노지훈

소속｜생리학교실/신경과학연구소

직위｜교수

소속｜신경과

직위｜교수 (겸임)

전공｜퇴행성 뇌질환 및 알츠하이머병

연구실｜문숙의학관 721호

전화｜02-2286-1188

팩스｜02-925-5492

이메일｜alzheimer@korea.ac.kr; alzheimer@naver.com

 

Jee Hoon Roh

Department｜Physiology / Neuroscience Research Institute

Academic Title｜Professor

Department｜Neurology

Academic Title｜Professor (Adjunct)

Major｜Neuroodegenerative disorders, Alzheimer's Disease

Location｜Moon-sook Medical Hall Room #721

Phone｜+82-2-2286-1188

Fax｜+82-2-925-5492

E-mail｜alzheimer@korea.ac.kr; alzheimer@naver.com

학력사항

1997 – 2003 ｜고려대학교 의학과 / 학사

2004 – 2006 ｜고려대학교 의학과 / 석사

2006 – 2009 ｜고려대학교 의학과 / 박사

경력사항

2003 – 2004 ｜고려대학교 의료원 수련의

2004 – 2009 ｜고려대학교 의료원 신경과 전공의, 전임의

2009 – 2010 ｜삼성서울병원 신경과 전임의

2010 – 2013 ｜Washington University in St. Louis 박사후과정 연구원

2013 – 2019 ｜서울아산병원 신경과 교수

2020 – 현재 ｜고려대학교 의과대학 신경과학연구소 교수

2021 – 현재 ｜고려대학교 의과대학 생리학교실 부교수, 교수

2022 – 현재 ｜고려대학교 안암병원 신경과 부교수, 교수 (겸임)

학술활동

2008 - 현재 ｜Society for Neuroscience 정회원

2008 - 현재 ｜American Academy of Neurology 정회원

2009 - 현재 ｜International Society to Advance Alzheimer Research and Treatment (ISTAART) 정회원

2014 - 현재 ｜International Society for Frontotemporal Dementia (ISFTD) 정회원

2008 - 현재 ｜대한신경과학회 정회원

2009 - 현재 ｜대한치매학회 정회원

2009 - 현재 ｜대한퇴행성신경질환학회 정회원

2010 - 현재 ｜Ad hoc reviewer of Nature Reviews Neuroscience, Molecular Psychiatry, Alzheimer's & Dementia, Alzheimer's Research & Therapy, Journal of Stroke, International Journal of Stroke, Journal of Clinical Neurology, Current Alzheimer Research, Journal of Alzheimer's Disease, Journal of Clinical Neuroscience, Scientific Reports, NeuroImage, Journal of Neuroimaging, European Radiology, Future Neurology, Experimental Neurobiology, PLoS One, JoVE, Brain Research, Brain and Behavior, BMC Medicine; Editorial Board Member, Experimental Neurobiology (Neurobiology of Diseases Section)

EDUCATION

1997 – 2003 ｜M.D. in Medicine/ Korea University College of Medicine, Seoul, Korea

2004 – 2006 ｜M.S. in Neurology / Korea University Graduate School of Medicine, Seoul, Korea

2006 – 2009 ｜Ph.D. in Neurology / Korea University Graduate School of Medicine, Seoul, Korea

PROFESSIONAL CAREER

2003 – 2004 ｜Internship, Korea University Medical Center, Seoul, Korea

2004 – 2009 ｜Resident / Fellow, Department of Neurology, Korea University Medical Center, Seoul, Korea

2009 – 2010 ｜Fellow, Department of Neurology, Samsung Medical Center, Seoul, Korea

2010 – 2013 ｜Postdoctoral Fellow, Department of Neurology, Washington University in St. Louis, MO, USA

2013 – 2019 ｜Professor, Department of Neurology, Asan Medical Center, Seoul, Korea

2020 – Present ｜Professor, Neuroscience Research Institute, Korea University College of Medicine, Seoul, Korea

2021 – Present ｜Associate Professor, Professor, Department of Physiology, Korea University College of Medicine, Seoul, Korea

2022 – Present ｜Associate Professor, Professor (Adjunct), Department of Neurology, Korea University Anam Hospital, Seoul, Korea

SOCIETY MEMBERSHIPS and ACADEMIC SERVICES

2008 - Present ｜Society for Neuroscience, Member

2008 - Present ｜American Academy of Neurology, Member

2009 - Present ｜International Society to Advance Alzheimer Research and Treatment (ISTAART), Member

2014 - Present ｜International Society for Frontotemporal Dementia (ISFTD), Member

2008 - Present ｜Korean Neurological Association (KNA), Member

2009 - Present ｜Korean Dementia Association (KDA), Member

2009 - Present ｜Korean Society of Neurodegenerative Disorders (KSND), Member

2010 - Present ｜Ad hoc reviewer of Nature Reviews Neuroscience, Molecular Psychiatry, Alzheimer's & Dementia, Alzheimer's Research & Therapy, Journal of Stroke, International Journal of Stroke, Journal of Clinical Neurology, Current Alzheimer Research, Journal of Alzheimer's Disease, Journal of Clinical Neuroscience, Scientific Reports, NeuroImage, Journal of Neuroimaging, European Radiology, Future Neurology, Experimental Neurobiology, PLoS One, JoVE, Brain Research, Brain and Behavior, BMC Medicine; Editorial Board Member, Experimental Neurobiology (Neurobiology of Diseases Section)

연구주제

주요 연구주제: 알츠하이머병, 퇴행성 뇌질환, 수면, 노화

노지훈 교수는 신경과 (Neurology) 전문의 및 의사 과학자로 알츠하이머병을 포함한 신경계 퇴행성 뇌질환을 연구하고 있습니다. 동물 모델에서 수면 및 뇌신경활성도와 관련된 알츠하이머병의 아밀로이드 병태생리를 연구하였으며 관련 중개연구를 지속하고 있습니다. 알츠하이머병 연속체 (Alzheimer’s disease continuum) 질환군에서 아밀로이드 및 타우 PET를 포함한 뇌영상 분석 연구 및 혈액기반 바이오마커 연구를 진행하였으며 상염색체우성 알츠하이머병 국제 공동연구를 진행하고 있습니다. 이외 노화 조절을 통한 퇴행성 뇌질환 연구를 진행중에 있습니다.

