Research Topic

Senses including touch and pain are an important starting point for our understanding of and interacting with the internal and external environment. We are studying the somatosensory mechanisms in the context of neurobiology. Particularly, we are focusing on the identities and functions of interface molecules located in the nerves and skin, transducing environmental changes into neural signals that eventually arrive at the brain. We are also trying to find chemical modulators of the functions of these sensory molecules that may modify our sensations or alleviate pain.

2021 Nobel Prize Special:

Dr. Ardem Patapoutian, my postdoctoral mentor, jointly with Dr. David Julius, was awarded the 2021 Nobel Prize in Physiology or Medicine!

- Subjects: Discoveries of receptors for temperature and touch

> Press Release from the Nobel Foundation, Sweden: https://www.nobelprize.org/prizes/medicine/2021/press-release/

> Nobel Prize Lecture: https://www.nobelprize.org/prizes/medicine/2021/patapoutian/lecture/

> Institutional congratulatory message from a former member in the Julius Lab and my scientific colleague, Dr. Makoto Tominaga affiliated with NIPS, an important MOU-based cooperative organization of Korea University College of Medicine: https://www.nips.ac.jp/eng/sp/release/2021/10/nobel_tominaga.html

Papers

https://scholar.google.com/citations?user=oY95o3gAAAAJ&hl=en

Yerin Kim*, Chaeeun Kim*, Hojin Lee, Minseok Kim, Haiyan Zheng, Ji Yeon Lim, Hye-In Yun, Minji Jeon, Jungmin Choi, Sun Wook Hwang. (2022) Gpr83 Tunes Nociceptor Function, Controlling Pain. Neurotherapeutics. doi: 10.1007/s13311-022-01327-3. Online ahead of print. (*equal contributors)

Wijeong Jang*, Ji Yeon Lim*, Seyoung Kang, Minseok Kim, Sun Wook Hwang#, Changsoo Kim#. (2022) Drosophila ppk19 encodes a proton-gated and mechanosensitive ion channel. Sci Rep. 12(1):18346. doi: 10.1038/s41598-022-23236-3. (*equal contributors; #co-corresponding authors)

Tae-Hwan Gil, Haiyan Zheng, Hyo Gyeong Lee, Ji-Won Shin, Sun Wook Hwang, Ki-Mo Jang, Ok Hee Jeon. (2022) Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis. Aging (Albany NY). 14(15):6006-6027. doi: 10.18632/aging.204204.

Pyung Sun Cho, Han Kyu Lee, Young In Choi, Seung In Choi, Ji Yeon Lim, Minseok Kim, Hyun Kim, Sung Jun Jung, Sun Wook Hwang. (2021) GPR171 Activation Modulates Nociceptor Functions, Alleviating Pathologic Pain. Biomedicines. 9(3):256. doi: https://doi.org/10.3390/biomedicines9030256

Haiyan Zheng, Ji Yeon Lim, Jae Young Seong, Sun Wook Hwang. (2020) The Role of Corticotropin-Releasing Hormone at Peripheral Nociceptors: Implications for Pain Modulation. Biomedicines. 8(12):623. doi: 10.3390/biomedicines8120623.

Jang Y*, Kim M*, Hwang SW. (2020) Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception. J Neuroinflammation. 17(1):30. doi: 10.1186/s12974-020-1703-1. (*equal contributors)

Ann J, Kim HS, Thorat SA, Kim H, Ha HJ, Choi K, Kim YH, Kim M, Hwang SW, Pearce LV, Esch TE, Turcios NA, Blumberg PM, Lee J. (2020) Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. J Med Chem. 63(1):418-424.

Jang W*, Lee S*, Choi SI*, Chae HS*, Han J, Jo H, Hwang SW#, Park CS#, Kim C#. (2019) Impairment of Proprioceptive Movement and Mechanical Nociception in Drosophila melanogaster larvae lacking Ppk30, a Drosophila Member of the DEG/ENaC Family. Genes Brain Behav. 18(5):e12545 (*equal contributors; #co-corresponding authors)

Choi G, Yang TJ, Yoo S, Choi SI, Lim JY, Cho PS, Hwang SW. (2019) TRPV4-Mediated Anti-nociceptive Effect of Suberanilohydroxamic Acid on Mechanical Pain. Mol Neurobiol. 56(1):444-453

Lee SH, Cho PS, Tonello R, Lee HK, Jang JH, Park GY, Hwang SW, Park CK, Jung SJ, Berta T. (2018) Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. J Allergy Clin Immunol. 142(4):1349-1352.e16.

