Education:      

 

1993.3-1997.2                B. S.         Department of Microbiology, Seoul National University

1997.3-1999.2                M.S.         Department of Microbiology, Seoul National University

1999.3-2003.8                Ph.D.        School of Biological Sciences, Seoul National University

 

Professional Career:

 

2004.11-2010.08            Postdoctoral Research Associate, Department of Molecular Microbiology,

                                         Washington University in St. Louis

2010.09-2013.08            Postdoctoral Research Associate, Department of Microbial Pathogenesis, Yale University

2013.04-2017.08            Assistant professor, Department of Genetic Engineering, Kyung Hee University

2017.09-2018.08            Associate professor, Department of Genetic Engineering, Kyung Hee University

2018.01-2018.02            Visiting Scientist, Department of Molecular Biology and Genetics, Johns Hopkins University

2018.09-2022.08            Associate professor, Department of Life Sciences, Korea University

2022.09-present              Professor, Department of Life Sciences, Korea University

 

 

 

 

 

 

59. Kim S, Kim S, Lee EJ* A Salmonella type I toxin promotes systemic infection by inhibiting FoF1 ATP synthase. bioRxiv 2025.05.26.656083; doi: https://doi.org/10.1101/2025.05.26.656083

58. Baek S, Cho YJ, Choi E, Choi S, Lee EJ* Elongation factor P controls ribosomal frameshift of a Salmonella antimicrobial resistance gene. bioRxiv 2024.09.11.612453; doi: https://doi.org/10.1101/2024.09.11.612453.

57. Choi S, Cho YJ, Baek S,  Choi E, Kim YK, Choi TS, Lee EJ* The HigB-like SehA toxin promotes non-replicating Salmonella inside macrophages by inhibiting ribonuclease III. Nucleic Acids Research, 2026, gkaf1534. https://doi.org/10.1093/nar/gkaf1534

56. Zhao Z, Omae K, Iwasaki W, Zhang Z, Pan F, Lee EJ, Ito K, Hattori M* Bioinformatics classification of the MgtE Mg²⁺ channel and de novo protein design for the stabilization of its novel subclass. Acta Biochimica et Biophysica Sinica 2025 accepted

55. Yi, S., Kim, B.S., Choi, E., Lee EJ*, Kim J* Medium dependent factors govern the functionality of engineered type III secretion systems. J Biol Eng 2025. https://doi.org/10.1186/s13036-025-00600-1.

54. Yun S, Kim S, Kim S, Noh M, Kim DK, Lee EJ*, Lee H*. Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection. Advanced Science 2025 Nov 23: e15042.

53. Baek S, Kim S, Lee EJ* A chromosomally integrated T7 RNA polymerase enables T7-derived expression in Salmonella enterica without compromising virulence. J Microbiol Biotechnol 2025 Nov 18;35:e2509023. doi: 10.4014/jmb.2509.09023.

52. Baek S, Choi S, Han Y, Choi E, Park S, Lee JS, Lee EJ*. PhoU interaction with the PhoR PAS domain is required for repression of the pho regulon and Salmonella virulence, but not for polyphosphate accumulation. J Microbiol. 2025 Sep;63(9):e2505013. doi: 10.71150/jm.2505013.

51. Kim D, Baek S, Lee CS, Lee EJ*, Hwang CS*. A pan-N-formylmethionine-specific antibody as a tool for analyzing Nα-terminal formylation. Methods Enzymol. 2025;718:185-214. doi: 10.1016/bs.mie.2025.06.001.

50. Kim J, Park J, Lee EJ, Cho YJ*, Lee JS*. Set1 is a critical transcriptional regulator in response to external signals in Candida albicans. Nucleic Acids Research 2025 Jul 8;53(13):gkaf632. doi: 10.1093/nar/gkaf632.

49. Oh BS, Kim J, Kwon M, Bang J, Lee KJ, Lee EJ, Cho YJ*. SimpleViz: A user-friendly, web-based tool for publication-ready data visualization in bioinformatics. Mol Cells. 2025 Jul;48(7):100222. doi: 10.1016/j.mocell.2025.100222.

48. Eun HJ, Jang SW, Park JH, Lee J, Lee KY, Lee EJ, Lee BJ*. Structural and functional analyses of STM14_5441-STM14_5442: A potential mechanism for persister formation against aminoglycosides. Drug Resist Updat. 2025 Mar;79:101210. doi: 10.1016/j.drup.2025.101210.

47. Park JY, Jang M, Choi E, Lee SM, Bang I, Woo J, Kim S, Lee EJ*, Kim D* ChIP-mini: a low-input ChIP-exo protocol for elucidating DNA-binding protein dynamics in intracellular pathogens. Nucleic Acids Research, 2025.Jan 24. 53(3):gkaf009. doi: 10.1093/nar/gkaf009.

