설 근 희 교수 [생리학 전공]

• Geun Hee SEOL, RN, PhD.
• Professor
• Department of Basic Nursing Science, College of Nursing
• KOREA UNIVERSITY
• Email: ghseol@korea.ac.kr | Phone: 82-2-3290-4922
•  

Dr. Geun-Hee Seol is Professor in the Department of Basic Nursing Science at Korea University College of Nursing. Following postdoctoral training in the Department of Neuroscience at Johns Hopkins University, she joined Korea University in 2006 and has since been engaged in research and education in basic and translational nursing science. Her research focuses on intracellular Ca²⁺ signaling and oxidative stress mechanisms underlying neuronal, vascular, and cardiovascular dysfunction, with particular emphasis on disease models associated with Ca²⁺ dysregulation, including neurodegenerative, neuroinflammatory, vascular, and stress-related disorders. Her laboratory investigates how natural products, essential oils, and bioactive compounds regulate Ca²⁺ homeostasis, ROS-associated signaling, neuroinflammation, endothelial dysfunction, and mitochondrial dysfunction under pathological conditions using cellular and animal disease models. Her translational research integrates cellular, animal, and clinical approaches to identify preventive and therapeutic strategies targeting hypertension, neurovascular diseases, and stress-related conditions, particularly through modulation of SOCE, L-type Ca²⁺ channels, and NOX2/ROS signaling pathways. Dr. Seol currently serves as Academic Editor or Editor for several international journals, including PLOS ONE, Frontiers in Medicine, and Medicine, and is an active member of the Society for Neuroscience, Sigma Theta Tau International, and the American Heart Association.

FIELDS OF INTEREST

•  Intracellular Ca²⁺ signaling
•  Ca²⁺ dysregulation in disease models
•  Neurovascular and cardiovascular dysfunction
•  Oxidative stress and ROS signaling
•  SOCE and L-type Ca²⁺ channels
•  Natural products and essential oils
 

Education & Training

• [신경과학 박사후연구원] Post-Doctoral Fellow in Neuroscience, Mind/Brain Institute, Dept. of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
• [생리학 박사]  Ph.D. in Physiology, College of Medicine, Ewha Womans University, Seoul, Korea.
• [생리학 석사]  M.S. in Physiology, College of Medicine, Ewha Womans University, Seoul, Korea.
• [간호학 학사]  B.S. in Nursing, Dept. of Nursing, Korea University, Seoul, Korea.

Professional Experiences

2025-Present: Editor, PLOS One
2025-Present: President, Korean Educational Association of Integrative Medicine
2022-Present: Editor, Frontiers in Medicine

2022-2023: Editor, Frontiers in Pediatrics

• 2022-2023: Editor, Journal of Korean Academy of Nursing (JKAN)
• 2018-2020: Vice President & Program Committee Chair, Sigma Theta Tau International Lambda Alpha Chapter-at-Large
• 2020-Present: Editor, Korean Society of Biological Nursing Science
• 2018-Present: Editor, Medicine
• 2017-2019: Director, Dept. of Nursing Education, Korea University The Graduate School of Education
• 2016-2018: Communications Committee Chair, Sigma Theta Tau International Lambda Alpha Chapter-at-Large
• 2015-Present: Professor, Dept. of Nursing, Korea University School of Nursing, Korea
• 2015-2017: Director, College of Nursing, Korea University
• 2015-2017: Director, Dept. of Nursing, Korea University Graduate School
• 2015-2025: Vice president, Korean Educational Association of Integrative Medicine
• 2014: Lead Guest Editor, Neural Plasticity
• 2013-2016: Editor, Korean Journal of Human Development
• 2012-Present: Editor, Korean Journal of Stress Research
• 2012-2015: Education Director, Korean Educational Association of Integrative Medicine
• 2011-Present: Counselor, Psychologic Affairs from Korea Psychology Counseling Association
• 2010-2015: Associate Professor, Dept. of Nursing, Korea University School of Nursing, Korea
• 2010-2012: Academic Director, Korean Educational Association of Integrative Medicine
• 2008-2010: Publication Director, Korean Educational Association of Integrative Medicine
• 2006-2010: Assistant Professor, Dept. of Nursing, Korea University School of Nursing, Korea
• 2006-2006: Post-doctoral Fellow, Dept. of Physiology, Eulji University School of Medicine, Korea
• 2004-2006: Post-doctoral Fellow, Mind/Brain Institute, Dept. of Neuroscience, Johns Hopkins University School of Medicine, USA

대학평가 국책 위원회 활동

• 2026-2028: 교육부[Ministry of Education] 인정기관심의위원회 위원
  2025-2027: 식품의약품안전처[MFDS] 식품의약품안전평가원 식품의약품규제과학혁신위원회 연구개발전문위원회 위원
  2023-2024: 한국연구재단[NRF] 학술진흥본부 총괄 심의위원회 위원
  2020-2023: 한국연구재단[NRF] 국립대학 육성사업 사업관리위원회 위원
  2020-2022: 교육부[Ministry of Education] 인정기관심의위원회 위원
• 2019-2020: 한국교육개발원[KEDI] 제3기 대학진단관리위원회 위원
• 2017-2019: 교육부[Ministry of Education] 인정기관심의위원회 위원
• 2017-2019: 한국교육개발원[KEDI] 제2기 대학평가관리위원회 위원
• 2015-2016: 한국대학평가원[KUAI] 인증운영위원회 위원
• 2014-2015: 한국대학평가원[KUAI] 인증기획위원회 위원

