∙ Bachelor: Korea University, Food Science, Korea, 1978
Professional Experiences
∙ Professor, Division/Dept. of Life Sci., Korea University, Seoul, Korea, 1995-present
∙ Instructor, Boston University, MA, USA. 1992-1995
∙ Post-doc, Harvard Medical School, MA, USA. 1990-1992
∙ Researcher, Agency for Defense Development, Seoul, Korea, 1981-1984
Publication
‣ Shin, N., C.W. Pyo, K.I. Jung, and S.-Y. Choi, Influenza A virus PB1-F2 is involved in regulation of cellular redox
state in alveolar epithelial cells, Biochem. Bioph. Res. Co., 459(4) (2015)
‣ Park, S.W., C.W. Pyo and S.-Y. Choi, High-efficiency lentiviral transduction of primary human CD34+ hematopoietic
cells with low-dose viral inocula. Biotechnol. Lett., 37(2), 281-288 (2015)
‣ Hwang, Y.W., N.K. Yoo, H.M. Yang and S.-Y. Choi, RNA polymerase III control elements are required for trans-activation
by the murine retroviral long terminal repeat sequences. Biochem. Bioph. Res. Co., 456(1), 110-115 (2015)
‣ Pyo, C.W., N. Shin, K.I. Jung, J.H. Choi, S.-Y. Choi, Alteration of copper-zinc superoxide dismutase 1 expression
by influenza A virus is correlated with virus replication. Biochem. Bioph. Res. Co., 450(1), 711-716 (2014)
‣ Park, J.H., Y.J Jeong, H.K. Won, S.-Y. Choi, and S.M. Oh, Activation of TOPK by lipopolysaccharide promotes induction
of inducible nitric oxide synthase through NF-kB activity in leukemia cells. Cellular Signalling, 26(5). 849-856 (2014)
‣ Pyo, C.W. J.H. Choi, S.M. Oh, and S.-Y. Choi, Oxidative stress-induced cyclin D1 depletion and its role in cell cycle
processing. Biochimica et Biophysica Acta, 1830(11), 5316-5325 (2013)
‣ Kim, C.W., K.N. Son, S.-Y. Choi and J. Kim, Human lactoferrin suppresses TNFα-induced Intercellular Adhesion Molecule-1
expression via competition with NF-kB in endothelial cells, FEBS Letters 586, 229-234 (2012)
‣ Kim, K.C., H.G. Kim, T.Y. Roh, J. Park, K.-M. Jung, J.S. Lee, S.-Y. Choi,, S.S., Kim, B.S. Choi, The effect of CD4
receptor downregulation and its downstream signaling molecules on HIV-1 latency. Biochem. Bioph. Res. Co., 404(2),
646-651 (2011)
‣ Yeom, M., J. Park. B. Lee. S.-Y. Choi. K.S. Kim. H. Lee. and D.H. Hahm, Lactoferrin inhibits the inflammatory and
angiogenic activation of bovine aortic endothelial cells. Inflamm. Res., 60,475-482 (2011)
‣ Kim, H.G., K.C. Kim, T.-Y. Roh, J. Park, K.-M. Jung, J.-S. Lee, S.-Y. Choi, S.S. Kim and B.-S. Choi, Gene silencing
in HIV-1 latency by polycomb repressive group. Virology Journal 8, 179 (2011)
‣ Oh, Y.T., K.C. Kim, K.J. Hong, H.S. Lee, D.H. Jang, J.S. Lee, S.-Y. Choi, S.S. Kim, B.S. Choi, Establishment of novel
cell lines latently infected with human immunodeficiency virus 1. Acta Virol. 55(2):155-159 (2011)
‣ Lee, H.S., K.Y. Lee, S.-Y. Choi, S.Y. Lee, Scale-up on mycelial morphology during liquid culture of Ganoderma lucidum,
KSBB J. 26, 357-364 (2011)
‣ Kim, E.J., J. Kwon, S.H. Park, C. Park, Y.B. Seo, H.K. Shin, H.K. Kim, K.S. Lee, S.-Y. Choi, D.H. Ryu, G.S. Hwang,
Metabolite profiling of Angelica gigas from different geographical origins using 1H NMR and UPLC-MS analyses. J. Agr.
