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Home > 생명과학대학 >생명과학부


Prof. 이상호


E-mail: sangho@korea.ac.kr


  • About Professor
  • Curriculum vitae
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile


    PhD (1989), Department of Anatomy & Human Biology, Division of Biomedical Sciences, King's College, University of London, London, U.K. (Developmental biology)



    Professional experiences

    83.10 - 87.12 (Visiting scientist) 
    Medical Research Council Experimental Embryology & Teratology Unit, St. George’s Hospital Medical School, London, U.K.



    88.01 - 89.02 (Non-clinical scientist) 
    Medical Research Council Experimental Embryology & Teratology Unit, St. George’s Hospital Medical School, London, U.K.



    89.03 - 96.05 (Assistant, Associate professor) 
    College of Natural Resources, Korea University, Seoul



    92.01 - 92.02 (Visiting scientist) 
    Department of Animal Production, University of College Dublin, Dublin, Ireland



    96.01 - 97.02 (Visiting scholar) 
    Department of Anatomy, University of Cambridge, Cambridge, U.K


    96.05 - Present (Professor) 
    School of Life Sciences and Biotechnology, Korea University, Seoul



    Contact us

    Rm. 441, Life Sciences Bldg. (Hana Science Hall), Division of Life Sciences,  

    145 Anam-Ro, Seongbuk-Gu, Seoul 02841 , Korea

    [02841, 서울특별시 성북구 안암로 145 고려대학교 생명과학부 하나과학관 A동 304호 ]

    e-mail : sangho@korea.ac.kr

    Phone : +82-2-3290-3423

  • Curriculum

     83.10 - 87.12 (Visiting scientist) Medical Research Council Experimental Embryology & Teratology Unit, St. George’s Hospital Medical School,  London, U.K. 
     88.01 - 89.02 (Non-clinical scientist) Medical Research Council Experimental Embryology & Teratology Unit, St. George’s Hospital Medical  School, London, U.K. 
     89.03 - 96.05 (Assistant, Associate professor) College of Natural Resources, Korea University, Seoul 
     92.01 - 92.02 (Visiting scientist) Department of Animal Production, University of College Dublin, Dublin, Ireland 
     96.01 - 97.02 (Visiting scholar) Department of Anatomy, University of Cambridge, Cambridge, U.K 
     96.05 - present (Professor) School of Life Sciences and Biotechnology, Korea University, Seoul


  • Publication

    International Journals


    49.  Khan GN, Kim EJ, Shin TS, Lee SH (2017) Heterogeneous cell types in single-cell-derived clones of MCF7 and MDA-MB-231 cells.  Anticancer Res 37, 2343-2354.  [Link]  


    48.  Khan GN, Kim EJ, Shin TS, Lee SH (2017) Azacytidine-induced chemosensitivity to doxorubicin in human breast cancer MCF7 cells. Anticancer Res 37, 2355-2364. [Link]  


    47.  Choi SS, Jung JY, DH Lee, Jo S, Kang JY, Park CS, Lee SH (2013) Possible involvement of SNAP-25 and synaptotagin VII in blastocoel formation during early mouse development. Int J Biol Sci (In Revision) . [Link]  


    46. Kim SU, Park YH, Kim JM, Sun SN, Song IS, Huang SM, Lee S-H, Chae JI, Hong S, Choi SS, Choi SC, Lee TH, King SW, Rhee SG, Chang KT, Lee SH*. Yu DY*. Lee DS * (2014) Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells. Stem Cells 32, 998-1011. [Link] 


    45. Kim SU Park YH, Min JS,, Sun HN, Han YH, Hua JM, TH Lee, Lee SR, Chang KY, Kang SW, Kim MJ, Yu DY*, Lee SH*, Lee DS* (2013) Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activation. J Neuroimmunol 259, 26-36. [Link]


    44. Choi SS, Jung JY, Lee DH, Kang JY, Lee SH (2013) Expression and regulation of SNAP-25 and synaptotagmin VII in developing mouse ovarian follicles via the FSH receptor. J Mol Histol , 44(1), 47-54. [Link]


    43. Choi SS, Lee DH, Lee SH (2012) Blueberry protects LPS-stimulated BV-2 microglia through inhibitin activities of p38 MAPK and ERK 1/2. Food Sci Biotechnol 21 (4), 1195-1201. [Link]


    42. Kim D, Choi E, Choi SS, Lee SH, Park J, Yun KS (2010) Measurement of single-cell deformability using impedance analysis on microfluidic chip. Jpn J Appl Phys  49, 127002.  [Link]


