주소: 서울특별시 성북구 안안동 5가 고려대학교 하나과학관 A동 402호

Education

• 1976~1980 : 서울대학교 약학대학 제약학과 (B.S.)
• 1980~1982 : 한국과학기술원 생물과학과 (M.S.)
• 1985~1990 : 미국 Harvard대학교 의과대학 생화학 및 분자약리학과 (Ph.D.)

Professional Experiences

• 1997.03~1998.02. : : 고려대학교 생명공학원 조교수, 부교수
• 1998.03~2006.02. : 고려대학교 세포사멸연구센터 소장
• 2005.03~2008.02: 현대기아 자연과학 석좌교수
• 2003.03~현재 : 고려대학교 생명과학부 교수
• 2014.09-현재: 고려대학교 벤트리 석좌교수

Awards

• 한국과학상 (2001년: 과학기술부/한국과학재단)
• 동헌생화학상 (2010년: 생화학분자생물학회)
• 국가석학 선정 (2006년: 교육인적자원부/학술진흥재단)
• 생명약학연구회 우수논문상 (2003년: 생명약학연구회)
• 우수한국인의과학자 20인 선정 (2002년: 대한의사협회)
• 과학기술우수논문상 (1997년: 한국과학기술단체총연합회)

국제학술지

• Eun Kyung Kim, Eui-Ju Choi* (2015) Compromised MAPK signaling in human diseases: an update. Arch Toxicol. in press.


• Jun Hoe Kim, Seung Beom Hong, Jae Keun Lee, Sisu Han, Kyung-Hye Roh, Kyung-Eun Lee, Yoon Ki Kim, Eui-Ju Choi & Hyun Kyu Song (2015) Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners. Autophagy 11:75-87


• Jae Keun Lee, Sang Gil Hwang, Jin Hee Shin, Jaekyung Shim, and Eui-Ju Choi* (2014) CIIA prevents SOD1(G93A)-induced cytotoxicity by blocking ASK1-mediated signaling. Front. Cell. Neurosci. 8:179. doi: 10.3389/fncel.2014.00179


• Seung Eun Lee, Jaekwang Lee, Charles Latchoumane, Boyoung Lee, Soo-Jin Oh, Zahangir Alam Saud, Cheongdahm Park, Ning Sun, Eunji Cheong, Chien-Chang Chen, Eui-Ju Choi, C. Justin Lee, and Hee-Sup Shin (2014) Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice. Proc Natl Acad Sci USA 111:11828-11833


• Hyun Sub Hwang, Sang Gil Hwang, Kyoung-Wan Yoon, Je-Hyun Yoon, Kyung-Hye Roh, Eui-Ju Choi* (2014) CIIA negatively regulates the Ras/mitogen-activated protein kinase signaling pathway through inhibiting the Ras-specific GEF activity of SOS1. Journal of Cell Science 15:1640-1646


• Jae keun Lee, Jin Hee Shin, Sang Gil Hwang, Byoung Joo Gwag, Ann C.McKee, Junghee Lee, Neil W. Kowall, Hoon Ryu, Dae-Sik Lim, and Eui-Ju Choi (2013) MST1 functions as a key modulator of neurodegeneratin in a mouse model of ALS. PNAS 110(29:12066-12071


• Sang-Moon Yun, Sun-Jung Cho, Jae Chun Song, Sung Yeon Song, Sangmee Ahn Jo, Chulman Jo, Keejung Yoon, Rudolph E. Tanzi, Eui-Ju Choi, Young Ho Koh (2013) SUMO1 modulates Ab generation via BACE1 accumulation. Neurobiol Aging 34:650-662


• Ji Soo Chae, Sang Gil Hwang, Dae-Sik Lim, Eui-Ju Choi (2012) Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1. Free Radical Biology and Medicine 53(2):2335-2343


