• 연구분야 : 암줄기세포 
•  
• 연구실 (전화) : 생명과학관 서관 207호 (02-3290-3059)
• 실험실 (전화) : 생명과학관 서관 L202호 및 206호 암성장조절실험실 (02-3290-3472)

Education

• Ph.D. 미국 미네소타대학교
• Post-Doc. 미국 하버드의대 다나파버 암연구소

Professional Experiences

• 2003-2006. 고려대학교 생명환경과학대학 생명산업과학부 조교수
• 2006-현재. 한국분자세포생물학회 정회원
• 2007-2011. 고려대학교 생명과학대학 생명공학부 부교수
• 2007-2009. 고려대학교 생명환경과학대학원 분자진단생명공학과 주임교수
• 2008-2010. 고려대학교 동물실험윤리위원회 위원
• 2009-2011. 고려대학교 생명과학대학 교무학생 부학장
• 2009-현재. 세포생물학회 정회원
• 2010-2011. 고려대학교 생명과학대학 생명과학계열 학부장
• 2011-2013. 대한신경종양학회 기초분과위원장
• 2011-현재. 고려대학교 생명과학대학 생명공학부 교수
• 2014-현재. 대한신경종양학회 특별운영위원

담당 교과목

• 학부강의 [세포생물학, 암생물학]
• 대학원강의 [분자종양유전학, 종양생물학특론, 종양생물학연구기법, 분자신호전달학]

Publications 

[2024]

 

Choi SH, Jang J, Kim Y, Park CG, Lee SY, Kim H, Kim H (2024) ID1high/activin Ahigh glioblastoma cells contribute to resistance to anti-angiogenesis therapy through malformed vasculature. Cell Death Dis. 2024 Apr 24;15(4):292.

 

Lee SY, Choi SH, Kim Y, Ahn HS, Ko YG, Kim K, Chi SW, Kim H (2024) Migrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells. BMC Biol. 2024 Jan 30;22(1):23.

 

[2023]

 

Kim JY, Hong N, Park S, Ham SW, Kim EJ, Kim SO, Jang J, Kim Y, Kim JK, Kim SC, Park JW, Kim H (2023) Jagged1 intracellular domain/SMAD3 complex transcritpionally regulates TWIST1 to drive glioma invasion. Cell Death Dis. 2023 Dec 13;14(12):822.

 

[2022]

 

Kim EJ, Kim JY, Kim SO, Ham SW, Choi SH, Hong N, Park MG, Jang J, Seo S, Lee K, Jeong HJ, Kim SJ, Jeong S, Min K, Kim SC, Jin X, Kim SH, Kim SH, Kim H (2021) JAG1 intracellular domain acts as a transcritpional cofactor that forms an oncogenic trasncriptional complex with DDX17/SMAD3/TGIF2. Cell Rep. 2022 Nov 22;41(8):111626

 

Seo S, Hong N, Song J, Kim D, Choi Y, Lee D, Jon S, Kim H (2022) Polymer Thin Film Promotes Tumor Spheroid Formation via JAK2-STAT3 Signaling Primed by Fibronectin-Integrin α5 and Sustained by LMO2-LDB1 Complex. Biomedicines.2022 Oct 24;10(11):2684

 

Choi SH, Park MJ, Kim H (2022) Inhibitor of differentiation 1 in U87MG glioblastoma cells promotes HUVEC sprouting through endothelin-1. Oncol Lett. 2022 Sep 27;24(5):413

 

Park CG, Choi SH, Lee SY, Eun K, Park MG, Jang J, Jeong HJ, Kim SJ, Jeong S, Lee K, Kim H (2021) Cytoplasmic LMO2-LDB1 complex activates STAT3 signaling through interaction with gp130-JAK in glioma stem cells. Cells. 2022 Jun 26;11(13):2031

 

[2021]

 

Lee SY, Choi SH, Lee MS, Kurmashev A, Lee HN, Ko Y, Lee K, Jeong S, Seong J, Kang JH, Kim H (2021) Retraction fibers produced by fibronectin-integrin a5b1 interaction promotes motility of brain tumor cells. FASEB J. Oct;35(10):e21906

 

Hwang SU, Eun K, Kim M, Yoon JD, Cai L, Choi H, Oh D, Lee G, Kim H, Kim E, Hyun SH (2021) Establishment of 3D Neuro-Organoids Derived from Pig Embryonic Stem-Like Cells. International Journal of Molecular Sciences. Mar 5;22(5):2600

