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고려대학교 교수소개

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생명과학대학

Home > 생명과학대학 >생명공학부

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Prof. 이동호

 

Tel: 02-3290-3017

E-mail: dongholee@korea.ac.kr

고려대학교 생명과학대학 서관 510호

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    충북대학교 약학대학 약학과 (1988/03/02-1992/02/26): 약학사

    충북대학교 대학원 약학과 (1992/03/02-1994/02/25): 약학석사

    University of Illinois at Chicago (1997/08/25-2001/12/31): Ph.D. (Dr. Kinghorn)

    Research Triangle Institute, Chemistry and Life Sciences Division: Postdoctoral chemist (Drs. Oberlies, Wall and Wani)

    한국생명공학연구원: 선임연구원

    대한약학회 Archives of Pharmacal Research: Associate Editor

    한국생약학회: 편집위원

    국립산림과학원: 겸임연구관

    한국기초과학지원연구원: 운영위원































































































































































































































































  • Profile

    천연물 대사체 실험실은 최신의 대사체분석 기법을 기반으로 신규 활성 물질을 신속하고 정확하게 분리, 분석 하는 것을 목표로, 식물 4,500 여종과 미생물 4,000 여종의 천연물 추출물 library를 확보하고 있으며, 효능이 확인된 추출물에 대하여 활성물질을 신속하고 정확하게 확인하기 위한 항균 및 항바이러스 스크리닝 기법도 자체적으로 구축하고 있으며, non-targeted metabolomic analysis(de-replication), targeted metabolomic analysis, NMR, MS, CD 등 첨단 spectroscopy 방법을 이용하여 효율적인 대사체학 기반 질환 타겟 천연물 유래 활성물질 고속 탐색 시스템 확립에 도전하고 있습니다.

     

    Location : 서울시 성북구 안암동5가 고려대학교 자연계캠퍼스 생명과학대학 서관 L513호
    Phone : 02-3290-3516
  • Publications

    2017

    Seung Mok Ryu, Jaeyoung Kwon, Young Hye Seo, Eun Gyeong Song, Seong Su Hong, Beom Seok Kim, Jin Sung Hong, Ki Hyun Ryu, Dongho Lee. Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper. Virus Research 2017, 227, 49-56 DOI: 10.1016/j.virusres.2016.09.013

     

    2016

    Won Je Lee, Chan Young Jeong, Jaeyoung Kwon, Vu Van Kien, Dongho Lee, Suk-Whan Hong, Hojoung Lee. Drastic anthocyanin increase in response to PAP1 overexpression in fls1 knockout mutant confers enhanced osmotic stress tolerance in Arabidopsis thaliana. Plant Cell Reports 2016, 35(11), 2369-2379 DOI:10.1007/s00299-016-2040-9

     

    Jing Xu, Maoqin Peng, Xiaocong Sun, Xingyu Liu, Ling Tong, Guochen Su, Yasushi Ohizumi, Dongho Lee, Yuanqiang Guo. Bioactive diterpenoids from Trigonostemon chinensis: Structures, NO inhibitory activities, and interactions with iNOS. Bioorganic & Medicinal Chemistry Letters 2016, 26(19), 4785-4789 DOI:10.1016/j.bmcl.2016.08.026

     

    Bae Joon Young, Lee Jin Woo, Jin Qinghao, Jang Hari, Lee Dongho, Kim Youngsoo, Hong Jin Tae, Lee Mi Kyeong, Lee Moon Soon, Hwang Bang Yeon. Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells. Chemistry and Biodiversity 2016, 00(00), 00-00 DOI:10.1002/cbdv.201600243

     

    Jing Xu, Shen Li, Xiaocong Sun, Jun Ma, Feng Liu, Ling Tong, Dongho Lee, Yasushi Ohizumi, Muhetaer Tuerhong, Yuanqiang Guo. Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects. Fitoterapia 2016, 113, 151-157 DOI: 10.1016/j.fitote.2016.07.012

     

    Jing Xu, Xiangrong Cao, Feng Liu, Jun Ma, Xingyu Liu, Ling Tong, Guochen Su, Yasushi Ohizumi, Dongho Lee, Lizhong Wang, Yuanqiang Guo. Characterization of diterpenoids from Caesalpinia decapetala and their anti-TMV activities. Fitoterapia 2016, 113, 144-150 DOI: 10.1016/j.fitote.2016.07.017

     