Lee GY, You DG, Lee HR, Hwang SW, Lee CJ, Yoo YD. (2018) Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics. J Cell Biol. 217(6):2059-2071. doi: 10.1083/jcb.201709001

Jang Y, Cho PS, Yang YD*, Hwang SW*. (2018) Nociceptive Roles of TRPM2 Ion Channel in Pathologic Pain. Mol Neurobiol. 55(8):6589-6600. doi: 10.1007/s12035-017-0862-2. (*co-corresponding authors)

Choi SI, Hwang SW. (2018) Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception. Biomol Ther. 26(3):255-267.

Yoo S*, Choi SI*, Lee S, Song J, Yang C, Bang S, Kim SU, Min KH#, Hwang SW#. (2017) Endogenous TRPV4 Expression of a Hybrid Neuronal Cell Line N18D3 and Its Utilization to Find a Novel Synthetic Ligand. J Mol Neurosci. 63(3-4):422-430. (*equal contributors; #co-corresponding authors)

Sung HY*, Jeong YT*, Lim JY*, Kim H, Oh SM, Hwang SW, Kwon JY, Moon SJ. (2017) Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds. Nat Commun. 8(1):1484. (*equal contributors)

Choi G, Hwang SW. (2016) Modulation of the Activities of Neuronal Ion Channels by Fatty Acid-Derived Pro-Resolvents. Front Physiol. 7:523.

Choi WI, Sahu A, Vilos C, Lee JH, Kim S, Hong YK, Sul D, Hwang SW, Lee SH, Tae G (2016) Chitosan functionalized thermosponge nano-carriers for prolonged retention and local delivery of chymopapain at the nucleus pulposus in porcine discs ex vivo. RSC Adv. 6(93): 90967-72.

Back MJ, Lee HK, Lee JH, Fu Z, Son MW, Choi SZ, Go HS, Yoo S, Hwang SW, Kim DK. (2016) P2X1 receptor-mediated Ca2+ influx triggered by DA-9801 potentiates nerve growth factor-induced neurite outgrowth. ACS Chem Neurosci. 7(11):1488-1498.

Lim JY, Choi SI, Choi G, Hwang SW (2016) Atypical sensors for direct and rapid neuronal detection of bacterial pathogens. Mol Brain. 9: 26.

Choi SI*, Lim JY*, Yoo S, Kim H#, Hwang SW# (2016) Emerging role of spinal cord TRPV1 in pain exacerbation. Neural Plast. 2016:5954890. (*equal contributors; # co-corresponders)

Lim JY, Park CK#, Hwang SW# (2015) Biological Roles of Resolvins and Related Substances in the Resolution of Pain. Biomed Res Int. 2015: 830930. (# co-corresponders)

Choi SI, Yoo S, Lim JY, Hwang SW (2014) Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation? Int J Mol Sci. 2014 Sep 17;15(9):16430-16457.

Yoo S, Lim JY, Hwang SW (2014) Sensory TRP channel interactions with endogenous lipids and their biological outcomes. Molecules 19(4) 4708-44.

Yoo S, Lim JY, Hwang SW (2013) Resolvins: endogenously-generated potent painkilling substances and their therapeutic perspectives. Curr Neuropharmacol. 11(6) 664-76.

Hwang SW (2013) Editorial: Advances in Research on Pharmacological Targets for Pain Relief. Curr Neuropharmacol. 11(6) 559.