• Jung-Soon Mo, Ji-Hye Yoon, Ji-Ae Hong, Mi-Yeon Kim, Eun-Jung Ann, Ji-Seon Ahn, Su-Man Kim, Hyeong-Jin Baek, Florian Lang, Eui-Ju Choi, Hee-Sae Park (2012) Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways. PLoS One 7:e37111


• Won Suk Yang, Hyeong-Gon Moon, Hee Sung Kim, Eui-Ju Choi,| Myeong-Hee Yu, Dong-Young Noh, and Cheolju Lee (2012) Proteomic Approach Reveals FKBP4 and S100A9 as Potential Prediction Markers of Therapeutic Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer. J. Proteome Research 11:1078-1088


• Jun-Ho Cho, Min-KyungLee, Kyoung Wan Yoon, Jungrok Lee, Ssang-Goo Cho, and Eui-Ju Choi* (2012) Arginine methylation-dependent regulation of ASK1 signaling by PRMT1. Cell Death & Differentiation (19:859-870)


• Hyun Sub Hwang, Sang Gil Hwang, Jun-Ho Cho, Ji Soo Chae, Kyoung Wan Yoon, Ssang-Goo Cho, Eui-Ju Choi* (2011) CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1. Journal of Cell Biology 195:377-386


• Hee Jae Yun, Je-Hyun Yoon, Jae Keun Lee, Kyung-Tae Noh, Kyoung-Wan Yoon, Sang Phil Oh, Hyun Jung Oh, Ji Soo Chae, Sang Gil Hwang, Eun Hee Kim, Gerd G. Maul, Dae-Sik Lim, and Eui-JuChoi* (2011) Daxx mediates activation-induced cell death in microglia by triggering MST1 signaling. EMBO J. 30:2465-2476


• H-J Kwak, Y-J Kim, K-R Chun, YM Woo, S-J Park, J-A Jeong, SH Jo, TH Kim, HS Min, JS Chae, E-J Choi, G Kim, S-H Shin, H-S Gwak, S-K Kim, E-K Hong, G-K Lee, K-H Choi, JH Kim, H Yoo, JB Park and S-H Lee (2011) Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas. Oncogene 30:2433-2442


• Mo JS, Ann EJ, Yoon JH, Jung J, Choi YH, Kim HY, Ahn JS, Kim SM, Kim MY, Hong JA, Seo MS, Lang F, Choi EJ, Park HS. (2011) Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. Journal of Cell Science 124:100-112


• Kwang Je Kim, Je-Wook Yu, Hyun Sub Hwang and Eui-Ju Choi* (2010) CIIA is a novel regulator of detachment-induced cell death. Cancer Research 70:6352-6358


• Cheongdahm Park, Jong-Hyun Kim, Bo-Eun Yoon, Eui-Ju Choi, C. Justin Lee, and Hee-Sup Shin (2010) T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray. Proc Natl Acad Sci USA. 107:14857-14862


• Je-Hyun Yoon, Eui-Ju Choi, and Roy Parker (2010) Dcp2 phosphorylation by Ste20 modulates stress granule assembly and mRNA decay in Saccharomyces cerevisiae. Journal of Cell Biology 189:813-827


• Mi-Yeon Kim, Eun-Jung Ann, Jung-Soon Mo, Mi-Sun Seo, Ji-Ae Hong, Jane Jung, Chan-Mi Park, Yun-Hee Choi, Ji-Hye Yoon, Min-Ji Song, Eui-Ju Choi, Pyung-Rheem Han, Hyang-Sook Hoe, Alan J. Whitmarsh and Hee-Sae Park (2010) JIP1 binding to RBP-Jk mediates crosstalk between Notch1 and JIP1-JNK signaling. Cell Death & Differentiation 17:1728-1738


• Chun-Seok Cho, Sukmook Lee, Geun Taek Lee, Hyun Ae Woo, Eui-Ju Choi, and Sue Goo Rhee (2010) Irreversible Inactivation of Glutathione Peroxidase 1 and Reversible Inactivation of Peroxiredoxin II by H2O2 in Red Blood Cells. Antioxid Redox Signal. 12:1235-1246