46. Park JY, Jang M, Lee SM, Woo J, Lee EJ, Kim D*. Unveiling the novel regulatory roles of RpoD-family sigma factors in Salmonella Typhimurium heat shock response through systems biology approaches. PLoS Genet. 2024 Oct 29;20(10):e1011464.

45. Oh J, Park S, Kim J, Yeom S, Lee JM, Lee EJ*, Cho YJ*, Lee JS*. Swd2/Cps35 determines H3K4 tri-methylation via interactions with Set1 and Rad6. BMC Biol (2024) 22, 105. https://doi.org/10.1186/s12915-024-01903-3.

44. Choi N, Choi E, Cho YJ, Kim MJ, Choi HW*, Lee EJ*. A shared mechanism of multidrug resistance in laboratory-evolved uropathogenic Escherichia coli. Virulence 2024 15(1). https://doi.org/10.1080/21505594.2024.2367648.

43. Baek S, Lee EJ*. PhoU: A Multifaceted Regulator in Microbial Signaling and Homeostasis. Current Opinion in Microbiology. 2024 Feb;77:102401.

42. Lee SM, Le HT, Taizhanova A, Nong LK, Park JY, Lee EJ, Palsson BO, Kim D*. Experimental promoter identification of a foodborne pathogen Salmonella enterica subsp. enterica serovar Typhimurium with near single base-pair resolution. Front Microbiol. 2024 Jan 4;14:1271121.

41. Kim M, Choi N, Choi E, Lee EJ*. ClC Chloride Channels in Gram-Negative Bacteria and Its Role in the Acid Resistance Systems. J Microbiol Biotechnol. 2023 Jul 28;33(7):857-863.

40. Song H, Choi E, Lee EJ*. Membrane-Bound Protease FtsH Protects PhoP from the Proteolysis by Cytoplasmic ClpAP Protease in Salmonella Typhimurium. J Microbiol Biotechnol. 2023 Jun 17;33(9):1-11.  

39. Ha N, Lee EJ*. Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium. J Microbiol 2023 Feb, https://doi.org/10.1007/s12275-023-00027-7

38. Song CH, Kim YH, Naskar M, Hayes BW, Abraham MA, Noh JH, Suk G, Kim MJ, Cho KS, Shin M, Lee EJ, Abraham SN, Choi HW. Lactobacillus crispatus Limits Bladder Uropathogenic E. coli Infection by Triggering a Host Type I Interferon Response. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2117904119. doi: 10.1073/pnas.2117904119. Epub 2022 Aug 8.

37. Koo H, Choi E, Park S, Lee EJ*, Lee JS*. Pat- and Pta-mediated protein acetylation is required for horizontally-acquired virulence gene expression in Salmonella Typhimurium. J Microbiol. 2022 Aug;60(8):823-831. doi: 10.1007/s12275-022-2095-y. Epub 2022 May 27. 

36. Choi S, Jeong G, Choi E, Lee EJ*. A Dual Regulatory Role of the PhoU Protein in Salmonella Typhimurium. mBio. 2022 Jun 28;13(3):e0081122. doi: 10.1128/mbio.00811-22. Epub 2022 May 31. 

35. Lee JH, Lee EJ*, Roe JH* (2022) uORF-mediated riboregulation controls transcription of whiB7/wblC antibiotic resistance gene. Molecular Microbiology, 117:179– 192, https://doi.org/10.1111/mmi.14834 (IF2020=3.501) 

34. Kim J, Park S, Kwon S, Lee EJ*, Lee JS* (2021) Set1-mediated H3K4 methylation is required for Candida albicans virulence by regulating intracellular level of reactive oxygen species. Virulence Accepted 10 September 2021, https://doi.org/10.1080/21505594.2021.1980988.

33. Choi E, Han Y, Park S, Koo H, Lee JS, Lee EJ* (2021) A translation-aborting small open reading frame in the intergenic region promotes translation of a Mg²⁺ transporter in Salmonella Typhimurium. mBio Apr 13, https://doi.org/10.1128/mBio.03376-20.

32. Han Y, Lee EJ* (2020) Substrate specificity of bacterial endoribonuclease toxins. BMB reports 53(12):611-621, https://doi.org/10.5483/BMBRep.2020.53.12.203

31. Yang J, Hwang I, Lee E, Shin SJ, Lee EJ, Rhee JH, Yu JW* (2020) Bacterial outer membrane vesicle-mediated cytosolic delivery of flagellin triggers host NLRC4 canonical inflammasome signaling. Front Immunol 11:581165. doi: 10.3389/fimmu.2020.581165.