Honors and Awards

• 2021 식품 우수기술 100선, 농림축산식품부 농업기술실용화재단[FACT]
• 2021 “명강의상” Best Teaching (Myoung) Award, Korea University The Graduate School of Education, Fall 2020
• 2019 Poster Award, Korean Society of Biological Nursing Science Conference
• 2018 Poster Award, Sigma Theta Tau International Lambda Alpha Chapter-at-Large Conference
• 2017 Excellent Poster Award, Korean Society of Biological Nursing Science Conference
• 2017 Poster Award, Sigma Theta Tau International Lambda Alpha Chapter-at-Large Conference
• 2017 Excellent Poster Award, Korean Society of Biological Nursing Science Conference
• 2016 Poster Award, Korean Society of Biological Nursing Science Conference
• 2015 Poster Award, Korean Society of Biological Nursing Science Conference
• 2014 Poster Award, Korean Society of Biological Nursing Science Conference
• 2013 “명강의상” Best Teaching (Myoung) Award, Korea University The Graduate School of Education, Spring 2013
• 2013 Excellent Paper Award, Korean Society of Stress Medicine Domestic Conference
• 2013 Poster Award, Korean Society of Adult Nursing International Conference
• 2012 “석탑강의상” Outstanding Teaching (Seok-tap) Award, Korea University, Fall 2011
• 2011 Award Certificate, Korean Educational Association of Integrative Medicine
• 2011 The Marquis Who’s Who in the World Publications
• 2011 “명강의상” Best Teaching (Myoung) Award, Korea University The Graduate School of Education, Spring 2011
• 2011 “석탑강의상” Outstanding Teaching (Seok-tap) Award, Korea University, Fall 2010
• 2011 Being listed for inclusion in ‘Marquis Who’s Who in the World 2011’ (세계인명사전등재)
• 2009 “석탑강의상” Outstanding Teaching (Seok-tap) Award, Korea University, Fall 2008
• 2008 Poster Award, The 13th Congress of the Asian College of Psychosomatic Medicine

*Corresponding author

• 
  Shin J, Seol GH^*, Kim YJ, Jeon H. (2026) Differential effects of ginsenosides on Ca2+ regulation in rotenone-treated neuronal and microglial cells. PLoS One. 21(8): e0356602
  
  Jeon H, Kim YJ, Seol GH^*. (2026) Ginsenoside Compound K Differentially Regulates Neuronal and Astrocytic Ca²⁺ Homeostasis Under Trimethyltin-Induced Stress. Pharmaceuticals (Basel). 19: 1376
  
  Kim YJ, Shin J, Seol GH^*. (2025) Linalyl acetate prevents D-galactose and nicotine-induced increases in intracellular Ca²⁺ by inhibiting phospholipase D hyperactivation in MOVAS and L6 cells. Biomed Pharmacother. 191:118538
  
  Choi IY, Kim YJ, Kim SY, Lee MK, Seol GH^*. (2025) Rb₁ restores palmitic acid-induced reduction of Ca²⁺ influx by activating PLC in EA cells and PLD in MOVAS cells. Biomed Pharmacother. 184:117927
  
  Son JW, Kang P, Min SS, Seol GH^*. (2025) Differential effects of clary sage (Salvia sclarea L.) oil and linalyl acetate on depression levels in diabetic foot ulcer patients with T2DM: a randomized blinded controlled trial. Front Med (Lausanne). 12:1523441
  
  Kim YJ, Lee MK, Kim U, Lee JM, Seol GH^*. (2024) Lavandula angustifolia Mill. inhibits high glucose and nicotine-induced Ca²⁺ influx in microglia and neuron-like cells via two distinct mechanisms. Biomed Pharmacother. 177:117062
  
  You J, Shin YK, Seol GH^*. (2024) Alleviating effect of lavender (Lavandula angustifolia) and its major components on postherpetic pain: a randomized blinded controlled trial. BMC Complement Med Ther. 24(1):54
  
  Seo E, Cho Y, Lee JM, Seol GH^*. (2023) Inhalation of Pelargonium graveolens Essential Oil Alleviates Pain and Related Anxiety and Stress in Patients with Lumbar Spinal Stenosis and Moderate to Severe Pain. Pharmaceuticals (Basel). 17(1):1
  
  Sung H, Han AY, Seol GH^*. (2023) BodyThink program-based body image education improves Korean adolescents' attitudes toward cosmetic surgery: randomized controlled trial. BMC Nurs. 22(1):481
  