• Eun Kyung Kim and Eui-Ju Choi * (2010) Pathological roles of MAPK signaling pathways in human diseases. BBA-Molecular Basis of Disease 1802:396-405


• Hyun Jung Oh, Mi Ju Kim, Su Jung Song, Tackhoon Kim, Dongjun Lee, Seung-Hae Kwon, Eui-Ju Choi,and Dae-Sik Lim (2010) MST1 Limits the Kinase Activity of Aurora B to Promote Stable Kinetochore-Microtubule Attachment. Curr. Biol. 20:416-422


• Kyoung Wan Yoon, Jun-Ho Cho, Jae Keun Lee, Young-Hee Kang, Ji Soo Chae, Young Mok Kim, Jeehyun Kim, Eun Kyung Kim, Sung Eun Kim, Ja-Hyun Baik, Ulhas P. Naik, Ssang-Goo Cho, and Eui-Ju Choi* (2009) CIB1 functions as a Ca2-sensitive modulator of stress-induced signaling by targeting ASK1. Proc Natl Acad Sci USA. 106:17389-17394.


• Sang Hyeok Woo, Sungkwan An, Hyung-Chahn Lee, Hyeon-Ok Jin, Sung-Keum Seo, Doo-Hyun Yoo, Kee-Ho Lee, Chang Hun Rhee, Eui-Ju Choi, Seok-Il Hong, and In-Chul Park (2009) A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. J. Biol. Chem. 284:30871-30880.


• Mi-Yeon Kim, Ji-Hye Park, Jung-Soon Mo, Eun-Jung Ann, Seung-Ok Han, Sang-Hyun Baek, Kyoung-Jin Kim, Suhn-Young Im, Jeen-Woo Park, Eui-Ju Choi, and Hee-Sae Park (2008) Downregulation by lipopolysaccharide of Notch signaling, via nitric oxide. Journal of Cell Science ,121:1466-1476.


• Jeon YJ, Choi JS, Lee JY, Yu KR, Ka SH, Cho Y, Choi EJ, Baek SH, Seol JH, Park D, Bang OS, Chung CH. (2008) Filamin B Serves as a Molecular Scaffold for Type I Interferon-induced JNK Signaling Pathway. Mol Biol Cell. 19:5116-5130


• Myung Jin Kim, Ji Soo Chae, Kwang Je Kim, Sang Gil Hwang, Kyoung Wan Yoon, Eun Kyung Kim, Hee Jae Yun, Jun-Ho Cho, Jeehyun Kim, Bong-Woo Kim, Hyung-chul Kim, Sang Sun Kang, Florian Lang, Ssang-Goo Cho and Eui-Ju Choi* (2007) Negative regulation of SEK1 signaling by serum- and glucocorticoid-inducible protein kinase 1. EMBO Journal 26:3075-3085


• Eun Kyung Kim, Kyung Tae Noh, Jae-Hyun Yoon, Jun-Ho Cho, Kyung Wan Yoon, Grey Dreyfuss and Eui-Ju Choi* (2007) Positive regulation of ASK1–mediated c-Jun NH 2 -terminal kinase signaling pathway by the WD-repeat protein Gemin5. Cell Death & Differentiation 14:1518-1528.


• Jung-Soon Mo, Mi-Yeon Kim, Seung-Ok Han, In-Sook Kim, Eun-Jung Ann, Kyu Shik Lee, Mi-Sun Seo, Jin-Young Kim, Seung-Chul Lee, Jeen-Woo Park, Eui-Ju Choi, Jae Young Seong, Cheol O Joe, Reinhard Fäessler, and Hee-Sae Park (2007) Integrin-Linked Kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase. Molecular and Cellular Biology 27:5565-5574.