 

Hong JH, Kang S, Sa JK, Park G, Oh YT, Kim TH, Yin J, Kim SS, D'Angelo F, Koo H, You Y, Park S, Kwon HJ, Kim CI, Ryu H, Lin W, Park EJ, Kim YJ, Park MJ, Kim H, Kim MS, Chung S, Park CK, Park SH, Kang YH, Kim JH, Saya H, Nakano I, Gwak HS, Yoo H, Lee J, Hur EM, Shi B, Nam DH, Iavarone A, Lee SH, Park JB (2021) Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma. Brain. Mar 3;144(2):636-654

 

[2020]

 

Park MG, Seo S, Ham SW, Choi SH, Kim H (2020) Dihydropyrimidinase-related protein 5 controls glioblastoma stem cell characteristics as a biomarker of proneural-subtype glioblastoma stem cells. Oncology Letters. Aug;20(2):1153-1162

 

Eun K, Hong N, Jeong YW, Park MG, Hwang SU, Jeong YIK, Choi EJ, Olsson PO, Hwang WS, Hyun SH, Kim H (2020) Transcriptional activities of human elongation factor-1a and cytomegalovirus promoter in transgenic dogs generated by somatic cell nuclear transfer. PLos One. Jun 3;15(6):e0233784

 

Yin J, Kim SS, Choi E, Oh YT, Lin W, Kim TH, Sa KJ, Hong JH, Park SH, Kwon HJ, Jin X, You Y, Kim JH, Kim H, Son J, Lee J, Nam DH, Choi KS, Shi B, Gwak HS, Yoo H, Lavarone A, Kim JH, Park JB (2020) ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages. Nature Communications. Jun 12;11(1):2978

 

Lee TG, Kim SY, Kim HR, Kim H, Kim CH (2020) Radiation Induces Autophagy via Histone H4 Lysine20 Trimethylation in Non-small Cell Lung Cancer Cells. Anticancer Research. May;40(5):2537-2548

 

Kim BH, Lee H, Park CG, Jeong AJ, Lee SH, Noh KH, Park JB, Lee CG, Paek SH, Kim H, Ye SK (2020) STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model. Cells. Mar 15;9(3):722

 

Kim JY, Kim JK, Kim H (2020) ABCB7 simultaneously regulates apoptotic and non apoptotic cell death by modulating mitochondrial ROS and HIF1a-driven NFkB signaling. Oncogene. Feb;39(9):1969-1982

 

[2019]

 

Jeon HY, Ham SW, Kim JK, Jin X, Lee SY, Shin YJ, Choi CY, Sa JK, Kim SH, Chun T, Jin X, Nam DH, Kim H (2019) Ly6G+ inflammatroy cells enable the conversion of cancer cells to cancer stem cells in an irradiated glioblastoma model. Cell Death & Differentiation. Oct;26(10):2139-2156

 

Park S, Hwang D, Yeo YS, Kim H, Kang J (2019) CONFIGURE: A pipeline for identifying context specific regulatory modules from gene expression data and its application to breast cancer. Jul 11;12(Suppl 5):97

 

Kim SB, Heo JI, Kim H, Kim KS (2019) Acetylation of PGC1a by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells. Journal of Gerontology Series A-Biological Sciences and Medical Sciences. May 16;74(6):787-793

 

Ham SW, Kim JK, Jeon HY, Kim EJ, Jin X, Eun K, Park CG, Lee SY, Seo S, Kim JY, Choi SH, Hong N, Lee YY, Kim H (2019) Korean Red ginseng extract inhibits glioblastoma propagation by blocking the Wnt signaling pathway. Journal of Ethnopharmacology. May 23;236:393-400

 

Choi SH, Kim H (2019) Characteristics of Cancer Stem Cells and Immune Checkpoint Inhibition. Journal of Life Science

 

Lee SY, Kim H (2019) Different Cytokine Dependency of Proneural to Mesenchymal Glioma Stem Cell Transition in Tumor Microenvironments. Journal of Life Science

 

Ham SW, Jeon HY, Jin X, Kim EJ, Kim JK, Shin YJ, Lee Y, Kim SH, Lee SY, Seo S, Park MG, Kim HM, Nam DH, Kim H (2019) TP53 gain-of-function mutation promotes inflammation in glioblastoma. Cell Death & Differentiation. Mar;26(3):409-425