  Lee SW, Shin YK, Lee JM, Seol GH^*. (2023) Inhalation of Origanum majorana L. essential oil while working reduces perceived stress and anxiety levels of nurses in a COVID-19 intensive care unit: a randomized controlled trial. Front Psychiatry. 14:1287282
  
  Park J, Shin YK, Kim U, Seol GH^*. (2023) Ginsenoside Rb₁ Reduces Hyper-Vasoconstriction Induced by High Glucose and Endothelial Dysfunction in Rat Aorta. Pharmaceuticals (Basel). 16(9):1238
  
  Kim U, Shin YK, Park J, Seol GH^*. (2023) Codonopsis lanceolata Extract Restores Smooth Muscle Vasorelaxation in Rat Carotid Arteries Even under High Extracellular K⁺ Concentrations. Nutrients. 15(17):3791
  
  Shin YK, Seol GH^*. (2023) Effects of linalyl acetate on oxidative stress, inflammation and endothelial dysfunction: can linalyl acetate prevent mild cognitive impairment? Front Pharmacol.. 14: 1233977
  
  Kim JY, Shin YK, Seol GH^*. (2023) Incidence and risk factors for pressure injury in hospitalized non-small cell lung cancer patients: A retrospective observational study. J Tissue Viability. 32(3): 377-382
  
  Kim EG, Chang W, Shin S, Adhikari AS, Seol GH, Song DY, Min SS. (2023) Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus. Korean J Physiol Pharmacol. 27(1): 113-125.
  
  Kim YJ, Shin YK, Seo E, Seol GH^*. (2022) Astrocytes Reduce Store-Operated Ca2+ Entry in Microglia under the Conditions of an Inflammatory Stimulus and Muscarinic Receptor Blockade. Pharmaceuticals (Basel). 15(12): 1521.
  
  Chang W, An J, Seol GH, Han SH, Yee J, Min SS. (2022) Trans-Anethole Alleviates Trimethyltin Chloride-Induced Impairments in Long-Term Potentiation. Pharmaceutics. 14(7): 1422.
  
  Seo E, Shin YK, Hsieh YS, Lee JM, Seol GH^*. (2022) Linalyl acetate restores colon contractility and blood pressure in repeatedly stressed-ulcerative colitis rats. Environ Health Prev Med. 27(0): 27.

  
  Han AY, Ha SM, Shin YK, Seol GH^*. (2022) Ginsenoside Rg-1 prevents elevated cytosolic Ca2+ via store-operated Ca2+ entry in high-glucose-stimulated vascular endothelial and smooth muscle cells. BMC Complement Med Ther. 22(1): 166.