    Jaeyoung Kwon, Nguyen Tuan Hiep, Dong-Woo Kim, Sungeun Hong, Yuanqiang Guo, Bang Yeon Hwang, Hak Ju Lee, Woongchon Mar, and Dongho Lee. Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects. Journal of Natural Products 2016, 79(08), 1938-1951 10.1021/acs.jnatprod.6b00204

     

    Jin Woo Lee, Qinghao Jin, Hari Jang, Dongho Lee, Sang Bae Han, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang. Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells. Bioorganic & Medicinal Chemistry Letters 2016, 26(14), 3351-3354 DOI: 10.1016/j.bmcl.2016.05.035

     

    Jaeyoung Kwon, Hyaemin Lee, Yeo Dae Yoon, Bang Yeon Hwang, Yuanqiang Guo, Jong Soon Kang, Jae-Jin Kim, and Dongho Lee. Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis. Journal of Natural Products 2016, 79(06), 1618-1693 DOI: 10.1021/acs.jnatprod.6b00207

     

    Qinghao Jin, Jin Woo Lee, Hari Jang, Ji Eun Choi, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, and Bang Yeon Hwang. Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells. Journal of Natural Products 2016, 79(06), 1548-1553 DOI: 10.1021/acs.jnatprod.5b01106

     

    Nguyen Hoai Nguyen, Jun Hyeok Kim, Jaeyoung Kwon, Chan Young Jeong, Wonje Lee, Dongho Lee, Suk-Whan Hong, Hojoung Lee. Characterization of Arabidopsis thaliana FLAVONOL SYNTHASE 1 (FLS1) -overexpression plants in response to abiotic stress. Plant Physiology and Biochemistry 2016, 103, 133-142 DOI: 10.1016/j.plaphy.2016.03.010

     

    Hye Mi Kim, Jin Su Lee, Jurdas Sezirahiga, Jaeyoung Kwon, Miran Jeong, Dongho Lee, Jung-Hye Choi and Dae Sik Jang. A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle. Molecules 2016, 21(5), 642- DOI: 10.3390/molecules21050642

     

    Yun-Seo Kil, Jaeyoung Kwon, Dongho Lee, and Eun Kyoung Seo. Three New Chalcones from the Aerial Parts of Angelica keiskei. Helvetica Chimica Acta 2016, 99(5), 393-397 DOI: 10.1002/hlca.201500519

     

    Jing Xu, Xiaocong Sun, Xingyu Liu, Maoqin Peng, Shen Li, Da-Qing Jin, Dongho Lee, Mark Bartlamd, Yuanqiang Guo. Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells. Journal of Functional Foods 2016, 23, 565-572 DOI: 10.1016/j.jff.2016.03.011

     

    Jing Xu, Feifei Ji, Xiangrong Cao, Jun Ma, Yasushi Ohizumi, Dongho Lee, Yuanqiang Guo. Sesquiterpenoids from an edible plant Petasites japonicus and their promoting effects on neurite outgrowth. Journal of Functional Foods 2016, 22, 291-299 DOI: 10.1016/j.jff.2016.01.012

     

    Jung-Min Park, Jun-Hyeong Lee, Chun-Soo Na, Dongho Lee, Jin-Yong Lee, Masahiko Satoh, Moo-Yeol Lee. Heartwood extract of Rhus verniciflua Stokes and its active constituent fisetin attenuate vasoconstriction through calcium-dependent mechanism in rat aorta. Bioscience, Biotechnology, and Biochemistry 2016, 80(3), 493-500 DOI: 10.1080/09168451.2015.1107464

     

    Sang-Pil Choi, Chang-Yong Choi, Kyungmin Park, Nahyun Kim, Hyun-Seuk Moon, Dongho Lee, Taehoon Chun. Glabretal-type triterpenoid from the root bark of Dictamnus dasycarpus ameliorates collagen-induced arthritis by inhibiting Erk-dependent lymphocyte proliferation. Journal of Ethnopharmacology 2016, 178(3), 13-16 DOI: 10.1016/j.jep.2015.10.043

     

    Chung-Oui Hong, Mi-Hyun Nam, Ji-Sun Oh, Jin-Won Lee, Cheong-Tae Kim, Kwon-Woo Park, Dong-Ho Lee, Kwang-Won Lee. Pheophorbide a from Capsosiphon fulvescens Inhibits Advanced Glycation End Products Mediated Endothelial Dysfunction. Planta Medica 2016, 82(01/02), 46-57 DOI: 10.1055/s-0035-1557829