• Jin Woo Kim, Myung Jin Kim, Kwang Je Kim, Hee Jae Yun, Ji Soo Chae, Sang Gil Hwang, Tong-Shin Chang, Hee-Sae Park, Kang-Woo Lee, Pyung-Lim Han, Ssang-Goo Cho, Tae-Wan Kim, and Eui-Ju Choi* (2005) Notch interferes with the scaffold function of JIP1 to inhibit the JNK signaling pathway. Proc. Natl. Acad. Sci. USA 102:14308-14313


• Yun-Suk Lee, Moon-Sun Jang, Jong-Soo Lee, Eui-Ju Choi, and Eunhee Kim (2005) SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification. EMBO Reports 6:949-955


• Min Sup Song, Su Jeong Song, Nagi G. Ayad, Jin Sook Chang, Joo Hyun Lee, Hyun Kyung Hong, Ho Lee, Naeyun Choi, Jhingook Kim, Hojoong Kim, Jin Woo Kim, Eui-Ju Choi, Marc W. Kirschner, and Dae-Sik Lim (2004) The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex. Nature Cell Biology 6:129-137.


• Kanghyun Ryoo, Sung-Ho Huh, Yong Hee Lee, Kyoung Wan Yoon, Ssang-Goo Cho, and Eui-Ju Choi* (2004) Negative Regulation of MEKK1-Induced Signaling by Glutathione S-Transferase Mu. Journal of Biological Chemistry 279:43589-43594


• Hee-Sae Park, Je-Wook Yu, Jun-Ho Cho, Mi-Sung Kim, Sung-Ho Huh, Kanghyun Ryoo, and Eui-Ju Choi* (2004) Inhibition of apoptosis signal-regulating kinase 1 (ASK1) by nitric oxide through a thiol-redox mechanism. Journal of Biological Chemistry 279:7584-7590.


• Jinwook Shin, Boyoun Park, Sunglim Cho, Sunray Lee, Youngkyun Kim, Seong-Ok Lee, Kwangmin Cho, Sungwook Lee, Bong-Suk Jin, Jin-Hyun Ahn, Eui-Ju Choi, and Kwangseog Ahn (2004) PML is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase. Journal of Biological Chemistry 279:40994-41003


• Won-Seok Choi, Dae-Seok Eom, Baek S. Han, Won K. Kim, Byung H. Han, Eui-Ju Choi, Tae H. Oh, George J. Markelonis, Jin W. Cho, and Young J. Oh (2004) Phosphorylation of p38 MAPK induced by oxidative stress is linked to activationof both caspase-8-and-9-mediated apoptotic pathways in dopaminergic neurons. Journal of Biological Chemistry 279:20451-20460


• Ssang-Goo Cho, Jin Woo Kim, Yong Hee Lee, Hyun Sub Hwang, Mi-Sung Kim, Kanghyun Ryoo, Myung Jin Kim, Kyung Tae Noh, Eun Kyung Kim, Jun-Ho Cho, Kyoung Wan Yoon, Eun-Gyung Cho, Hee-Sae Park, Sung Wook Chi, Min-Jae Lee, Sang Sun Kang, Hidenori Ichijo, and Eui-Ju Choi* (2003) Identification of a novel anti-apoptotic protein that antagonizes ASK1 and CAD activities. Journal of Cell Biology 163:71-81.


• Tong-Shin Chang, Myung Jin Kim, Kanghyun Ryoo, Jihyun Park, Soo-Jung Eom, Jaekyung Shim, Keiichi I. Nakayama, Keiko Nakayama, Motowo Tomita, Katsuhiko Takahashi, Min-Jae Lee, and Eui-Ju Choi* (2003) p57 KIP2 Modulates Stress-Activated Signaling by Inhibiting c-Jun NH2-Terminal Kinase/Stress-Activated Protein Kinase. Journal of Biological Chemistry 278:48092-48098.