•  

• Kim M, Shin YK, Seol GH^*. (2021) Inhalation of clary sage oil before chemotherapy alleviates anxiety and stress without changing blood pressure: A randomized controlled trial. J Korean Biol Nurs Sci. 23(4):267-275.
•  
• Wu C, Jeong MY, Kim JY, Lee G, Kim JS, Cheong YE, Kang H, Cho CH, Kim J, Park MK, Shin YK, Kim KH, Seol GH, Koo SH, Ko G, Lee SJ. (2021) Activation of ectopic olfactory receptor 544 induces GLP-1 secretion and regulates gut inflammation. Gut Microbes. 13(1):1987782.
•  
• Seo E, Shin YK, Hsieh YS, Lee JM, Seol GH^*. (2021) Linalyl acetate as a potential preventive agent against muscle wasting in rheumatoid arthritis rats chronically exposed to nicotine. J Pharmacol Sci. 147(1):27-32.
•  
• Hsieh YS, Shin YK, Seol GH^*. (2021) Protection of the neurovascular unit from calcium-related ischemic injury by linalyl acetate. Chin J Physiol. 64:88-96.
•  
• Shin YK, Hsieh YS, Han AY, Kwon S, Kang P, Seol GH^*. (2020) Sex-specific susceptibility to type 2 diabetes mellitus and preventive effect of linalyl acetate. Life Sci. 260:118432.
•  
• Shin YK, Lee SY, Lee JM, Kang P, Seol GH^*. (2020) Effects of Short-Term Inhalation of Patchouli Oil on Professional Quality of Life and Stress Levels in Emergency Nurses: A Randomized Controlled Trial. J Altern Complement Med. 26(11):1032-1038.
•  
• Kim MK, Han AY, Shin YK, Lee KW, Seol GH^*. (2020) Codonopsis lanceolata Contributes to Ca2+ Homeostasis by Mediating SOCE and PLC/IP3 Pathways in Vascular Endothelial and Smooth Muscle Cells. Planta Med. 86(18):1345-1352.
•  
• Shin YK, Hsieh YS, Han AY, Kwon S, Seol GH^*. (2020) Sex differences in cardio-metabolic and cognitive parameters in rats with high-fat diet-induced metabolic dysfunction. Experimental Biology and Medicine. 245(11): 977-982
•  
• Bae AH, Kim G, Seol GH, Lee SB, Lee JM, Chang W, Min SS. (2020) Delta- and mu-opioid pathways are involved in the analgesic effect of Ocimum basilicum L in mice. J Ethnopharmacol. 250: 112471
•  
• Shin YK, Hsieh YS, Han AY, Lee KW, Seol GH^*. (2020) Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in pre-hypertensive adults: A double-blind, randomized controlled trial. Phytotherapy Research. 34: 340-348
•  
• Shin YK, Han AY, Hsieh YS, Kwon S, Kim J, Lee KW, Seol GH^*. (2019) Lancemaside A from Codonopsis lanceolata prevents hypertension by inhibiting NADPH oxidase 2-mediated MAPK signalling and improving NO bioavailability in rats. J Pharm Pharmacol. 71(9): 1458-1468
•  
• Hsieh YS, Shin YK, Han AY, Kwon S, Seol GH^*. (2019) Linalyl acetate prevents three related factors of vascular damage in COPD-like and hypertensive rats. Life Sci. 232: 116608
•  
• Lee YS, Kim H, Kim J, Seol GH^*, Lee KW. (2019) Lancemaside A, a major triterpene saponin of Codonopsis lanceolata enhances regulation of nitric oxide synthesis via eNOS activation. BMC Complement Altern Med. 19(1): 110
•  
• Lee G, Park J, Kim MS, Seol GH, Min SS. (2019) Analgesic effects of eucalyptus essential oil in mice. Korean J Pain. 32(2): 79-86
•  
• Hsieh YS, Kwon S, Lee HS, Seol GH^*. (2018) Linalyl acetate prevents hypertension-related ischemic injury. PLoS One. 13(5): e0198082
•  
• Kwon S, Hsieh YS, Shin YK, Kang P, Seol GH^*. (2018) Linalyl acetate prevents olmesartan-induced intestinal hypermotility mediated by interference of the sympathetic inhibitory pathway in hypertensive rat. Biomed Pharmacother. 102: 362-368
•  
• Seo E, Kang P, Seol GH^*. (2018) Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Biomed Pharmacother. 102: 249-253
•  
• Shin YK, Hsieh YS, Kwon S, Lee HS, Seol GH^*. (2018) Linalyl acetate restores endothelial dysfunction and hemodynamic alterations in diabetic rats exposed to chronic immobilization stress. J Appl Physiol. 124(5): 1274-1283
•  
• Han AY, Lee YS, Lee HS, Kwon S, Lee KW, Seol GH^*. (2018) Codonopsis lanceolata extract prevents hypertension in rats. Phytomedicine. 39: 119-124
•  
• Kim JR, Kang P, Kim KY, Seol GH^*. (2017) Cardiovascular effects of linalyl acetate in acute nicotine exposure. Environ Health Prev Med. 22(42): 1-7
•  
• Kim KY, Lee HS, Seol GH^*. (2017) Anti-inflammatory effects of trans-anethole in a mouse model of chronic obstructive pulmonary disease. Biomed Pharmacother. 91: 925-930
•  
• Chae JS, Heo N, Kwak CH, Cho W, Seol GH, Yoon W, Kim H, Fray DJ, Vilian A.T.E., Han Y, Huh YS, Roh KC. (2017) A biocompatible implant electrode capable of operating in body fluids for energy storage devices. Nano Energy. 34: 86-92
•  