RESEARCH INTERESTS

Research Topics: Alzheimer’s disease, Neurodegenerative disorders, Sleep, Aging

Dr. Jee Hoon Roh is a trained neurologist and has worked on basic and translational research in Alzheimer’s disease (AD) and neurodegenerative disorders. Dr. Roh has published several leading papers on how sleep or brain neuronal activities affect the amyloid beta metabolism in the brain with Dr. David M. Holtzman at Washington University. He has now extended the findings in humans using in vivo pathology PET images and sleep monitoring. Dr. Roh also pioneered in blood-based biomarkers of AD in collaboration with several leading groups in the field. Dominantly Inherited Alzheimer Network (DIAN)-Korea and senescence-associated research are among the major works that Dr. Roh is actively engaged in.

Patents, Books, Awards, and Grants

Patents

INTERNATIONAL

01 | Diagnostic Kit for Diagnosis of Alzheimer’s Disease Using Dissociation of Protein Aggregates/Europe/2019/EP2990801B1

02 | Diagnostic Kit for Diagnosis of Abnormal Protein Aggregation- or Misfolding-Related Diseases Using Dissociation of Protein Aggregates/USA/2018/US10006920B2

03 | タンパク質凝集体の溶解を用いたタンパク質の非正常な凝集またはミスフォールディングと関連した疾患または疾病を診断する診断キット/Japan/2017/JP6189526B2

 

DOMESTIC

01 | 체내 단백질 응집체의 용해를 이용한 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환 또는 질병을 진단하는 혈액진단키트/대한민국/2016.05.02/10-1619238-0000

02 | 혈액 중 단백질 응집체의 용해를 통한 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환 또는 질병을 진단하는 진단키트/대한민국/2016.05.11/10-1621935-0000

03 | 퇴행성 뇌질환 진단에 적합한 이미지 바이오 마커를 획득하는 방법, 장치 및 이를 이용하여 퇴행성 뇌질환을 진단하는 방법/대한민국/2017/10-1696061-0000

 

Books

Gene Therapy in Neurological Disorders. ELSEVIER (Academic Press), 2018. ISBN 978-0128098134. Chapter 7. Lentiviral Vector Delivery of Orexin Gene to Study Potential Role of Orexin and Sleep Modulation in the Pathogenesis of Alzheimer's Disease.

Dementia Cases. 뇌미인, 2016. ISBN 979-11-956781-6-7. Chapter 6. Alzheimer's Disease (Familial Alzheimer's Disease); Chapter 7. Vascular Dementia (Multi-Infarct Dementia); Chapter 23. Treatable Dementia (Neurosyphilis); Chapter 28. Treatable Dementia (Wernicke's Encephalopathy).

 

Awards

2012 ｜ Julius Axelrod Travel Award (NINDS), Society for Neuroscience

2012 ｜ Postdoctoral Fellow Award in North America, Association of Korean Neuroscientists

2013 ｜ Future Medical Investigator Award, LG Life Science

2013 ｜ Young Investigator Award, Seoul Medical Association

 

Grants

01 | New Therapeutic Target in Alzheimer’s Disease: The Sleep-Wake Cycle^* / American Academy of Neurology (AAN) and American Brain Foundation / Clinical Research Training Fellowship / 2011-2013

^*The first Korean recipient of the Clinical Research Training Fellowship from the AAN.

02 | 알츠하이머병 동물 모델에서 수면 각성 주기와 오렉신 조절을 통한 아밀로이드 베타 병리 치료 효과 / 한국연구재단 / 신진연구자지원사업(장비지원) / 2013-2016

03 | 병리진단에 근접한 알츠하이머병 진단 및 바이오 센서 기반 치매 예측 모델 제시 / 보건복지부 / 치매극복기술개발사업 / 2014-2019

04 | 한국형 상염색체 우성 알츠하이머병 네트워크 구축 / 보건복지부 / 치매극복기술개발사업 / 2014-2019

05 | 다중영상기반 치매 조기진단 및 예측 융합임상기술 개발 / 보건복지부 / 치매극복기술개발사업 / 2014-2019

06 | 알츠하이머성 경도인지장애 진단 시스템 개발 / 산업통상자원부 / 산업핵심기술개발사업 / 2015-2018

07 | 퇴행성뇌질환 진단 및 치료를 위한 마이크로바이옴 분석 기반 한-스위스 국제협력 연구 / 보건복지부 / 보건의료기술교류 / 2021-2022

08 | DIAN 바이오마커 기반 인지예비능 분석 / 보건복지부 / 치매극복연구개발 / 2021-2023

09 | 세포 노화 조절을 통한 알츠하이머병 핵심병리 변화 분석 / 한국연구재단 / 창의도전연구 / 2021-2023

10 | 아밀로이드 이외 바이오마커 기반 신규 알츠하이머병 진단기술의 임상적 의의 검증 / 보건복지부 / 치매극복연구개발 / 2022-2026

SCIE Publications

01｜Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Farlow, Serge Gauthier, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, John C. S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, Alzheimer’s Disease Neuroimaging Initiative (ADNI)*, Dominantly Inherited Alzheimer Network (DIAN) Study Group* & Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group*. Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease. NATURE COMMUNICATIONS; 2021 Sep 9;12(1):5346. DOI(10.1038/s41467-021-25492-9). (*DIAN Consortium authorship†) [IF=14.919]

