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고려대학교 교수소개

Knowledge & Innovation

생명과학대학

Home > 생명과학대학 >생명과학부

소개

Prof. 고영규

Tel: 02-3290-3453 (office)

     02-3290-3961 (Lab.)
E-mail: ygko@korea.ac.kr

 

  • About Professor
  • Curriculum vitae
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile

    ▶ 세포외 공간에서 존재하는 나노튜브 : 본 연구실은 아래 그림과 같이 생쥐 일차 간세포 (mouse primary hepatocytes) 의 세포외 공간에서 세포와 세포를 연결시키는 수많은 나노튜브관을 위상차 현미경으로 최초로 관찰하였음 . 이 관은 액틴 필라멘트와 지질래프트막으로 구성되어 있기 때문에 터널링 나노튜브 (Tunneling Nanotubes,TNT) 라고 함

    ▶ 새로운 연구를 할 것인가 ? : 많은 연구자들은 우연히 TNT 를 관찰하여 왔으나 무시하고 지나쳐 왔음 . TNT 논문을 보고 나서야 “내 실험실도 TNT 를 관찰했었는데 ... ”하면서 후회함 (Bryant, Curr. Biol., 17, R655, 1999). 빈약한 정보와 모든 것을 새롭게 시작하여야 하는 두려움 때문에 많은 연구자들은 더 이상 연구를 진행하지 못하였음 . 

    ▶ TNT 연구의 네 가지 핵심 질문들 : 포유동물세포에서 TNT 가 처음 발견된 지 12 년이 지났지만 다음과 같은 네 가지 핵심 질 문들은 해결되지 않고 있음 . 본 실험실은 이 질문에 도전하고 있음 . 
     
     • TNT 는 어떤 기전으로 형성되는가 ? 
     • TNT 의 구성성분은 무엇인가 ? 
     • TNT 의 생리학적 기능은 무엇인가 ? 
     • TNT 의 의생명학적 응용은 가능한가 ?

     

     

    터널링 나노튜브 연구센터: TNT 연구의 핵심 질문을 풀기 위해서 열 분의 교수님과 더불어 터널링 나노튜브 연구센터를 운영 중에 있음.

    고영규: 터널링 나노튜브 연구센터 센터장

     

  • Curriculum

    education 

    박사 (1989-1994): 오스틴 소재 텍사스 주립대학 생명과학과
    석사 (1985-1987): 고려대학교 생물학과
    학사 (1981-1985): 고려대학교 생물학과

    professional experience  

    2016-현재 : 고려대학교 터널링나노튜브 연구센터 소장
    2008-현재 : 고려대학교 생명과학부 교수
    2005- 2008: 고려대학교 생명과학부 부교수
    2002- 2008: 고려대학교 생명과학부 조교수
    1999- 2002: 서울대학교 약학대학 창의연구단 책임연구원
    1996- 1999: 서울대학교 의과대학 암연구소 박사후 과정
    1994- 1996: Univ. of Texas Southwestern Medical School, 박사후 과정

    수상 경력

    석탑강의상 6 회 수상 (2003, 2009, 2010, 2011, 2012, 2013 년 )
    우수강의상 3 회 수상 (2010, 2011, 2012 년 )
    명강의상 1 회 수상 ( 교육대학원 , 2014 년 )

  • Publications

     

     

    My H-index is 36 in Google Scholar and 31 in Web of Science.
     
    Year 2017
      1. Shin, K., Ko, YG and Jeong J (2017) Dexamethasone-induced expression of atrogenes is regulated by Fbxw7b in mouse primary   

         myoblasts. Cell Biology International. 41, 213-220. 

     

      2. Lee, HC., Her, NG., …. Ko, YG, and Lee, JS (2017) Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct

          targeting of PDZ binding kinase. Cell Death Dis., 8, e2693; doi:10.1038/ccdis.2017.116 

     

      3. Yu, D.-M., Jung, S. H., An, H.-T., Hong, J., …., and Ko, Y.-G. (2017) Caveolin-1 deficiency induces cellular senescence with

         mitochondrial  dysfunction. Aging Cell, In press. 

     

      4. Jung, SH., Lee HC., Hwang HJ., … Ko, YG., Park, HJ., and Lee, JS (2017) Acyl-CoA thioesterase 7 is involved in cell cycle

         progression  via regulation of PKCz-p53-p21 signaling pathway. Cell Death Dis. In press 

     

      5. Lee, HC., Jung, SH., …. Ko, YG., Gorospe, M., and Lee, JS. (2017) Wig1 dictates Ago2-mediated gene silencing in miRNA-dependent         manners. Nucleic Acids Res., In press. 

     

      6. Lee, H., Kim, BW, Kim JW, Hong J, Lee, JW, Kim HL, Lee, JS, and Ko, YG (2017) Extracellular reactive oxygen species is generated by       cell-surface oxidative phosphorylation complexes. Submitted to Free Radical Biol. Med. Under revision.

     

      7. Lee, H., Park, J. S., Bahn, M.-S., Hong, J., Yu, D.-M., …., and Ko, Y.-G. (2017) Tunneling nanotubes regulate hepatic gluconeogenesis.        EMM, Under 2nd revision. 

     

      8. Yoon, Y R., Shin, S. W., Ko, Y.-G., Rhyu, I. J., Kim, D.-H., Seong, J. K., and Baik, J.-H. (2017) Glucose-regulated protein 78 binds to and      regulates the melnocrotin-4 receptor. Submitted to Diabetes.