• Jin Woo Kim, Ji Eun Lee, Myung Jin Kim, Eun-Gyung Cho, Ssang-Goo Cho, and Eui-Ju Choi* (2003) Glycogen Synthase Kinase 3b is a Natural Activator of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase 1 (MEKK1). Journal of Biological Chemistry 278:13995-14001.


• Hee-Sae Park, Ssang-Goo Cho, Chang Kyun Kim, Hyun Sub Hwang, Kyung Tae Noh, Mi-Sung Kim, Sung-Ho Huh, Myung Jin Kim, Kanghyun Ryoo, Eun Kyung Kim, Woo Jin Kang, Jae-Seon Lee, Jeong-Sun Seo, Young-Gyu Ko, Sunghoon Kim, and Eui-Ju Choi* (2002) The heat shock protein Hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Molecular and Cellular Biology 22:7721-7730.


• Jaesun Chun, Taegun Kwon, Eunjung Lee, Pann-Ghill Suh, Eui-Ju Choi, and Sang Sun Kang (2002) The Na+/H+ exchanger regulatory factor 2 mediates phosphorylation of serum- and glucocorticoid-induced protein kinase 1 by 3-phosphoinositide-dependent protein kinase 1. Biochemical and Biophysical Research Communications 298:207-217.


• Hee-Sae Park, Mi-Sung Kim, Sung-Ho Huh, Jihyun Park, Jongkyeong Chung, Sang Sun Kang, and Eui-Ju Choi* (2002) Akt (Protein Kinase B) negatively regulates SEK1 by means of protein phosphorylation. Journal of Biological Chemistry 277:2573-2578.


• Daeyoup Lee, Jin Woo Kim, Taegun Seo, Sun Gwan Hwang, Eui-Ju Choi, and Joonho Choe (2002) SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. Journal of Biological Chemistry 277: 22330-22337 .


• Se Bok Jang, Yong-Soon Cho, Soo-Jung Eom, Eui-Ju Choi, Kyung-Hwa Kim, Pann-Ghill Suh, and Byung-Ha Oh (2002) Crystallization and preliminary X-ray crystallographic analysis of SEDL. Acta Crystallographica (section D) ( Acta Crystallogr D Biol Crystallogr) D58:564-566.


• Ji-Young Kim, Hee-Sae Park, Suim Kang, Eui-Ju Choi, and Ick Young Kim (2002) Redox regulation of cytosolic glycerol-3 phosphate dehydrogenase: Cys 102 is the target of the redox control and essential for the catalytic activity. Biochim. Biophys. Acta 1569:67-74 .


• Ssang-Goo Cho, and Eui-Ju Choi* (2002) Apoptotic signaling pathways: caspases and stress-activated protein kinases. Journal of Biochemistry and Molecular Biology 35:24-27.


• Jin Woo Kim, Tong-Shin Chang, Ji Eun Lee, Sung-Ho Huh, Seung Woo Yeon, Wan Seok Yang, Cheol O Joe, Inhee Mook-Jung, Rudolph E. Tanzi, Tae-Wan Kim, and Eui-Ju Choi* (2001) Negative Regulation of the SAPK/JNK signaling pathway by Presenilin 1. Journal of Cell Biology 153:457-463.


• Hee-Sae Park, Jae-Seon Lee, Sung-Ho Huh, Jeong-Sun Seo, and Eui-Ju Choi* (2001) Hsp72 Functions as a Natural Inhibitory Protein of c-Jun N-terminal Kinase. EMBO Journal 20:446-456.


• Jin Woo Kim, Cheol O Joe*, and Eui-Ju Choi* (2001) Role of RIP in tumor necrosis factor-alpha-dependent MEKK1 activation. Journal of Biological Chemistry 276:27064-27070.