     

    Jin Woo Lee, Chul Lee, Qinghao Jin, Hari Jang, Dongho Lee, Ha-Jin Lee, Jong Won Shin, Sang Bae Han, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, and Bang Yeon Hwang. Diterpenoids from the Roots of Euphorbia fischeriana with Inhibitory Effects on Nitric Oxide Production. Journal of Natural Products 2016, 79(01), 126-131 DOI: 10.1021/acs.jnatprod.5b00789

     

    Jing Xu, Jing Kang, Xiaocong Sun, Xiangrong Cao, Kasimu Rena, Dongho Lee, Quanhui Ren, Shen Li, Yasushi Ohizumi, and Yuanqiang Guo. Di- and Triterpenoids from the Leaves of Casearia balansae and Neurite Outgrowth Promoting Effects of PC12 Cells. Journal of Natural Products 2016, 79(01), 170-179 DOI: 10.1021/acs.jnatprod.5b00815

     

    Hari Jang, Jin Woo Lee, Chul Lee, Qinghao Jin, Jeong Yeon Choi, Dongho Lee, Sang Bae Han, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells. Archives of Pharmacal Research 2016, 39(01), 127-132 DOI: 10.1007/s12272-015-0667-7

     

    2015

    Jaeyoung Kwon, Young Hye Seo, Jae-Eun Lee, Eun-Kyoung Seo, Shen Li, Yuanqiang Guo, Seung-Beom Hong, So-Young Park, and Dongho Lee. Spiroindole Alkaloids and Spiroditerpenoids from Aspergillus duricaulis and Their Potential Neuroprotective Effects. Journal of Natural Products 2015, 78(11), 2572-2579 DOI : 10.1021/acs.jnatprod.5b00508

     

    Se-Jin Jeong, Jong-Gil Park, Sinai Kim, Hyae Yon Kweon, Seungwoon Seo, Dae-Seung Na, Dongho Lee, Cheol Yi Hong, Chun-Soo Na, Mi-Sook Dong, Goo Taeg Oh. Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice. Archives of Pharmacal Research 2015, 38(11), 2049-2058 DOI: 10.1007/s12272-015-0579-6

     

    Hari Jang, Jin Woo Lee, Qinghao Jin, Soo-Young Kim, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee and Bang Yeon Hwang. Biflavones and Furanone Glucosides from Zabelia tyaihyonii. Helvetica Chimica Acta 2015, 98(10), 1419-1325 DOI: 10.1002/hlca.201500054

     

    Eung Tae Yeon, Jin Woo Lee, Chul Lee, Qinghao Jin, Hari Jang, Dongho Lee, Jong Seog Ahn, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, and Bang Yeon Hwang. neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production. Journal of Natural Products 2015, 78(9), 2292-2296 DOI: 10.1021/acs.jnatprod.5b00126

     

    Tien Thanh Vu, Chan Young Jeong, Hoai Nguyen Nguyen, Dongho Lee, Sang A Lee, Ji Hye Kim, Suk-Whan Hong, and Hojoung Lee. Characterization of Brassica napus FLAVONOL SYNTHASE (BnFLS) involved in flavonol biosynthesis in Brassica napus L. Journal of Agricultural and Food Chemistry 2015, 63(35), 7819-7829 DOI: 10.1021/acs.jafc.5b02994

     

    Jaeyoung Kwon, Sunita Basnet, Jin Woo Lee, Eun-Kyoung Seo, Nanzad Tsevegsuren, Bang Yeon Hwang, Dongho Lee. Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Bioorganic & Medicinal Chemistry Letters 2015, 25(16), 3314-3318 DOI: 10.1016/j.bmcl.2015.05.062

     

    Hyuk-Hwan Song, In-Sik Shin, So Yeun Woo, Su Ui Lee, Min Hee Sung, Hyung Won Ryu, Doo-Young Kim, Kyung-Seop Ahn, Hyeong-Kyu Lee, Dongho Lee, Sei-Ryang Oh. Piscroside C, a novel iridoid glycoside isolated from Pseudolysimachion rotundum var. subinegrum suppresses airway inflammation induced by cigarette smoke. Journal of Ethnopharmacology 2015, 170, 20-27 DOI: 10.1016/j.jep.2015.04.043

     