     

      9. Lee, H, Yoo, DM, Lee, JS, and Ko, YG (2017) CD133 is an A-kinase anchor protein. Will be submitted to Gastroenterology.

     

      10. Jung, S.-H., Lee, H. C., Park, H. A., Lee, M., Hong, M., Yu, D.-M., Jung, Y. R., kim, Y. N., Ko, Y.-G., Park, H. J., and Lee, J.-S. (2017)           Integrin a6b4-Src-Akt signaling induces cellular senescience by counteracting apoptosis in irradiated tumor cells and tissues. Will be             submitted to Nat. Cell Biol.

     

     

     

    Year 2016
     
      1. Hwang, H.-J., Jung, S. H., Lee, H. C., Han, N. K., Bae, I. H., Lee, M., Han, Y.-H., Kang, Y.-S., Lee, S.-J., Park, H. J., Ko, Y.-G.,
        and Lee, J.-S. (2016) Idenfication of novel therapeutic targets in the secretome of ionizing radiation-induced senescent 
        tumor cells. Oncology Reports. 35. 841-850.
     
      2. Lee, H., Kim, S.-H., Lee, J.-S., Yang, Y.-H., Nam, J.-M., Lee, J.-S., Kim, B.-W., and Ko, Y.-G. (2016) Mitochondrial oxidative
         phosphorylation complexes exist in the sarcolemma of skeletal muscle. BMB Reports, 49, 116-121.
     
      3. Jung, SH, Lee, HC, Yu, DM., Kim, BC, Park, SM, Lee, YS, Park, HJ, Ko, Y-G, and Lee, J-S (2016) Haparan sulfation
         is essential for the prevention of cellular senescence.   Cell Death Differ., 23, 417-429.
     
       4 . Hong, J., Park, J.-S., Lee, H., Heong, J.-M., Yun, H. H., Ko, Y.-G * ., and Lee, J.-W * . (2016) Myosin heavy chain is
         stabilized by BCL-2 interacting cell death suppressor (BIS) in skeletal muscle. Exp. Mol. Med., 48:e225.
         * co-corresponding author
     
      5. Tan, T., Ko, Y.-G * ., and Ma, J * . (2016) Dual function of MG53 in membrane repair and insulin signaling.
         BMB Reports, In press. * co-corresponding author
     
      6. Kim, B.-C., Hwang, H.-J., Lee, H., Park, J.-S., Ahn, H. T., Ko, J., Lee, J.-S., and Ko, Y.-G. (2016)
          Antibody neutralization of cell-surface gC1qR prevents lemellipodia formation and tumorigenesis.
         Oncotarget. Under revision.
     
      7. Yu, D.-M., Jung, S. H., An, H.-T., Hong, J., …., and Ko, Y.-G. (2016) Caveolin-1 deficiency induces
          cellular senescence with mitochondrial dysfunction. Under revision in Cancer Res.
     
       8. Lee, H., Park, J. S., Bahn, M.-S., Hong, J., Yu, D.-M., …., and Ko, Y.-G. (2016) Tunneling nanotubes
           regulate hepatic gluconeogenesis. Under review in Hepatology.
     
     
      Year 2015                    
                
        1 . Jeong, Y.-J., And Jung, M.-G., Son, Y., Jang, J. H., Kim, S. H., Ko, Y.-G., Lee, Y.-S., and Lee, H. J. (2015) Coniferyl      
          aldehyde attenuates radiation enteropathy by inhibiting cell death and promoting endothelial cell function.
          PLos One, e0128552.
     
       2. Lee, H.-C., Hong, M.-N., Jung, S. H., Kim, B. C., Suh, Y. J., Ko, Y.-G., Lee, Y.-S., Lee, B.-Y., Cho, Y.-G., Myung,
         S.-H., and Lee, J.-S. (2015) Effect of extremely low frequency magnetic fields on cell proliferation
         and gene expression. Bioelectromagnetics. 36, 506-516.
     
        Year 2014    
     
       1 . Hong, J., Kim, B.-W., Choo, H.-J., Park, J.-J., Yu, D.-M., Lee, H., Yoon, G., Lee, J.-S., and Ko, Y.-G. (2014) Mitochondrial
          complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation. J. Biol.
          Chem., 289, 20012-20025. “Recommended in Faculty of 1000Prime”. 8 citations.
     
       2 . Kim, B.-C., Yoo, H.-J., Lee, H.-C., Kang, K.-A., Jung, S.-H., Lee, H.-J., Lee, M., Park, S., Yi, Y.-H., Lee, Y.-S., Ko, Y.-G.* ,  
            and Lee J.-S. (2014) Evaluation of premature senescence and senescence biomarkers in carcinoma cells and
           xenograft mice exposed to single or fractionated irradiation. Oncol. Rep. , 31, 2229-2235. * co-corresponding author
     
         
        3 . Nguyen, N., Yi, J.-S., Park, H., Lee, J.-S., and Ko, Y.-G. (2014) Mitsugumin 53 (MG5) ligase ubiquitinates focal adhesion
            kinase during skeletal myogenesis. J. Biol. Chem. , 289, 3209-3216. 7 citations.
     