 

02｜Eun-Joo Kim, Seong-Ho Koh, Jungsoon Ha, Duk L Na, Sang Won Seo, Hee-Jin Kim, Kyung Won Park, Jae-Hong Lee, Jee Hoon Roh, Jay C Kwon, Soo Jin Yoon, Na-Yeon Jung, Jee H Jeong, Jae-Won Jang, Hee-Jin Kim, Kee Hyung Park, Seong Hye Choi, SangYun Kim, Young Ho Park, Byeong C Kim, Young-Eun Kim, Hyuk Sung Kwon, Hyun-Hee Park, Jeong-Hwa Jin. Increased telomere length in patients with frontotemporal dementia syndrome. JOURNAL OF THE NEUROLOGICAL SCIENCES;2021 Sep 15;428:117565. DOI(10.1016/j.jns.2021.117565).

 

03｜Hwang J, Kim CM, Kim JE, Oh M, Oh JS, Yoon YW, Kim JS, Lee JH, Roh JH. Clinical Implications of Amyloid-Beta Accumulation in Occipital Lobes in Alzheimer's Continuum. BRAIN SCIENCES; 2021 Sep 18;11(9):1232. DOI(10.3390/brainsci11091232)

 

04｜Kim, M; Kim, SJ; Park, JE; Yun, J; Shim, WH; Oh, JS; Oh, M; Roh, JH; Seo, SW; Oh, SJ; Kim, JS. Combination of automated brain volumetry on MRI and quantitative tau deposition on THK-5351 PET to support diagnosis of Alzheimer's disease. SCIENTIFIC REPORTS; 2021 May 14;11(1):10343. DOI(10.1038/s41598-021-89797-x).

 

05｜Pichet Binette A; Vachon-Presseau, É; Morris, J; Bateman, R; Benzinger, T; Collins, DL; Poirier, J; Breitner, JCS; Villeneuve, S; Allegri, R; Amtashar, F; Bateman, R; Benzinger, T; Berman, S; Bodge, C; Brandon, S; Brooks, W; Buck, J; Buckles, V; Chea, S; Chhatwal, J; Chrem, P; Chui, H; Cinco, J; Clifford, J; Cruchaga, C; D‘Mello, M; Donahue, T; Douglas, J; Edigo, N; Erekin-Taner, N; Fagan, A; Farlow, M; Farrar, A; Feldman, H; Flynn, G; Fox, N; Franklin, E; Fujii, H; Gant, C; Gardener, S; Ghetti, B; Goate, A; Goldman, J; Gordon, B; Graff-Radford, N; Gray, J; Gurney, J; Hassenstab, J; Hirohara, M; Holtzman, D; Hornbeck, R; DiBari, SH; Ikeuchi, T; Ikonomovic, S; Jerome, G; Jucker, M; Karch, C; Kasuga, K; Kawarabayashi, T; Klunk, W; Koeppe, R; Kuder-Buletta, E; Laske, C; Lee, J-H; Levin, J; Marcus, D; Martins, R; Mason, NS; Masters, C; Maue-Dreyfus, D; McDade, E; Montoya, L; Mori, H; Morris, J; Nagamatsu, A; Neimeyer, K; Noble, J; Norton, J; Perrin, R; Raichle, M; Ringman, J; Roh, JH; Salloway, S; Schofield, P; Shimada, H; Shiroto, T; Shoji, M; Sigurdson, W; Sohrabi, H; Sparks, P; Suzuki, K; Swisher, L; Taddei, K; Wang, J; Wang, P; Weiner, M; Wolfsberger, M; Xiong, C; Xu, X; Tam, A; Labonté, A; Pichet BA; Faubert, AM; Mathieu, A; Madjar, C; Carrier, CE; Dansereau, C; Kazazian, C; Lepage, C; Picard, C; Maillet, D; Michaud, D; Couture, D; Dea, D; Cuello, C; Barkun, A; Evans, A; Courcot, B; Tardif, C; Debacker, C; Jack, CR; Fontaine, D; Knopman, DS; Maultaup, G; Near, J; Leoutsakos, J; Maltais, JR; Brandt, J; Pruessner, J; Morris, JC.; Breitner, JCS; Poirier, J; Cheewakriengkrai, L; Münter, LM; Collins, L; Chakravarty, M; Sager, MA; Dauar-Tedeschi, M; Eisenberg, M; Rajah, N; Aisen, P; Toussaint, J; Rosa-Neto, P; Bellec, P; Kostopoulos, P; Etienne, P; Tariot, PN.; Orban, P; Sperling, RA.; Hoge, R; Thomas, RG.; Gauthier, S; Craft, S; Villeneuve, S; Montine, TJ.; Nair, V; Bohbot, V; Venugopalan, V; Fonov, V; Ituria-Medina, Y; Khachaturian, ZS.; Teigner, E; Anthal, E; Yu, E; Ferdinand, F; Pogossova, G; Mayrand, G; Duclair, G; Gagné, G; Newbold-Fox, H; Leppert, I; Vallée, I; Vogel, JW.; Tremblay-Mercier, J; Frenette, J; Frappier, J; Kat, J; Miron, J; Wan, K; Mahar, L; Carmo, L; Théroux, L; Dadar, M; Dufour, M; Lafaille-Magnan, ME; Appleby, M; Savard, M; Tuwaig, M; Petkova, M; Rioux, P; Meyer, PF; El-Khoury, R; Gordon, R; Giles, R; Das, S; Wang, S; Tabrizi, S; Mathotaarachchi, S; Dubuc, S; Lee, T; Beaudry, T; Gervais, V; Pagé, V; Gonneaud, J; Ayranci, G; Pascoal, TA.; Desautels, R; Benbouhoud, F; Saint-Fort, EF; Verfaillie, SCJ.; Farzin, S; Salaciak, A; Tullo, S; Vachon-Presseau, E; Daoust, LA; Köbe, T; Spreng, N; McSweeney, M; Nilsson, N; Pishnamazi, M; Bedetti, C. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease. BIOLOGICAL PSYCHIATRY; 2021 Apr 15;89(8):776-785. DOI(10.1016/j.biopsych.2020.01.023). [IF=13.382] §H2