    Taehun Lee, Jaeyoung Kwon, Dongho Lee, and Woongchon Mar. Effects of Cudrania tricuspidata Fruit Extract and Its Active Compound, 5,7,3′,4′-Tetrahydroxy-6,8-diprenylisoflavone, on the High Affinity IgE Receptor-Mediated Activation of Syk in Mast Cells. Journal of Agricultural and Food Chemistry 2015, 63(22), 5459-5467 DOI: 10.1021/acs.jafc.5b00903

     

    Dong-Woo Kim, Kyoung-tae Lee, Jaeyoung Kwon, Hak Ju Lee, Dongho Lee, Woongchon Mar. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sciences 2015, 130, 25-30 DOI: 10.1016/j.lfs.2015.02.026

     

    Qinghao Jin, Chul Lee, Jin Woo Lee, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Jin Sook Kim, Joo-Hwan Kim, Mi Kyeong Lee, Bang Yeon Hwang. Geranylated Flavanones from Paulownia coreana and Their Inhibitory Effects on Nitric Oxide Production. Chemical and Pharmaceutical Bulletin 2015, 63(5), 384-387 DOI: 10.1248/cpb.c14-00839

     

    Bo-Hyung Kim, Jaeyoung Kwon, Dongho Lee, Woongchon Mar. Neuroprotective Effect of Demethylsuberosin, a Proteasome Activator, against MPP+-induced Cell Death in Human Neuroblastoma SH-SY5Y Cells. Planta Medica Letters 2015, 2(1), e15-e18 DOI: 10.1055/s-0035-1545936

     

    Nguyen Tuan Hiep, Jaeyoung Kwon, Dong-Woo Kim, Bang Yeon Hwang, Hak-Ju Lee, Woongchon Mar, Dongho Lee. Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata. Phytochemistry 2015, 111, 141-148 DOI:10.1016/j.phytochem.2014.10.021

     

    Xiang Hua Han, Chul Lee, Jin Woo Lee, Qinghao Jin, Hari Jang, Ha Ju Lee, Dongho Lee, Sung-Joon Lee, Jin Tae Hong, Mi Kyeong Lee and Bang Yeon Hwang. Two New Iridoids from the Stem of Catalpa ovata. Helvetica Chimica Acta 2015, 98(3), 381-385 DOI: 10.1002/hlca.201400203

     

    Jin Woo Lee, Ji Hoon Lee, Chul Lee, Qinghao Jin, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang. Inhibitory Constituents of Sophora tonkinensis on Nitric Oxide Production in RAW 264.7 Macrophages. Bioorganic & Medicinal Chemistry Letters 2015, 25(4), 960-962 DOI: 10.1016/j.bmcl.2014.12.012

     

    Yaoyao Jia, Seyoung Kim, Jiyoung Kim, Bobae Kim, Chunyan Wu, Ji Hae Lee, Hee-jin Jun, Nahyun Kim, Dongho Lee and Sung-Joon Lee. Ursolic acid improves lipid and glucose metabolism in high-fat-fed C57BL/6J mice by activating peroxisome proliferator-activated receptor alpha and hepatic autophagy. Molecular Nutrition & Food Research 2015, 59(2), 344-354 DOI: 10.1002/mnfr.201400399

     

    Nahyun Kim, Kyu-Won Cho, Seong Su Hong, Bang Yeon Hwang, Taehoon Chun, Dongho Lee. Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus. Bioorganic & Medicinal Chemistry Letters 2015, 25(3), 621-625 DOI: 10.1016/j.bmcl.2014.12.007

     

    Jun-Hyeong Lee ,Mikyung Kim, Kyung-Hwa Chang, Cheol Yi Hong, Chun-Soo Na, Mi-Sook Dong, Dongho Lee, and Moo-Yeol Lee. Antiplatelet Effects of Rhus verniciflua Stokes Heartwood and Its Active Constituents—Fisetin, Butein, and Sulfuretin—in Rats. Journal of Medicinal Food 2015, 18(1), 21-30 DOI: 10.1089/jmf.2013.3116

     

    2014

    Seunghan Sun, Yun-Ho Choi, Chun-Soo Na, Dongho Lee, Hye Hyun Yoo, Cheol Yi Hong, Byung Yoon Ahn, Mi-Sook Dong. Estrogenic activity of a Rhus verniciflua extract and its major components. Journal of Functional Food 2014, 11, 250-260 DOI: 10.1016/j.jff.2014.09.014

     

