고려대학교 의과대학 생화학교실 교수

Education

• 박사(1987-1992): Tufts University, Boston, MA, U.S.A. 면역학전공
• 석사(1985-1987): 고려대학교 대학원 의학과, 생화학전공
• 학사(1979-1985): 고려대학교 의과대학 의학과, 의학전공

Professional Experiences

• 2013-현재: 고려대학교 대학원 해부병리계 주임교수
• 2013-2018: 고려대학교 의과대학 기초의학위원장
• 2013-2013: 생화학분자생물학회 선거위원장
• 2012–2012: 생화학분자생물학회 부회장
• 2007–2008: 대한생화학 분자생물학회 운영위원장
• 2005–2009: 고려대학교 의과대학 생화학교실 주임교수
• 2005–2009: 한국분자의학영양연구소 소장
• 2005-현재: 대한생화학 분자생물학회 대의원
• 2002-2003: Visiting assoicate professor, UCSF, San Francisco, CA, USA
• 1996-1999: 고려대학교 생명공학원 겸임교수
• 1998-2001: Experimental and Molecular Medicine 편집간사
• 1993-현재: 교수, 고려대학교 의과대학 생화학분자생물학교실
• 1986-1987: UNU fellowship, New England Medical Center, Tufts University, Boston, MA, USA