        4 . Kang, K.-A., Lee, H.-C., Lee, J.-J., Hong, M.-N., Park, M.-J., Choi, H.-D., Kim, Na., Ko, Y.-G.* , and Lee, J.-S.* (2014)
            Effects of combined radiofrequency radiation exposure on levels of reactive oxygen species in
            neuronal cells. J. Radiat. Res. , 55, 265-276. * co-corresponding author
     
          Year 2013                       
     
     
       1. Yi, J.-S., Ham, Y.-M., Lee, N.-R., …, Lee, C.-S., Lee, J.-S., Ko, Y.-G. (2013) MG53-induced IRS-1 ubiquitination negatively
           regulates skeletal myogenesis and insulin signaling. Nat . Commun . 4:2354 doi: 10.1038/ncomms3354 . 27 citations
     
       2. Yi, J.-S., Moon, D.-K., Park, J.-S., Lee, H., Lee, J.-W., Lee, J.-S., Kim, S.-J., Cho, B.-R., Lee, S.-W.*, and Ko, Y.-G. * (2013)
           PTRF/Cavin-1 is essential for multidrug resistance in cancer cells. J. Proteome Res. , 12, 605-614.
           * co-corresponding author. 15 citations.
     
       3. Jung, K.-J., Rho, J.-K., Kim, Y.-M., Jung, J. E., Jin, Y. G., Ko, Y.-G., Lee, J.-S.,   Lee, J. C., Park, M.-J. (201 3 ) Upregulation of
          CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. Oncogene ,
          32, 209-221. 78 citations.
     
         
            
    Year 2012           
     
     
     1. Kim, B. C., Lee, H. C., Lee, J.-J., Choi, C.-M., Kim, D.-K., Lee, J. C., Ko, Y.-G., and Lee, J.-S. (2012) Wig1 prevents cellular
        senescence via regulation of p21 mRNA decay through control of RISC recruitment. EMBO J., 31, 4289-4303. 10 citations
     
      2. Park, J.-J., Yi, J. Y., Jin, Y. B., Lee, Y.-J., Lee, J.-S., Lee, Y.-S., Ko, Y.-G.* , and Lee, M.* (2012) Sialylation of epidermal
         growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells. Biochem.
         Parmacol. , 83, 849-857. * co-corresponding author. 38 citations.
     
      3. Han, N.-K., Kim, B.-C., Lee, H.-C., Lee, Y.-J., Park, M.-J., Chi, S.-G., Ko, Y.-G., and Lee, J.-S. (2012)
          Secretome analysis of ionizing radiation-induced senescent cancer cells reveals that secreted RKIP
          plays a critical role in neighboring cell migration. Proteomics, 12, 2822-2832. 12 citations.
     
      4. Park, JJ., Seo, SM., Kim, EJ, and Lee YJ, Ko YG, Ha J, and Lee M. (2012) Berberine inhibits human colon cancer
          cell migration via AMP-activated protein kinase-mediated downregulation of integrin b1 signaling. Biochem.
          Biophys. Res. Commun., 426, 461-467. 42 citations.
      
      5. Hong M.-N., Kim, B.-C., Ko, Y.-G., Lee, Y.-S., Hong, S.-C., Kim, T., Pack, J.-K., Choi, H.-D., Kim, N., and Lee, J.-S.
         (2012) Effects of 837 and 1950 MHz radiofrequency radiation exposure alone or com b ined on oxidative stress
         in MCF10A cells. Bioelectromagnetics . 33, 604-611 . 9 citations.
     
      6. Lee, M., Park, J.-J., Ko, Y.-G.* , and Lee, Y.-S.* (2012) Cleavage of ST6Gal I by radiation-induced BACE1 inhibits
          Gogi-anchored ST6Gal-mediated sialyation of integrin b1 and migration in colon cancer cells. Radiation
          Oncology , 7, 47. * co-corresponding author. 8 citations.
     
      7. Park, J.-J., Jin, Y. B., Lee, Y.-J., Lee, J.-S., Lee, Y.-S., Ko, Y.-G.* , and Lee, M.* (2012) KAI1 suppresses HIF-1a and
          VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer. BMC Cancer . 12, 81.
         * co-corresponding author. 14 citations
     
      8. Hong, M.-N., Kim, B.-C., Ko, Y.-K., Lee, Y.-S., Hong, S.-C., Kim, T., Pack, J.-K., Choi, H.-D., and Lee, J.-S.
         (2012) Effects of combined radiofrequency radiation exposure on the oxidative stress.
        Bioelectromagnetics . 53, 79-86. 9 citations.
     
      9. Kim, S., Seo, J., Ko, Y.-G., Huh, Y.-D., and Park, H. (2012). Lipid-binding properties of TRIM72.
           BMB Reports . 45, 26-31.
     
     
    Year 2011   
     
     
     1. Kim, K.-B., Lee, J.-H., Yi, J.-S., Yoo, D.-M., Kwon, Y.-C., Ahn, B.-Y., Cho, H. Kim, Y.-K., Yoo, H.-J., Lee, J.-S.,
        and Ko, Y.-G . , (2011) Cell surface gC1qR is a key regulator for lamellipodia formation and cancer
        metastasis. J. Biol. Chem. , 286, 23093-23101. “A paper of the week” . 25 citations
     
     2. Kim, J.-H., Kim, H., Yoon, Y.-S., Xu, W., Yoon, J.-K., Choi, S.-E., Ko, Y.-G. , Kim, M.-J., Lee, S.-J., Wang,
        H.-J., Yoon, G. (2011) Involvement of mitophage in o n cogenic K-Ras-induced transformation:
        overcoming a cellular energy deficit from glucose deficiency. Autophagy . 7, 1187-1198. 48 citations.
     