• Yu SH, Seol GH^*. (2017) Lavandula angustifolia Mill. Oil and Its Active Constituent Linalyl Acetate Alleviate Pain and Urinary Residual Sense after Colorectal Cancer Surgery: A Randomised Controlled Trial. Evid Based Complement Alternat Med. 2017: 3954181
•  
• Seol GH^*, Kim KY. (2016) Eucalyptol and Its Role in Chronic Diseases. Adv Exp Med Biol. 929: 389-398 Book Chapter
•  
• Han AY, Lee HS, Seol GH^*. (2016) Foeniculum vulgare Mill. increases cytosolic Ca²⁺ concentration and inhibits store-operated Ca²⁺ entry in vascular endothelial cells. Biomed Pharmacother. 84: 800-805
•  
• Kang P, Ryu KH, Lee JM, Kim HK, Seol GH^*. (2016) Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca2+ modulation. Biomed Pharmacother. 82: 467-471
•  
• Park H, Seol GH, Ryu S, Choi IY. (2016) Neuroprotective effects of (-)-linalool against oxygen-glucose deprivation-induced neuronal injury. Arch Pharm Res. 39(4): 555-564
•  
• Seol GH, Kang P, Lee HS, Seol GH^*. (2016) Antioxidant activity of linalool in patients with carpal tunnel syndrome. BMC Neurology. 16(1): 17
•  
• Hwang MJ, Seol GH^*. (2015) Cerebral oxygenation and pain of heel blood sampling using manual and automatic lancets in premature infants. J Perinat Neonatal Nurs. 29(4): 356-362
•  
• Kim KY, Lee HS, Seol GH^*. (2015) Eucalyptol suppresses matrix metalloproteinase-9 expression through an extracellular signal-regulated kinase-dependent nuclear factor-kappa B pathway to exert anti-inflammatory effects in an acute lung inflammation model. J Pharm Pharmacol. 67(8): 1066-1074
•  
• Lee HS, Kang P, Kim KY, Seol GH^*. (2015) Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-kB Activation. Korean J Physiol Pharmacol. 19(2): 183-189
•  
• Kang P, Seol GH^*. (2015) Linalool elicits vasorelaxation of mouse aortae through activation of guanylyl cyclase and K+ channels. J Pharm Pharmacol. 67(5): 714-719
•  
• Yang HJ, Kim KY, Kang P, Lee HS, Seol GH^*. (2014) Effects of Salvia sclarea on chronic immobilization stress induced endothelial dysfunction in rats. BMC Complement Altern Med. 14(1): 396
•  
• Ryu S, Park H, Seol GH^*, Choi IY. (2014) 1,8-Cineole ameliorates oxygen-glucose deprivation/reoxygenation-induced ischemic injury by reducing oxidative stress in rat cortical neuron/glia. J Pharm Pharmacol. 66(12): 1818-1826
•  
• Kim KY, Seo HJ, Min SS, Park M, Seol GH^*. (2014) The effect of 1,8-cineole inhalation on preoperative anxiety: a randomized clinical trial. Evid Based Complement Alternat Med. 2014: 820126
•  
• Ryu S, Seol GH, Park H, Choi IY. (2014) Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation. Neurol Sci. 35: 1541-1547
•  
• Choi SY, Kang P, Lee HS, Seol GH^*. (2014) Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial. Evid Based Complement Alternat Med. 2014: 756518
•  
• Moon HK, Kang P, Lee HS, Min SS, Seol GH^*. (2014) Effects of 1,8-Cineole on Hypertension Induced by Chronic Exposure to Nicotine in Rats. J Pharm Pharmacol. 66(5): 688-693
•  
• Kang P, Suh SH, Min SS, Seol GH^*. (2013) Citrus bergamia Risso elevated intracellular Ca2+ in human endothelial cells due to release of Ca2+ from primary intracellular stores. Evid Based Complement Alternat Med. 2013: 759615
•  
• Kang P, Kim KY, Lee HS, Min SS, Seol GH^*. (2013) Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice. Life Sci. 93(24): 955-961
•  
• Seol GH^*, Lee YH, Kang P, You JH, Park M, Min SS. (2013) Randomized controlled trial for Salvia sclarea or Lavandula angustifolia: Differential effects on blood pressure in female patients with urinary incontinence undergoing urodynamic examination. J Altern Complement Med. 19(7): 664-670
•  
• Kang P, Suh SH, Min SS, Seol GH^*. (2013) The essential oil Citrus bergamia Risso induces vasorelaxation of mouse aorta by activating K+ channels and inhibiting Ca2+ influx. J Pharm Pharmacol. 65(5): 745-749
•  
• You JH, Kang P, Min SS, Seol GH^*. (2013) Bergamot essential oil differentially modulates intracellular Ca2+ levels in vascular endothelial and smooth muscle cells: a new finding seen with Fure-2. J Cardiovasc Pharm. 61(4): 324-328
•  
• Jun YS, Kang P, Min SS, Lee JM, Kim HK, Seol GH^*. (2013) Effect of eucalyptus oil inhalation on pain and inflammatory responses after total knee replacement: A randomized clinical trial. Evid Based Complement Alternat Med. 2013: 502727
•  
• Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS. (2013) Phorbol 12-myristate 13-acetate enhances long-term potentiation through activation of a protein kinase Cδ and ε in hippocampus. Korean J Physiol Pharmacol. 17(1): 51-56
•  