    41. Sun HN, Kim SU, Huang SM, Kim JM, Park YH, Kim SH, Yang HY, Chung KJ, Lee TH, Choi HS, Min JS, Park MK, Kim SK, Lee SR, Chang KT, Lee SH, Yu DY, Lee DS (2010) Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades. J Neurochem 114 (1), 39-50. [Link]


    40. Hong S, Kang JK, Park JJ, Ryu ES, Choi SS, Lee SH, Lee JH, Seo JS (2010) Association of matrix metalloproteinase-3 with cardiogenic activity during noggin-induced differentiation of mouse embryonic stem cells. Int J Cardiol 141 (1), 49-60. [Link]


    39. Song HY, Choi CO, Kim MY, Kim BY, Yoon YJ, Song DY, Park JC, Kang PD, Lee SH, Bae YJ, Lee BH (2009) Characterization of neuronal apoptosis in the ventral ganglia of postembryonic silkworms Bombyx mori (Lepidoptera: Bombycidae). Eur J Entomol 106 (4), 507-518. [Link]


    38. Kim Y, Lee SH, Kim B (2009) Droplet-based magnetically activated cell separation (DMACS): Analysis of separation efficiency based on the variation of flow-induced circulation in a pendent drop. Anal Bioanal Chem 395 (7), 2415-2421. [Link]


    37. Kim Y, Lee J, An J, Lee SH, Kim B (2009) Effect of a blind spot in a dielectrophoretic field on the separation of human breast cancer cells (MCF 7). J Mech Sci Tech 23 (11), 3132-3139.  [Link]


    36. An J, Lee J, Lee SH, Park J, Kim B (2009) Separation of malignant human breast cancer epithelial cells from healthy epithelial cells using an advanced dielectrophoresis-activated cell sorter (DACS). Anal Bioanal Chem 394 (3), 801-809. [Link]


    35. Kim J, Park J, Na K, Yang S, Baek J, Yoon E, Choi SS, Lee SH, Chun K, Park J, Park S (2008) Quantitative evaluation of cardiomyocyte contractility in a 3D microenvironment. J Biomech 41 (11), 2396-2401. [Link]


    34. Kim SU, Hwang CN, Sun HN, Jin MH, Han YH, Lee H, Kim JM, Yu DY, Lee DS, Lee SH (2008) Peroxiredoxin I is an indicator of microglia activation and protects against hydrogen peroxide-mediated microglial death. Biol Pharm Bull 31 (5), 820-825. [Link]


    33. Na DS, Lee H, Kim SU, Hwang CN, Lee SH, Kang JY, Kim JK, and Pak JJ (2008) Comparative study of P19 EC stem cell differentiation in between conventional hanging drop and the zebrafish chorion as a bio-derived material. J Biomater Appl 23 (1), 73-84.  [Link]


    32. Kim C, Lee IH, Lee K , Ryu SS , Lee SH , Lee KJ , Lee JW , Kang JY , Kim TS (2007) Multi-well chip for forming a uniform embryoid body in a tiny droplet with mouse embryonic stem cells. Biosci Biotechnol Biochem 71 (12), 2985-2991. [Link]


    31. Park J, Ryu S, Kim J, Cha J, Baek J, Park S, Kim B, Lee SH (2007) A three-dimensional model of fluid-structural interactions for quantifying the contractile force for cardiomyocytes on hybrid biopolymer microcantilever. J Biomech 40 (13), 2823-2830. [Link]


    30. Lee JW, Lee KS, Cho NN, Ju BK, Lee KB, Lee SH (2007) Topographical guidance of mouse neuronal cell on SiO 2 microtracks. Sensors Actuators B 128 (1), 252-257. [Link]


    29. Kim YH, Hong S, Lee SH, Lee K, Yun S, Kang Y, Paek K-K, Ju BK, and Kim B (2007) Novel platform for minimizing cell loss on separation process: Droplet-based magnetically activated cell separator (DMACS). Rev Sci Instru 78 (7), 074301. [Link]


    28. Kwon KW, Choi SS, Lee SH, Kim B, Lee SN, Park MC, Kim P, Hwang SY, Suh KY (2007) Label-free, microfluidic separation and enrichment of human breast cancer cells by adhesion difference. Lab Chip 7 (11), 1461-1468. [Link]


    27. Kwon KW, Choi SS, Kim B, Lee SN, Lee SH, Park MC, Kim P, Park S, Kim Y, Park J, Suh KY (2007) Separation of human breast cancer and epithelial cells by adhesion difference in a microfluidic channel. J Semicond Technol Sci 7 (3), 140-150. [Link]


    26. Kim J, Park J, Yang S, Baek J, Kim B, Lee SH, Yoon E-S, Chun K, Park S (2007) Establishment of a fabrication method for a long-term actuated hybrid cell robot. Lab Chip7 (11), 1504-1508. [Link]