Chiu I, Heesters B, von Hehn C, Wainger B, Zhao F, Ghasemlou N, Tran J, Strominger A, Muralidharan S, Horswill A, Bubeck-Wardenburg J, Carroll M, Hwang SW, Woolf CJ (2013) Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 501(7465):52-7.(featured in ‘News and Views’ in the same issue)

Kim S#, Hwang SW# (2013) Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger. Arch Pharm Res. 36(7):783-91. (# co-corresponders)

Cho H, Jang Y, Lee B, Chun H, Jung J, Kim SM, Hwang SW, Oh U (2013) Voluntary movements as a possible non-reflexive pain assay. Mol Pain. 9(1):25. 

Chatzigeorgiou M*, Bang S*, Hwang SW#, Schafer WR# (2013) tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans. Nature 494(7435): 95-9. (*equal contributors; #co-corresponding authors; featured in ‘News and Views’ in the same issue)

Lee IK, Han IH, Hwang SW, Ryu JJ (2012) Analysis of attachment, proliferation and differentiation response of human mesenchymal stem cell to various implant surfaces coated with rhBMP-2. J Korean Acad Prosthodont 50(1): 44-52.

Bang S, Yoo S, Yang T, Cho H, Hwang SW (2012) Nociceptive and proinflammatory effects of dimethylallyl pyrophosphate via TRPV4 activation. Br J Pharmacol. 166(4): 1433-43.

Bang S, Yoo S, Yang TJ, Cho H, Hwang SW (2012) 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 165(3):683-92.

Bang S*, Yang TJ*, Yoo S, Heo TH#, Hwang SW# (2012) Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben. Neurosci Lett. 506(2):297-302. (* equal contributors. # co-corresponders)

Bang S, Yoo S, Yang TJ, Cho H, Hwang SW (2011) Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. Pain. 152(5):1156-64.

Kim S, Kim JC, Sul D, Hwang SW, Lee SH, Kim YH, Tae G (2011) Nanoparticle formulation for controlled release of capsaicin. J Nanosci Nanotechnol. 11(5):4586-91.

Bang S, Yoo S, Oh U, Hwang SW (2010) Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation. Arch Pharm Res. 33(10):1509-20.

Ryu JJ, Yoo S, Kim KY, Park JS, Bang S, Lee SH, Yang TJ, Cho H, Hwang SW (2010) Laser-modulation of heat and capsaicin receptor TRPV1 leads to thermal Antinociception. J Dent Res. 89(12):1455-60.

Bang S, Yoo S, Yang TJ, Cho H, Kim YG, Hwang SW (2010) Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. Br J Pharmacol. 161(3):707-20.

Chung AY, Kim MJ, Kim D, Bang S, Hwang SW, Lim CS, Lee S, Park HC, Huh TL (2010) Neuron-specific expression of atp6v0c2 in zebrafish CNS. Dev Dyn. 239(9):2501-8.

Chatzigeorgiou M, Yoo S, Watson JD, Lee WH, Spencer WC, Kindt KS, Hwang SW, Miller DM, Treinin M, Driscoll D, Schafer WR (2010) Specific roles for DEG/ENaC and TRP channels in mechanical and thermal sensation in C. elegans polymodal nociceptors. Nat Neurosci. 13(7):861-8.

Bang S, Yoo S, Yang TJ, Cho H, Hwang SW (2010) Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3. J Biol Chem. 285(25):19362-71.

Lee S, Moon CS, Sul D, Lee J, Bae M, Hong Y, Lee M, Choi S, Derby R, Kim B, Kim J, Yoon JS, Wolfer L, Kim J, Wang J, Hwang SW, Lee SH (2009) Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus. Clin Biochem. 42(15):1504-11.

Bang S, Yoo S, Hwang SW (2009) Gabapentin attenuates the activation of transient receptor potential A1 by cinnamaldehyde. Exp Neurobiol. 18(1):1-7.

Yoo S, Han S, Park YS, Oh U, Lee JH, Hwang SW (2009) Lipoxygenase inhibitors suppressed carrageenan-induced Fos-expression and inflammatory pain responses in the rat. Mol Cells. 27(4):417-22.

Bang S, Hwang SW (2009) Polymodal ligand sensitivity of TRPA1 and its modes of interactions. J Gen Physiol. 133(3):257-62.

Kim KY, Bang S, Han S, Nguyen YH, Kang TM, Kang KW, Hwang SW (2008) TRP-independent inhibition of the phospholipase C pathway by natural sensory ligands. Biochem Biophys Res Commun. 370(2):295-300.