 

Choi SH, Kim JK, Jeon HY, Eun K, Kim H (2019) OCT4B Isoform Promotes Anchorage-Independent Growth of Glioblastoma Cells. Molecules and Cells. Feb 28;42(2):135-142

 

Eun K, Park MG, Jeong YW, Jeong YI, Hyun SH, Hwang WS, Kim SH, Kim H (2019) Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research. BMC Biotechnology. Jan 3;19(1):1

 

[2018]

 

Jeong EH, Lee TG, Ko YJ, Kim SY, Kim HR, Kim H, Kim CH (2018) Anti-tumor effect of CDK inhibitors on CDKN2A defective squamous cell lung cancer cells. Cellular Oncology. Dec;41(6):663-675

 

Kim E, Hwang SU, Yoon JD, Kim H, Lee G, Hyun SH (2018) Isolation and characterization of GFAP-positive porcine neural stem/progenitor cells derived from a GFAP-CreERT2 transgenic piglet. BMC Veterinary Research. Nov 7;14(1):331

 

Kim JK, Jeon HM, Jeon HY, Oh SY, Kim EJ, Jin X, Kim SH, Kim SH, Jin X, Kim H (2018) Conversion of glioma cells to glioma stem-like cells by angiocrine factors. Biochemical and Biophysical Research Communications. Feb 19;496(4):1013-1018

 

Jin X, Jin X, Kim LJY, Dixit D, Jeon HY, Kim EJ, Kim JK, Lee SY, Yin J, Rich J, Kim H (2018) Inhibition of ID1-BMPR2 Intrinsic Signaling Sensitizes Glioma Stem Cells to Differentiation Therapy. Clinical Cancer Research. Jan 15;24(2):383-394

 

Yin J, Jung JE, Choi S, Kim SS, Oh YT, Kim TH, Choi E, Lee SJ, Kim H, Kim EO, Lee YS, Chang HJ, Park JY, Kim Y, Yun T, Heo K, Kim YJ, Kim H, Kim YH, Park JB, Choi SW (2018) Inhibition of BMP signaling overcomes acquired resistance to ccetuximab in oral squamous cell carcinomas. Cancer Letters. Feb 1;414:181-189

 

Kim EJ, Jin X, Kim OR, Ham SW, Park SH, Kim H (2018) Glioma stem cells and their non-stem differentiated glioma cells exhibit differences in mitochondrial structure and function. Oncology Reports. Jan;39(1):411-416

 

[2017]

 

Hwang SU, Eun K, Yoon JD, Kim H, Hyun SH (2017) Production of transgenic pigs using a pGFAP-CreERT2/EGFPLoxP inducible system for central nervous system disease models. Journal of Veterinary Science. May 31;19(3):434-445

 

Seo S, Jeon HY, Kim H (2017) Comparison of Cellular Transforming Activity of OCT4, NANOG, and SOX2 in Immortalized Astrocytes. DNA and Cell Biology. Nov;36(11):1000-1009

 

Jin X, Jin X, Kim H (2017) Cancer stem cells and differentiation therapy. Tumor Biology. Oct;39(10):1010428317729933

 

Eun K, Hwang SU, Jeong YW, Seo S, Lee SY, Hwang WS, Hyun SH, Kim H (2017) SV40 Large T Antigen Disrupts Embryogenesis of Canine and Porcine Somatic Cell Nuclear Transfer Embryo. Biological Procedures Online. Oct 18;19:13

 

Jeon HY, Park CG, Ham SW, Choi SH, Lee SY, Kim JY, Seo S, Jin X, Kim JK, Eun K, Kim EJ, Kim H (2017) BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence. Journal of Medicinal Food. Sep;20(9):838-845

 

Lee SY, Kim JK, Jeon HY, Ham SW, Kim H (2017) CD133 Regulates IL-1b Signaling and Neutrophil Recruitment in Glioblastoma. Molecules and Cells. Jul 31;40(7):515-522

 

Ham SW, Jeon HY, Kim H (2017) Verapamil augments carmustine- and irradiation-induced senescence in glioma cells by reducing intracellular reactive oxygen species and calcium ion levels. Tumor Biology. May;39(5):1010428317692244

 

Lee TG, Jeong EH, Kim SY, Kim HR, Kim H, Kim CH (2017) Fhit, a tumor suppressor protein, induces autophagy via 14-3-3t in non-small cell lung cancer cells. Oncotarget. May 9;8(19):31923-31937