 

06｜Park, S; Oh, M; Kim, J; Lee, JH; Yoon, Y; Roh, JH*. F-18-THK-5351, Fluorodeoxyglucose, and Florbetaben PET Images in Atypical Alzheimer's Disease: A Pictorial Insight into Disease Pathophysiology BRAIN SCIENCES; 2021 Apr 6;11(4):465. DOI(10.3390/brainsci11040465), (*corresponding author).

 

07｜Oh, M; Oh, SJ; Lee, SJ; Oh, JS; Roh, JH; Chung, SJ; Lee, JH; Lee, CS; Kim, JS. Clinical Evaluation of(18)F-PI-2620 as a Potent PET Radiotracer Imaging Tau Protein in Alzheimer Disease and Other Neurodegenerative Diseases Compared With(18)F-THK-5351. CLINICAL NUCLEAR MEDICINE; 2020 Nov;45(11):841-847. DOI(dx.doi.org/10.1097/rlu.0000000000003261). [IF=7.794] §H2

 

08｜Barthélemy, NR; Li, Y; Joseph-Mathurin, N; Gordon, BA.; Hassenstab, J; Benzinger, TLS.; Buckles, V; Fagan, A M; Perrin, RJ.; Goate, AM.; Morris, JC.; Karch, CM.; Xiong, C; Allegri, R; Mendez, PC; Berman, SB.; Ikeuchi, T; Mori, H; Shimada, H; Shoji, M; Suzuki, K; Noble, J; Farlow, M; Chhatwal, J; Graff-Radford, NR.; Salloway, S; Schofield, PR.; Masters, CL.; Martins, RN.; O’Connor, A; Fox, NC.; Levin, J; Jucker, M; Gabelle,A; Lehmann, S; Sato, C; Bateman, RJ.; McDade, E; Dominantly Inherited Alzheimer Network (DIAN*). A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. NATURE MEDICINE; 2020 Mar;26(3):398-407; DOI(dx.doi.org/10.1038/s41591-020-0781-z). (*DIAN Consortium authorship†). [IF=53.440] §H1

 

09｜Son, HJ; Oh, JS; Oh, M; Kim, SJ; Lee, JH; Roh, JH*; Kim, JS*. The clinical feasibility of deep learning-based classification of amyloid PET images in visually equivocal cases. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; 2020 Feb;47(2):332-341. DOI(dx.doi.org/10.1007/s00259-019-04595-y). (*co-corresponding author). [IF=9.236] §H2

 

10｜Suh, CH; Shim, H; Kim, SJ; Roh, JH; Lee, JH; Kim, MJ; Park, S; Jung, W; Sung, J; Jahng, GH. Alzheimer's Dis Neuroimaging Development and Validation of a Deep Learning-Based Automatic Brain Segmentation and Classification Algorithm for Alzheimer Disease Using 3D T1-Weighted Volumetric Images. AMERICAN JOURNAL OF NEURORADIOLOGY; 2020 Dec;41(12):2227-2234. DOI(10.3174/ajnr.A6848).

 

11｜8 Li, L; Kim, HJ; Roh, JH; Kim, M; Koh, W; Kim, Y; Heo, H; Chung, JH; Nakanishi, M; Yoon, T; Hong, CP; Seo, SW; Na, DL; Song, JW. Pathological manifestation of the induced pluripotent stem cell-derived cortical neurons from an early-onset Alzheimer's disease patient carrying a presenilin-1 mutation (S170F). CELL PROLIFERATION; 2020 Apr;53(4):e12798. DOI(10.1111/cpr.12798).

 

12｜Lee, YB; Yoo, K; Roh, JH; Moon, WJ; Jeong, Y. Brain-State Extraction Algorithm Based on the State Transition (BEST): A Dynamic Functional Brain Network Analysis in fMRI Study. BRAIN TOPOGRAPHY; 2019 Sep;32(5):897-913. DOI(10.1007/s10548-019-00719-7).

 

13｜Kim, HR; Lee, P; Seo, SW; Roh, JH; Oh, M; Oh, JS; Oh, SJ; Kim, JS; Jeong, Y. Comparison of Amyloid beta and Tau Spread Models in Alzheimer's Disease. CEREBRAL CORTEX; 2019 Sep 13;29(10):4291-4302. DOI(10.1093/cercor/bhy311).

 

14｜Dube, Umber; Del-Aguila, Jorge L; Li, Zeran; Budde, John P; Jiang, Shan; Hsu, Simon; Ibanez, Laura; Fernandez, Maria Victoria; Farias, Fabiana; Norton, Joanne; Gentsch, Jen; Wang, Fengxian; Salloway, Stephen; Masters, Colin L; Lee, Jae-Hong; Graff-Radford, Neill R; Chhatwal, Jasmeer P; Bateman, Randall J; Morris, John C; Karch, Celeste M; Harari, Oscar; Cruchaga, Carlos; Dominantly Inherited Alzheimer Network (DIAN*). An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. NATURE NEUROSCIENCE; 2019 Nov;22(11):1903-1912. DOI(10.1038/s41593-019-0501-5). (*DIAN Consortium authorship†). [IF=24.884] §H2

 

15｜Li, L*; Roh, JH*; Kim, HJ; Park, HJ; Kim, M; Koh, W; Heo, H; Chang, JW; Nakanishi, M; Yoon, T; Na, DL; Song, J. The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction. EXPERIMENTAL NEUROBIOLOGY; 2019 Jun;28(3):329-336. DOI(10.5607/en.2019.28.3.329). (*contributed equally to this manuscript).