     
     Year 2010
     
     
    1. Lee, J.-J., Lee, J.-W., Ko, Y.-G . , Hong, S. I., and Lee, J.-S. (2010) Prevention of premature senescence
        requires JNK regulation of Bcl-2 and reactive oxygen species. Oncogene , 29, 561-575. 34 citations.
          
    2. Park, E.-Y., Kwon, O.-B., Joen, B. C., Lee, C.-S., Ko, Y.-G.* and Song, H.-K. * (2010) Crystal structure
        of PRY-SPRY domain of human TRIM72. Proteins (IF=2.813) . 78, 790-795. * co-corresponding author. 22 citations.
     
      3. Kim, K.-B., Byun, H.-O., Han, N.-K., Ko, Y.-G. , Choi, H.-D., Kim, N., Pack, J.- K., and Lee,
         J.-S. (2010) Two-dimensional electrophoretic analysis of radio frequency readiation-exposed MCF7 breast cancer cells.
         J. Radiol. Res. , 51, 205-213. 21 citations.
     
      4. Lee, C.-S., Ham, Y.-M., Kim, B.-W., Kwon, O.-B., Choo, H.-J., Jang, S.-Y., Chi, S.-G., Kim, J.-Y., Kim, J.-H.,
         and Ko, Y.-G. (2010) TRIM72 negatively regulates myogenesis by targeting insulin receptor substrate-1.
          Cell Death Differ . , 17, 1254-1265. 35 citations.
     
      5. Jung, S.-Y., and Ko, Y.-G. (2010) TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally
        activated by the synergism of MyoD (or myogenin) and MEF2. Biochem. Biophys. Res. Commun. , 396, 238-245. 16 citations.
     
      6. Kim, B.-W., Lee, J.-W., Choo, H.-J., Lee, C.-S., Jung, S.-Y., Yi, J.-S. ..., and Ko, Y.-G. (2010) Mitochondrial oxidative phosphorylation system is recruited to detergent-resistant lipid rafts during myogenesis. Proteomics , 10, 2498-2515. “Cover paper” . 17 citations.
     
      7. Kim, J., Ahn, S., Ko, Y.-G. , Boo, Y.-C., Chi, S.-G., Ni, C.-W., Go, Y.-M., and Park, H. (2010) X-lined inhibitor of apoptosis
          protein controls integrin {alpha}5-mediated cell adhesion and migration. Am. J. Physiol. Hear Circ. Physiol. . 299,
          H300-309 . 18 citations.
      
       8. Kim, B.-W., Lee, C.-S., Yi, J.-S., Lee, J.-W., Choo, H.-J., Jung, S.-Y., ....., and Ko, Y.-G. (2010) Novel biological insights
           from lipid raft proteomics; the mitochondrial oxidative phosphorylation system is associated with detergent-
           resistant lipid rafts. Expert Rev. Proteomics , 7, 849-866 . 16 citations.
     
    Year 2009        
     
     1. Kim, K.-B., Kim, B.-W., Choo, H.-J., Kwon, Y.-C., Ahn, B.-Y., Choi, J.-S., Lee, J.-S., and Ko, Y.-G.
       (2009) Proteome analysis of adipocyte lipid rafts reveals that gC1qR plays essential roles in adipogenesis
       and insulin signal transduction. Proteomics, 9, 2373-2382. “Selected in the issue” 31 citations
     
      2. Byun, H.-O., Han, N.-K., Lee, H.-J., Kim, K.-B., Ko, Y.-G. , Yoon, G., Lee, Y.-S., Hong, S.-I., and Lee,
       J.-S. (2009) Cathepsin D and eukaryotic translation elongation factor 1 as markers of stress-induced
       premature senescence. Cancer Res. , 69, 4638-4637 . 56 citations.
     
      3. Yi, J.-S., Choo, H.-J., Lee, C.-S., Kim, H.-M., Cho, B.-R., Ham, Y.-M., and Ko, Y.-G. (2009)
       Ginsenoside induces ligand-independent Fas activation via lipid raft disruption. Biochem.
       Biophys. Res. Commun. (IF=2.595) , 385, 154-159 . 39 citations.
     
      4. Kim, K. M., Cho, H., Choi, K., Kim, J., Kim, B.-W., Ko, Y.-G. , Jang S. K., and Kim, Y. K. (2009)
          A new MIF4G domain-containing protein PIROT directs the pioneer round of translation. Genes Develop.
         (IF=12.889), 23, 2033-2045 . 54 citations.
     
    Year 2008        
     
    1. Kim, H.-M., Choo, H.-J., Ko, Y.-G. , Jeon, S.-J., Kim, C. H., Joo, T., and Cho, B.-R. (2008) Two-photon
        fluorescent probes for lipid raft imaging. Effect of chain length. ChemBioChem. 9, 2830-2838 . 19 citations.
     
      2. Lee, J. J., Kwak, H.-J., Lee, Y.-M., Park, M.-J., Ko, Y.-G. , Choi, H.-D., Kim, N., Pack, J.-K., Hong, S.-I., and Lee,
       J.-S. (2008) Radiofrequency radiation does not affect cell cycle, cellular migration, and invasion.
       Bioelectromagnetics, 29,615-625 . 13 citations.
     