• Kim H, Han SH, Quan HY, Jung YJ, An J, Kang P, Park JB, Yoon BJ, Seol GH^*, Min SS. (2012) Bryostatin-1 promotes long-term potentiation via activation of PKCα and PKCε in the hippocampus. Neuroscience. 226: 348-355
•  
• Kang P, Jung KM, Min SS, Seol GH^*. (2012) Effect of basil essential oil-inhalation on pain, anxiety and vital sign in patients with chronic low back pain before spine surgery: A double-blind, randomized controlled trial. Korean J Str Res. 20(3): 169-178
•  
• Min SS, An J, Lee JH, Seol GH, Im JH, Kim HS, Baik TK, Woo RS. (2011) Neuregulin-1 prevents amyloid β-induced impairment of long-term potentiation in hippocampal slices via ErbB4. Neurosci Lett. 505(1): 6-9
•  
• Seol GH^*, Jung MH. (2011) Effect of bergamot essential oil-inhalation on chronic pain after surgery for lumbar spinal stenosis. J Korean Biol Nurs Sci. 13(2): 156-163
•  
• You JH, Kim MY, Moon HK, Min SS, Seol GH^*. (2011) Effect of clary sage-inhalation on pain and stress during the treatment of periodontitis. J Korean Acad Oral Health. 35(1): 32-40
•  
• Seol GH, Shim HS, Kim PJ, Moon HK, Lee KH, Shim I, Suh SH, Min SS. (2010) Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats. J Ethnopharmacol. 130(1):187-190
•  
• Min SS, Han SH, Yee J, Kim C, Seol GH, Im JH, Kim HT, Lee KC, Kim HY, Lee MJ. (2009) Antinociceptive effects of the essential Oil of Ocimum basilicum in mice. Korean J Pain. 22(3): 206-209
•  
• Zhang GH, Min SS, Seol GH, Lee KS, Han H, Kim YI, Han HC. (2009) Inhibition of the N-methyl-D-aspartate receptor unmasks the antinociception of endogenous opioids in the periphery. Pain. 143(3): 233-237
•  
• Min SS, Quan HY, Ma J, Han JS, Jeon BH, Seol GH^*. (2009) Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area. Neurosci Lett. 456(1): 20-24
•  
• Min SS, Quan HY, Ma J, Lee KH, Back SK, Na HS, Han SH, Yee JY, Kim C, Han JS, Seol GH^**. (2009) Impairment of long-term depression induced by chronic brain inflammation in rats. Biochem Biophys Res Commun. 383(1):93-97
•  
• Lee MJ, Shim HS, Seol GH, Kim PJ, Han SH, Yee J, Kim C, Lee KC, Kim HY, Min SS. (2008) Effects of intra-articular injection of agmatine and clonidine into the knee joint cavity on the induction and maintenance of arthritic pain in rats. Korean J Anesthesiol. 54(6): 656-661
•  
• Liang GH, Kim JA, Seol GH, Choi S, Suh SH. (2008) The Na+/Ca2+exchanger inhibitor KB-R7943 activates large-conductance Ca2+-activated K+ channels in endothelial and vascular smooth muscle cells. Eur J Pharmacol. 582(1-3): 35-41
•  
• Seol GH, Ziburkus J, Huang S, Song L, Kim IT, Takamiya K, Huganir RL, Lee HK, Kirkwood A. (2007) Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity. Neuron. 55(6): 919-929
•  
• Song JA, Jang SO, Lim YJ, Lee SJ, Kim SY, Seol GH. (2007) Factors affecting loneliness in community dwelling Korean elders. J Korean Acad Fundam Nurs. 14(3): 371-381
•  
• Choi SY, Chang J, Jiang B, Seol GH, Min SS, Han JS, Shin HS, Gallagher M, Kirkwood A. (2005) Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex. J Neurosci. 25(49): 11433-11443
•  
• Seol GH, Kim MY, Liang GH, Kim JA, Kim YJ, Oh S, Suh SH. (2005) Sphingosine-1-phosphate–induced intracellular Ca2+ mobilization in human endothelial cells. Endothelium 12(5) 263-267
•  
• Kim MY, Seol GH, Liang GH, Kim JA, Suh SH. (2005) Na+-K+ pump activation inhibits endothelium-dependent relaxation by activating the forward mode of Na+/Ca2+ exchanger in mouse aorta. Am J Physiol Heart Circ Physiol. 289(5): H2020-2029
•  
• Seol GH, Ahn SC, Kim JA, Nilius B, Suh SH. (2004) Inhibition of endothelium-dependent vasorelaxation by extracellular K+: a novel controlling signal for vascular contractility. Am J Physiol Heart Circ Physiol. 286(1): H329-339
•  
• Ahn SC, Seol GH, Kim JA, Suh SH. (2004) Characteristics and a functional implication of Ca2+-activated K+ current in mouse aortic endothelial cells. Pflugers Arch. 447(4): 426-435
•  
• Jeon SH, Seol GH, Suh SH, Park SH. (2004) Nitric oxide-induced intracellular Ca2+ modulation in macrovascular endothelial cells. Korean Circulation J. 34(9): 600-609
•  
• You JY, Seol GH, Suh SH, Ahn JH. (2004) Regulatory mechanism of vascular contractility by extracellular K+: effect on endothelium-dependent relaxation and smooth muscle contractility. Korean J Thorac Cardiovasc Surg. 37(3): 210-219
•  
• Seol GH, Kim J, Cho SH, Kim WK, Kim JW, Kim SJ. (2001) The inhibitory effect of opioid on the hyperpolarization-activated cation currents in rat substantia gelatinosa neurons. Korean J Physiol Pharmacol. 5(5):373-380