 

Eun K, Jeon HM, Kim SO, Choi SH, Lee SY, Jin X, Kim SC, Kim H (2017) A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells. Biochemical and  Biophysical Research Communications. Apr 29;486(2):564-570

 

Kim EJ, Kim SH, Jin X, Jin X, Kim H (2017) KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc. Cell Death Differentiation. Apr;24(4):649-659

 

Eun K, Ham SW, Kim H (2017) Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting. BMB Reports. Mar;50(3):117-125

 

[2016]

 

Jin X, Jeon HM, Jin X, Kim EJ, Yin J, Jeon HY, Sohn YW, Oh SY, Kim JK, Kim SH, Jung JE, Kwak S, Tang KF, Xu Y, Rich J, Kim H (2016) The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells. Cell Reports. Aug 9;16(6):1629-1641

 

Eun K, Hwang SU, Jeon HM, Hyun SH, Kim H (2016) Comparative Analysis of Human, Mouse, and Pig Glial Fibrillary Acidic Protein Gene Structures. Anim Biotechnology. 27(2):126-32

 

Yoo H, Kim E, Hwang SU, Yoon JD, Jeon Y, Park KM, Kim KJ, Jin M, Lee CK, Lee E, Kim H, Kim G, Hyun SH (2016) Ultrastructural comparison of porcine putative embryonic stem cells derived by in vitro fertilization and somatic cell nuclear transfer. Journal of Reproduction and Development. Apr 22;62(2):177-85

 

Kim E, Hwang SU, Yoo H, Yoon JD, Jeon Y, Kim H, Jeung EB, Lee CK, Hyun SH (2016) Putative embryonic stem cells derived from porcine cloned blastocysts using induced pluripotent stem cells as donors. Theriogenology. Mar 1;85(4):601-16

 

• Jeon HY, Kim JK, Ham SW, Oh SY, Kim J, Park JB, Lee JY, Kim SC, Kim H (2016) Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype. Tumor Biology. May;37(5):5857-67

 

[2015]

 

Hwang SU, Jeon Y, Yoon JD, Cai L, Kim EH, Yoo H, Kim KJ, Park KM, Jin M, Kim H, Hyun SH (2015) Effect of ganglioside GT1b on the in vitro maturation of porcine oocytes and embryonic develpment. Journal of Reproduction and Development. 61(6):549-57

 

Cai L, Jeon Y, Yoon JD, Hwang SU, Kim E, Park KM, Kim KJ, Jin MH, Lee E, Kim H, Jeung EB, Hyun SH (2015) The effects of human recombinant granulocyte-colony stimulating factor treatment during in vitro maturation of porcine oocyte on subsequent embryoni development. Theriogenology. Oct 15;84(7):1075-87

•  
• Park CG, Sohn YW, Kim EJ, Kim SH, Kim SC, Kim H (2015) LIM domain only 2 induces glioma invasion via cytosolic p27KIP1. Tumor Biology. Feb;37(2):2473-80.


• Choi SA, Lee JY, Kwon SE, Wang KC, Phi JH, Choi JW, Jin X, Lim JY, Kim H, Kim SK (2015) Human Adipose Tissue-Derived Mesenchymal Stem Cells Target Brain Tumor-Initiating Cells. Plos One 10(6): e0129292


• Hahm SW, Park J, Oh SY, Lee CW, Park KY, Kim H, Son YS (2015) Anticancer Properties of Extracts from Opuntia humifusa Against Human Cervical Carcinoma Cells. Journal of Medicinal Food. 18(1): 31-44


• Kim EJ, Kim SO, Jin X, Ham SW, Kim J, Park JB, Lee JY, Kim SC, Kim H (2015) Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1. Tumor Biology. 36(4): 2921-2928.


• Kim JK, Jeon HY, Kim H (2015) The molecular mechanisms underlying the therapeutic resistance of cancer stem cells. Archives of Pharmacal Research. 38(3): 389-401.