     3. Lee, S.-J., Choi, D., Rhim, H., Choo, H.-J., Ko, Y.-G. , Kim, C.-G., and Kang S. (2008) PHB2 interacts with
       RNF2 and represses CP2c-stimulated transcription. Mol. Cell Biochem. , 319, 69-77. 9 citations.
     
      4. Choo, H.-J., Kim, B.-W., Kwon, O.-B., Lee, C.-S., Choi, J.-S. and Ko, Y.-G. (2008) Secretion of adenylate
        kinase 1 is required for extracellular ATP synthesis in C2C12 myotubes. Exp. Mol. Med. , 40, 220-228.
        11 citations.
     
      5. Kim, K.-B., and Ko, Y.-G. (2008) Isolation of detergent-resistant lipid rafts for proteomic analysis.
         Methods Mol. Biol. 424, 413-422. 24 citations.
     
      Year 2007  
     
    1. Kim, H.-M., Fang, X. Z., Yang, P. R., Yi, J.-S., Ko, Y.-G. , Piao, M. J., Chung, Y. D., Park, Y. W., Jeon,
       S.-J., and Cho, B.-R. (2007) Design of molecular two-photon probes for in vivo imaging 2H-Benzo
       [h]chromene-2-one derivatives. Tetrahedron Lett. 48, 2791-2795 . 44 citations.
     
      2. Kim, H.-B., Yang, P. R., Seo, M. S., Yi, J.-S., Hong, J. H., Jeon, S.-J., Ko, Y.-G. , Lee, K. J., and
        Cho, B. R. (2007) Magnesium ion selective two-photon fluorescent probe based on a Benzo[h]
        chromene derivative for in vivo imaging. J. Org. Chem. , 72, 2088-2096 . 100 citations.
     
      3. Kim, H.-M., Choo, H.-J., Jung, S.-Y., Ko, Y.-G. , Park, W.-H., Jeon, S.-J., Kim, C. H., Joo, T., and Cho,
         B. R. (2007) A two-photon fluorescent probe for lipid raft imaging: C-laurdan. ChemBioChem, 8,
         553-559. 133 citations.
     
     4. Kim, H. M., Jung, C., Kim, B. R., Jung, S.-J., Hong, J. H., Ko, Y.-G. , Lee, K. J., and Cho, B. R.
        (2007) Environment-sensitive two-photon probe for intracellular free magnesium ions in live tissue.
          Angew. Chem. Int. Ed. , 46, 1-5 . 99 citations.
     
      5. Jin, J.-K., Ahn, B.-H., Na, Y.-J. Kim, J.-I., Kim, Y.-S., Choi, E.-K., Ko, Y.-G. , Chung K. C., Kozlowski,
         P. B., and Min, D. S. (2007) Phospholipase D1 is associated with amyloid precursor protein in
         Alzheimer’s disease. Neruobiol. Aging , 28, 1015-1027 . 29 citations.
          
    Year 2006
     
    1. Park, S. G., Kang, Y. S., Kim, J. Y., Lee C. S., Ko, Y.-G. , Lee, W. J., Lee, K.-U., Yeon, Y. I., and Kim,
        S. (2006) Hormonal activity of AIMP/p43 for glucose homeostasis. Proc. Nat’l. Acad. Sci. U. S. A . ,
        103, 14913-14918 . 49 citations.
     
      2. Kim, S.-I., Yi, J. S., and Ko, Y.-G. (2006). Amyloid b oligomerization is induced by brain lipid rafts.
         J. Cell. Biochem., 99, 878-889. 75 citations
     
      3. Choo, H.-J., Kim, J.-H., Kwon, O.-B., Lee, C. S., Lee, J. Y., Han, S. S., Youn, Y.-S., Yoon G., Choi,
        K.-M., and Ko, Y.-G. (2006) Mitochondria are impaired in the adipocytes of type 2 diabetic mice.     
        Diabeteologia. 49, 784-791. “Introduced in commentary section” . 216 citations.
     
      4. Kim, K.-B., Lee, J.-W., Jung, S.-Y., Chi, S.-G., and Ko, Y.-G. (2006)
        Oxidation-reduction respiratory chains and ATP synthase complex are localized in the lipid rafts
       originating from plasma membrane. Proteomics , 6, 2444-2453. “Cover paper” . 81 citations .
     
     5. Rhee K. H., Nam, K. H., Lee W. H., Ko, Y.-G. , Kim, E. E., and Hwang K.-Y. (2006)
        Expression, purification, and preliminary X-ray crystallographic analysis of the complex
        G(alphai3)-RGS5 from human with GDP/Mg2+/AlF4-. Protein Pept. Lett., 13, 945-949
     
      Year 2005
     
     
    1. Yi, J.-S., Kim, J.-H., Park, S. G., Kim, S., and Ko, Y.-G. (2005) Aminoacyl-tRNA synthetase-interacting
        multi-functional protein, p43, is imported to endothelial cells via lipid rafts. J. Cell. Biochem., 96,
        1286-1295 . 8 citations.
     
     2. Park, Y.-K., Lee, J.-W., Ko, Y.-G. , Hong, S., and Park, S.-H. (2005) Lipid rafts are required for efficient
         signal transduction by CD1d. Biochem. Biophys. Res. Commun. , 327, 1143-54. 30 citations.
     