    Dong Hyuk Lee, Dongho Lee and Jae Won Lee. Statistical Methods for Classification of Medicinal Plants. Journal of Chemistry and Chemical Engineering 2014, 8, 698-706 www.davidpublishing.com/DownLoad/?id=17941

     

    Jaeyoung Kwon, Nguyen Tuan Hiep, Dong-Woo Kim, Bang Yeon Hwang, Hak Ju Lee, Woongchon Mar, and Dongho Lee. Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata. Journal of Natural Products 2014, 77(8), 1893-1901 DOI: 10.1021/np500364x

     

    Quinghao Jin, Chul Lee, Jin Woo Lee, Eung Tae Yeon, Dongho Lee, Sang Bae Han, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, and Bang Yeon Hwang. 2-Phenoxychromones and Prenylflavonoids from Epimedium koreanum and Their Inhibitory Effects on LPS-Induced Nitric Oxide and Interleukin-1β Production. Journal of Natural Products 2014, 77(7), 1724-1728 DOI: 10.1021/np400831p

     

    Joo-Hyun Hong, Jaejung Lee, Mihee Min, Seung-mok Ryu, Dongho Lee, Gyu-Hyeok Kim, Jae-Jin Kim. 6-Pentyl-α-pyrone as an anti-sapstain compound produced by Trichoderma gamsii KUC1747 inhibits the germination of ophiostomatoid fungi. Holzforschung 2014, 00, 132-138 DOI: 10.1515/hf-2013-0171

     

    Jae-Woo Han, Jeong-Do Kim, Jung-Min Lee, Jong-Hyun Ham, Dongho Lee and Beom-Seok Kim. Structural elucidation and antimicrobial activity of new phencomycin derivatives isolated from Burkholderia glumae strain 411gr-6. Journal of Antibiotics 2014, 67(10), 721-723 DOI: 10.1038/ja.2014.50

     

    Jin Woo Lee, Chul Lee, Qinghao Jin, Eung Tae Yeon, Dongho Lee, Soo-Young Kim, Sang Bae Han, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang. Pyranocoumarins from Glehnia littoralis inhibit the LPS-induced NO production in macrophage RAW 264.7 cells. Bioorganic & Medicinal Chemistry Letters 2014, 24(12), 2717-2719 DOI: 10.1016/j.bmcl.2014.04.046

     

    JaeYoung Kwon, Nahyun Kim, DongHyuk Lee, Ah-Reum Han, Jae Won Lee, Eun-Kyoung Seo, Je-Hyun Lee, Dongho Lee. Metabolomics approach for the discrimination of raw and steamed Gastrodia elata using liquid chromatography quadrupole time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2014, 94, 132-138 DOI: 10.1016/j.jpba.2014.01.032

     

    Nahyun Kim, Seung Mok Ryu, DongHyuk Lee, Jae Won Lee, Eun-Kyoung Seo, Je-Hyun Lee, Dongho Lee. A metabolomic approach to determine the geographical origins of Anemarrhena asphodeloides by using UPLC-QTOF MS. Journal of Pharmaceutical and Biomedical Analysis 2014, 92, 47-52 DOI: 10.1016/j.jpba.2013.12.040

     

    Jiho Ryu, Hyun Jae Lee, Su Hyun Park, Jinwoong Kim, Dongho Lee, Sang Kook Lee, Yeong Shik Kim, Jang-Hee Hong, Jeong Ho Seok, Choong Jae Lee. Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D3 and deapi-platycodin on production and secretion of airway mucin in vitro. Phytomedicine 2014, 21(4), 529-533 DOI: 10.1016/j.phymed.2013.10.004

     

    Eun Jee Kim, Dongho Lee, Bong Chul Chung, Heesoo Pyo, Jeongae Lee. Association between urinary levels of bisphenol-A and estrogen metabolism in Korean adults. Science of The Total Environment.2014, 470-471, 1401-1407 DOI: 10.1016/j.scitotenv.2013.07.040

     

    2013

    Sun-A Kim, Seung Hyun Kim, In Sook Kim, Dongho Lee, Mi-Sook Dong, Chun-Soo Na, Nguyen Xuan Nhiem, Hye Hyun Yoo. Simultaneous determination of bioactive phenolic compounds in the stem extract of Rhus verniciflua stokes by high performance liquid chromatography. Food Chemistry 2013, 141(4), 3813-3819 DOI: 10.1016/j.foodchem.2013.06.068

     