    25. Hong S, Kang JK, Bae CJ, Ryu ES, Lee SH, Lee JH (2007) Development of efficient cardiac differentiation method of mouse embryonic stem cells. Key Eng Mater 342-342, 25-28. [Link]


    24. Hwang CN, Hong S, Choi SS, Lee KS, Park SS, Lee SH (2006) Dual reporter genes enabling cell tracing with viable and reliable selection of various cell types. Biotechnol Lett 28 (5), 287-293.  [Link]


    23. Lee JW, Na DS, Kang JY, Lee SH, Ju BK (2006) Differentiation of mouse P19 embryonic carcinoma stem cells injected into an empty zebrafish egg chorion in a microfluidic device. Biosci Biotechnol Biochem 70 (6), 1325-1330. [Link]


    22.   Kim D-H, Hwang CN, Sun Y, Kim B, Lee SH, Nelson BJ (2006) Mechanical analysis of chorion softening in pre-hatching stages of zebrafish embryos. IEEE Trans Nanobios 5 (2), 89-94. [Link]


    21. Kim D-H, Park JY, Suh KY, Kim PN, Choi SK, Ryu SC, Park SH., Lee SH, Kim B (2006) Fabrication of patterned micromuscles with high activity for powering biohybrid microdevices, Sensors Actuators B 117 (2), 391-400.  [Link]


    20. Kim D-H, Kim P, Song I, Cha JM, Lee SH, Kim B, Suh KY (2006) Guided three-dimensional growth of functional cardiomyocytes on polyethylene glycol nanostructures.Langmuir 22 (12), 5419-5426.  [Link]


    19. Wang AG, Kim SU, Lee SH, Kim SK, Seo SB, Yu DY, Lee DS (2005) Histone deacetylase 1 contributes to cell cycle and apoptosis. Biol Pharm Bull 28 (10), 1966-1970. [Link]


    18. Lee JW, Na DS, Chae SK, Kim C, Kang JY, Ju BK, Lee H, Kim SU, Hwang CN, Lee SH (2005) Using the chorions of fertilized zebrafish eggs as a biomaterial for the attachment and differentiation of mouse stem cells. Langmuir 21 (17), 7615-7620. [Link]


    17. Kim D-H, Sun Y, Yun S, Lee SH, Kim B (2005) Investigating chorion softening of zebrafish embryos with a microrobotic force sensing system. J Biomech 38 (6), 1359-1363.  [Link]


    16. Park J, Ryu J, Choi SK, Seo E, Cha JM, Ryu S, Kim J, Kim B, Lee SH (2005) Real time measurement of the contractile force of self-organized cardiomyocytes on a hybrid biopolymer microcantilever. Anal Chem 77 (20), 6571-6580. [Link]


    15. Kim P, Kim DH, Kim B, Choi SK, Lee SH, Khademhosseini A, Langer R, Suh KY (2005) Fabrication of nanostructures of polyethylene glycol for applications to protein adsorption and cell adhesion. Nanotechnology 16 (10), 2420-2426. [Link]


    14. Park J, Kim B, Choi SK, Lee SH, Lee K-I (2005) An efficient cell separation system using 3D-asymmetric microelectrodes. Lab Chip 5 (11), 1264-1270. [Link]


    13. Jin M-H, Lee Y-H, Kim J-M, Sun H-N, Moon E-Y, Shong MH, Kim S-U, Lee SH, Yu D-Y, Lee D-S (2005) Characterization of neural cell types expressing peroxiredoxins in mouse brain. Neurosci Lett 381 (3), 252-257. [Link]


    12. Kim SU, Han YH, Lee TH, Hyun BH, Lee SH, Lee DS, Yu DY (2004) Effective production of microinjectable blastocysts for germ-line transmission of embryonic stem cells. Exp Anim 53 (5), 475-477.  [Link]


    11. Lee WS, Yoon SJ, Yoon TK, Cha KY, Lee SH, Shimasaki S, Lee SH, Lee KA (2004) Effects of bone morphogenic protein-7 (BMP-7) on primordial follicular growth in the mouse ovary. Mol Reprod Dev 69 (2), 159-163. [Link]


    10. Kim J, Choi SC , Kim TH, Kim KD, Cho SY, Park SS, Lee SH (2001) Isolation of neuronal precursors from differentiating P19 embryonal carcinoma cells by neuronal Tα1-promoter-driven GFP. Int J Dev Neurosci 19 (7), 631-638. [Link]