     
      Year 2004
     
    1. Kim, B.-W., Choo, H.-J., Lee, J.-W., Kim, J.-H., and Ko, Y,-G. (2004)   Extracellular ATP is generated by
        ATP synthase complex in adipocyte lipid rafts. Exp. Mol. Med. , 36, 476-85. 117 citations
     
      2. Kim, K.-B., Kim, S.-I., Choo, H.-J., Kim, J.-H., and Ko, Y.-G. (2004) Two dimensional electrophoretic
         analysis reveals that lipid rafts are intact at physiological temperatures. Proteomics , 4, 3527-35.
        35 citations.
     
      3. Bae, T.-J., Kim, M.-S., Kim, J.-W., Kim, B.-W., Choo, H.-J., Lee, J.-W., Kim, K.-B., Lee, C.-S., Kim, J.-H.,
        Chang, S. Y., Kang, C.-Y., Lee, S.-W., and Ko, Y.-G. (2004) Lipid raft proteome reveals ATP synthase
       complex in the cell surface. Proteomics , 4, 3536-48. 1 57 citations
     
       Year 2003
     
     
    1. Han, J., Lee, C.-S., Yun, C.-Y., Lee, B.-H., Ko, Y.-G. , Kang, C.-S., Lee, S.-D., Hwang, J.-S.,
        Kang, S.-W., and Kim, H.-R. (2003) Cloning and expression of male-specific protein (MSP)
        from the hemolymph of greater wax moth, Galleria mellonella L. Arch. Insect. Biochem. Physiol.
       54, 110-120. 10 citations.
     
     
    Year 2002
     
    1. Park, H., Park, S. G., Kim, J., Ko, Y.-G. , and Kim, S. (2002) Signaling pathways fo TNF production
        induced by human aminoacyl-tRNA synthetase-associating factor, p43. Cytokine 20,
       148-153 . 61 citations.
     
    2. Park, H.-S., Cho, S.-G., Kim, C.-K., Hwang, H.-S., Noh, K.-T., Kim, M.-S., Huh, S.-H., Kim, M.-J.,
        Ryoo, K., Kim, E.-K., Kang, W.-J., Lee, J.-S., Seo, J.-S., Ko, Y.-G. , Kim, S., and Choi, E.-J. (2002)
        Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol.
        Cell. Biol. 22, 7721-7730 . 162 citations.
     
      3. Park, S. G., Kang, Y.-S., Ahn, Y. H., Lee, S. H., Kim, K. R., Kim, K. W., Koh, G.-Y., Ko, Y.-G. .,
       and Kim, S. (2002) Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43,
       in angiogenesis. J. Biol. Chem. 277, 45243-45248 . 134 citations.
     
      4. Ko, Y.-G. , Park, H., and Kim, S. (2002) Novel regulatory interactions and activities of mammalian
       tRNA synthetases . Proteomics 2, 1304-1310. 35 citations.
     
      5. Kim, J.-Y., Kang, Y.-S., Lee, J.-W., Kim, H-J., Ahn, Y. H., Park, H., Ko, Y.-G. , and Kim, S. (2002).
        p38 is essential for cellular stability of macromolecular tRNA synthease complex and viability
        of mice. Proc. Nat’l. Acad. Sci. U. S. A. 102, 7912-1916 . 99 citations.
     
       Year 2001    
     
      
    1. Ko, Y.-G. , Kang, Y.-S., Park, H., Seol, W., Kim, J., Kim, T., Park, H.-S., Choi, E.-J. and Kim,
       S. (2001) Apoptosis signal-regulating kinase 1 controls the proapoptotic function of Daxx in the
       cytoplasm. J. Biol. Chem. 276, 39103-39106. 124 citations .
     
      2. Ko, Y.-G. , Park, H., Kim, T., Lee, J.-W., Park, S. G., Kim, J. E., Seol, W., Lee, W.-H., Park, J.-E.,
       and Kim, S. (2001) A cofactor of tRNA synthetase is released to upregulate proinflammatory
       chemokines and enriched in atherosclerosis lesions. J. Biol. Chem. 276, 23028-23033. 134 citations .
     
     3. Ko, Y.-G. Kim, E.-K., Park, H., Kim, T, Park, H.-S., Choi, E.-J., and Kim, S. (2001) Glutamine-dependent
       antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase
       1. J. Biol. Chem . 276, 6030-6036. 139 citations
     
        Year 2000
     
    1. Kang, J.-W., Kim, T., Ko, Y.-G., Rho, S. B., Park, S. G., Kim, M. J., Kwon, H. J., and Kim, S.
       (2000) Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA
       synthetases. J. Biol. Chem. 275, 31682-31688. 36 citations.
     
    2. Lee, C.-Y., Lee, J.-S., Ko, Y.-G., J.-I. Kim, and Seo, J.-S. (2000) Hsp70 inhibits apoptosis
      downstream of cytochrome c release and upstream of caspase-3 activation. J. Biol. Chem.
        275, 25665-25671. 460 citations.
     
    3. Kim, T., Park, S. G., Kim, J. E., Seol, W., Ko Y.-G. * , and Kim, S. (2000) Catalytic peptide of human
       glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex.
        J. Biol. Chem. 275, 21768-21772.   * Corresponding author .   39 citations.
     
    4. Park, W.-Y., Park, J.-S., Cho, K.-A., Kim, D.-I., Ko, Y.-G., Seo, J.-S., and Park, S.-C.
       (2000) Up-regulation of caveolin attenuates EGF signaling in senescent cells. J. Biol. Chem.
       275, 20847-20852. 189 citations.
     