Food Chem. 59(16):8806-15 (2011)
‣ Lee, S.H., H.M. Hwang, C.W. Pyo, D.H. Hahm, and S.-Y. Choi, E2F1-directed Activation of Bcl-2 Is Correlated with
Lactoferrin-Induced Apoptosis in Jurkat Leukemia T Lymphocytes, Biometals, 23(3), 507-514 (2010)
‣ Choi, H.M., Y.A. Lee, S.H. Lee, S.J. Hong, D.H. Hahm, S.-Y. Choi, H.I. Yang, M.C. Yoo and K.S. Kim, Adiponectin may
contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor,
matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory
mediators, Arthritis Res. Ther., 11 (6), R161 (2009)
‣ Kim, S.A., J.H. Baek, S.J. Lee, S.-Y. Choi, W. Hur, and S.Y. Lee, A novel method for air drying aloe leaf slices
by covering with filter papers as a shrink-proof layer, J. Food Sci., 74(9), 462-470 (2009)
‣ Lee, S.H., C.W. Pyo, D.H. Hahm, J. Kim and S.-Y. Choi, Iron-saturated lactoferrin stimulates cell cycle progression
through PI3K/Akt pathway, Mol. Cells, 28, 37-42 (2009)
‣ Kang, J.I., S.N. Kwon, S.H. Park, Y.K. Kim, S.-Y. Choi, J.P. Kim and B.Y. Ahn, PKR protein kinase is activated by
hepatitis C virus and inhibits viral replication through translational control. Virus Research, 142, 51-56 (2009)
‣ Lee, S.H., S.W. Park, C.W. Pyo, N.K. Yoo, J. Kim and S.-Y. Choi, Requirement of JNK-associated Bcl-2 pathway for
human lactoferrin-induced apoptosis in Jurkat leukemia T cell line. Biochimie, 91, 102-108 (2009)
‣ Pyo, C.W., S.H. Lee, and S.-Y. Choi, Oxidative Stress Induces PKR-Dependent Apoptosis via IFN-gamma Activation Signaling
in Jurkat T cells. Biochem. Bioph. Res. Co., 377, 1001-1006 (2008)
‣ Pyo, C.W., Y.L. Yang, N.K. Yoo, and S.-Y. Choi, Reactive oxygen species activate HIV long terminal repeat via post-translational
control of NF-kB. Biochem. Bioph. Res. Co., 376, 180-185 (2008)
‣ Park, J.Y., H.W. Yoo, B.R. Kim, R. Park, S.-Y. Choi* and Y. Kim*(co-correspondence), Identification of a novel human
Rad51 variant that promotes DNA strand exchange with prominent expression in the testis. Nucleic Acids Res. 36(10)
3226-3234) (2008)
‣ Yoo, N.K., C.W. Pyo, Y. Kim, B.Y. Ahn, and S.-Y. Choi, Vaccinia virus-mediated cell cycle alteration involves inactivation
of tumor suppressors associated with Brf1 and TBP. Cell. Microbiol. 10(3), 583-592) (2008)
‣ Oh, S.M., S.H. Lee, B.J. Lee, N.K. Yoo, C.W. Pyo, S.Y. Lee, J. Kim, and S.-Y. Choi, A distinct role of neutrophil
lactoferrin in RelA/p65 phosphorylation on Ser536 by recruiting TRAFs to IKK signaling complex. J. Immunol., 179(9),
5686-5692 (2007)
‣ Park, S.W. and S.-Y. Choi, Long-term expression of von Willebrand factor by VSV-G pseudotyped lentivirus to aid functional
activity of secreted B-domain deleted coagulation factor VIII. Mol. Cells., 24(1), 125-131 (2007)
‣ Yang, H.M., H.J. Do, D.K. Kim, J.K Park, W.K Chang, H.M., Chung, S.-Y. Choi*, J.H. Kim*(co-correspondence), Transcriptional
regulation of human Oct4 by steroidogenic factor-1. J. Cell. Biochem., 101(5), 1198-1209 (2007)
‣ Kim, C.W., K.N. Son, S. Choi and J. Kim, Human lactoferrin upregulates expression of KDR/Flk-1 and stimulates VEGF-A-mediated
endothelial cell proliferation and migration. FEBS Lett. 580, 4332-4336 (2006)
‣ Park, S.H., J.D. Choi, J.I. Kang, S.-Y. Choi, S.B. Hwang, J.S. Kim, and B.Y. Ahn, Attenuated expression of interferon-induced
protein kinase PKR in a simian cell devoid of type I interferons. Mol. Cells. 21, 21-28 (2006)
‣ Son, H.J., S.H. Lee. and S.-Y. Choi, Human lactoferrin controls the level of retinoblastoma protein and its activity.