    9. Choi SC, Kim J, Kim TH, Cho SY, Park SS, Kim KD, Lee SH (2001) Cloning and characterization of a type II integral transmembrane protein gene, Itm2C, that is highly expressed in the mouse brain. Mol Cells 12 (3), 391-397. [Link]


    8. Cho SY, Jeon JW, Lee SH, Park SS (2000) p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells. Biochem J 352 (Pt 3), 645-650.  [Link]


    7. Park SC, Lee SH, Han SS (2000) Establishment of a phagocytic cell line from Bombina orientalis . Meth Cell Sci 22 (1), 1-7.  [Link]


    6. Cho SY, Cho SY, Lee SH, Park SS (1999) Differential expression of mouse disabled2 gene in retinoic acid-treated F9 embryonal carcinoma cells and early mouse embryos. Mol Cells 9 (2), 179-184. [Link]


    5. Choi SK, Lee SH, Chang HI (1998) Changes of nuclear glycoproteins in normal and Simian virus 40-transformed WI-38 human lung fibroblasts, Mol Cells 8 (6), 724-730. [Link]


    4. Jeon JT, Lee SH, Hong KC, Park SS (1994) Isolation and cloning of a male-specific DNA fragment from genomic DNA in pigs (Sus scrofa). Mol Cells 4 (3), 301-307. [Link]


    3. Wood MJ, Whittingham DG, Lee SH (1992) Fertilization failure of frozen mouse oocytes is not due to premature cortical granule release. Biol Reprod 46 (6), 1187-1195.  [Link]    


    2. Lee SH, Ahuja KK, Gilburt DG, Whittingham DG (1988) The appearance of glycoconjugates associated with cortical granule release during mouse fertilization.Development 102 (3), 595-604. [Link]


    1. Lee SH, Ahuja KK (1987) An investigation using lectins of glycocomponents of mouse spermatozoa during capacitation and sperm-zona binding. J Reprod Fertil 80 (1), 65-74.  [Link]



    National Journals

    65. Park KW, Choi SS, Lee DH, Lee H, Choi SK , Park CS, Lee SH (2011) Characterizations of cell lineage markers in the bone marrow cells of recloned GFP pigs for possible use of stem cell population. Reprod Dev Biol 35 (1), 23-31. [Link]


    64. Hwang CN, Lee DH and Lee SH (2009) Different responses in brain regions upon heat shock in adult zebrafish (Danio rerio ). Dev Reprod 13 (3), 199-205. [Link]


    63. Choi SC, Choi SK, Choi SS, Kin SU, Cho NN, Jung JY, Park CS, Lee S-H, Lee SH (2004) Liposome-mediated electric gene delivery into fetal and adult gonads. Reprod Dev Biol 28, 71-76. [Link]


    62. Choi SC, Yeon HH, Choi SK, Lee H, Hong S, Park CS, Lee S-H, Lee SH (2004) Characterization of foetal gonad-derived cells by stem cell markers. Reprod Dev Biol 28, 65-70. [Link]


    61. Lee HJ, Kim JC, Kim KD, Lee SH, Song HB (2002) Organ culture of ovary isolated from juvenile mice. Korean J Emb Trans 17 (3), 195-201. [Link]


    60. Lee HJ, Kim SY, Kim KD, Lee SH, Song HB (2002) In vitro development of preantral follicles isolated from juvenile mice. Korean J Emb Trans 17 (3), 203-209. [Link]


    59. Hwang CN, Song KC, Lee H, Yoon JM, Kim KD, Lee SH, Park HY (2001 ) Development of transgenic fish for the production of human EGF protein. Korean J Anim Reprod 25 (3), 277-286. [Link]


    58. Lee KS, Lee H, Kim KD, Lee SH (2000) Identification of putative embryonic stem cells derived from embryonic blastodermal cells of fertilized hen's eggs. Korean J Poult Sci 27 (1), 73-78. [Link]


    57. Lee KS, Lee H, Kim KD, Park SS, Lee SH (2000) Recolonization of transfected blastodermal cells in developing embryos after transferring into UV-irradiated fertilized hen's eggs. Korean J Poult Sci 27 (2), 155-161. [Link]


    56. Lee HJ, Seo SW, Lee KH, Kim KD, Lee SH (2000) Production and cryopreservation of sexed embryos after micromanipulative biopsy and PCR. Korean J Emb Trans 15 (2), 175-180. [Link]


    55. Lee KR, Kim KD, Lee SH, Hong KC (1999) Sex determination of porcine embryos and somatic cells by PCR and FISH using the porcine Y-specific probe. Anim Genet Breed 2 (2), 91-98. [Link]


