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고려대학교 교수소개

Knowledge & Innovation

생명과학대학

Home > 생명과학대학 >생명공학부

소개

Prof. 송문정

Tel: 02-3290-3019(Lab: 3513)

Fax: 3291-3012

E-mail: moonsong@korea.ac.kr

  • About Professor
  • Curriculum vitae
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile

    송문정
    생명과학관 서관 307호 (Lab: L208)
    Phone : 02- 3290-3019 (Lab: 3513) 
    FAX : 02- 3291-3012

     

  • Curriculum

    Education 
     
     1997-2002 Ph.D. in Molecular and Medical Pharmacology, School of Medicine, University of California at Los Angeles, California, U.S.A 
    1994-1996 M. S. in Pharmacology, College of Pharmacy, Seoul National University, Seoul, Republic of Korea
    1990-1994 B. S., Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, Republic of Korea (magna cum laude)
     
     
    Professional Experiences 
     
     2009- Associate Professor, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    2006-2009 Assistant Professor, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    2004-2006 Assistant Professor, Department of Microbiology, College of Medicine, Hallym University, Chuncheon, Republic of Korea
    2002-2004 Postgraduate Researcher, Department of Molecular and Medical Pharmacology, School of Medicine, University of California at Los Angeles, California, USA
    1996-1997 Associated Researcher, Institute of Immunology and Immunological Diseases, Department of Microbiology, College of Medicine, Yonsei University 

     

  • Publication

    2017

     

     Yee Ching Ng, Ye Won Kim, Seungbo Ryu, Ariel Lee, Jeong-Su Lee and Moon Jung Song, 2017. Suppression of norovirus by natural phytochemicals from Aloe vera and Eriobotryae Folium. Food Control 73, 1362-1370.

     

     

     

    2016

     

     Ah-reum Han, Hye-Ri Kang, Jonghyeon Son, Do Hoon Kwon, Sulhee Kim, Woo Cheol Lee, Hyun Kyu Song, Moon Jung Song and Kwang Yeon Hwang, 2016. The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism. Nucleic acids research 44, 9483-9493.

     

     

     

    2015

     

     Seungbo Ryu, Hyun Ju You, Ye Won Kim, Ariel Lee, Gwang Pyo Ko, Sung-Joon Lee and Moon Jung Song, 2015. Inactivation of norovirus and surrogates by natural phytochemicals and bioactive substances. Molecular nutrition & food research 59, 65-74

     

     Woo-Chang Cheong, Hye-Ri Kang, Hyunyee Yoon, Suk-Jo Kang, Jenny P.-Y. Ting and Moon Jung Song, 2015a. Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome. PloS one 10, e0126456.

     

     Woo-Chang Cheong, Joo-Hee Park, Hye-Ri Kang and Moon Jung Song, 2015b. Downregulation of Poly(ADP-Ribose) Polymerase 1 by a Viral Processivity Factor Facilitates Lytic Replication of Gammaherpesvirus. J Virol 89, 9676-9682.

     

     

     

    2014

     

     Hyunju Kang,Jaehyung Song,Kwangman Choi,Hyeongki Kim,Miri Choi, So-Young Lee, Chonsaeng Kim, Sang Jun Lee, Moon Jung Song, Hyojeung Kang, Sung Hoon Back, Sang-Bae Han, Sungchan Cho, 2014a. Efficient lytic induction of Kaposi's sarcoma-associated herpesvirus (KSHV) by the anthracyclines. Oncotarget 5, 8515-8527.

     

     Hye-Jeong Cho and Moon Jung Song, 2014. A gammaherpesvirus establishes persistent infection in neuroblastoma cells. Molecules and cells 37, 518-525.

     

     Seonyoung Choi,Ji-youn Lim, Yoonjin Kim, Moon Jung Song, Woon-Won Jung, Jung Bok Seo, Jacob Lee and Donggeun Sul, 2014. Plasma proteomic analysis of patients infected with H1N1 influenza virus. Proteomics 14, 1933-1942.

     

     Hye-Ri Kang, Woo-Chang Cheong, Ji-Eun Park, Seungbo Ryu, Hye-Jeong Cho, Hyunyee Youn, Jin-Hyun Ahn and Moon Jung Song, 2014b. Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response. J Virol 88, 6832-6846.

     

     

     

    2013

     

     Hye-Jeong Cho, Seon-Gyeong Jeong, Ji-Eun Park, Jin-Ah Han, Hye-Ri Kang, Dongho Lee and Moon Jung Song, 2013. Antiviral activity of angelicin against gammaherpesviruses. Antiviral research 100, 75-83.