 

16｜Kim, JE; Park, SH; Hong, YJ; Hwang, J; Han, NE; Lee, SM; Roh, JH; Kim, JS; Lee, JH. Qualitative Comparison of Semantic Memory Impairment in Patients with Amnestic Mild Cognitive Impairment Based on beta-Amyloid Status. JOURNAL OF CLINICAL NEUROLOGY; 2019 Jan;15(1):27-37. DOI(10.3988/jcn.2019.15.1.27).

 

17｜Lee, DH; Lee, P; Seo, SW; Roh, JH; Oh, M; Oh, JS; Oh, SJ; Kim, JS; Jeong, Y. Neural substrates of cognitive reserve in Alzheimer's disease spectrum and normal aging. NEUROIMAGE; 2019 Feb 1;186:690-702. DOI(10.1016/j.neuroimage.2018.11.053). [IF=6.556] §H1

 

18｜Son, HJ; Oh, JS; Roh, JH; Seo, SW; Oh, M; Lee, SJ; Oh, SJ; Kim, JS. Differences in gray and white matter F-18-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; 2019 Feb;46(2):357-366. DOI(10.1007/s00259-018-4125-x). [IF=9.236] §H2

 

19｜Preische, Oliver; Schultz, Stephanie A.; Apel, Anja; Kuhle, Jens; Kaeser, Stephan A.; Barro, Christian; Gräber, Susanne; Kuder-Buletta, Elke; LaFougere, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Masters, Colin L.; Martins, Ralph; Schofield, Peter R.; Rossor, Martin N.; Graff-Radford, Neill R.; Salloway, Stephen; Ghetti, Bernardino; Ringman, John M.; Noble, James M.; Chhatwal, Jasmeer; Goate, Alison M.; Benzinger, Tammie L. S.; Morris, John C.; Bateman, Randall J.; Wang, Guoqiao; Fagan, Anne M.; McDade, Eric M.; Gordon, Brian A.; Jucker, Mathias; Dominantly Inherited Alzheimer Network (DIAN*). Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease. NATURE MEDICINE; 2019 Feb;25(2):277-283. DOI(10.1038/s41591-018-0304-3). [IF=53.440] §H1

 

20｜Park, JE; Yun, J; Kim, SJ; Shim, WH; Oh, JS; Oh, M; Roh, JH; Seo, SW; Oh, SJ; Kim, JS. Intra-individual correlations between quantitative THK-5351 PET and MRI-derived cortical volume in Alzheimer's disease differ according to disease severity and amyloid positivity. PLOS ONE; 2019 Dec 13;14(12):e0226265. DOI(10.1371/journal.pone.0226265).

 

21｜Kim, Y*; Yoo, YK*; Kim, HY*; Roh, JH*; Kim, J; Baek, S; Lee, JC; Kim, HJ; Chae, MS; Jeong, D; Park, D; Lee, S; Jang, H; Kim, K; Lee, JH; Byun, BH; Park, SY; Ha, JH; Lee, KC; Cho, WW; Kim, JS; Koh, JY; Lim, SM; Hwang, KS*. Comparative analyses of plasma amyloid-beta levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system. SCIENCE ADVANCES; 2019 Apr 17;5(4):eaav1388. DOI(10.1126/sciadv.aav1388). (*contributed equally to this manuscript). [IF=14.136] §H2

 

22｜Li, L*; Roh, JH*; Chang, EH; Lee, Y; Lee, S; Kim, M; Koh, W; Chang, JW; Kim, HJ; Nakanishi, M; Barker, RA; Na, DL; Song, J. iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia. EXPERIMENTAL NEUROBIOLOGY; 2018 Oct;27(5):350-364. DOI(10.5607/en.2018.27.5.350). (*contributed equally to this manuscript).

 

23｜Kim, EJ; Kim, YE; Jang, JH; Cho, EH; Na, DL; Seo, SW; Jung, NY; Jeong, JH; Kwon, JC; Park, KH; Park, KW; Lee, JH; Roh, JH; Kim, HJ; Yoon, SJ; Choi, SH; Jang, JW; Ki, CS; Kim, SH. Analysis of frontotemporal dementia, amyotrophic lateral sclerosis, and other dementia-related genes in 107 Korean patients with frontotemporal dementia. NEUROBIOLOGY OF AGING; 2018 Dec;72:186.e1-186.e7. DOI(10.1016/j.neurobiolaging.2018.06.031).

 

24｜Chung, J; Yoo, K; Lee, P; Kim, CM; Roh, JH; Park, JE; Kim, SJ; Seo, SW; Shin, JH; Seong, JK; Jeong, Y. Normalization of cortical thickness measurements across different T1 magnetic resonance imaging protocols by novel W-Score standardization. NEUROIMAGE; 2017 Oct 1;159:224-235. DOI(10.1016/j.neuroimage.2017.07.053). [IF=6.556] §H1

 

25｜Park, JE; Park, B; Kim, SJ; Kim, HS; Choi, CG; Jung, SC; Oh, JY; Lee, JH; Roh, JH; Shim, WH. Alzheimer's Dis Neuroimaging Initiative (ADNI). Improved Diagnostic Accuracy of Alzheimer's Disease by Combining Regional Cortical Thickness and Default Mode Network Functional Connectivity: Validated in the Alzheimer's Disease Neuroimaging Initiative Set. KOREAN JOURNAL OF RADIOLOGY; Nov-Dec 2017;18(6):983-991. DOI(10.3348/kjr.2017.18.6.983).