    54. Lee KS, Kim KD, Lee SH (1999) Cracking hen's eggs for transgenesis without cracking them. Korean J Poult Sci 26 (2), 109-118. [Link]


    53. Lee HJ, Seo SW, Choi SC, Park SS, Kim KD, Lee SH, Song HB (1997) In vitro development of blastomeres isolated from bovine early embryo. Korean J Emb Trans 12 (3), 335-341. [Link]


    52. Lee HJ, Seo SW, Lee KH, Kim KD, Lee SH, Song HB (1997) Effects of β-mercaptoethanol addition on early bovine embryo during in vitro development. Korean J Anim Reprod 21 (4), 389-396. [Link]


    51. Seo SW, Lee HJ, Choi SC, Kim, KD, Lee SH (1997) Predetermination of sex in bovine preimplantation embryos produced in vitro using micromanipulative biopsy and PCR.Korean J Emb Trans 12 (3), 325-333. [Link]


    50. Chung Y, Jeon JT, Kim KD, Lee SH, Hong KC (1996) Sex determination in somatic and embryonic cells of the pig by FISH and PCR. Korean J Anim Reprod 20 (3), 323-331. [Link]


    49. Lee KH, Lee HJ, Lee SH (1996) Production and characterization of monoclonal antibodies to porcine zona pellucida. Korean J Emb Trans 11 (1), 71-80. [Link]


    48. Seo SW, Lee HJ, Kim KD, Park SS, Lee SH (1996) Applications of PCR and PRINS for the sexing in bovine preimplantation embryos. Korean J Fertil Steril 23 (3), 341-349. [Link]


    47. Jeon JT, Lee SH, Hong KC, Park SS (1995) Sex determination in somatic and embryonic cells of the pig by cloned male-specific DNA fragments. Korean J Emb Trans10 (1), 91-100. [Link]


    46. Jung Y, Lee HJ, Lee SH, Park SS, Hong KC (1995) Limited development of in vitro fertilization or chemically activated porcine follicular oocytes. Korean J Emb Trans 10 (2), 139-144. [Link]


    45. Kim CM, Paik JS, Lee SH (1995) Delayed sperm penetration into frozen-thawed zona-free hamster oocytes. Korean J Emb Trans 10 (3), 243-250. [Link]


    44. Lee HJ, Seo SW, Jung Y, Byun TH, Lee SH, Song HB (1995) Developmental ability of bovine early embryos in chemically defined media. Korean J Emb Trans 10 (2), 163-169. [Link]


    43. Lee HJ, Seo SW, Lee SH, Song HB (1995) Development ability of bovine early embryo blastomere in vitro in embedding matrix. Korean J Emb Trans 10 (2), 171-175. [Link]


    42. Lee HJ, Seo SW, Lee SH, Song HB (1995) In vitro development and the improving effects of bovine embryos in simple media. Korean J Emb Trans 10 (3), 251-256. [Link]


    41. Seo SW, Lee HJ, Kim KD, Park SS, Lee SH (1995) Predetermination of sex in bovine embryos by PCR. Korean J Emb Trans 10 (2), 145-151. [Link]


    40. Byun TH, Tokunaga T, Imai H, Kim JS, Lee SH (1994) The production of chimaeric mice by embryonic stem cell carrying human luteinizing hormone gene. Korean J Emb Trans 9 (3), 243-247. [Link]


    39. Choi SC, Yoo HJ, Lee SH (1994) Analysis of cortical granule exocytosis and pronucleus formation in bovine oocyte upon exposure to Ca 2+ ionophore A23187 and phorbol 12-myristate 13-acetate. Korean J Anim Sci 36 (2), 144-153. [Link]


    38. Jeon JT, Lee SH, Hong KC, Park SS (1994) Isolation and cloning of a male-specific DNA fragment from genomic DNA in pigs (Sus scrofa ). Mol Cells 4 (3), 301-307. [Link]


    37. Kim SB, Lee H, Byun TH, Jeon JT, Lee SH, Song HB (1994) Early development of parthenogenetically activated porcine oocyte after in vitro maturation for various periods.Korean J Emb Trans 9 (1), 117-125. [Link]


    36. Kim TH, Park JY, Lee SH, Chang HI (1994) Possible glycosylation of H1 histone in murine liver nucleus. Korean Biochem J 27 (3), 240-244. [Link]


    35. Lee H, Kim SU, Kim JS, Byun TH, Lee SH (1994) Isolation and culture of mouse primordial germ cells. Korean J Emb Trans 9 (3), 255-260. [Link]


    34. Lee JH, Choi SY, Joo WJ, Park HY, Lee SH (1994) Early development of loach oocytes activated by parthenogenetic agents. Korean J Anim Sci 18 (3), 183-189. [Link]