국제학술지

• 1. Kim HS, Lim JM, Kim JY, Kim Y, Park S, Sohn J. Panaxydol, a component of Panax ginseng, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models. Int J Cancer 2016 138(6):1432-41
• 2. Park SI, Park SJ, Lee J, Kim HE, Park SJ, Sohn JW, Park YG. Inhibition of cyclic AMP response element-directed transcription by decoy oligonucleotides enhances tumor-specific radiosensitivity. Biochem Biophys Res Commun 2016 469(3):363-9
• 3. Lee B, Kwon E, Kim Y, Kim JH, Son SW, Lee JK, Kim DW, Sohn J, Kim TH, Ji JD. 1α,25-Dihydroxyvitamin D3 upregulates HIF-1 and TREM-1 via mTOR signaling. Immunol Lett 2015 163(1):14-21
• 4. Kim TH, Lee B, Kwon E, Choi SJ, Lee YH, Song GG, Sohn J, Ji JD. Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D3 in human monocytes/macrophages. Immunol Lett 2013 154(1-2):80-5
• 5. Kim HD, Yu SJ, Kim HS, Kim YJ, Choe JM, Park YG, Kim J, Sohn J. IL-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38MAPK. J Biol Chem 2013 288(40):28743-54
• 6. Kim TH, Lee B, Kwon E, Choi CH, Sung IH, Kim Y, Sohn J, Ji JD. 1,25- dihydroxyvitamin D3 inhibits directly human osteoclastogenesis by down- regulation of the c-Fms and RANK expression Joint Bone Spine 2013 80:307-14
• 7. Kim HD, Jang C-Y, Choe JM, Sohn J, Kim J. Phenylbutyric acid induces the cellular senescence through an Akt/p21WAF1 signaling pathway. Biochem Biophys Res Commun 2012. 422:213–218
• 8. Kim JY, Yu S-J, Oh HJ, Lee JY, Kim Y, Sohn J. Panaxydol induces apoptosis through an increased intracellularcalcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species Apoptosis 2011. 16(4):347-58
• 9. Lee BN, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, Lee YH, Song GG, Kim Y, Lee JY, Sohn J, Ji JD. Upregulation of interleukin-1β production by 1,25-dihydroxyvitamin D(3) in activated human macrophages. Mol Biol Rep 2011 38(3):2193-201
• 10. Lee B, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, Lee YH, Song GG, Sohn J, Park-Min KH, Ivashkiv LB, Ji JD. Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta. J Immunol 2010 185(10):5926-34
• 11. Lee JY, Kim HS, Kim JY, Sohn J. Nuclear translocation of p21(WAF1/CIP1) protein prior to its cytosolic degradation by UV enhances DNA repair and survival. Biochem Biophys Res Commun 2009 390(4):1361-6.
• 12. Kim JE, Koo KH, Kim YH, Sohn J, Park YG. Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model. Exp Mol Med 2008 40(6):709-20
• 13. Cheon H, Woo YS, Lee JY, Kim HS, Kim HJ, Cho S, Won NH, Sohn J. Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages. Exp Mol Med 2007 39(4):524-34
• 14. Lee JY, Yu SJ, Park YG, Kim J, Sohn J GSK-3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation Mol Cell Biol 2007 27(8):3187-3198
• 15. Cheon H, Rho YH, Choi SJ, Lee YH, Song GG, Sohn J, Won NH, Ji JD. Prostaglandin E2 augments IL-10 signaling and function. J Immunol 2006 177(2):1092-100
• 16. Cho TH, Park H-Y, Cho S, Sohn J, Yoon YW, Cho J-E, Cho S-W The time course of biological and immunochemical allergy states induced by anisakis simplex larvae in rats Clin Exp Immunol 2006 143(2):203-8
• 17. Kim HJ, Rho YH, Choi SJ, Lee YH, Cheon HJ, Um JW, Sohn J, Song GG, Ji JD. 15-Deoxy-delta(12,14)-PGJ(2) inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. Exp Mol Med 2005 37(3):179-85
• 18. Sohn J, Lee CW, Lee JH, Lee KC, Son CS, Lee JW, Ha-Lee YM. Mutation analysis of hepatitis B virus promoters in chronically infected children. Arch Virol 2005 150(8):1639-51
• 19. Ji JD, Kim HJ, Rho YH, Choi SJ, Lee YH, Cheon HJ, Sohn J, Song GG. Inhibition of IL-10-induced STAT3 activation by 15-deoxy-{Delta}12,14-prostaglandin J2. Rheumatology (Oxford) 2005 44(8):983-8
• 20. Jeon SH, Woo C-W, Lee JH, Sohn J, Lee KC, Son CS, Lee JW Activation of caspase-3 in hydrogen peroxide-induced apoptosis of human leukemia HL60 cells. Korean J Pediatric Hematol-Oncol 2004 11(2) 228-35
• 21. Cheon H, Sun YK, Yu SJ, Lee YH, Ji JD, Song GG, Lee JH, Kim MK and Sohn J Platelet-derived growth factor-AA increases IL-1β and IL-8 expression and activates NF-κB in rheumatoid fibroblast-like synoviocytes Scand J Immunol 2004 60(5):455-62
• 22. Yu S-J, Kim HS, Cho S-W, and Sohn J IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1 Exp Mol Med 2004 36(4): 372-9
• 23. Choe JG, Kim M-K, Oh EJ, Yu EJ, Sohn J, Park MK, and Park GH Pharmacokinetics of 111In-labeled triplex-forming oligonucleotide targeting human N-myc gene. Mol Cells 2002 14(1):93-100
• 24. Park GH, Choe J, Choo H-J, Park YG, Sohn J, and Kim M-K. Genome-wide expression profiling of 8-chloroadenosine- and 8-chloro-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray. Exp Mol Med 2002 34(3):184-93
• 25. Cheon H, Yu SJ, Yoo DH, Chae IJ,　Song GG, and Sohn J. Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin Exp Immunol 2002 127(3):547-52
• 26. Lee YH, Ji JD, Sohn J, and Song GG. Polymorphisms of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathies. Clin Rheumatol 2001 20(6):420-2
• 27. Ryu C-K, Pie J-E, Choe JG, Cheon J, Sohn J, Seidel J, Paik DS, Green MV, Paik CH, and Kim MK. Differential diagnosis of chemical-induced hepatobiliary toxicities using a new hepatobiliary imaging agent in mice Environmental Mutagens & Carcinogens 2001 21(1):1-8
• 28. Ji JD, Choi SJ, Kim YR, Cheon HJ, Lee YH, Kim TH, Jun JB, Chae IJ, Song GG, Yu DH, Kim SY, and Sohn J Effects of PPARgamma on the expression of inflammatory cytokines and apoptosis induction in rheumatoid synovial fibroblasts and monocytes. J Autoimmun 2001 17(3):215-21