Patents

• 
  (2025.09) Methods for suppressing the increases in intracellular Ca2+ concentrations in microglia using astrocytes. 국내특허등록
  
  (2023.03) Dementia animal model comprising dementia risk factors characterized by male-specific dementia predicting markers and its manufacturing method. 국내특허등록
  
  (2023.01) Composition for Preventing or Treating Sarcopenia Comprising Linalyl Acetate. 국내특허등록
  
  (2022.10) Composition for Preventing or Improving Anxiety Disorder Comprising Linalyl Acetate. 국내특허등록
•  
• (2021.10) Composition for reducing high sensitivity C-reactive protein level in subjects with prehypertension comprising Codonopsis lanceolata extract, 특허등록
•  
• (2021.02) Chronic stress-exposed animal model of diabetes mellitus characterized by overproduction of nitric oxide, vascular endothelial dysfunction and heat rate reduction. its manufacturing method and uses thereof, 특허등록
•  
• (2020.12) Composition for Preventing or Treating Vascular Disease Comprising Codonopsis Lanceolata Extract containing Lancemaside A. 특허등록
•  
• (2020.12) Animal Model of Chronic Obstructive Pulmonary Disease with Pulmonary Hyper-vasorelaxation and Hypertension, Its Manufacturing Method and Uses Thereof. 특허등록
•  
• (2019.04) Composition for Preventing or Treating Olmesartan-Induced Tachycardia Comprising Linalyl Acetate. 특허등록
•  
• (2019.04) Composition for Preventing or Treating Olmesartan-Induced Intestinal Hypermotility Comprising Linalyl Acetate. 특허등록
•  
• (2017.05) Pharmaceutical Composition for Preventing or Treating Diabetes Comprising Linalyl Acetate. 특허등록

Books

• [저서] (2026) Human Anatomy, 1^st ed. (인체해부학 제1판), 현문사
   

  [저서] (2024) Human Physiology, 2^nd ed. (생리학 제2판), 현문사

   

• [저서] (2023) (초등학교) 보건: 5~6, 지구문화

•  

  [저서] (2023) (초등학교) 보건: 교사용 지도서: 5~6학년, 지구문화

•  

  [저서] (2021) Human Physiology, 1^st ed. (생리학 1판), 현문사

•  

  [역서] (2020) Human Diseases, 8^th ed. (병태생리학 8판), 바이오사이언스
   

  [역서] (2014) Essentials of Anatomy and Physiology (해부생리학), 8^th ed., 현문사
   

  [역서] (2014) Human Diseases, 7^th ed. (병태생리학 7판), 바이오사이언스
   

  [역서] (2014) Introduction to Clinical Pharmacology, 7^th ed. (임상약리학 7판), 엘스비어코리아
   

  [역서] (2013) Color Atlas of Pathophysiology (그림으로 이해하는 병태생리학), 서울메디메디아
   

  [역서] (2013) Pathophysiology (병태생리학: 질병의 경과와 회복 촉진), 정문각
   

  [저서] (2013) Essential of medical terminology (에센스) 의학용어, 메디시언
   

  [역서] (2010) Pharmacology (약리학), 정문각
   

  [역서] (2009) Human Diseases, 6^th ed. (병태생리학 6판), 바이오사이언스
   

  [역서] (2009) Comprehensive Stress Management (포괄적 스트레스 관리), 아카데미아

Reserch Interests

Ca²⁺ Dysregulation, Oxidative Stress, and Preventive Translational Research Using Natural Products and Disease Models

Our research focuses on intracellular Ca²⁺ signaling and oxidative stress mechanisms underlying neuronal, vascular, and cardiovascular dysfunction in health and disease. In particular, we investigate disease models associated with Ca²⁺ dysregulation, including neurodegenerative, neuroinflammatory, vascular, and stress-related disorders. Our laboratory aims to better understand how natural products, essential oils, and bioactive compounds regulate Ca²⁺ homeostasis, ROS-associated signaling, neuroinflammation, endothelial dysfunction, and mitochondrial dysfunction under pathological conditions.

Current studies emphasize preventive and translational approaches using cellular and animal disease models to identify potential strategies for disease prevention and health promotion. We are particularly interested in the roles of store-operated Ca²⁺ entry (SOCE), L-type Ca²⁺ channels, NOX2/ROS signaling, and neurovascular interactions in disease progression and therapeutic modulation. Our long-term goal is to develop evidence-based preventive and integrative interventions targeting hypertension, neurovascular dysfunction, stress-related disorders, and cardio-metabolic diseases.

Main Research Topics

•  Intracellular Ca²⁺ signaling and Ca²⁺ dysregulation in disease models

•  Oxidative stress, ROS signaling, and mitochondrial dysfunction

•  Neurovascular and cardiovascular dysfunction

•  Natural products, essential oils, and bioactive compounds

•  Stress-related disorders and cardio-metabolic diseases

•  Preventive and translational research using cellular and animal models

•  SOCE, L-type Ca²⁺ channels, and NOX2/ROS-associated pathways

Research Project as Principal Investigator

2024.05-2027.04 [한국연구재단] 개인기초연구(이공)우수연구-중견연구(유형1) (725,895,000원) 흰쥐에서 고혈당/고혈압에 의한 이상지질혈증 수준이 인지장애에 미치는 성별에 따른 핵심 기전과 후보 생리활성 천연물 발굴 및 예방 기술 규명 (연구책임자)
 

2021.03-2024.02 [한국연구재단] 개인기초연구사업 (이공)(유형1-2)중견연구 (587,729,000원) 청소년기 흰쥐에서 불균형 식이에 의한 인슐린 저항성이 인지기능 저하와 정서 장애에 미치는 성별에 따른 핵심 기전 및 리나릴 아세테이트를 활용한 예방 기술 규명 (연구책임자)

2018.06-2021.05 [한국연구재단] 이공학개인기초연구사업 기본연구 (162,500,000원) 장운동과다증을 동반한 만성스트레스로 유발된 고혈압 동물모델에서 방향성 천연물 추출물의 제어기전 연구 (연구책임자)