    33. Lee JH, Park SS, Park HY, Lee SH (1994) Teratogenesis in loach (Misgurnus mizolepis) produced by microinjection of foreign DNA into fertilized eggs. Korean J Toxicol 10 (2), 313-321. [Link]


    32. Lee SH (1994) Micromanipulation of animal oocyte; It’s use and extension. Trends Biotechnol (KIST Genet Eng Cntr) . 2 (1), 54-59. [Link]


    31. Park KS, Lee SH and Song HB (1994) Influences of different culture conditions on nuclear maturation and cumulus cell layers of mouse follicular oocytes in vitro. Korean J Anim Sci 36 (6), 613-622. [Link]


    30. Park KS, Lee SH, Song HB (1994) In vitro fertilization and polyspermy in follicular oocytes matured in various culture conditions. Korean J Fertil Steril 21 (2), 177-182. [Link]


    29. Park SE, Byun TH, Kim YC, Kim JS, Lee SH (1994) Establishment of embryonic stem cell line from ICR mouse blastocyst. Korean J Emb Trans 9 (3), 213-220. [Link]


    28. Son CI, Byun TH, Park CK, Shin DK, Yoon YD, Lee SH (1994) Production of SPF mice via embryo transfer after cryopreservation. Agric Res Rep 36 (2), 632-637. [Link]


    27. Yoo HJ, Choi SC , Park SS, Lee SH (1994) In vitro development of porcine pronucleate embryos after nuclear visualization and DNA microinjection. Korean J Anim Sci 36 (1), 25-31. [Link]


    26. Choi SC, Chun JH, Lee SH (1993) Isolation of bovine spermatozoa components by physical or chemical treatments. Korean J Anim Reprod 17 (4), 339-346.  [Link]


    25. Jeon JT, Lee SH, Park SS (1993) Development of a plasmid vector (pSS4) for the use of animal transgenesis. Korean J Anim Reprod 17 (3), 263-267. [Link]


    24. Kim SJ, Park SE, Lee SH (1993) Nuclear changes occurring during canine oocyte maturation in vitro. Korean J Anim Reprod 17 (3), 249-255. [Link]


    23. Ko TH, Lee SH (1993) Establishment of a biological assay for the fertilizing ability of equine spermatozoa. Korean J Anim Sci 35 (3), 175-179. [Link]


    22. Ko TH, Lee SH (1993) Histological and biochemical components in equine spermatogenic field. Korean J Anim Sci 35 (5), 377-383. [Link]


    21. Lee HK, Choi SC, Yoo HJ, Lee SH (1993) Direct effects of monosodium glutamate on early development in vitro of mouse embryos. Korean J Lab Anim Sci 8 (2), 189-197. [Link]


    20. Lee JH, Byun TH, Yoo HJ, Lee SH (1993) Isozyme patterns of lactate dehydrogenase in follicular components. Korean J Anim Reprod 17 (3), 257-262.  [Link]


    19. Lee JH, Park HY, Lee SH (1993) Spatial and temporal analysis of early embryonic development in loach (Misgurnus mizolepis). Korean J Anim Sci 35 (3), 155-162. [Link]


    18. Oh KT, Lee JH, Park KS, Yoo HJ, Lee SH (1993) In vitro maturation and parthenogenetic development of cryopreserved bovine follicular oocyte. Korean J Emb Trans 8 (2), 133-138. [Link]


    17. Park HY, Rho SC, Kang KR, Lee SH, Yoon JM (1993) Breeding and reproductive studies on Korean native loach: 2. Histological changes in female pituitary gland and oocyte. Anim Resources Res (Kunkook Univ) .18, 23-35. [Link]


    16. Park SE, Park SS, Lee SH (1993) Isolation of mouse inner cell mass and its further development in vitro. Korean J Fertil Steril 20 (3), 243-252. [Link]


    15. Seo KD, Byun TH, Lee SH (1993) Time-course biosynthesis of polypeptides in cumulus cells during bovine oocyte maturation in vitro. Korean J Anim Sci 35 (5), 385-389. [Link]


    14. Seo KD, Lee JH, Shim KS, Lee SH (1993) Spermatogenic activity in male mink prior to breeding season. Korean J Anim Reprod 35 (1), 24-31. [Link]


    13. Yoo HJ, Choi SC, Lee SH (1993) Maximization of the numbers of follicular oocytes recovered from the bovine ovaries. Korean J Anim Reprod 17 (2), 149-157. [Link]


    12. Yoo HJ, Choi SC, Lee SH (1993) Nuclear maturation and pronuclei formation in bovine oocytes matured in vitro for prolonged period. Korean J Anim Reprod 17 (4), 331-337. [Link]