30. Jang SW, Yoou MH, Hong WJ, Kim YJ, Lee EJ*, Jung KH* (2020) Re-Analysis of 16S Amplicon Sequencing Data Reveals Soil Microbial Population Shifts in Rice Fields under Drought Condition. Rice July 2, 13:44 https://doi.org/10.1186/s12284-020-00403-6

29. Lee JH, Yoo JS, Kim Y, Kim JS, Lee EJ*, Roe JH* (2020). The WblC/WhiB7 transcription factor controls intrinsic resistance to translation-targeting antibiotics by altering ribosome composition. mBio Apr 14, 11:e00625-20. https://doi.org/10.1128/mBio.00625-20.

28. Park S, Cho YJ, Jung D, Jo K, Lee EJ, Lee JS* (2020). Microbial Diversity in Moonmilk of Baeg-nyong Cave, Korean CZO. Front Microbiol Apr 23, 11:613. doi: 10.3389/fmicb.2020.00613.

27. Shin J, Park S, Lee JS, Lee EJ, Youn HD* (2020) Complete genome sequence and comparative analysis of Streptomyces seoulensis, a pioneer strain of nickel superoxide dismutase. Genes Genom 42, 273-281, Online 2019 Dec 3, doi: 10.1007/s13258-019-00878-8.

26. Han Y, Lee EJ* (2020) Detecting Salmonella Type II flagella production by transmission electron microscopy and immunocytochemistry. J Microbiol 58 (4): 245-251, doi: 10.1007/s12275-020-9297-y.

25. Choi S, Choi E, Cho YJ, Nam D, Lee J, Lee EJ* (2019) The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages. Nat Commun 10:3326 doi: 10.1038/s41467-019-11318-2.

24. Choi E, Nam D, Choi J, Park S, Lee JS, Lee EJ* (2019) Elongation factor P controls translation of the mgtA gene encoding a Mg²⁺ transporter during Salmonella infection. MicrobiologyOpen 8:e00680 doi: 10.1002/mbo3.680.

23. Yeom S, Oh J, Lee EJ, Lee JS* (2018) Positive charge of arginine residues on histone H4 tail is required for maintenance of mating type in Saccharomyces cerevisiae. J Microbiol & Biotechnol 28:1573-1579.

22. Baek J, Choi E, Lee EJ* (2018) A rule governing the FtsH-mediated proteolysis of the MgtC virulence protein from Salmonella enterica serovar Typhimurium. J Microbiol 56:565-570.

21. Choi E, Han Y, Cho YJ, Nam D, Lee EJ* (2017) A trans-acting leader RNA from a Salmonella virulence gene. Proc Natl Acad Sci USA 114:10232-10237.

20. Choi E, Choi S, Nam D, Park S, Han Y, Lee JS, Lee EJ* (2017) Elongation factor P restricts Salmonella’s growth by controlling translation of a Mg²⁺-transporter gene during infection. Sci Rep Feb 9 doi: 10.1038/srep42098.

19. Nam D, Choi E, Shin D, Lee EJ* (2016) tRNA^Pro-mediated downregulation of elongation factor P is required for mgtCBR expression during Salmonella infection. Mol Microbiol 102:221-232.

18. Lee JW, Lee EJ* (2015) Regulation and function of the Salmonella MgtC virulence protein. J Microbiol 53:667-672.

17. Choi E, Kwon K, Lee EJ* (2015) A single amino acid of a Salmonella virulence protein contributes to pathogenicity by protecting from the FtsH-mediated proteolysis. FEBS Lett 589:1346-1351.

16. Pontes MH, Lee EJ, Choi JJ, Groisman EA* (2015) Salmonella promotes virulence by repressing cellulose production. Proc Natl Acad Sci USA 112:5183-5188.

15. Lee EJ, Choi JJ, Groisman EA* (2014) Control of a Salmonella Virulence Locus by Proline-Charged tRNA^Pro. Proc Natl Acad Sci USA 111:3140-3145.

14. Groisman EA*, Hollands K, Kriner MA, Lee EJ, Park SY, Pontes MP (2013) Magnesium Transport, Homeostasis, and Bacterial Virulence. Annual Rev Genetics 47:643-664. 

13. Lee EJ, Pontes MP, Groisman EA* (2013) A Bacterial Virulence Protein Promotes Pathogenicity by Inhibiting the Bacterium’s Own F₁F_o ATP synthase. Cell 154:146-156.