2016.11-2018.10 [한국연구재단] 이공학개인기초연구사업 기본연구 (100,000,000원) 방향성 천연물의 저산소성 뇌혈관 손상 제어 기전 규명 (연구책임자)
 

2016.03-2019.03 [산림청] 융복합기반임산업의신산업화기술개발지원사업 (235,098,920원) 더덕추출물의 지표성분의 심혈관계 작용기전 및 임상중재에 대한 연구 (연구책임자)

2012.05-2015.04 [한국연구재단] 중견연구자지원 핵심공동연구 (606,000,000원) 아로마의 허혈성 뇌손상 억제 효과 및 시냅스 가소성 변화에 관한 연구 (연구책임자)

2010.05-2013.04 [한국연구재단] (이공)일반연구자-신진연구(연구장비지원)(194,527,000원) 염증성 통증모델에서 아로마를 이용한 진통 효능 기전 연구 (연구책임자)

2009.05-2012.04 [한국연구재단] (이공)일반연구자지원-여성과학자 (139,762,000원) 혈관긴장도에 미치는 아로마의 항고혈압 기전에 대한 연구 (연구책임자)

2007.05-2010.02 [한국과학재단] 특정기초연구 (140,216,980원) 아로마의 허혈성 뇌손상 억제 효과 및 시냅스 가소성 변화에 관한 연구 (연구책임자)

2004.03-2006.02 [한국과학재단] 해외PostDoc연수지원사업 (12,437,260원) 노령쥐의 인지기능과 해마 LTD와의 상관관계 연구 (연구책임자)

Undergraduate Program

• · Basic Nursing Science I (기초간호과학I; 해부생리학I)

  · Basic Nursing Science Lab I (기초간호과학실습I; 해부생리학실습I)

  · Basic Nursing Science II (기초간호과학II; 해부생리학II)

  · Introduction to Basic Nursing Science Research (기초간호과학연구입문)

  · Basic Nursing Science III (기초간호과학III; 병태생리학)

  · Basic Nursing Science IV (기초간호과학IV; 약리학)

Grduate Program

• · Pathophysiology (병태생리학)
  · Pharmacology (약리학)

  · Advanced Basic Nursing Science (기초간호과학특론)

  · Seminar in Basic Nursing Science (기초간호과학연구세미나)

  · Seminar in Pathophysiology (병태생리학세미나)

  · Basic Research Ethics (연구윤리의기초) [4단계 BK21 기초공통]

기초간호과학 연구실

Current members

• · 김유진(박사후연구원)  

  · 신지우(박사과정)  

  · 전하영(석사연구원)
  · 최선희(석사과정)
  · 피승현(조교)  
  · 박연진(학부연구생) 
  · 신채원(학부연구생) 

  · 김수민(학부연구생)  

   

Former members

• · 홍희상(석사)
• · 김미영(석사)
• · 김선미(석사)
• · 문혜경(석사)
• · 정명희(석사)
• · 이윤희(석사)
• · 정금미(석사)
• · 유지혜(석사)
• · 강푸름(석사)
• · 전양숙(석사)
• · 서효진(석사)
• · 황미정(석사)
• · 문혜경(박사, 호서대 간호학과 조교수)
• · 김주리(석사)
• · 양효정(석사)
• · 설근혜(석사)
• · 최인녕(연구교수)
• · 김가영(박사후연구원, 2015 가천대 간호학과 조교수)
• · 한아영(석사)
• · 유소현(석사)
• · 강푸름(박사)
• · 이희수(연구원)
• · 서은혜(석사)
• · 김미란(석사)
• · 권순호(석사)
• · 신유경(석사)
• · 이수연(석사)
• · 김민경(석사)
• · 이소영(석사)
• · 강푸름(박사후연구원, 2020 우석대 간호학과 조교수)
• · YU-SHAN HSIEH(박사, 2021 National Taipei University of Nursing and Health Science 조교수)
• · 한아영(박사)
• · 윤지은(석사)
• · 전선미(석사)
• · 신유경(박사)
• · 김문숙(석사)
• · 한아영(박사후연구원, 2021 순천대 간호학과 조교수)
• · 신유경(박사후연구원)
• · 서은혜(박사, 2024 계명대 간호학과 조교수)
• · 김유진(석사)
• · 하수민(석사)
• · 김재연(석사)
• · 이은샘(석사)
• · 이상욱(석사)
• · 정현주(석사)
• · 유지영(석사)
• · 김의환(석사)
• · 박주빈(석사)
• · 성현화(석사)
  · 조윤아(석사)
• · 이민경(석사) 
• · 전성민(학부연구생) 
• · 손지원(석사) 
• · 최인녕(연구원) 
• · 차민경(학부연구생) 
• · 이채현(학부연구생) 
  

  · 박연진(학부연구생) 

  · 김예빈(석사) 

  · 김유진(박사, 2025.8.) 

  · 신지우(석사) 
  · 전하영(석사)