Kim MR, Choi HS, Heo TH, Hwang SW, Kang KW (2008) Induction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells. Biochem Biophys Res Commun. 369(2):547-53.

Petrus M, Peier AM, Bandell M, Hwang SW, Huynh T, Olney N, Jegla T, Patapoutian A (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain 3(1):40.

Bang S, Kim KY, Yoo S, Kim YG, Hwang SW (2007) Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation. Eur J Neurosci 26(9):2516-23.

Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A (2007) An ion channel essential for sensing chemical damage. J Neurosci 27(42): 11412-15.

Hwang SW, Oh U (2007) Current concepts of nociception: nociceptive molecular sensors in sensory neurons. Curr Opin Anaesthesiol 20(5): 427-34.

Bang S, Kim KY, Yoo S, Lee SH, Hwang SW (2007) Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci Lett 425(2):120-5.

Yoon SY, Kwon YB, Kim HW, Roh DH, Seo HS, Han HJ, Lee HJ, Beitz AJ, Hwang SW, Lee JH (2007) Peripheral bee venom's anti-inflammatory effect involves activation of the coeruleospinal pathway and sympathetic preganglionic neurons. Neurosci Res 59(1): 51-9.

Macpherson LJ*, Hwang SW*, Miyamoto T, Dubin AE, Patapoutian A, Story GM (2006) More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci 32(4): 335-43. (* equal contributors)

Bandell M, Dubin AE, Petrus MJ, Orth A, Mathur J, Hwang SW, Patapoutian A (2006) High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nat Neurosci 9(4): 493-500.

Kim S*, Kang C*, Shin CY, Hwang SW, Yang YD, Shim WS, Park MY, Kim E, Kim M, Kim BM, Cho H, Shin Y, Oh U (2006) TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1. J Neurosci 26(9): 2403-12. (* equal contributors)

Macpherson LJ, Geierstanger BH, Viswanath V, Bandell M, Eid SR, Hwang S, Patapoutian A (2005) The Pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol 15(10): 929-34. (cover issue)

Moqrich A*, Hwang SW*, Earley TJ, Petrus MJ, Murray AN, Spencer KSR, Andahazy M,  Story GM, Patapoutian A (2005) Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307(5714): 1468-72. (* equal contributors)

Bandell M*, Story GM*, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41(6): 849-57. (* equal contributors)

Jung J*, Shin JS*, Lee SY*, Hwang SW, Koo J, Cho H, Oh U (2004) Phosphorylation of vanilloid receptor 1 by Ca+2/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem. 279(8): 7048-54. (* equal contributors)

Viswanath V,  Story GM, Peier AM, Petrus MJ, Lee VM, Hwang SW, Patapoutian A, Jegla T (2003) Opposite thermosensor in fruitfly and mouse. Nature 423(6942): 822-3.

Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like Channel expressed in nociceptive Neurons, is activated by cold temperatures. Cell 112(6): 819-29. (cover issue)

Jung J, Lee SY, Hwang SW, Cho H, Shin J, Kang YS, Kim S, Oh U (2002) Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. J Biol Chem 277(46): 44448-54.

Shin J, Cho H, Hwang SW, Jung J, Shin CY, Lee SY, Lee M-G, Choi YH, Kim J, Haber NA, Reichling DB, Khasar S, Levine JD, Oh U (2002) Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl Acad Sci U S A 99(15) 19150-55.

Hwang SW, Oh U (2002) Hot channels in airways: pharmacology of the vanilloid receptor. Curr Opin Pharmacol 2(3): 235-42.

Shin JS, Wang M, Hwang SW, Cho H, Cho SY, Kwon MJ, Lee S, Oh U (2001) Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists. Neurosci Lett 299(1-2): 135-9.

Lee J, Lee J, Kim J, Kim SY, Chun MW, Cho H, Hwang SW, Oh U, Park YH, Marquez VE, Beheshti M, Szabo T, Blumberg PM (2001) N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3 -methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. Bioorg Med Chem 9(1): 19-32.

