;388(Pt 1):217-25.

    2004


    • TAZ interacts with TTF-1 and regulates expression of surfactant protein-C.
    • Park KS, Whitsett JA, Di Palma T, Hong JH, Yaffe MB, Zannini M.
    • J Biol Chem. 2004 Apr 23;279(17):17384-90. Epub 2004 Feb 17.

    2003


    • Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.
    • Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Tidor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR.
    • Mol Cell Biol. 2003 Aug;23(15):5376-87.
     

  • Research

    본 연구실에서는 아래와 같은 연구들을 진행 중이다.

     

    1) 조직 재생 과정의 분자 기전 연구
    - 근육 재생 과정에서 근육 줄기세포의 증식 및 활성을 조절하는 분자생물학적 기전을 규명하고 이를 조절하는 기술을 개발하여 근육 손상 및 근감소증에 대한 치료 기반을 제시한다.
    - 간 손상 후 재생 과정에서 간/담관세포의 기능을 이해하고 동물모델 및 오가노이드 모델을 활용하여 분자생물학적 기전을 확립한다.
     
    2) 간섬유화 조절 기전 연구 및 약물 표적 발굴
    - 대사이상성 지방간염(MASH)에서 전사조절인자 TAZ 단백질의 기능을 규명하고 활성 조절 인자를 발굴한다.
    - TAZ 활성 조절 스크리닝 시스템을 활용하여 MASH 치료를 위한 선도물질을 발굴한다. 
     
    3) 뒤센근이영양증(Duchenne Muscular Dystrophy) 병인 기전 연구
    - 뒤센근이영양증 모델 시스템을 활용하여 분자생물학적으로 병인을 분석하고 치료 기반을 제시한다.
    - 발굴된 표적 인자를 활용하여 치료를 위한 선도물질을 발굴한다. 
     
    4) 역학적 신호전달(Mechanotransduction)을 통한 근육 및 혈관세포 활성화 기전 연구
    - 근육 줄기세포 및 혈관 세포에서 물리적 신호(인장, 기질 경도등)에 따른 활성 조절 신호를 분석하고 그 기전을 확립한다.
    - 운동을 통한 근육 줄기세포의 활성 조절 기전을 분석하고 근감소증 치료 기반을 제시한다. 
    - 혈관세포에서 운동의 효능을 분석하고 대사 질환의 예방 효과를 검증한다.

  • Teaching

    학부 강의

    - 유전학, 분자생물학

    대학원 강의

    - 의약생명과학, 분자유전학

  • Lab Members

    Current Members
    •  
    •  
    • 오호택
    • Ph.D.
    • PostDoc
    •  

    유기돈

    석박사통합과정

     

    허웅

    석박사통합과정

     

    박지건

    석박사통합과정

     

    신소민

    석사과정

     

    도유진

    석사과정

     

    양혜진

    석박사통합과정

    •  
    Former
    •  
    •  
    • 김경민
    • Ph.D.
    • Emory University
    •  
    •  
    • 황준하
    • Ph.D.
    • (주)멥스젠 수석연구원
    •  

    김아름

    Ph.D.

    University of North Carolina Linberger Comprehensive Cancer Center

     

    • 임형신
    • Ph.D.
    • 한양대학교 약학대학 부교수
    •  
    • 박병덕
    • Ph.D.
    • 계명대학교 약학대학 조교수

     

    • 변미란
    • Ph.D.
    • 경희대학교 약학대학 연구교수

     

    • 박현진
    • M.S.
    • (주)휴온스

     

    • 장은영
    • M.S.
    • LG생활건강
    •  
    •  
    • 김선아
    • M.S.
    • Roche

     

    이연경

    M.S.

    녹십자

    •  
    • 방민수
    • M.S.
    • 아모레 퍼시픽
    •  
    • 문성아
    • Researcher
    • 서울아산병원
    •  
    • 이참한
    • M.S.
    • (주)싸이토젠
    •  
    • 성미경
    • M.S.
    • (주)두래
    •  
    • 조항준
    • M.S.
    • 케이셀바이오뱅킹 주식회사
    •  
    • 이요한
    • M.S.
    • LG생명과학
    •  

     

    • 박현진
    • M.S.
    • (주)휴온스