     

     

     

    2012

     

     Hye-Ri Kang, Hye-Jeong Cho, Sungbum Kim, In Ho Song, Tae Sup Lee, Seungmin Hwang, Ren Sun and Moon Jung Song, 2012. Persistent infection of a gammaherpesvirus in the central nervous system. Virology 423, 23-29.

     

     Cheol-Woo Noh, Hye-Jeong Cho, Hye-Ri Kang, Hyun Yong Jin, Shaoying Lee, Hongyu Deng, Ting-Ting Wu, Vaithilingaraja Arumugaswami, V., Ren Sun and Moon Jung Song, 2012. The virion-associated open reading frame 49 of murine gammaherpesvirus 68 promotes viral replication both in vitro and in vivo as a derepressor of RTA. J Virol 86, 1109-1118.

     
     
    2009
     
     Seungmin Hwang, Kyeong Seon Kim, Emilio Flano, Ting-Ting Wu, Leming M. Tong, Ann N. Park, Moon Jung Song, David Jesse Sanchez, Ryan M. O ` Connell, Genhong Cheng, and Ren Sun. 2009. Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon resonse.     Cell Host & Microbe  . 19:166-178 
     
     Hye-Jeong Cho, Sungbum Kim, Sung-Eun Kwak, Tae-Cheon Kang, Hee-Sung Kim, Hyung-Joo Kwon, Yoon-Won Kim, Yong-Sun Kim, Eun-Kyung Choi, and Moon Jung Song. 2009. Age-dependent pathogenesis of murine gammaherpesvirus 68 infection of the central nervous system  . Molecules and Cells . 27:105-111 
     
    Vaithilingaraja Arumugaswami, Ronika Sitapara, Seungmin Hwang, Moon Jung Song, Tuyet Ngoc Ho, Nancy Qi Su, Eric Y. Sue, Vidhya Kanagavel, Fangfang Xing, Xiaolin Zhang, Minglei Zhao, Hongyu Deng, Ting-Ting Wu, Sudhakar Kanagavel, LuLu Zhang, Sugandha Dandekar, Jeanette Papp, and Ren Sun. 2009. High-Resolution Functional Profiling of a Gammaherpesvirus RTA Locus in the Context of the Viral Genome  . Journal of Virology . 83:1811-1822 
     
     
     
    2008  
     
     Yong Ho Huh, Young Eui Kim, Eui Tae Kim, Jung Jin Park, Moon Jung Song , Hua Zhu, Gary S. Hayward, and Jin-Hyun Ahn. 2008. Binding STAT2 by the Acidic Domain of Human Cytomegalovirus IE1 Promotes Viral Growth and Is Negatively Regulated by SUMO  . Journal of Virology  . 82:10444-10454
     
     Hye-Jeong Cho, Fuqu Yu, Ren Sun, Dongho Lee, and  Moon Jung Song . 2008. Lytic induction of Kaposi`s sarcoma-associated herpesvirus in primary effusion lymphoma cells with natural products identified by a cell-based fluorescence moderate-throughput screening  . Archieves of Virology . 153:1517-1525
     
     David Jesse Sanchez, Daniel Miranda Jr., Vaithilingaraja Arumugaswami, Seungmin Hwang, Adam E. Singer, Ashkon Senaati, Arash Shahangian, Moon Jung Song , Ren Sun, and Genhong Cheng. 2008. A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon.  Journal of Virology. 82:2208-2217
     
     
     
    2007  
     
     Sangmi Lee, Hye-Jeong Cho, Jung-Jin Park, Yong-Sun Kim, Seungmin Hwang, Ren Sun, and Moon Jung Song . 2007. The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication.  Journal of Virology. 81:9870-9877
     
     Fuqu Yu, Josephine N. Harada, Helen J. Brown, Hongyu Deng, Moon Jung Song , Ting-Ting Wu, Juran Kato-Stankiewicz, Christian G. Nelson, Jeffrey Vieira, Fuyuhiko Tamanoi, Sumit K. Chanda, Ren Sun. 2007. Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus.  Public Library of Science Pathogens.  3:e44
     
     
     
    2006
      
     Brian S. Bowser, Stephanie Morris, Moon Jung Song , Ren Sun and Blossom Damania. 2006. Characterization of Kaposi`s sarcoma-associated herpesvirus (KSHV) K1 promoter activation by RTA.  Virology. 348:309-327
     
     
     