Kwak J, Wang MH, Hwang SW, Kim TY, Lee SY, Oh U (2000) Intracellular ATP increases capsaicin-activated channel activity by interacting with nucleotide-binding domains. J Neurosci 20(22): 8298-304.

Hwang SW, Cho H, Kwak J, Lee SY, Kang CJ, Jung J, Cho S, Min KH, Suh YG, Kim D, Oh U (2000) Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A 97(11): 6155-60.

Jung J, Hwang SW, Kwak J, Lee SY, Kang CJ, Kim WB, Kim D, Oh U (1999) Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J Neurosci 19(2): 529-38.

Kwak JY, Jung JY, Hwang SW, Lee WT, Oh U (1998) A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance. Neuroscience 86(2): 619-26.

Oh U, Hwang SW, Kim D (1996) Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons. J Neurosci 16(5): 1659-67.

Book Chapters

Lee S, Hwang SW (2013.11) Peptide neurotoxins targeting voltage-gated ion channels and their therapeutic implications. Frontiers in clinical drug research - Central Nervous System. Atta-ur-Rahman (Ed.) Bentham Science Publishers: 100-65 (eISBN: 978-1-60805-779-5; ISBN: 978-1-60805-780-1; ISSN :2214-6318)

Park CK, Hwang SW (2013.02) Pain sensor molecules of the primary afferent nerves and their nociceptive modalities. Advances in Medicine and Biology series 61: Leon V. Berhardt (Ed.) Nova Science Publishers Incorporated: 47-90 (ISSN 2157-5398; ISBN: 978-1-62417-319-6)

Yoo S, Bang S, Hwang SW (2012.12) Sensory TRP channel interaction with lipids: their implications in pain modulation. Advances in Medicine and Biology series 57: Leon V. Berhardt (Ed.) Nova Science Publishers Incorporated: 1-35 (ISSN: 0065-2598; ISBN: 978-1-62257-454-4)

Yoo S, Hwang SW (2012.10) Nociceptive and Non-Nociceptive Roles of TRPV3 and Its “Druggability”: In Methods in Pharmacology and Toxicology series XI: TRP Channels in Drug Discovery volume I: Szallasi A, Biro T (Ed.) Springer/Humana Press: 237-56 (ISBN 978-1-62703-077-9)

Hwang SW (2005) Molecular Biology of TRPV1 and Related Receptors: In Acute and Chronic Cough: Redington AE and Morice AH (Ed.) Taylor and Francis Group: 1-24 (ISBN 0824759583, 9780824759582)

Patents

Republic of Korea Patent Application No. 10-2021-0072913: Hwang SW, Kim C, Lim JY (06/04/2021)  Composition for suppressing pruritus comprising pamoic acid as an active ingredient.

Republic of Korea Patent Application No. 10-2020-0055026: Hwang SW, Cho PS (05/08/2020)  Composition for Suppressing Pain Containing 5-Methacrylamidoisophthalic Acid.

Republic of Korea Patent Application No. 10-2020-0055025: Hwang SW, Cho PS (05/08/2020) Composition for Suppressing Pain Containing BigLEN.

Republic of Korea Patent No. 10-1681229: Hwang SW, Yang TJ, Yoo S (11/24/2016) Use of Vorinostat as a novel TRPV4 inhibitor.

Republic of Korea Patent No. 10-1415881: Hwang SW, Bang S, Yoo S (06/30/2014) Method for Screening TRPV4 Inhibitor Using Butamben.

Republic of Korea Patent No. 10-1415880: Hwang SW, Bang S, Yoo S (06/30/2014) New TRPA1 inhibitor and its use thereof

Republic of Korea Patent No. 10-1223990: Hwang SW, Bang S (01/14/2013) Composition for screening of TRPV4 activators or inhibitors, method for isolating TRPV4 positive or negative neurons, and method for screening TRPV4 activators or inhibitors, using DMAPP or its salt

Republic of Korea Patent No. 10-1222525: Hwang SW, Bang S (01/09/2013) Compositions and methods for suppressing pain and screening methods for pain suppressant using TRPV3 inhibition