• Lee D, Na J, Ryu J, Kim HJ, Nam SH, Kang M, Jung JW, Lee MS, Song HE, Choi J, Lee GH, Kim TY, Chung JK, Park KH, Kim SH, Kim H, Seo H, Kim P, Youn H, Lee JW (2015) Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells. Hepatology. 61(6): 1978-1997


• Yin J, Park G, Kim TH, Hong JH, Kim YJ, Jin X, Kang S, Jung JE, Kim JY, Yun H, Lee JE, Kim M, Chung J, Kim H, Nakano I, Gwak HS, Yoo H, Yoo BC, Kim JH, Hur EM, Lee J, Lee SH, Park MJ, Park JB (2015) Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells. Plos Biology. 13(5): e1002152


• Kim SH, Kim EJ, Hitomi M, Oh SY, Jin X, Jeon HM, Beck S, Jin X, Kim JK, Park CG, Chang SY, Yin J, Kim T, Jeon YJ, Song J, Lim YC, Lathia JD, Nakano I, Kim H (2015) The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells. Cell Death & Differentiation. 22(9): 1517-1525.


• Kim JK, Jin X, Ham SW, Lee SY, Seo S, Kim SC, Kim SH, Kim H (2015) IRF7 promotes glioma cell invasion by inhibiting AGO2 expression. Tumor Biology. 36(7): 5561-5569


• Yin J, Park G, Lee JE, Choi EY, Park JY, Kim TH, Park N, Jin X, Jung JE, Shin D, Hong JH, Kim H, Yoo H, Lee SH, Kim YJ, Park JB, Kim JH (2015) DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis. Brain. 138(Pt 9): 2553-2570
•  
• [2014]
•  
• Jeon HM, Kim SH, Jin X, Park JB, Kim SH, Joshi K, Nakano I, Kim H (2014) Crosstalk between glioma-initiating cells and endothelial cells drives tumor progression. Cancer Research. 74(16): 4482-4492


• Kim JK, Lee SY, Park CW, Park SH, Yin J, Kim J, Park JB, Lee JY, Kim H*, Kim SC* (2014) Rab3a promotes brain tumor initiation and progression. Molecular Biology Reports. 41(9): 5903-5911 (*correspondence).


• Kim JK, Jin X, Sohn YW, Jin X, Jeon HY, Kim EJ, Ham SW, Jeon HM, Chang SY, Oh SY, Yin J, Kim SH, Park JB, Nakano I, Kim H (2014) Tumoral RANKL activates astrocytes that promote glioma cell invasion through cytokine signaling. Cancer Letters. 353(2): 194-200
•  
• [2013]
•  
• Oh SY, Kang HJ, Kim YS, Kim H*, Lim YC* (2013) CD44-negative cells in head and neck squamous carcinoma also have stem-cell like traits. European Journal of Cancer. 49(1): 272-280 (*correspondence).


• Jin X, Jin X, Sohn YW, Yin J, Kim SH, Joshi K, Nam DH, Nakano I, Kim H (2013) Blockade of EGFR signaling promotes glioma stem-like cell invasiveness by abolishing ID3-mediated inhibition of p27(KIP1) and MMP3 expression. Cancer Letters. 328(2): 235-242


• Jin X, Jin X, Jung JE, Beck S, Kim H (2013) Cell surface Nestin is a biomarker for glioma stem cells. Biochemical and Biophysical Research Communications. 433(4): 496-501


• Oh SY, Kim H (2013) Molecular culprits generating brain tumor stem cells. Brain Tumor Research and Treatment. 1(1): 9-15
•  
• [2012]


• Lim YC, Oh SY, Kim H (2012) Cellular characteristics of head and neck cancer stem cells in the type IV collagen-coated adherent cultures. Experimental Cell Research. 318(10): 1104-1111.


• Jin X, Kim SH, Jeon HM, Beck S, Sohn YW, Yin J, Kim JK, Lim YC, Lee JH, Kim SH, Kang SH, Pian X, Song MS, Park JB, Chae YS, Chung YG, Lee SH, Choi YJ, Nam DH, Choi YK, Kim H (2012) Interferone Regulatory Factor 7 regulates glioma stem cells by IL6 and Notch signaling. Brain. 135: 1055-1069.
•  
• [2011]
•  
• Jin X, Yin J, Kim SH, Sohn YW, Beck S, Lim YC, Nam DH, Choi YJ, Kim H (2011) EGFR-AKT-SMAD signaling promotes formation of glioma stem-like cells and tumor angiogenesis via ID3-driven cytokine induction. Cancer Research. 71(22): 7125-7134.