• Ssang-Goo Cho, Yong Hee Lee, Hee-Sae Park, Kanghyun Ryoo, Keon Wook Kang, Jihyun Park, Soo-Jung Eom, Myung Jin Kim, Tong-Shin Chang, Soo-Yeon Choi, Jaekyung Shim, Youngho Kim, Mi-Sook Dong, Min-Jae Lee, Sang Geon Kim, Hidenori Ichijo, and Eui-Ju Choi* (2001) Glutathione S-Transferase Mu Modulates the Stress-Activated Signals by Suppressing Apoptosis Signal-Regulating Kinase 1 (ASK1). Journal of Biological Chemistry 276:12749-12755.


• Yousang Gwack, Seungmin Hwang, Hyewon Byun, Chunghun Lim, Jin Woo Kim, Eui-Ju Choi, and Joonho Choe (2001) Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50 Represses p53-Induced Transcriptional Activity and Apoptosis. Journal of Virology 75:6245-6248.


• Young-Gyu Ko, Young-Sun Kang, Heonyong Park, Wongi Seol, Jinyoung Kim, Taeho Kim, Hee-Sae Park, Eui-Ju Choi, and Sunghoon Kim (2001) Apoptosis signal-regulating kinase 1 controls the proapoptotic function of Daxx in the cytoplasm. Journal of Biological Chemistry 276:39103-39106 .


• Soo-Jung Eom, Eun Young Kim, Ji Eun Lee, Hyo Jung Kang, Jaekyung Shim, Seong Up Kim, Byoung Joo Gwag, and Eui-Ju Choi* (2001) Zn2+ Induces Stimulation of the c-Jun N-terminal Kinase Signaling Pathway through Phosphatidylinositol 3-Kinase. Molecular Pharmacology 59:981-986.


• Young-Gyu Ko, Eun-Kyoung Kim, Taeho Kim, Heonyong Park, Hee-Sae Park, Eui-Ju Choi, and Sunghoon Kim (2001) Glutamine-dependent Anti-apoptotic Interaction of Human Glutaminyl-tRNA Synthetase with Apoptosis Signal-regulating Kinase 1. Journal of Biological Chemistry 276:6030-6036.


• Hee-Sae Park, Sung-Ho Huh, Mi-Sung Kim, Soo Hwan Lee, and Eui-Ju Choi* (2000) Nitric Oxide Negatively Regulates c-Jun N-terminal Kinase/Stress-Activated Protein Kinase via S-Nitrosylation. Proc. Natl. Acad. Sci. USA 97:14382-14387.


• Hee-Sae Park, Eun Park, Mi-Sung Kim, Kwangseog Ahn, Ick Young Kim, and Eui-Ju Choi* (2000) Selenite Inhibits the c-Jun N-terminal Kinase/ Stress-Activated Protein Kinase (JNK/SAPK) through a Thiol Redox Mechanism. Journal of Biological Chemistry 275:2527-2531.


• Hee-Sae Park, Sung-Ho Huh, Youngho Kim, Jaekyung Shim, Seung-Hoon Lee, Il-Seon Park, Yong-Keun Jung, Ick Young Kim, and Eui-Ju Choi* (2000) Selenite Negatively Regulates Caspase-3 through a Redox Mechanism. Journal of Biological Chemistry 275:8487-8491.


• Jaekyung Shim, Hee-Sae Park, Myung Jin Kim, Jihyun Park, Eun Park, Ssang Goo Cho, Soo-Jung Eom, Han-Woong Lee, Cheol O Joe, and Eui-Ju Choi* (2000) Rb Protein Downregulates the Stress-Activated Signals through Inhibiting c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase. Journal of Biological Chemistry 275: 14107-14111.


• Jin Woo Kim, Eui-Ju Choi, and Cheol O Joe (2000) Activation of death inducing signaling complex (DISC) by the pro-apoptotic C terminal fragment of RIP. Oncogene 19:4491-4499.