Republic of Korea Patent No. 10-1187714: Hwang SW, Bang S (09/26/2012) Novel TRPV3 inhibitor and its use thereof

Republic of Korea Patent No. 10-1187715: Hwang SW, Bang S (09/26/2012) Novel TRPA1 inhibitor and its use thereof

Republic of Korea Patent No. 10-1187716: Hwang SW, Bang S (09/26/2012) Novel TRPV4 inhibitor and its use thereof

Republic of Korea Patent No. 10-1138317: Lee SH, Sul DG, Tae GY, Hwang SW, Derby R, Kang S (04/13/2012) Sustained Release Therapeutic Agent For Intervertebral Disc And Preparation Method Thereof

Republic of Korea Patent No. 10-1129365: Lee SH, Sul DG, Tae GY, Hwang SW, Derby R, Kang S (03/15/2012) Sustained Release Therapeutic Agent For Intervertebral Disc And Preparation Method Thereof

Republic of Korea Patent No. 10-1091810: Hwang SW, Bang S (12/02/2011) Method for activation of Transient receptor potential cation channel, subfamily V, member 1 using a novel activator

Republic of Korea Patent No. 10-1063352: Hwang SW, Bang S (09/01/2011) A compound for inhibiting TRPA1 function and use thereof

Republic of Korea Patent No. 10-1044599: Lee SH, Sul DG, Tae GY, Hwang SW, Derby R, Hong YK (06/21/2011) Sustained release therapeutic agent for intervertebral disc and preparation method thereof.

Republic of Korea Patent No. 10-1034300: Hwang SW, Bang S (05/03/2011) A compound for inhibiting TRPV3 function and use thereof 

Republic of Korea Patent No. 10-1034299: Hwang SW, Bang S (05/03/2011) A compound for modulating TRPV3 function and use thereof.

Republic of Korea Patent No. 10-0951656: Hwang SW, Bang S, Lee SH (03/31/2010) Activator for transient receptor potential vanilloid 2 comprising probenecids.

Republic of Korea Patent No. 10-0325581: Oh U, Hwang SW (02/07/2002) Novel use of lipoxygenase products or their derivatives as capsaicin channel activator.

United States Patent No. 8,022,050: Hwang SW, Bang S (09/20/2011) A compound for inhibiting TRPA1 function and use thereof.

United States Patent No. 7,960,130: Hwang SW, Bang S (06/14/2011) Method for activation of Transient receptor potential cation channel, subfamily A, member 1 using acetaldehyde.

United States Patent No. 7,915,012: Hwang SW, Bang S, Lee SH (03/29/2011) Method for Screening for Inhibitors of TRPV2 activation.

United States Patent No. 7,763,429: Hwang SW, Bang S (07/27/2010) Compound containing farnesyl diphosphate for modulating TRPV3 function and use thereof.

United States Patent No. 6,673, 840: Oh U, Hwang SW (01/06/2004) Use of lipoxygenase metabolite of arachidonic acid and its derivatives in capsaicin-channel agonist.

Professional Experience

2020.02 – present     Head of Department of Biomedical Sciences, Graduate School, Korea University

2020.02 – present     Head of Department of Medicine, Graduate School, Korea University

2020.01 – present     Scientific Committee vice-Chair, the Korean Pain Research Society (IASP chapter)

2018.02 – present     Chairperson of General Affairs, the Korea Pain Research Consortium

2018.01 – present     Scientific Program Committee Member, the Korean Physiological Society

2017.06 – present     Editorial board, The Open Pain Journal

2016.02 – present     Editorial board, Animal Cells and Systems

2015.12 – present     Deputy-Director, BK21 graduate program of Korea University College of Medicine

2015.08 – present     Associate Editor, Frontiers in Molecular Neuroscience

2005.03 – present     Assistant, Associate, and Full Professor, Korea University College of Medicine, Korea

2018.04 – 2019.12    Planning Committee Member, the Korean Pain Research Society (IASP chapter)

2016.01 – 2016.12    Financial Affairs Committee Member, the Korean Society for Brain and Neuroscience

2015.06 – 2016.07    Organizing Committee of the meeting of Asia Oceania Society for Comparative Endocrinology