• Lim S-H, Choi SA, Lee JY, Wang K-C, Phi JH, Lee D-H, Song SH, Song JH, Jin X, Kim H, Lee HJ, Lim I, Kim SU, Kim S-K (2011) Therapeutic targeting of subdural medulloblastomas using human neural stem cells expressing carboxylesterase. Cancer Gene Therapy. 18: 817-824


• Beck S, Jin X, Yin J, Kim SH, Lee NK, Oh SY, Jin X, Kim MK, Kim EB, Son JS, Kim SC, Nam DH, Kim SH, Kang SK, Kim H*,Choi YJ* (2011) Identification of a peptide that interacts with Nestin protein in brain cancer stem cells. Biomaterials. 32: 8518-8528. (*correspondence).


• Jeon HM, Sohn YW, Oh SY, Kim SH, Beck S, Kim S, Kim H (2011) ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9*-mediated suppression of SOX2. Cancer Research. 71: 3410-3421.


• Yin J, Kim JK, Moon JH, Beck S, Piao D, Jin X, Kim SH, Lim YC, Nam DH, You S, Kim H*, Choi YJ* (2011) hMSC-mediated concurrent delivery of endostatin and carboxylesterase to mouse xenografts suppresses glioma initiation and recurrence. Molecular Therapy. 19(6): 1161-1169. (*correspondence).


• Jin X, Jeon HY, Joo KM, Kim JK, Jin J, Kim SH, Kang BG, Beck S, Lee SJ, Kim JK, Park AK, Park WY, Choi YJ, Nam DH, Kim H (2011) Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. Cancer Research. 71: 3066-3075.


• Beck S, Jin X, Sohn YW, Kim JK, Kim SH, Yin J, Pian X, Kim SC, Nam DH, Choi YJ, Kim H (2011) Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression. Molecules and Cells. 31: 9-15.


• Lim YC, Oh SY, Cha YY, Kim SH, Jin X, Kim H (2011) Cancer stem cell traits in squamospheres derived from primary head and neck squamous cell carcinomas. Oral Oncology. 47: 83-91. (Cover article)
•  
• [2010]
•  
• Park HJ, Kim JK, Jeon HM, Oh SY, Kim SH, Nam DH, Kim H (2010) The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells. Molecules and Cells. 30: 403-408.


• Jin X, Beck S, Sohn YW, Kim JK, Kim SH, Yin J, Pian X, Kim SC, Choi YJ, Kim H (2010) Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor. Experimental and Molecular Medicine. 42: 574-582.
•  
• [2008]
•  
• Jeon HM, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, DePinho RA, Chin L, Kim H (2008) Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and Notch signaling. Genes & Development. 22: 2028-2033. (Cover article)


• Joo KM, Kim SY, Jin X, Song SY, Kong DS, Lee JI, Jeon JW, Kim MH, Kang BG, Jung Y, Park WY, Lee DS, Kim H*, Nam DH* (2008) Clinical and biological implication of CD133-positive and CD133-negative cells in glioblastomas. Laboratory Investigation. 88: 808-815. (*correspondence).


• Nam DH, Jeon HM, Kim SY, Kim MH, Lee YJ, Lee MS, Kim H, Joo KM, Lee DS, Price JE, Bang SI, Park WY (2008) Activation of notch signaling in a xenograft model of brain metastasis. Clinical Cancer Research. 14(13): 4059-4066.


• Lee JS, Gil JE, Kim JH, Kim TK, Jin X, Oh SY, Sohn YW, Jeon HM, Park HJ, Park JW, Shin YJ, Chung YG, Lee JB, You S, Kim H (2008) Brain cancer stem-like cell genesis from p53-deficient mouse astrocytes by oncogenic Ras. Biochemical and Biophysical Research Communications. 365: 496-502.
•  
• [2007]
•  
• Kim TK, Lee JS, Oh SY, Jin X, Choi YJ, Lee TH, Lee EH, Choi YK, You S, Chung YG, Lee JB, DePinho RA, Chin L, Kim H (2007) Direct transcriptional activation of PML by IRF3 induces the p53-dependent growth inhibition of cancer cells. Cancer Research. 67(23): 11133-11140.


• Oh SY, Sohn YW, Park JW, Park HJ, Jeon HM, Kim TK, Lee JS, Jung JE, Jin X, Chung YG, Choi YK, You S, Lee JB, Kim H (2007) Selective cell death of oncogenic Akt-transduced brain cancer cells by etoposide through ROS-mediated damage. Molecular Cancer Therapeutics. 6(8): 2178-2187.