• 29. Lee YH, YR Kim, JD Ji, J Sohn, and Song GG. p53 codon 72 polymorphism and rheumatoid arthritis. J Rheumatol 2001 28(11):2392-4
• 30. Lee YH, YR Kim, JD Ji, J Sohn, and GG Song. Polymorphisms of the CTLA-4 exon 1 and promoter gene in systemic lupus erythematosus. Lupus 2001 10(9):601-5
• 31. Lee YH, YR Kim, JD Ji, J Sohn, and GG Song. Fas promoter -670 polymorphism is associated with development of anti-RNP antibodies in systemic lupus erythematosus. J Rheumatol 2001 28(9):2008-11
• 32. Pyon HS, YM Ha-Lee, GG Song, and J Sohn Analysis of immunoglobuin kappa light chain gene variable region expressed in the rheumatoid synovial B cells Scand J Immunol 2001 53(5):503-9
• 33. Lee J-N, D-Y Lee, I-H Ji, G-E Kim, HN Kim, J Sohn, S Kim, and C-W Kim Purification of soluble β-glucan with immune-enhancing activity from cell wall of yeast. Biosci Biotechnol Biochem 2001 65 (4): 837-41
• 34. Ha-Lee YM, J Lee, H Pyun, Y Kim, J. Sohn, YJ Cho, and Y Kim Sequence variations of hepatitis B virus promoter regions in persistently infected patients. Arch Virol 2001 146:279-92
• 35. Moon J, S-J Yu, H-S Kim, and J Sohn Induction of G1 cell cycle arrest and p27KIP1 increase by panaxydol isolated from Panax ginseng. Biochem Pharm 2000 59:1109-16
• 36. Lee JE, J Sohn, JH Lee, KC Lee, CS Son, YC Tockgo Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells. Exp Mol Med 2000 32(1): 42-6
• 37. Ha-Lee YM, Y Lee, YK Kim, J Sohn Cross-linking of CD4 induces cytoskeletal association of CD4 and p56lck. Exp Mol Med 2000 32(1): 23-8
• 38. Park MH, TJ Yoon, HJ Chun, SJ Lee, G Lee, KH Kim, CW Song, SH Um, SW Lee, JH Choi, CD Kim, HS Ryu, SJ Yu, J Sohn, and JH Hyun Effect of interferon-gamma on growth and cell cycle progression of stomach cancer cells. Korean J Gastroenterol 2000 33(1):38-50
• 39. Cho H, S-J Yu, JY Roh, W-I Hwang, and J Sohn Molecular Mechanism of the antiproliferative effect by ginseng panaxynol on a human malignant melanoma cell line, SK-MEL-1. J Ginseng Res 1999 23(3): 190-7
• 40. Kim HN, JN Lee, G-E Kim. Y-M Ha-Lee, CW Kim, and J Sohn Comparative study of immune-enhancing activity of crude and mannoprotein-free yeast beta-glucan preparations. J Microbiol Biotech 1999. 9(6):826-31
• 41. Rho YG, S-j Yu, H-J Cheon, and J Sohn Effects of TGF-β, GM-CSF, and PDGF on proliferation and expression of cytokine and metalloproteinase genes in rheumatoid synovial cells. Korean J Immunol 1998. 20(2):119-27
• 42. Sohn J, C-H Lee, D-J Chung, S-H Park, I Kim, and WI Hwang. Effects of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cell lines. Exp Mol Med 1998. 30 (1):47-51
• 43. Kim HJ, JY Roh, JO Choi, SH Park, IS Kim, J Sohn and CK Ryu Effects of lipid soluble components of Korean Red Ginseng on proliferation and cell cycle regulation factors in human melanoma cell lines. J Korean Cancer Assoc 1997. 29(6): 965-76
• 44. Kim MJ, B-S Kim, SY Lee, J Sohn, CY Kim, M-S Choi, and M-U Choi Effect of glycerophospholipid on oleate-dependent phospholipase D in mammalian source. Bull. Korean Chem Soc 1997. 18(11):1204-7
• 45. Sohn J, DH Woo, DJ Chung, and WI Hwang. Heavy chain V regions of IgG produced by rheumatoid synovial B cells. Korean J Immunol 1997. 19(2):171-80.
• 46. Cheon J, DJ Chung, JJ Kim, SK Koh, and J Sohn Growth inhibition of renal cell carcinoma cell lines in vitro by interleukin-4 alone, and combination with interferon-α, or tumor nerosis factor-α. Int J Urology 1996. 3:192-7
• 47. Chung DJ, GG Song, and J Sohn Immunoglobulin light chain variable region genes of the B cell lines derived from the peripheral blood of a rheumatoid arthritis patient. Korean J Immunol 1996. 18:13-23
• 48. Park YG, M-K Kim, J Sohn, GH Park, and CK Ryu γ-Glutamyltransferase in adult rat hepatocyte during proliferation. Exp Mol Med 1996. 28:17-23
• 49. Sigurdardottir D, J Sohn, J Kass, and E Selsing Regulatory regions 3' of the immuniglobulin heavy chain intronic enhancer differentially affect expression of a heavy chain transgene in resting and activatid B cells. J Immunol 1995. 154:2217-25.
• 50. Kim M-K, Y-G Park, J Sohn, G-H Park and C-K Ryu Application of six Monoclonal antibodies in vitro and in vivo assays to evaluate the tissue specificity of γ-glutamyltransferase. Korean J Biochem 1995. 27:105-15
• 51. Sohn J, BH Kim, DJ Chung, SM Ra and CK Ryu Immunoglobulin light chain variable region gene of a B cell line derived from the rheumatoid synovium Korean J Immunol 1995. 17:65-72.
• 52. Cheon J , DJ Chung, JB Choi, SK Koh and J Sohn Interleukin-4 receptor expression on human renal cell carcinoma cell lines by a reverse transcription-polymerase reaction. Korean J Urol 1995. 36:121-7
• 53. Sohn J, RM Gerstein, C-L Hsieh, M Lemer, and E Selsing Somatic hypermutation of an immunoglobulin μ heavy chain transgene. J Exp Med 1993. 177:493-504
• 54. Hwang WI and J Sohn Comparative Study on the cytotoxic activities of red ginseng of Korea and China (III). Korean J Ginseng Sci 1993. 17:196-202
• 55. Yamada Y, K Kimball, S Okusawa, G Vachin., N Margolis, J Sohn, JJ Lee, G Wakabayashi, K McAdam, J Burke, C Dinarello, and JA Gelfand Cytokines, acute phase proteins, and tissue injury: C-reactive protein opsonizes dead cells for debridement and stimulates cytokine production. Ann N Y Acad Sci Micronutrients and immune functions 1990. 587: 351-61.