Biochem. Cell Biol. 84: 345-350 (2006)
‣ Kim, D.H., K.H. Yoo, Y.S. Yim, J. Choi, H.L. Jung, K.W. Sung, K.S. S.E. Yang, W.I. Oh, Choi, Y.S. Yang, S.-Y. Choi,
and H.H. Koo, Cotransplanted bone marrow-derived mesenchymal stem cell enhanced engraftment of hematopoietic stem
cells in MSC-dose dependent manner in NOD/SCID mice. J. Kor. Med. Sci. 21, 1000-1004 (2006)
‣ Lee, S.H., J.I. Yang, S.M. Hong, D.H. Hahm, S.Y. Lee, I.H. Kim and S.-Y. Choi, Phosphorylation of Peptides Derived
from Isolated Soybean Protein: Effects on Calcium Binding, Solubility and Influx into Caco-2 Cells. Biofactors 23(3),
121-128 (2005)
‣ Yang, H.M., Do, H.-J., Oh, J.H., Kim, J.H., Choi, S.-Y., Cha, K.Y., Chung, H.M., Kim, J.H., Characterization of putative
cis-regulatory elements that control the transcriptional activity of the human Oct4 promoter. J. Cell. Biochem. 96(4),
821-830 (2005)
‣ Kim, J.H., S.K. Choi, S.-Y. Choi, H.K. Kim, and H.I. Chang, Suppressive effects of Astaxanthin isolated from the
Xanthophyllomyces dendrorhous mutant on ethanol-induced gastric mucosal injury in rats. Biosci. Biotech. Biochem.
69(7), 1300-1305 (2005)
‣ Kim, D.H., K.H. Yoo, K.S. Choi, J. Choi, S.-Y. Choi, S.-E. Yang, Y.S. Yang, H.L. Jung, K.W. Sung and H.H. Koo, Gene
expression profile of cytokine and growth factor during differentiation of bone marrow-derived mesenchymal stem cell.
Cytokine 31, 119-126 (2005)
‣ Park, J.W., S.-Y. Choi, H.J. Hwang, and Y.-B. Kim, Fungal mycoflora and mycotoxins in Korean polished rice destined
for humans. Int. J. Food Micro. 103(3), 305-314 (2005)
‣ Kim, H.H., K.S. Ahn, H. Han, S.Y. Choung, S.-Y. Choi, and I.H. Kim, Decursin and PDBu: two PKC activators distinctively
acting in the megakaryocytic differentiation of K562 human erythroleukemia cells. Leuk. Res. 29(12):1407-1413 (2005)
‣ Yang, H.N., J.G. Nam, S.S. Kim, S.-Y. Choi, and J.S. Lee, Analysis on quasispecies of HIV-1 env gene by single clone
per PCR. J. Bacteriol. Virol. 35:2 134-140 (2005)
‣ Oh, S.M., C.W. Pyo, Y. Kim, and S.-Y. Choi, Neutrophil lactoferrin upregulates the human p53 gene through induction
of NF-kB activation cascade. Oncogene 23, 8282-8291 (2004)
‣ Yang, J.I, S.H. Lee, D.H. Hahm, I.H. Kim and S.-Y. Choi, Enhancement of Calcium Binding Quality of Proglycinin Peptides
by Chemical Phosphorylation. J. Microbiol. Biotechnol. 14:3, 607-611 (2004)
‣ Park, S.W. and S.-Y. Choi, Stable Gene transfer system by pseudotyped retrovirus vectors in hematopoietic progenitor
cells from human bone marrow. Mol. Cells. 17, 297-230 (2004)
‣ Kim, M.S. S.S. Kim, S.T. Jung, J.Y. Park, H.W. Yoo, J. Ko, K. Csiszar, S.-Y. Choi, and Y. Kim, Expression and purification
of enzymatically active forms of the human lysyloxidase-like protein 4. J. Biol. Chem. 278: 52071-52074 (2003)
‣ Choi, S.-Y.*(correspondence), H.J. Kim, J.I. Yang, and H.I. Chang, Translation initiation factor IF1-dependent stimulation
of 30 S preinitiation complex formation: Rapid isolation and fMet-tRNA binding activity of IF1. J. Microbiol. Biotech.