 

 

26｜Chae, MS; Kim, J; Jeong, D; Kim, Y; Roh, JH; Lee, SM; Heo, Y; Kang, JY; Lee, JH; Yoon, DS; Kim, TG; Chang, ST; Hwang, KS. Enhancing surface functionality of reduced graphene oxide biosensors by oxygen plasma treatment for Alzheimer's disease diagnosis. BIOSENSORS & BIOELECTRONICS; 2017 Jun 15;92:610-617. DOI(10.1016/j.bios.2016.10.049). [IF=10.618] §H2

 

27｜Hong, YJ; Kim, CM; Kim, JE; Roh, JH; Kim, JS; Seo, SW; Na, DL; Lee, JH. Regional amyloid burden and lacune in pure subcortical vascular cognitive impairment. NEUROBIOLOGY OF AGING; 2017 Jul;55:20-26. DOI(10.1016/j.neurobiolaging.2017.03.010).

 

28｜Kim, GH; Seo, SW; Jung, K; Kwon, OH; Kwon, H; Kim, JH; Roh, JH; Kim, MJ; Lee, BH; Yoon, DS; Hwang, JW; Lee, JM; Jeong, JH; You, H; Heilman, KM; Na, DL. The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment. JOURNAL OF NEUROLOGY; 2016 Jan;263(1):89-99. DOI(10.1007/s00415-015-7946-6).

 

29｜Hong, YJ; Kim, CM; Jang, EH; Hwang, J; Roh, JH*; Lee, JH*. White Matter Changes May Precede Gray Matter Loss in Elderly with Subjective Memory Impairment. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS; 2016;42(3-4):227-235. DOI(10.1159/000450749). (*co-corresponding author).

 

30｜Hong, YJ; Jang, EH; Hwang, J; Roh, JH; Kwon, M; Lee, D; Lee, JH. Effect of Midazolam on Memory During Fiberoptic Gastroscopy Under Conscious Sedation. CLINICAL NEUROPHARMACOLOGY; Mar-Apr 2015;38(2):47-51. DOI(10.1097/WNF.0000000000000067).

 

31｜Park, SA; Kang, JH; Kang, ES; Ki, CS; Roh, JH; Youn, YC; Kim, SY; Kim, SY. A Consensus in Korea Regarding a Protocol to Reduce Preanalytical Sources of Variability in the Measurement of the Cerebrospinal Fluid Biomarkers of Alzheimer's Disease. JOURNAL OF CLINICAL NEUROLOGY; 2015 Apr;11(2):132-41. DOI(10.3988/jcn.2015.11.2.132).

 

32｜Hong, YJ; Jang, EH; Hwang, J; Roh, JH; Lee, JH. The Efficacy of Cognitive Intervention Programs for Mild Cognitive Impairment: A Systematic Review. CURRENT ALZHEIMER RESEARCH; 2015;12(6):527-42. DOI(10.2174/1567205012666150530201636).

 

33｜Kim, CM; Hwang, J; Lee, JM; Roh, JH*; Lee, JH*; Koh, JY; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Amyloid Beta-Weighted Cortical Thickness: A New Imaging Biomarker in Alzheimer's Disease. CURRENT ALZHEIMER RESEARCH; 2015;12(6):563-71. DOI(10.2174/1567205012666150530202124). (*co-corresponding author).

 

34｜Roh, JH; Lee, JH. Recent Updates on Subcortical Ischemic Vascular Dementia. JOURNAL OF STROKE; 2014 Jan;16(1):18-26. DOI(10.5853/jos.2014.16.1.18).

 

35｜Roh, JH; Jiang, H; Finn, MB; Stewart, FR; Mahan, TE; Cirrito, JR; Heda, A; Snider, BJ; Li, MJ; Yanagisawa, M; de Lecea, L; Holtzman, DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease. JOURNAL OF EXPERIMENTAL MEDICINE; 2014 Dec 15;211(13):2487-96. DOI(10.1084/jem.20141788). [IF=14.307] §H2

 

36｜Dalal, J*; Roh, JH*; Maloney, SE; Akuffo, A; Shah, S; Yuan, H; Wamsley, B; Jones, WB; Strong, CD; Gray, PA; Holtzman, DM; Heintz, N; Dougherty, JD. Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation. GENES & DEVELOPMENT; 2013 Mar 1;27(5):565-78. DOI(10.1101/gad.207654.112). (*contributed equally to this manuscript). [IF=11.361] §H2

 

37｜Yoon, CW; Seo, SW; Park, JS; Kwak, KC; Yoon, U; Suh, MK; Kim, GH; Shin, JS; Kim, CH; Noh, Y; Cho, H; Kim, MJ; Kim, JH; Roh, JH; Lee, JM; Na, DL. Cerebellar Atrophy in Patients with Subcortical-Type Vascular Cognitive Impairment. CEREBELLUM; 2013 Feb;12(1):35-42. DOI(10.1007/s12311-012-0388-0).

 

38｜Musiek, ES; Lim, MM; Yang, GR; Bauer, AQ; Oi, L; Lee, Y; Roh, JH; Ortiz-Gonzalez, X; Dearborn, JT; Culver, JP; Herzog, ED; Hogenesch, JB; Wozniak, DF; Dikranian, K; Giasson, BI; Weaver, DR; Holtzman, DM; FitzGerald, GA. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration JOURNAL OF CLINICAL INVESTIGATION; 2013 Dec;123(12):5389-400. DOI(10.1172/JCI70317). [IF=14.808] §H2

 

39｜Roh, JH; Huang, YF; Bero, AW; Kasten, T; Stewart, FR; Bateman, RJ; Holtzman, DM. Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of Amyloid-beta in Mice with Alzheimer's Disease Pathology. SCIENCE TRANSLATIONAL MEDICINE; 2012 Sep 5;4(150):150ra122. DOI(10.1126/scitranslmed.3004291). [IF=17.956] §H2

 

40｜Kim, JH; Lee, JW; Kim, GH; Roh, JH; Kim, MJ; Seo, SW; Kim, ST; Jeon, S; Lee, JM; Heilman, KM; Na, DL. Cortical asymmetries in normal, mild cognitive impairment, and Alzheimer's disease. NEUROBIOLOGY OF AGING; 2012 Sep;33(9):1959-66.DOI(10.1016/j.neurobiolaging.2011.06.026).