• Won-Seok Choi, So-Young Yoon, In Ick Chang, Eui-Ju Choi, Hyewhon Rhim, Byung K. Jin, Tae H. Oh, Stanislaw Krajewski, John C. Reed, and Young J. Oh. (2000) Correlation between structure of Bcl-2 and its inhibitory function of JNK and caspase activity in dopaminergic neuronal apoptosis. Journal of Neurochemistry 74:1621-1626.


• Sungwook Lee, Juhan Yoon, Boyoun Park, Youngsoo Jun, Mirim Jin, Ha Chin Sung, Ik-Hwan Kim, Seongman Kang, Eui-Ju Choi, Byung Yoon Ahn and Kwangseog Ahn. (2000) Structural and Functional Dissection of the Human Cytomegalovirus US3 in Binding Major Histocompatibility Complex Class I Molecules. J. Virol. 74:11262-11269.


• Kim, I.-J., Lee, K.-W., Park, B. Y., Lee, J.-K., Park, J., Choi, I. Y., Eom, S.-J., Chang, T.-S., Kim, M. J., Yeom, Y. I., Chang, S. K., Lee, Y.-D., Choi, E.-J.*, and Han, P.-L*. (1999) Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain. J. Neurochem. 72: 1335-1343.


• Choi, W.-S., Yoon, S.-Y., Oh, T. H., Choi, E.-J., O'Malley, K. L., and Oh, Y. J. (1999) Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: Role of caspases, ROS and JNK. J. Neuroscience Research 57:86-94.


• Ko, H. W., Park, K.-Y., Kim, H., Han, P.-L., Kim, Y. U., Gwag, B. J.*, and Choi, E.-J.* (1998) Ca 2+ -mediated Activation of c-Jun N-terminal Kinase and Nuclear Factor kappa B by NMDA in Cortical Cell Cultures. J. Neurochem. 71: 1390-1395.


• Park, J., Kim, I., Oh, Y. J., Lee, K.-W., Han, P.-L., and Choi, E.-J.* (1997) Activation of c-Jun N-terminal Kinase Antagonizes an Anti-apoptotic Action of Bcl-2. J. Biol. Chem. 272: 16725-16728.


• Kim, H., Shim, J., Han, P.-L., and Choi, E.-J.* (1997) Nitric Oxide Modulates the c-Jun N-terminal Kinase/Stress-Activated Protein Kinase Activity through Activating c-Jun N-terminal Kinase Kinase (JNKK/SEK). Biochemistry 36: 13677-13681.


• Jaekyung Shim, Heejeong Lee, Jihyun Park, Hanshin Kim, and Eui-Ju Choi* (1996) A Non-Enzymatic p21 Protein Inhibitor of Stress-Activated Protein Kinases. Nature 381: 804-807.

Research Area

세포는 끊임없이 외부 환경 변화 혹은 스트레스에 적절히 대응하면서 세포의 항상성을 유지해야한다 . 다양한 스트레스 자극 ( 예 : oxidative stress, neurotoxin, 그외 독성물질 ) 에 의해 세포의 여러 기능이 손상되고 세포의 항상성이 파괴되면 세포사멸이 촉진된다 . 잘못 발생된 세포사멸은 퇴행성뇌신경질환 , 암 , 염증질환 등의 여러 질환의 발병 원인이 된다 .

생명의 본질을 분자적 수준에서 이해하기 위해서는 세포사멸 현상이 어떤 메카니즘을 통해 조절되는 지를 분석하고 이에 관련된 제어인자와 신호전달체계를 규명하는 것이 필수적이다 . 세포 사멸 조절기전 연구는 생명의 본질과 세포 항상성을 이해하고자 하는 학문적 가치 뿐 만 아니라 여러 관련 질환들의 새로운 예방 / 치료 방법 개발에 응용할 수 있는 중요한 정보를 제공할 수 있다 . 이와 같이 세포사멸 연구는 무한한 응용 가능성을 제시하는 연구 분야이다 .