11(6), 986-993 (2001)
‣ Oh, S.M., D.H. Hahm, I.H. Kim, and S.-Y. Choi, Human neutrophil lactoferrin trans-activates the matrix metalloproteinase
1 gene through stress-activated MAPK signaling modules. J. Biol. Chem. 276:45, 42575-42579 (2001)
‣ Park, H.J., S.H. Kim, S.T. Lim, D.H. Shin, S.-Y. Choi, and K.T. Hwang, Grease resistance and mechanical properties
of isolated soy protein coated paper. J. Amer. Oil Chem. Soc. 77(3): 273-277 (2000)
‣ Kim, M.R.,
S.-Y. Choi*(correspondence), C.S. Kim, C.W. Kim, S. Utsumi, and C.H. Lee, Amino acid sequence analysis of bitter
peptides from a soybean proglycinin subunit synthesized in E. coli. Biosci. Biotech. Biochem. 63:12 2069-2074 (1999)
‣ Kim, M.R., S.-Y. Choi, and C.H. Lee, Molecular characterization and bitter taste formation of tryptic hydrolysis
of 11S glycinin. J. Microbiol. Biotech. 9:4 509-513 (1999)
‣ Jang, J.E., S.-Y. Choi, Y.H. Ko, K.H. Kim, K.S. Ahn, C.H. Park, J.H. Yang, S.J. Nam, and S.S. Yoon, Evaluation of
VEGF expression in breast cancer. J. Kor. Can. Assoc. 31:3 483-491 (1999)
‣ Min, K.H., Y.C. Sung, S.-Y. Choi, and B.Y. Ahn, Functional interactions between conserved motifs of hepatitis C virus
RNA helicase NS3 protein. Virus Genes 19:1 33-43 (1999)
‣ Faller, D.V., H. Weng, D.T. Graves, and S.-Y. Choi, Moloney murine leukemia virus activates monocyte chemotactic
protein-1 protein expression and chemotactic activity. J. Cell. Physiol. 172 (2) 240-252 (1997)
‣ Faller, D.V., H. Weng, and S.-Y. Choi, Activation of collagenase IV gene expression and enzymatic activity by the
Moloney murine leukemia long terminal repeat. Virology 227 (2): 331-342 (1997)
‣ Choi, S.-Y., K. Van de Mark, and D.V. Faller, Identification of cis-acting element in the class I Major Histocompatibility
Complex gene promoter responsive to activation by retroviral sequences. J. Virol. 71: 965-970 (1997)
‣ Weng, H., S.-Y. Choi, and D.V. Faller, The Moloney retroviral long terminal repeat trans-activates AP-1-inducible
genes and AP-1 transcription factor binding. J. Biol. Chem. 270: 13637-13644 (1995)
‣ Choi, S.-Y. and D.V. Faller, A transcript from the long terminal repeats of a murine retrovirus associated with trans-activation
of cellular genes. J. Virol. 69: 7054-7060 (1995)
‣ Choi, S.-Y. and D.V. Faller (1994) The long terminal repeats of a murine retrovirus encode a trans-activator for
cellular genes. J. Biol. Chem. 269: 19691-19694
‣ Murtha-Riel, P, M.V. Davies, B.J. Scherer, S.-Y. Choi, J.W.B. Hershey, and R.J. Kaufman, Expression of a phosphorylation-resistant
eukaryotic initiation factor 2 α-subunit mitigates heat shock inhibition of protein synthesis. J. Biol. Chem. 268:
12946-12951 (1993)
‣ Choi, S.-Y., J. Scherer, J. Schnier, M.V. Davies, R.J. Kaufman, and J.W.B. Hershey, Stimulation of protein synthesis
in COS cells transfected with variants of the α-subunit of initiation factor eIF-2, J. Biol. Chem. 267: 286-292 (1992)
Research
The specific goals of our laboratory are to establish an interdisciplinary approach to investigate the fundamental control mechanisms of gene expression process in conjunction with viral infection and stress-related disorders. Current efforts focus on the investigation of the biological roles of cellular and viral gene factors and their impacts on cellular defense mechanism. One of these studies has been extended to the establishment of a gene therapy technique in bone marrow or primary cells. These works will be thus allowing us to provide a ultimate therapy scheme for the treatment of a variety of cellular disorder and deficiency.
Research Area
‣ Transcriptional and translational control of cellular and viral genes
‣ Control mechanism in degenerative diseases
‣ Physiologically functional molecules and their roles in cell metabolism
Ongoing Projects
‣ Control of gene expression in response to virus infection and ER stress
‣ Biomedical approach to therapeutic defenses in degenerative diseases
‣ Lentivirus-based regulated-secretion system for the treatment of haemophilia A