12. Kim HS, Lee EJ, Cho YH, Roe JH* (2013) Post-translational regulation of a developmental catalase, CatB, involves a metalloprotease, SmpA and contributes to proper differentiation and osmoprotection of Streptomyces coelicolor. Res Microbiol 164:327-334.

11. Lee EJ, Groisman EA* (2012) Tandem Attenuators Control Expression of the Salmonella mgtCBR Virulence Operon. Mol Microbiol 86:212-224.

10. Lee EJ, Groisman EA* (2012) Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA. Nature 486:271-275.

9. Park SY, Cromie MJ, Lee EJ, Groisman EA* (2010).  A bacterial mRNA leader that employs different mechanisms to sense disparate intracellular signals. Cell 142:737-748.

8. Lee EJ, Groisman EA* (2010) An antisense RNA that governs the expression kinetics of a multifunctional virulence gene. Mol Microbiol 76:1020-1033.

7. Shin D, Lee EJ, Huang H, Groisman EA* (2006) A positive feedback loop promotes transcription surge that jump-starts Salmonella virulence circuit. Science 314:1607–1609.

6. Ahn BE, Cha J, Lee EJ, Han AR, Thompson CJ, Roe JH* (2006) Nur, a nickel-responsive regulator of the Fur family, regulates superoxide dismutases and nickel transport in Streptomyces coelicolor.  Mol Microbiol 59:1848-58.

5. Lee EJ, Karoonuthaisiri N, Kim HS, Park JH, Cha CJ, Kao CM, Roe JH* (2005) A master regulator s^B governs osmotic and oxidative response as well as differentiation via a network of sigma factors in Streptomyces coelicolor. Mol Microbiol  57:1252-1264.

4. Lee EJ, Cho YH, Kim HS, Ahn BE, Roe JH* (2005) Regulation of s^B by an anti- and an anti-anti-sigma factor in Streptomyces coelicolor in response to osmotic stress. J Bacteriol 186:8490-8498.

3. Lee EJ, Cho YH, Kim HS, and Roe JH* (2004) Identification of sigB-dependent promoters using consensus-directed search of Streptomyces coelicolor genome. J Microbiol 42:147-151.

2. Cho YH, Lee EJ, Ahn BE, Roe JH* (2001) SigB, an RNA polymerase sigma factor required for osmoprotection and proper differentiation of Streptomyces coelicolor. Mol Microbiol 42:205-214.

1. Cho YH, Lee EJ, Roe JH* (2000) A developmentally regulated catalase required for proper differentiation and osmoprotection of Streptomyces coelicolor. Mol Microbiol 35:150-160.

준비 중입니다.

Microbiology 1

 

Microbiology 2

 

Microbiology lab

Life at MGL

 

Drawing by 나경

 

2026-02-26 백승우, 윤민지, 김민지 졸업

 

 

2025-12-19 lab

 

 

2025-07-04 K-Club

 

2023-10-23 MSK

 

 

 

2023-08-31 방장이취임식

 

2023-08-25 한윤탁 박사졸업

 

2023-06-26 테라리움 워크샵

 

2023-06-08 강릉 BRL 워크샵

 

2023-05-15 

 

2023-02-21 형근 아림 성규 졸업

 

2022-12-21 실험실저녁

 

2022-09 분자세포생물학회 참석

 

2022-08 수민 졸업

 

2022-06 ASM microbe Washington DC 참석

 

2022-05-02 실험실저녁

 

2022-02-25 규상졸업

 

2021-05-15

 

2020-11-13

 

2020  online classes

 

2020-08-24 미생물학 실험 답사

 

2020-05-15 스승의 날

 

2020-03-20 규상졸업

 

2019-12-27 송년회

 

 

2019-10-03 미생물학 실험 답사

 

 

 

2019-08-22

 

 

 

Current Members

 

최은나

연구교수

eunna77@korea.ac.kr

 

최수민

연구교수

pinkdt@korea.ac.kr

 

김민정

석박사통합과정

summer5060@naver.com

 

 

조규상

박사과정

yourbtkd@naver.com

 

 

김서연

석박사통합과정

sy6230@naver.com

 

최낙준

석박사통합과정

skrwns1215@naver.com

 

백승우

박사후 연구원

blancotiger@korea.ac.kr

 

하나경

석박사통합과정

hanaky222@korea.ac.kr

 

김성규

석박사통합과정

Noy Shiri

석사과정

 

이나윤

석사과정

 

          김동욱

석박사통합과정

duk0425@gmail.com

          

 

Past Members

 

한윤탁

박사졸업

 

윤민지

석사졸업

 

김민지

석사졸업

 

송형근

석사졸업

 

안아림

석사졸업

 

정경화

석사졸업

 

장석원

석사졸업