 

41｜Kim, GH; Jeon, S; Seo, SW; Kim, MJ; Kim, JH; Roh, JH; Shin, JS; Kim, CH; Im, K; Lee, JM; Qiu, AQ; Kim, ST; Na, DL. Topography of cortical thinning areas associated with hippocampal atrophy (HA) in patients with Alzheimer's disease (AD). ARCHIVES OF GERONTOLOGY AND GERIATRICS; Mar-Apr 2012;54(2):e122-9. DOI(10.1016/j.archger.2011.10.013).

 

42｜Seo, SW; Lee, JH; Jang, SM; Kim, ST; Chin, J; Kim, GH; Kim, JH; Roh, JH; Kim, MJ; Kim, SH; Na, DL. Neurochemical alterations of the entorhinal cortex in amnestic mild cognitive impairment (aMCI): A three-year follow-up study. ARCHIVES OF GERONTOLOGY AND GERIATRICS; Jan-Feb 2012;54(1):192-6. DOI(10.1016/j.archger.2011.04.002).

 

43｜Roh, JH; Holtzman, DM. Stealth Attack: Plaque-Specific Antibody Allows for Efficient A beta Removal without Side Effects. NEURON; 2012 Dec 6;76(5):859-61. DOI(10.1016/j.neuron.2012.11.018). [IF=17.173] §H2

 

44｜Seo, SW; Lee, JM; Im, K; Park, JS; Kim, SH; Kim, ST; Ahn, JH; Kim, MJ; Kim, GH; Kim, JH; Roh, JH; Cheong, HK; Na, DL. Cardiovascular Risk Factors Cause Cortical Thinning in Cognitively Impaired Patients Relationships Among Cardiovascular Risk Factors, White Matter Hyperintensities, and Cortical Atrophy. ALZHEIMER DISEASE & ASSOCIATED DISORDERS; Apr-Jun 2012;26(2):106-12. DOI(10.1097/WAD.0b013e31822e0831).

 

45｜Roh, JH; Park, MH; Ko, D; Park, KW; Lee, DH; Han, C; Jo, SA; Yang, KS; Jung, KY . Region and frequency specific changes of spectral power in Alzheimer's disease and mild cognitive impairment. CLINICAL NEUROPHYSIOLOGY; 2011 Nov;122(11):2169-76. DOI(10.1016/j.clinph.2011.03.023).

 

46｜Roh, JH; Qiu, AQ; Seo, SW; Soon, HW; Kim, JH; Kim, GH; Kim, MJ; Lee, JM; Na, DL. Volume reduction in subcortical regions according to severity of Alzheimer's disease. JOURNAL OF NEUROLOGY; 2011 Jun;258(6):1013-20. DOI(10.1007/s00415-010-5872-1).

 

47｜Bero, AW; Yan, P; Roh, JH; Cirrito, JR; Stewart, FR; Raichle, ME; Lee, JM; Holtzman, DM. Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. NATURE NEUROSCIENCE; 2011 Jun;14(6):750-6. DOI(10.1038/nn.2801). [IF=24.884] §H2

 

48｜Kim, MJ; Im, K; Lee, JM; Park, A; Chin, J; Kim, GH; Kim, JH; Roh, JH; Seo, SW; Na, DL. Cortical Thinning in Verbal, Visual, and Both Memory-predominant Mild Cognitive Impairment. ALZHEIMER DISEASE & ASSOCIATED DISORDERS; Jul-Sep 2011;25(3):242-9. DOI(10.1097/WAD.0b013e3182076d31).

 

49｜Roh, JH; Kim, JB; Seo, HS; Kwon, DY; Park, MH. Teaching NeuroImages: Posterior cerebral artery susceptibility vessel sign on T2*-weighted gradient echo imaging. NEUROLOGY; 2011 Jul 26;77(4):e25. DOI(10.1212/WNL.0b013e3182267b60). [IF=9.910] §H2

 

50｜Roh, JH; Suh, MK; Kim, EJ; Go, SM; Na, DL; Seo, SW. GLUCOSE METABOLISM IN PROGRESSIVE NONFLUENT APHASIA WITH AND WITHOUT PARKINSONISM. NEUROLOGY; 2010 Sep 14;75(11):1022-4. DOI(10.1212/WNL.0b013e3181f25ebb). [IF=9.910] §H2

 

51｜Seok, HY; Eun, MY; Choi, JY; Roh, JH; Park, MH; Park, KW; Kwon, DY. Atypical Spontaneous Intracranial Hypotension With a Head-Shaking Headache. HEADACHE ; 2010 Jul;50(7):1211-4. DOI(10.1111/j.1526-4610.2010.01704.x).

 

52｜Lyu, I; Seong, JK; Shin, SY; Im, K; Roh, JH; Kim, MJ; Kim, GH; Kim, JH; Evans, AC; Na, DL; Lee, JM. Spectral-based automatic labeling and refining of human cortical sulcal curves using expert-provided examples. NEUROIMAGE; 2010 Aug 1;52(1):142-57. DOI(10.1016/j.neuroimage.2010.03.076). [IF=6.556] §H1

 

53｜Roh, JH; Kim, BJ; Jang, JH; Seo, WK; Lee, SH; Kim, JH; Oh, K; Park, KW; Lee, DH; Koh, SB. The relationship of pain and health-related quality of life in Korean patients with Parkinson's disease. ACTA NEUROLOGICA SCANDINAVICA; 2009 Jun;119(6):397-403. DOI(10.1111/j.1600-0404.2008.01114.x).