    5. Ko, Y.-G. , Kang, Y.-S., Kim, E.-K., Park, S.-K., and Kim, S. (2000) Nucleolar localization of
       human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. J. Cell Biol .
      149 , 567-574. 87 citations .
     
    6. Lee, S. W., Ko, Y.-G., Bang, S. H., Kim, S., and Kim, K-S. (2000) Death effector domain of
       a mammalian apoptosis mediator, FADD, induces bacterial cell death. Mol. Microbiol . 35 , 1540-1549.
      20 citations.
     
    7. Ko, Y.-G. , Kang, Y.-S., and Seo, J.-S. (2000) Caveolin-1 internalization by heat shock or
       hyperosmotice shock. Exp. Cell Res . 255 , 221-228. 36 citations.
     
      Year 1999-1988
     
    1. Ko, Y.-G. , Lee, J.-S., Kang, Y.-S., Ahn, J.-H., and Seo, J.-S. (1999) TNF-alpha-mediated
       apoptosis is initiated in caveolae-like domains. J. Immunol ., 162, 7217-7223 . 143 citations .
     
    2. Ahn J.-H., Ko, Y.-G., Park, W.-Y., Kang, Y.-S., Chung, H.-Y. and Seo, J.-S. (1999)
     
    Suppression of ceramide-mediated apoptosis by HSP70 . Mol. Cells 9 , 200-206 . 51 citations.
     
    3. Ko, Y.-G. , Liu, P., Pathak, R. K., Craig, L., and Anderson, R. G. W. (1998) Early effects of
        pp60v-src kinase activation on caveolae. J. Cell Biochem . 71 , 524-535. 41 citations.
     
      4. Liu, P., Ying, Y., Ko, Y.-G., and Anderson, R. G. W. (1996) Localization of platelet-derived
       growth factor-stimulated phosphorylation cascade to caveolae. J. Biol. Chem . 271 , 10299-10303. 391 citations.
     
    5. Thompson G. A. Jr., Morita, N., Okuyama, H., Kim, Y., Ko, Y.-G., and Hung, C.-Y. On the presence
        of glycosylphosphatidylinositol-anchored proteins in plants. Plant Lipid Metabol., 227-229, 1995. 1 citations.
     
    6. Ko, Y.-G. , Hung, C.-Y., and Thompson, G. A. Jr. (1995) Temperature regulation of the Tetrahymena
       mimbres glycosylphosphatidylinositol-anchored protein lipid composition. Biochem. J. 307, 115-121 . 14 citations.
     
     7. Hung, C.-Y., Ko, Y.-G. , Thompson, G. A. Jr. (1995) Temperature-induced alteration of
         inositolphosphorylceramides in the putative glycosylated lipid precursors of Tetrahymena mimbres
        glycosylphosphatidylinositol-anchored proteins. Biochem. J . , 307, 107-113. 10 citations.
     
     8. Ko, Y.-G. , and Thompson, G. A. Jr. (1995) Purification of glycosylphosphatidylinositol-anchored proteins
         by modified Triton X-114 partitioning and preparative gel electrophoresis. Anal. Biochem . 224, 166-172. 42 citations.
     
      9. Ko, Y.-G. , and Thompson, G. A. Jr. (1992) Immobilization antigens from Tetrahymena thermophila are
        glycosylphosphatidylinositol-linked proteins. J. Protozool . 39 , 719-723. 25 citations.
     
      10. Ko, Y.-G. , and Kim, H.-R. (1988) Purification, characterization and synthesis of vitellin from thecabbage
         butterfly, Pieris rapae L. Korean Biochem. J . 21 , 471-478.
     
     11. Yeo, J.-W., Ko, Y.-G., and Kim H.-R. (1988) Some characteristics of hemolymph yolk protein in
         Pieris rapae L. Korean J. Entomol . 18 , 27-34.
     
     12. Kim, H.-R., Ko, Y.-G., and Mayer (1988) Purificaton, characterization and synthesis of vitellin from the
         cabbage butterfly, Pieris rapae L. Arch. Insect Biochem. Physiol . 9 , 67-79. 13 citations.
     
     
    Patents
         

    1. Young-Gyu Ko, Jae-Sung Yi, Chang-Seok Lee (2013) Use of TRIM72 as a target for muscle and heart enhancer. European Patent. Patent No., EP 2 185 174 B1. Date of Patent: Mar. 16, 2016

     

    2. 고영규 (2014) MG53-UBE2H 상호작용을 이용한 제 2형 당뇨 치료제의 스크리닝 방법. 국내특허 제 10-1460737호. 등록일2014년 11월 5일

     

    3. Young-Gyu Ko, Jae-Sung Yi, Chang-Seok Lee (2013) Use of TRIM72 as a target for muscle and heart enhancer. United States Patent. Patent No., US 8,383,602 B2. Date of Patent: Feb. 26, 2013

     

    4. 고영규 (2013) 층상 위족 형성 및 암 전이 조절용 조성물. 국내특허 제 10-1282374호. 등록일2013년 6월 28일

     

    5. 고영규, 이재성, 이창석 (2013) 근육 및 심장 강화제의 타겟으로서 TRIM72의 용동. 국내특허 제 10-10483164호. 등록일2011년 7월 5일

     

    6. Sunghoon Kim and Young-Gyu Ko (2006) Method of inducing production of IL-8 or TNF by in vitro administration of an N-terminal polypeptide of p43. United States Patent. Patent No., US 7,037,505 B2. Date of Patent: May 2, 2006

     

     
     
     
  • Research

    Research Area

     원형질막에 호르몬 수용체와 신호전달물질들이 제멋대로 흩뜨려져 있다면 세포신호전달은 느리고 비효율적으로 일어날 것이다 .