    11. Byun TH, Lee JH, Park SE, Lee SH (1992) Analysis of protein patterns of cellular and fluidal components in the porcine follicular contents. Korean J Anim Reprod 16 (4), 289-299. [Link]


    10. Byun TH, Lee SH (1992) Morphological and cellular criteria of ovaries, follicles and oocytes for in vitro maturation in the pig. Korean J Emb Trans 7 (2), 97-110. [Link]


    9. Lee HK, Choi SC, Yoo HJ, Lee SH (1992) Direct effects of monosodium glutamate on early development of mouse embryos. Korean J Lab Anim Sci 8 (2), 189-197. [Link]


    8. Lee SH, Byun TH, Lee JH, Kim HJ, Hong KC (1992) Normal fertilization and development of early embryos in gilts treated with allyl trenbolone (Regumate). Korean J Anim Sci 34 (5), 257-262. [Link]


    7. Lee SH, Hong KC, Jeon JT (1992) Induction of estrous synchronization in gilts by allyl trenbolone. Korean J Anim Sci 34 (5), 253-256. [Link]


    6. Song HB, Seo BB, Kim KS, Park SE and Lee SH (1992) Dependence of mouse embryonic development in vitro on the exposed period to oviductal environment. Korean J Fertil Steril 19(2), 117-123. [Link]


    5. Byun TH, Lee JH, Park SS, Lee SH (1991) Biosynthesis of proteins in the oocyte - cumulus complex during maturation in vitro of porcine oocyte. Korean J Anim Sci 33 (7) 543-551. [Link]


    4. Byun TH, Lee SH, Song HB (1991) Development of a rapid staining method for nucleus of the oocyte from domestic animals. Korean J Anim Sci 33 (1), 25-31. [Link]


    3. Lee SH, Jeon WM, Kim YK, Lee SU, Jeong SY (1991) Electophoretic analysis of major proteins in bovine milk. Korean J Anim Sci 33 (5), 392-398. [Link]


    2. Ko TH, Kim HS, Lee SH, Song HB (1990) Preservation of extended Thoroughbred semen at low temperature. Korean J Anim Reprod 14 (3), 199-204. [Link]


    1. Lee JK, Song HB, Lee SH (1981) A study on optimum interval between inseminations   in artificial insemination. Korean J Anim Reprod 5 (1), 36-42. [Link]


    47.  Choi SS, Jung JY, DH Lee, Jo S, Kang JY, Park CS, Lee SH (2013) Possible involvement of SNAP-25 and synaptotagin VII in blastocoel formation during early mouse development. Int J Biol Sci (In Revision) . [Link]  

  • Research

    Vertebrate development from a fertilized egg to adult form is a dynamic process, involving cleavage, cell proliferation and differentiation. In particular, germ cell lineages and somatic stem cells are fascinating materials for the study of vertebrate embryogenesis and regeneration process upon damage. Among the many critical components involved in stem cell maintenance and differentiation, stem cell niche (microenvironments) is one of the regulatory components in the process. Stem cell niche includes many different molecules consisting of the extracellular matrix and adjacent cell membrane components. It also includes diffusible factors derived from immune responses and diet nutrients from the peripheral blood vessels. The goal is to understand how this highly complex niche may regulate stem cell population including cancer stem cells. By manipulating molecules, cells and tissues, we look into the properties, and functions of the niche questioned. Some of the clues obtained should provide new ways of maintaining, improving and repairing natural stem cell niche, leading to mild treatments of the damaged tissues and insights into cancer prevention and treatments. [Korean]

  • Teaching

    준비 중입니다.

  • Lab Members


    -   Gul Nabi Khan (MSc, Quaid-e-Azam University Islamabad Pakistan), gulnabi@korea.ac.kr


    -   Tae Seop Shin (BSc, Life Sciences), shints@korea.ac.kr



    Previous lab members



    -  Tae Ho Byun (PhD, 1992, KU), Vice president, Pangen Inc.


    -  Tae Hyuk Ko (PhD, 1994, KU) Manager, Business Service Team, Korea University

    -  Seung Cheol Choi (MSc, 1994, KU; PhD, 2001, KU) Research Professor,  Korea Univ Medical School

    -  Hyung Jin Yoo (MSc, 1994, KU; PhD, 1999, U Cambridge, U.K.) Research Officer, Harvard  Medical School

    -  Seung Woon Seo (MSc, 1997, KU; PhD, 2003, U Warwick, U.K.)  Research professor, Catholic Medical School.

    -  Woo Sik Lee (MD, MSc, 1999, Yonsei U; PhD, 2003, KU) Professor, CHA University.