 

54｜Roh, JH; Kim, JH; Oh, K; Kim, SG; Park, KW; Kim, BJ. Cortical Laminar Necrosis Caused by Rapidly Corrected Hyponatremia. JOURNAL OF NEUROIMAGING; 2009 Apr;19(2):185-7. DOI(10.1111/j.1552-6569.2008.00244.x).

 

55｜Koh, SB; Roh, JH; Kim, JH; Oh, K; Kim, BJ; Kim, GS; Park, BK; Kim, SJ; Yoon, JS. Ultrasonographic findings of shoulder disorders in patients with Parkinson's disease. MOVEMENT DISORDERS; 2008 Sep 15;23(12):1772-6. DOI(10.1002/mds.22191). [IF=10.338] §H2

 

56｜Roh, JH; Park, KW; Kim, BJ. Deep gray matter lesion caused by hypoglycemia. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION; 2008 Mar;87(3):249-50. DOI(10.1097/PHM.0b013e318164a950).

 

57｜Roh, JH; Koo, YS; Jang, SH; Park, MH. Medulla compression caused by vertebral artery dolichoectasia. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY; 2008 Feb;79(2):222. DOI(10.1136/jnnp.2007.123885). [IF=10.154] §H2

 

58｜Roh, JH; Kim, JH; Koo, Y; Seo, WK; Lee, JM; Lee, YH; Park, MH. Teaching NeuroImage: Diverse MRI signal intensities with Wernicke encephalopathy. NEUROLOGY; 2018 Aug;57(8):1039-1053. DOI(10.1212/01.wnl.0000308951.21103.49). [IF=9.910] §H2

 

59｜Kim, JH; Roh, JH; Koh, SB. Reversible injury of internal capsule and splenium in a patient with transient hypoglycemic hemiparesis. CEREBROVASCULAR DISEASES; 2006;22(4):282-3.DOI(10.1159/000094330).

 

60｜Roh, JH; Koh, SB; Kim, JH. Orbital myositis in Behcet's disease: A case report with MRI findings. EUROPEAN NEUROLOGY; 2006;56(1):44-5. DOI(10.1159/000095142).

 

†DIAN Consortium Authorship: Consortia authorship. If a consortium is listed as a collective of authors, all members of the consortium are considered authors and must be listed in the published article as such. (https://www.nature.com/nature-research/editorial-policies/authorship).

 

 

 

 

Non-SCIE Publications

01｜Park, KH; Lim, J-S; Seo, SW; Jeong, Y; Noh, Y; Koh, S-H; Bae, J; Park, SA; Yang, S-J; Kim, HJ; Chin, J; Roh, JH.; An, SSA.; Korean Dementia Association; "Executive Summary of the 2019 International Conference of Korean Dementia Association: Exploring the Novel Concept of Alzheimer's Disease and Other Dementia: a Report from the Academic Committee of the Korean Dementia Association", Dementia and Neurocognitive Disorders (대한치매학회지), vol.19, no.2, pp.39~53, 2020.06; DOI(10.12779/dnd.2020.19.2.39).

 

02｜Hwang, J; Kim, JE; Roh, JH; Lee, J-H; "Human Herpes Virus 6 Encephalitis Following Bone Marrow Transplantation with Uncommon Magnetic Resonance Imaging Findings", Dementia and Neurocognitive Disorders (대한치매학회지), vol.15, no.3, pp.88, 2016.09; DOI(10.12779/dnd.2016.15.3.88).

 

03｜Hwang, J; Kim, CMi Jeon, S; Lee, JM; Hong, YJ; Roh, JH*; Lee, J‐H; Koh, J‐Y; Na, DL.; Alzheimer's Disease Neuroimaging Initiative; "Prediction of Alzheimer's disease pathophysiology based on cortical thickness patterns", Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol.2, no.1, pp.58~67, 2016.01; DOI(10.1016/j.dadm.2015.11.008), (*corresponding author).

Undergraduate MED 125 Physiology

TV Documentary

KBS ‘생로병사의 비밀’ 2017 (28:58)
‘잠들지 못하는 뇌의 경고’

 

KBS ‘생로병사의 비밀’ 2018 (39:38)
‘늙지 않는 뇌의 비밀’

 

Newspapers & Interviews

INTERNATIONAL

AAN Neurology Today 2011
‘Up & Coming: Exploring the Sleep-Wake Cycle as a Target for AD Intervention’

 

AAN Neurology Today 2012
‘Disrupted Sleep-wake Cycle Associated with Abeta Aggregation, Suggesting a Potential Biomarker for Alzheimer's Disease’

 

AAN Neurology Today 2013
‘Antibody Reduced Plaque By More Than Half in Animal Model of Alzheimer's Disease’

 

DOMESTIC

조선일보 2014
‘숙면이 치매 막아줘’

 

조선일보 2015
’전혀 기억 못하면 치매, 힌트 줘야 생각나면 건망증’

 

동아일보 2015
‘꿀잠’이 알츠하이머 치매 예방한다’

 

동아일보 2016
‘알츠하이머 유전자’ 대물림 국내 가족 첫 추적 조사’

 

조선일보 2017
‘밤에 졸리고 아침에 깨고… '24시간 생체시계' 비밀 풀다’

 

동아일보 2019
‘핏방울로 알츠하이머 치매 진단…정확도 최대 90%’