• Stegh A, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L (2007) Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes & Development. 21: 98-111.
•  
• [2006]
•  
• Kim TK, Lee JS, Jung JE, Oh SY, Kwak S, Jin X, Lee SY, Lee JB, Chung YG, Choi YK, You S, Kim H (2006) Interferon regulatory factor 3 activates p53-dependent cell growth inhibition. Cancer Letters. 242: 215-221.
•  
• [2005]
•  
• Jung JE, Kim TK, Lee JS, Oh SY, Kwak S, Jin X, Sohn JY, Song MK, Sohn YW, Lee SY, Pian X, Lee JB, Chung YG, Choi YK, You S, Kim H (2005) Survivin inhibits anti-growth effects of p53 activated by aurora B. Biochemical and Biophysical Research Communications. 336: 1164-1171.

Kim EJ, Kim JY, Kim SO, Ham SW, Choi SH, Hong N, Park MG, Jang J, Seo S, Lee K, Jeong HJ, Kim SJ, Jeong S, Min K, Kim SC, Jin X, Kim SH, Kim SH, Kim H (2021) JAG1 intracellulr domain acts as a transcritpional cofactor that forms an oncogenic trasncriptional complex with DDX17/SMAD3/TGIF2. (Under review)

 

Research Topic

 

 

암줄기세포의 발생과 특성을 조절하는 신호 전달 기전 연구

 

 

종양 조직 내 복잡한 군집을 형성하고 있는 세포들 중 일부 줄기세포의 특성을 가진 미분화 암세포만이 종양을 형성할 수 있다는 사실이 알려지게 되었습니다. 암줄기세포라는 이름으로 불리는 이들 세포들은 주어진 환경에 종양조직의 대부분을 차지하는 세포들로 분화되어 종양조직 자체를 형성 할 뿐 아니라 항암제나 방사선 치료에 저항성을 가지고 있어 종양재발의 원인이 되는 세포로 알려져 있습니다. 이러한 암줄기세포의 근원이 되는 세포의 발생 원인을 밝히는 연구로서 성체줄기세포나 전구세포와 같이 지속적으로 분열 가능한 세포의 특정 유전자에 돌연변이가 발생하면 암줄기세포로 발전되는 것이 가능하다는 것과 함께 분화된 암세포에서도 종양유전자의 활성과 암억제유전자의 기능 손실에 추가적으로 줄기세포 특성 결정인자의 에피제네틱 발현 변화가 유도됨에 따라 암줄기세포로 역분화 또는 리프로그래밍이 될 수 있는 현상에 대한 연구를 진행하고 있습니다.

 

암줄기세포와 표적 맞춤형 치료법 개발 연구

 

기존의 암 치료방법은 종양 조직의 성장 억제 및 사멸을 목표로 한 방법으로 이러한 접근법은 종양 조직내의 대다수를 차지하고 있는 분화되어 종양 형성능이 없는 세포들에 선택적으로 작용하지만, 새로이 종양을 형성할 수 있는 암줄기세포에는 효과가 한정적이라는 문제가 있었습니다. 또한 이로 인해 기존의 종양치료가 악성 암줄기세포 군집의 성장을 유도하여 종양 재발을 촉진할 수도 있다는 가능성 마저 제시되고 있습니다. 따라서 본 연구실에서는 암줄기세포를 특이적으로 사멸시키는 것이 종양 재발과 타 조직으로의 전이를 억제할 수 있을 것으로 생각하고 암줄기세포와 이들의 발생 및 특성 조절에 중요한 표적 분자를 탐색하고 이를 암줄기세포 표적 약물전달시스템에 응용하고자 하는 연구를 수행하고 있습니다.

[학부강의]

 

세포생물학

암생물학

 

[대학원강의]

 

분자종양유전학

종양생물학특론

종양생물학연구기법

분자신호전달학

[2024년 4월 기준]

 

석박사 통합과정

홍나영 (nyhong0311@naver.com)

박민기 (ak114859@gmail.com)

장준석 (kkc4152@naver.com)

박민지 (drannepark@naver.com)

김윤지 (yoonjikim0710@gmail.com)

곽민서 (minseo990326@korea.ac.kr)

윤승현 (2020140335@korea.ac.kr)

김수아 (lvelmo@naver.com)

 

박사과정 

김경미 (학연산과정, gm810@kirams.re.kr)

 

학부연구생

이재혁 (tomy832800@gmail.com)

 

랩매니저

이은실 (euslee@korea.ac.kr)