우리 실험실은 세포사멸 및 세포 항상성 제어기전 관련 세포신호전달 연구를 하고 있다 . 특히 , programmed cell death(apoptosis, necroptosis), autophagy, inflammation 에 대한 분자적 기전 연구와 퇴행성뇌신경독성 (neurodegeneration) 관련 질환들의 발병기전 연구를 하고 있다 . 연구의 주된 목표는 다음과 같다.

• ● cell death, autophagy 관련 새로운 조절 유전자 / 단백질 발굴 및 제어기전 규명
• ● 뇌신경질환 ( 퇴행성뇌질환 , 뇌경색 / 뇌졸중 ) 발병 기전에서의 cell death 및 autophagy 제어인자의 역할 규명
• ● 질환 ( 뇌신경질환 , 암 ) 발병 기전에서의 inflammation-signaling 의 역할 규명

Ongoing Project

• ● neurodegeneration (brain ischemia, ALS, parkinson’s disease) 발병 기전에서의 stress-induced cell death/autophagy 제어인자의 역할 연구
• ● (i) stress-induced cell death/autophagy 에 의한 neuroinflammation 제어기전 연구 , (ii) inflammation pathway 에 대한 새로운 제어유전자 / 단백질 발굴 및 작용기전 연구
• ● 우리 연구실에의해 세포사멸 제어인자로 처음 보고된 단백질 (CIIA, CIB 등 ) 의 질환 ( 뇌신경질환 , 암 , 염증질환 ) 발병 조절기전 연구
• ● inflammation (NF-kB pathway)/apoptosis (caspase cascade)/necroptosis (RIP1-RIP3 pathway) 상호간의 신호전달 cross-talk 제어 기전 연구

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연구교수 (Research Professor)

• 김은경 (Eun Kyung Kim) ekim88@korea.ac.kr
• 이재근 (Jae Keun Lee) mtguys@korea.ac.kr

연구원 (Researcher)

• 이루미 (Rumi Lee) tslove123@korea.ac.kr

석/박사 통합과정 (Integrated Master's & Doctor's Course)

• 이라나 (Ra Na Lee) rana@korea.ac.kr
• 노민영 (Min Young Roe) ksana87@naver.com

박사과정 (Doctor's Course)

• 이인영 (INYOUNG LEE) iysalaing@naver.com
• 노경혜 (Kyung Hye Roh) kyunghyeroh@gmail.com

석사과정 (Master's Course)

• 임소정 (So Jung Lim) teel88@naver.com

Lab Alumni

학교

김영호 교수 ( 원광대 ), 김인정 교수 (Yale Univ., 미국 ), 김진우 교수 (KAIST), 박희세 교수 ( 전남대 ), 유제욱 교수 ( 연세대 ), 이용희 교수 ( 충북대 ), 이지은 교수 ( 성균관대 ), 조쌍구 교수 ( 건국대 ), 지성욱 교수 ( 고려대 ), 창동신 교수 ( 이화여대 ), 한선영 교수 ( 경상대 )

정부/국책 연구소

김광제 박사 ( 식품의약품안전처 ), 김형철 박사 ( 한국산업기술평가관리원 ) 노경태 박사 ( 국군의학연구소 ) , 유강현 박사 ( 한국과학기술연구원 ), 황상길 박사 ( 질병관리본부 )

산업계

김명진 박사 ( 한독약품 ), 윤희재 박사 ( 삼성 바이오로직스 ), 조은경 박사 ( 태평양기술연구원 ), 채지수 박사 (Perkin-Elmer Korea), 신승호 ( 셀트리온 ), 이우상 ( 삼성 바이오로직스 ), 최향 ( 한독약품 )

Post-Doc 연수과정

조준호 박사 (NIH, 미국 ), 김미성 박사 (Harvard Univ., 미국 ), 노현철 박사 (Harvard Univ., 미국 ), 윤제현 박사 (NIH, 미국 ), 윤경완 박사 (MGH, Harvard Univ., 미국 )