    -  Jae Hyun Lee (PhD, 1998, KU) (주) 지텍바이오메디컬

    -  Sung Eun Park (MSC, 1993, KU; PhD, 2003, KU)  

    -  Sun Uk Kim (MSc, 1996, KU; PhD,  2005, KU) National Primate Research Center, KRIBB, Daejeon

    -  Kwang Hee Lee (MSc, 1996, KU) Researcher, National Veterinary Research Quarantine Service

    -  Hwang Lee (MSc, 1995, KU) Researcher, National Veterinary Research Quarantine Service

    -  Wan Jong Joo (MSc, 1997, KU) Researcher, USA

    -  Hong Joon Lee (MSc, 1997, KU; PhD, 2007, KU) Researcher, Brain Disease Research Center , Ajou University

    -  Jae Won Jeon (MSc, 2001, KU) Researcher, KRIBB, Daejeon.

    -  Joon Kim, PhD, Professor, Lab of Disease Functional Genomics, Graduate School of Medical Sci & Eng, KAIST, Daejeon

    -  Tae Hyung Kim (MSc, 2001, KU) Amorepacific Co.

    -  Su Young Choi, MSc, Senior Researcher, Life Science R&D Institute, Rexgene Biotech Co., Ltd.

    -  Mi Jin Park (MSc, 2001, KU)

    -  Seung Kyu Choi (MSc, 2002, KU)

    -  Ki Seok Lee (MSc, 2000, KU; PhD, 2007, Vienna U) Post-doc.

    -  Sun Young Moon (MSc, 2002, KU)

    -  Ida Lee (MSc, 2001, KU) Researcher, Korea Food & Drug Administration

    -  Hwa Soon Oh (MSc, 2003, KU) Researcher, Maria Clinic

    -  Hong Hee Yeon (MSc, 2003, KU) Woong Bee Meditech Co.

    -  Joo Young Jung (MSc, 2005, KU)

    -  Su Hong (MSc, 2006, KU; PhD, KAIST, 2014) Bio&Brain Engineering, KAIST

    -  Chang Nam Hwang, PhD, Resarcher, Quarantine & Inspection Division, National Fishery Products Quality Management Service, Minstry of Oceans & Fisheries, Gyeonggido

    -  Na Na Cho (MSc, 2007, KU) Researcher , Woong Bee Meditech Co.

    -  Dong Soo Kim (PhD, Liverpool U, 1998) Post-doc, KU

    -  Hyo Soon Chung (PhD, Kyung Sang Natl U, 2004) Post-doc, KU

    -   Seungho Jo (MSc, Cell Biol., 2014, KU), elia86@korea.ac.kr

    -  Eun Jin Kim (MSc,2016, KU), eunjink@korea.ac.kr

    Previous BSc internship training members


    -  Ji Yong Oh (BSc, 2000, KU)

    -  Mi Sun Lim (BSc, 2000, KU)

    -  Man Shik Choi (BSc, 2001, KU)

    -  Soon Won Lee (BSc, 2001, KU)

    -  Min Shin (BSc, 2001, KU)

    -  Jae Soek Lee (BSc, 2001, KU)

    -  Jae Man You (BSc, 2001, KU)

    -  Sun Joo Lee (BSc, 2003, KU)

    -  Sang Hyup Lee (BSc, 2003, KU)

    -  Sung Kyun Moon (BSc, 2003, KU)

    -  Su Hong (BSc, 2003, KU)

    -  Joo Young Jung (BSc, 2003, KU)

    -  Jin Hyuk Park (BSc, 2004, KU)

    -  Dong-Hun Lee (BSc, 2004, KU)

    -  Jung-Kyu Ryu (BSc, 2004, KU)

    -  Min Seok Jeon (BSc internship, 2004, University College London, UK) 

    -  Mi Young Kim (BSc, 2005, KU)

    -  Eun Kyoung Bae (BSc, 2006, KU)

    -  Seok Hyun Kim (BSc, 2007, KU)

    -  Sun Min Jung (BSc, 2007, KU)

    -  Hee Sun Kim (BSc, 2007, KU)

    -  Yeo Sun Hong (BSc internship, 2007, Imperial College London, UK)

    -  Han Bin Lee (BSc internship, 2008, University College London, UK)

    -  Si Eun Chung (BSc internship, 2009, Bristol University, UK)

    -  Kyu Yong Song (BSc internship, 2009, Taegu Oriental Medical School)

    -  HaeJee Yoon (BSc Internship, 2009, Michigan University, USA)

    -  Han Bit Kang (BSc Internship, 2013, Jacobs University, Bremen, Germany)