    Chul Lee, Jin Woo Lee, Qinghao Jin, Hak Ju Lee, Sung-Joon Lee, Dongho Lee, Myung Koo Lee, Chong Kil Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang. Anti-inflammatory constituents from the fruits of Vitex rotundifolia. Bioorganic & Medicinal Chemistry Letters 2013, 23(21), 6010-6014 DOI: 10.1016/j.bmcl.2013.08.004

     

    Bing Tian Zhao, Su Yang Jeong, Kyoung Hwangbo, Dong Cheul Moon, Eun-Kyoung Seo, Dongho Lee, Je-Hyun Lee, Byung-Sun Min, Eun-Sook Ma, Jong Keun Son, Mi Hee Woo. Quantitative analysis of betaine in Lycii Fructus by HILIC-ELSD. Archives of Pharmacal Research 2013, 36 (10), 1231-1237 DOI: 10.1007/s12272-013-0148-9

     

    Hye-Jeong Cho, Seon-Gyeong Jeong, Jie-Eun Park, Jin-Ah Han, Hye-Ri Kang, Dongho Lee, Moon Jung Song. Antiviral activity of angelicin against gammaherpesviruses. Antiviral Research 2013, 23(14), 4263-4266 DOI: 10.1016/j.antiviral.2013.07.009

     

    Ui Joung Youn, Yun-Seo Kil, Joo-Won Nam, Yoo Jin Lee, Jinwoong Kim, Dongho Lee, Je-Hyun Lee and Eun-Kyoung Seo. New Pyrrole Alkaloids with Bulky N-Alkyl Side Chains Containing Stereogenic Centers from Lycium chinense. Helvetica Chimica Acta 2013, 96(8), 1482-1487 DOI: 10.1002/hlca.201200608

     

    Seong Su Hong, Sungeun Hong, Hak Ju Lee, Woongchon Mar, Dongho Lee. A New Prenylated Flavanone from the Root Bark of Morus. Bulletin of the Korean Chemical Society 2013, 34(8), 2528-2530 DOI: 10.5012/bkcs.2013.34.8.2528

     

    Chul Lee, Jin Woo Lee, Qinghao Jin, Dae Sik Jang, Sung-Joon Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages. Bioorganic & Medicinal Chemistry Letters 2013, 23(14), 4263-4266 DOI: 10.1016/j.bmcl.2013.04.032

     

    Kwon Ki Bang, Cheong-Yong Yun, Chul Lee, Qinghao Jin, Jin Woo Lee, Sang-Hun Jung, Dongho Lee, Mi Kyeong Lee, Jin Tae Hong, Youngsoo Kim, Bang Yeon Hwang. Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa. Bioorganic & Medicinal Chemistry Letters 2013, 23(11), 3334-3337 DOI: 10.1016/j.bmcl.2013.03.096

     

    Mastura Abd Malek, Minh-Hien Hoang, Yaoyao Jia, Ji Hae Lee, Hee Jin Jun, Dong-Ho Lee, Hak Ju Lee, Chul Lee, Myung Koo Lee, Bang Yeon Hwang, Sung-Joon Lee. Ombuin-3-O-β-d-glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors α and δ/β. Biochemical and Biophysical Research Communications. 2013, 430(4), 1322-1328 DOI: 10.1016/j.bbrc.2012.12.020

     

    2012

    Hee-jin Jun, Minh-Hien Hoang, Jin Woo Lee, Jia Yaoyao, Ji-Hae Lee, Dong-Ho Lee, Hak-Ju Lee, Woo-Duck Seo, Bang Yeon Hwang, Sung-Joon Lee. Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells. Biotechnology Letters 2012, 34(12), 2213-2221 DOI: 10.1007/s10529-012-1036-y

     

    Young Mi Kim, Joongku Lee, Sang-Hong Park, Changyoung Lee, Jae Won Lee, DongHyuk Lee, Nahyun Kim, Dongho Lee, Hyang Yeon Kim and Choong Hwan Lee. LC-MS-based chemotaxonomic classification of wild-type Lespedeza sp. and its correlation with genotype. Plant Cell Reports 2012, 31(11), 2085-2097. (2012. 11) (IF 2.274) DOI: 10.1007/s00299-012-1319-8

     

    Nahyun Kim, Kemok Kim, DongHyuk Lee, Yoo-Soo Shin, Kyong-Hwan Bang, Seon-Woo Cha, Jae Won Lee, Hyung-Kyoon Choi, Bang Yeon Hwang, and Dongho Lee. Nontargeted Metabolomics Approach for Age Differentiation and Structure Interpretation of Age-Dependent Key Constituents in Hairy Roots of Panax ginseng. Journal of Natural Products 2012, 75(10), 1777-1784 DOI: 10.1021/np300499p