국내학술지

• 1. 손정원, 류총근 신생 백서 및 carcinogen 투여 백서 간내 γ-glutamyl transferase에 관한 연구. 최신의학 1992. 35:25-34
• 2. 강신영, 손정원, 류총근 미맥혼식이 cholesterol 및 무기질 대사에 미치는 영향 고려대학교 의과대학 논문집 1986. 23:27-37

Research Topic

1. 세포노화의 기전과 암치료에 대한 응용

세포노화는 세포자멸사와 함께 암발생에 대한 세포의 주요 방어기전이다. 예를 들면 Ras oncogene이 활성화되었을 때, 정상 세포는 암화되기 보다는 세포노화가 일어나 증식을 멈추게 됨으로써 암발생이 방지되며, 세포노화를 극복하였을 때 비로서 세포의 증식과 암화가 진행되게 된다. 그러나 최근에는 암 발생 후 치료 과정에서 화학요법제에 노출된 암세포가 대부분 사멸하게 되지만 일부는 스트레스성 세포노화를 겪고 살아남게 되며 이러한 세포가 암 줄기세포의 성질을 획득함으로써 세포노화가 암의 재발, 항암제 내성, 전이등에 기여하는 것으로 의심받고 있다. 그러므로 세포노화 기전의 이해는 암 발생기전의 이해는 물론 성공적인 암치료 전략의 개발을 위해서도 필수적이라고 할 수 있다.

 현재 우리 실험실에서는 암세포의 세포노화기전을 연구하고 있으며, 여기서 p38 MAPK, NADPH oxidase 활성화에 의한 산화스트레스와 함께 소포체 스트레스(ER stress)가 중요한 역할을 하는 것을 밝혔고, 소포체 스트레스에 의한 unfolded protein response를 매개하는 3가지 센서 분자중 ATF6α가 세포노화를 매개하는 역할을 하는 분자임을 규명하였다.

2. 인삼 panaxydol 성분의 항암 작용과 기전

인삼의 C17 polyacetylene 성분들은 항암효과를 가지는 것으로 알려져 있다. 우리 실험실에서는 이들 중 panaxydol이 암세포의 세포사멸을 유도하는 분자 기전을 규명하였다. panaxydol은 EGFR 활성화와 소포체 칼슘 방출에 의한 세포내 칼슘농도 증가, JNK와 p38 MAPK 활성화 및 NADPH oxidase 활성화, 소포체 스트레스에 의한 PERK 활성화를 통하여 미토콘드리아 경로의 세포자멸사가 유도됨을 보고하였다. 또한 panaxydol은 생쥐 암모델을 이용한 실험에서도 뛰어난 항암효과를 항암치료제로 개발될 수 있는 가능성이 높다.

• 생화학: 의예과, 의학과
• 면역학: 의학과
• 세포생물학: 의예과
• 종양의 분자세포생물학: 대학원
• 실험생화학: 대학원

김용진: 박사과정

채화정: 조교