2014.12 – 2015.12    Scientific Program Committee, the Korean Society for Brain and Neuroscience

2014.11 – 2016.01    Lead Guest Editor, Mediators of Inflammation

2014.01 – 2014.12    General Affairs Committee, Translational Research Institute for Incurable diseases, Korea University

2014.01 – 2015.12    Adjunct Professor, Department of Physiology, Korea University College of Medicine, Korea

2014.01 – 2014.12    Award Committee Member, Korean Society for Molecular and Cellular Biology, Korea

2014.01 – 2014.02    Grant reviewer for U.S.-Israel Binational Science Foundation

2013.08 – 2013.12    Scientific Committee, Translational Research Institute for Incurable diseases, Korea University, Korea

2012.09 – 2013.12    Current Neuropharmacology, Guest Editor

2012.06 – 2014.02     ISRN Pain, Editorial board

2012.02 – 2013.01     Visiting Research Scholar, Harvard Medical School, MA, USA (P.I. Dr. Clifford Woolf)

2011.08 – 2013.07     Adjunct Professor, Department of Neuroscience, Korea University College of Medicine, Korea

2011.05 – 2012.08     Organizing Committee of the New World of Anion and Cation Channel Conference, Jeju 2012

2010.07 – 2010.12     Secretary, the Korean Society for Brain and Neuroscience

2010.06 – 2012.06     Co-secretary, the Korea Pain Research Consortium

2010.02 – 2012.02     Adjunct Professor, Korea University College of Science and Technology, Korea

2008.04 – 2009.11     Local Organizing Committee, The 22nd Meeting of the International Society for Neurochemistry, Busan

2008.12 – 2010.07     General Executive, the Korean Society for Brain and Neuroscience

2007.05 – 2007.12     Neurobiology subcommittee, Brain Research Promotion Law (Braintech 21), Korea

2006.12 – 2011.10     Steering Committee of the Medical Research Institute, Korea University Ansan Hospital, Korea

2002.09 – 2005.07     Research Associate, The Scripps Research Institute, CA, USA (P.I. Dr. Ardem Patapoutian)

2001.03 – 2002.08     Postdoc, National Creative Research Initiatives, Seoul National University, Seoul, Korea

2001.09 – 2002.02     Lecturer (Physiology), College of Pharmacy, Duksung Women’s University, Seoul, Korea

2001.03 – 2001.08     Lecturer (Anatomy and Physiology), Graduate School of Health Science and Social Welfare, Sahmyook University

Education

1994.03 – 1996.02    M.S. in Pharmacology, Graduate School, Seoul National University, Seoul, Korea

Current Members

Minseok Kim Ph.D. (research professor) minseok7929@korea.ac.kr

Collaborations: altered neuronal and cardiac excitability in degenerative diseases

Yerin Kim M.S. (Research Scientist of KU Neuroscience Institute)  yrzzz1111@korea.ac.kr

Collaborations: Neuropeptide-mediated somatosensation

Chaeeun Kim (graduate student)  chae_0329@korea.ac.kr

Collaborations: Biologics normalizing hyperexcitable synapses

Hye-In Yun (graduate student) dbs0984@korea.ac.kr

Collaborations: human nociceptor differentiation, human DRG organoid

Miri Kim (graduate student) mrkim347@gmail.com

Collaborations: Biologics normalizing hyperexcitable synapses

Alumni

Sangsu Bang Ph.D., Postdoc, Duke University, USA

Kyungyoon Kim M.S., Scientist, Medifron DBT Co. Ltd., Korea

Sungjae Yoo Ph.D., Engineer, Neuroservice, France

Tae-Jin Yang M.S., Scientist, DI Biotech Ltd., Korea

Haiyan Zheng M.D., Ph.D., The First Affiliated Hospital, Zhejiang University School of Medicine, China

Seung-In Choi Ph.D., Postdoc, Korea University, Korea

Ji Yeon Lim Ph.D., Research professor, Korea University, Korea

Pyung Sun Cho Ph.D. Scientist, GMeX Co. Ltd., Korea

Geunyeol Choi Ph.D.c. deputy section chief, Innoboost Inc., Korea