     

    Sanggil Choe, Sang Hee Woo, Dong Woo Kim, Yonghoon Park, Hwakyung Choi, Bang Yeon Hwang, Dongho Lee, Suncheun Kim. Development of target components extraction method from GC-MS data with in-house program for metabolite profiling. Analytical Biochemistry 2012, 426(2), 94-102 DOI: 10.1016/j.ab.2012.04.010

     

    Jung-Jin Lee, Hyun Yang, Yeong-Min Yoo, Seong Su Hong, Dongho Lee, Hyun-Jung Lee, Hak-Ju Lee, Chang-Seon Myung, Kyung-Chul Choi and Eui-Bae Jeung. Morusinol Extracted from Morus alba Inhibits Arterial Thrombosis and Modulates Platelet Activation for the Treatment of Cardiovascular Disease. Journal of Atherosclerosis and Thrombosis 2012, 19(6), 516-522 DOI: 10.5551/jat.10058

     

    Hee Taek Kim, Hyeok-Jin Ko, Nahyun Kim, Duwoon Kim, Dongho Lee, In-Geol Choi, Hee Chul Woo, Myoung Dong Kim and Kyoung Heon Kim. Characterization of a recombinant endo-type alginate lyase (Alg7D) from Saccharophagus degradans. Biotechnology Letters 2012, 34(6), 1087-1092 DOI: 10.1007/s10529-012-0876-9

     

    Ji Hae Lee, Hee-jin Jun, Minh-Hien Hoang, Yaoyao Jia, Xiang Hu Han, Dong-Ho Lee, Hak-Ju Leec Bang Yeon Hwang, Sung-Joon Lee. Catalposide is a natural agonistic ligand of peroxisome proliferator-activated receptor-α. Biochemical and Biophysical Research Communications 2012, 422(4), 568-572 DOI: 10.1016/j.bbrc.2012.05.025

     

    Sun-Hwa Ha, Ye Sol Jeong, Sun-Hyung Lim, Jae Kwang Kim, Dongho Lee, Jong-Yeol Lee, and Young-Mi Kim. Carotenoid metabolic engineering in flowering plants. Korean Journal of Horticultural Science & Technology 2012, 30(2), 107-122 DOI: 10.7235/hort.2012.11116

     

    Nguyen Tuan Hiep, Yun-hyeok Choi, Nahyun Kim, Seong Su Hong, Seung-Beom Hong, Bang Yeon Hwang, Hak-Ju Lee, Sung-Joon Lee, Dae Sik Jang, and Dongho Lee. Polyhydroxylated Macrolides from Seimatosporium discosioides and Their Effects on the Activation of Peroxisome Proliferator-Activated Receptor Gamma. Journal of Natural Products 2012, 75(4), 784-788 DOI: 10.1021/np200955z

     

    Jin Woo Lee, Cheong-Yong Yun, Eunmiri Roh, Chul Lee, Qinghao Jin, Kwon Ki Bang, Sang-Hun Jung, Dongho Lee, Mi Kyeong Lee, Youngsoo Kim, Bang Yeon Hwang. Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana. Bioorganic & Medicinal Chemistry Letters 2012, 22(8), 2927-2931 DOI: 10.1016/j.bmcl.2012.02.047

     

    Ahrom Ham, Hak Ju Lee, Seong Su Hong, Dongho Lee, Woongchon Mar. Moracenin D from Mori Cortex Radicis Protects SH-SY5Y Cells against Dopamine-induced Cell Death by Regulating Nurr1 and α-Synuclein Expression. Phytotherapy Research 2012, 26(4), 620-624 DOI: 10.1002/ptr.3592

     

    Jeong Do Kim, Jae Woo Han, In Cheon Hwang, Dongho Lee, Beom Seok Kim. Identification and biocontrol efficacy of Streptomyces miharaensis producing filipin III against Fusarium wilt. Journal of Basic Microbiology 2012, 52(2), 150-159 (2012. 04) (IF 1.266) DOI: 10.1002/jobm.201100134

     

    Ngan Thi Thanh Nguyen, Quang Hong Tran, Tai Huu Bui, Seok Bean Song, Dongho Lee, and Young Ho Kim. Anti-inflammatory and PPAR Transactivational Effects of Components from the Stem Bark of Ginkgo biloba. Journal of Agricultural and Food Chemistry 2012, 60(11), 2815-2824 DOI: 10.1021/jf204768d