    2005  
     
    Moon Jung Song , Seungmin Hwang, Wendy H. Wong, Ting-Ting Wu, Sangmi Lee, Hsiang-I Liao, and Ren Sun. 2005. Identification of viral genes essential for replication of murine gamma-herpesvirus 68 using signature-tagged mutagenesis.  Proceedings of National Academy of Sciences of the United States of America. 102:3805-3810 
     
     
    Tammy M. Rickabaugh, Helen J. Brown, Ting-Ting Wu, Moon Jung Song , Seungmin Hwang, Hongyu Deng, Katherine Mitsouras, and Ren Sun. 2005. Kaposi`s sarcoma-associated herpesvirus/human herpesvirus 8 RTA reactivates murine gammaherpesvirus 68 from latency.  Journal of Virology. 79:3217-3222
     
     
     
    2004  
     
    Moon Jung Song , Seungmin Hwang, Wendy Wong, June Round, DeeAnn Martinez-Guzman, Yaron Turpaz, Jie Liang, Ben Wong, Reid C. Johnson, Michael Carey, and Ren Sun. 2004. The DNA architectural protein HMGB1 facilitates RTA-mediated viral gene expression in gamma-2 herpesviruses.  Journal of Virology. 78:12940-12950
     
     
     
    2003
      
     DeeAnn Martinez-Guzman, Tammy Rickabaugh, Ting-Ting Wu, Helen Brown, Steven Cole, Moon Jung Song , Leming Tong, and Ren Sun. 2003. Transcription program of murine gammaherpesvirus 68.  Journal of Virology. 77:10488-10503 
     
     
    Moon Jung Song , Hongyu Deng, and Ren Sun. 2003. Comparative study of regulation of RTA-responsive genes in Kaposi`s sarcoma-associated herpesvirus/human herpesvirus 8.  Journal of Virology. 77:9451-9462 
     
     
    Helen J. Brown, Moon Jung Song , Hongyu Deng, Ting-Ting Wu, Genhong Cheng, and Ren Sun. 2003. NF-kappaB inhibits gammaherpesvirus lytic replication.  Journal of Virology. 77:8532-8540 
     
     
     
    2002 
     
     Hongyu Deng, Moon Jung Song , Julia T. Chu, and Ren Sun. 2002. Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi`s sarcoma-associated herpesvirus).  Journal of Virology. 76:8252-8264. 
     

     

  • Research

    Research Topic 
     
    Virus-Host Interactions  
    - 바이러스와 숙주 면역계와의 상호작용: 
       면역회피 기전연구
      염증성싸이토카인 분비 조절 기전연구
     
    - 바이러스의 조직 및 세포 친화성 결정인자
     
    - 바이러스 생활주기 및 재활성 조절 인자 연구
     
    - 바이러스 백신개발, 재활성 조절 물질 검색 및 개발
      
     
    Lab Profile 
     
    종양유전자(ocogene)이나 종양억제유전자(tumor-suppresser gene)의 발견에서 확인되듯이 세포 내 많은 유전자 발현 조절 및 신호전달 체계는 바이러스와 숙주세포와의 상호작용을 연구하는 과정에서 밝혀졌다. 또한, 바이러스는 감염 후 숙주면역세포의 감시활동을 회피하기 위한 기전을 형성하는데, 이에 대한 연구는 종종 인체 면역시스템에 대한 새로운 통찰을 제시하기도 한다.
     
    본 연구실의 주요 연구 대상인 허피스바이러스는 고령화, 장기이식 또는 HIV 감염 등으로 인한 숙주의 면역 저하 시 재활성화 되는 대표적인 기회감염 병원균(opportunistic pathogen)으로서, 한번 생체에 감염되면 잠복감염을 형성하여 평생 동안 그 감염이 지속되면서 숙주세포와 상호작용을 하기 때문에 바이러스-숙주 상호작용 연구에 최적의 모델시스템을 제공한다.
     
    본 연구실에서는 감마허피스 바이러스의 동물 모델로 가장 널리 이용되는 murine gammaherpesvirus-68 (MHV-68)를 모델로 이용하여, 바이러스와 숙주간의 상호작용을 연구하고 있다. Bacterial artificial chromosome(BAC) 기법을 활용하여 바이러스 유전체를 조작하고, 바이러스와 숙주의 상호작용을 in vitro와 in vivo 수준에서 연구함으로써 바이러스가 일으키는 감염성 질환의 예방 및 치료를 위한 중요한 후보 유전자를 발굴하고자 한다. 또한, 바이러스 생활주기의 조절인자에 대한 연구와 이를 통한 종양 용해성 치료물질을 탐색 및 항바이러스제 개발 연구도 진행 중이다. 

     

  • Teaching

    준비 중입니다.

  • Lab Members

    준비 중입니다.