    따라서 원형질막에는 신호전달물질들을 조직적으로 모아서 세포신호전달의 중심지로 작용하는 지질래프트 (lipid rafts) 가 존재한다 .

    본 연구실은 지질래프트의 비교 단백질체학으로 당뇨병 , 근육병 , 노화 , 암 등의 원인이 될 수 있는 신규 신호전달단백질들을 동정하였다 .

    이들 지질래프트 단백질들의 기능을 이해하기 위해서 아데노바이러스 , siRNA, 유전자 적중생쥐 등 최신의 분자세포생물학적 실험기법을 사용하고 있다 . 특히 근육분화 동안 발현되기 시작하는 TRIM72/MG53 가 IRS-1 의 유비퀴티네이션을 유도하여 근육분화를 음성적으로 조절하기 때문에 TRIM72/MG53 적중 생쥐에서 인슐린저항성이 사라짐을 증명하였다 .

    더불어 암세포 , 노화세포 , 지방세포 , 근육세포에서 특이적으로 발현되는 지질래프트 단백질들을 다수 동정하여 이들 단백질들의 기능을 연구하고 있다 .

    본 연구실은 지질래프트 연구를 수행하는 중 지질래프트 단백질인 CD133 이 터널링나노튜브 (TNT) 의 형성에 중요한 역할을 수행한다는 것을 증명하였다 . 현재 CD133 에 의해서 만들어진 TNT 의 생물학적 기능연구에 모든 인적 - 물적 자원을 쏟아 붓고 있다 . 
     최근 사이언스 학술지는 지질래프트 분야를 미래의 노벨상 분야로 선정하였다 (Mysteries of the Cell. Science, 334, 1046-1051, 2011).

    Ongoing Project

    • 선도연구센터 지원사업 터널링 나노튜브 연구센터 ( 센터장 , 고영규 ): 2015-2022, 13 억 / 년 
    • 인슐린 저항성 치료제로서 MG53-IRS-1 결합억제제의 개발 ( 연구책임자 , 고영규 ): 204-2019, 5 억 / 년

  • Teaching

     

    • 생리학I(전공과목): 석탑강의상 7회 수상(2003, 2009, 2010, 2011, 2012, 2013, 2016년), 우수 강의상 1회 수상(2014)

    • 생리학(교육대학원): 명강의상 1회 수상(2014년)

    • 생명공학과 미래사회(핵심교양과목): 우수강의상 3회 수상(2010, 2011, 201, 2014년)

    • 일반생물학

  • Lab Members

    Current

    • Dr. Lee, Sungsoo(연구교수, Ph. D. from URI.)

    • Dr. Kim, Bong-Woo(연구교수, Ph. D. from Korea Univ.)

    • Dr. Lee, Hyun(박사후 과정, Ph. D. from Korea Univ.)

    • Yoo, Dong-Min(박사후 과정, Ph. D. from Korea Univ.)

    • Park, Jun Seob(석박사 통합과정)

    • Kim, Ki-Tae(석사과정)

    • Lee, Hwa-Yeon(석사과정)

    • Yoon,Seo-Yeon(석사과정)

    • Byun,Jo-Hyeun(석사과정)

    • Eom,Min-Ji(석사과정)

    • Seo, Young-Yee(터널링나노튜브 연구센터 행정직원)

     

     

     

    Former       

     

    • Dr. Lee, Je-Jung:

    • Dr. Kim, Bum-Chan: Samsung Inc.

    • Hong, Jin: Postdocter in Baylor University

    • Dr. Jung-Jin Park: Research Professor in Chungbuk Nat’l Univ.

    • Dr. Nga Nguyen: A professor in Vietnam

    • Dr. Joong-Won Lee: Postdocter in Scripps Inistitute

    • Dr. Chang-Seok Lee: Postdocter in Baylor Univ.

    • Dr. Hyo-Jung Choo: Postdocter in Emory Univ.

    • Dr. Jae-Sung Yi: Postdoctor in Yale Univ.

    • Dr. Young-Mi Ham: Postdoctor in Harvard Univ.

    • Ji-Yoen Lee (M. S.): 농업진흥연구소 연구원

    • Dr. Tae-Jung Bae: Postdocter in USA

    • Jun-Woo Kim (M. S.): LG 생명과학 연구원

    • Dr. Soon-Young Jang: Postdocter in Yonsei Univ. Medical School

    • Chan-Woong Park (M. S.): 생명공학연구소 연구원

    • Joo-Hyung Lee (M. S.): 박사후과정생, Baylor Univ.

    • Na-Rae Lee (M. S.): 유한양행 연구원

    • Kim, Seung-Hyub: 경희대 치과대 학생

    • Hwang, Hyun-Jeong (M. S.): 박사과정, Inha Univ

    • Lee, Jeong-Woo (M. S.): 변리사

    • Ban, Myong-Seok: 병역특례 근무중

    • Choi, Bo-Woon:

     

    Research

     

    Ongoing Project

     

    • 선도연구센터 지원사업 터널링 나노튜브 연구센터(센터장, 고영규): 2015-2022, 13억/년

     

    • 인슐린 저항성 치료제로서 MG53-IRS-1 결합억제제의 개발(연구책임자, 고영규): 204-2019, 5억/년