     

    Seong Su Hong, Ji Hae Lee, Wonsik Jeong, Nahyun Kim, Hui Zi Jin, Bang Yeon Hwang, Hak-Ju Lee, Sung-Joon Lee, Dae Sik Jang, Dongho Lee. Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes. Bioorganic & Medicinal Chemistry Letters 2012, 22(6), 2347-2349 DOI: 10.1016/j.bmcl.2012.01.070

     

    Hak Ju Lee, Da Hyun Lyu, Uk Koo, Kung-Woo Nam, Seong Su Hong, Kem Ok Kim, Kyeong Ho Kim, Dongho Lee, and Woongchon Mar. Protection of prenylated flavonoids from mori cortex radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. Archives of Pharmacal Research 2012, 35 (1), 163-170 DOI: 10.1007/s12272-012-0118-7

     

    Qinghao Jin, Xiang Hua Han, Seong Su Hong, Chul Lee, Sanggil Choe, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang. Antioxidative oligostilbenes from Caragana sinica. Bioorganic & Medicinal Chemistry Letters 2012, 22(2), 973-976 DOI: 10.1016/j.bmcl.2011.12.012

     

    Ji Sang Hwang, Seon A Lee, Seong Su Hong, Xiang Hua Han, Chul Lee, Dongho Lee, Chong-Kil Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages. Bioorganic & Medicinal Chemistry Letters 2012, 22(1), 706-708 DOI: 10.1016/j.bmcl.2011.10.043

     

    Seung-Ok Yang, Yoo-Soo Shin, Sun-Hee Hyun, Sayeon Cho, Kyong-Hwan Bang, Dongho Lee, Seung Phill Choi, Hyung-Kyoon Choi. NMR-based metabolic profiling and differentiation of ginseng roots according to cultivation ages. Journal of Pharmaceutical and Biomedical Analysis 2012, 58 (25), 19-26 DOI: 10.1016/j.jpba.2011.09.016

     

    (Edited: 2016.10.26)

     

  • Research

     

    본 연구는 삶의 질 향상을 위한 건강에 대한 관심이 증가함에 따라 안정성이 높고 독성이 낮은 천연물 기반의 효능 물질의 분리정제 및 선도물질을 도출함으로써 천연물 유래 의약품 개발을 위한 핵심 기반 기술로 적용될 것으로 기대하고 있습니다.

     

    나아가, mass-based metabomics를 통해 환경적 요인에 따른 기원생물의 대사 변화 패턴을 LC와 GC-MS 장비를 사용하여 분석, 농촌진흥청에서 지원한 BG 21 프로젝트에서는 UPLC-QTOF MS를 기반으로 Panax ginseng (인삼)의 연근별 판별법을 개발하였고 이에 해당하는 주요 metabolite를 규명하여 Journal of Natural Products에서 Jack L. Beal Awards를 수상하였습니다.

     

    따라서 본 천연물 대사체 실험실에서는 천연물 의약품 개발의 첫 단계로써 인간에게 유용하게 사용되는 대사 물질을 다양한 장비를 통해 분리, 분석하고 그 구조의 해석을 토대로, 데이터베이스를 구축하여 대사회로의 총체적인 흐름과 그 특징을 이해하는 연구자를 양성하는데 초점을 맞추고 있습니다.

     

     

  • Teaching

    준비 중입니다.

  • Lab Members

    Current
    김금옥, kikeko@korea.ac.kr

    김민지, viviana88@korea.ac.kr

    류승목, mogijjang@korea.ac.kr

    서영혜, wnsl1118@nate.com

    정예솔, yesol@korea.ac.kr

    최유진, raim17@daum.net

    Giang Do Hoang, giangdh.91@gmail.com

     
    Alumni

    권재영 (한국과학기술연구원)

    김경환 (종근당건강)

    김나현 (국립산림과학원)

    김성웅 (넥스트비티)

    김연수

    김은지 (한국과학기술연구원)

    배민지 (한국과학기술연구원)

    안주현 (Waters)

    이혜민

    정원식 (경기과학기술진흥원)

    최윤혁 (경기과학기술진흥원)

    홍성수 (경기과학기술진흥원)

    Nguyen Tuan Hiep (Vietnam National Institute of Medicinal Materials)