Prof. Ham graduated from  Korea University College of Medicine, Korea in 1993 and achieved The Doctor of Medicine (M.D.) in Psychiatry at the graduate school of Korea University in 2003. He continued the training at Korea University Hospitals and other hospitals in Korea for many years. He has worked as a full-time psychiatrist and professor at Korea University Hospital since 2009.

He also has been a consultant doctor at National Pension Service and some more governmental institutions in Korea. From September 2013 for one year, he worked as a Visiting Professor at the Department of Psychiatry in the School of Medicine at the University of Pittsburgh, USA.

 

He has received the grants from a number of institutions and Korea government for the researches that are focusing on the multidisciplinary approaches such as neuroimaging and Big Data to study major depressive disorders. He has authored or co-authored more than 130 publications over the last 10 years.

Education

Medical School

Korea University, Collegeof Medicine, Seoul, Korea 1989-1993, M.D.

Graduate School

Korea University, GraduateSchool, Seoul, Korea 1995-1997, M.M.Sc.

Korea University, GraduateSchool, Seoul, Korea 2001-2004, Ph.D.(Medical Science)

Professional Experiences

Proessor

Department of Psychiatry, KoreaUniversity College of Medicine

2012-present

Visiting Professor

Departmentof Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

2013-2014

Associate Professor

Department of Psychiatry,Korea University College of Medicine

2009-2012

Assistant Professor

Department of Psychiatry,Hallym University College of Medicine

2004-2008

Professional Memberships

National

• KoreanMedical Association, 1993-
• KoreanNeuropsychiatric Association, 1998-
• KoreanAcademy of Sleep Medicine 1998-
• TheKorean Society of Biological Psychiatry 1998-
• KoreanSociety for Depressive and Bipolar Disorders 2001-
• KoreanAcademy of Anxiety Disorders 2004-
• KoreanCollege of Neuropsychopharmacology 2004-

International

• Resident Award, Korean Neuropsychiatric Association 1997

• Honors and Awards

• Young Investigator Award, Korean Society for Depressive and Bipolar Disorders 2006
• The best poster award, World Psychiatric Association, Regional Meeting 2007
• The best poster award, Korean Academy of Biological Psychiatry 2007
• GSK Young Investigator Award, Korean Neuropsychiatric Association 2007
• Research Award, Korean Society for Depressive and Bipolar Disorders 2010
• GSK Research Award, Korean Neuropsychiatric Association 2012
• Lundbeck Neuroscience Research Award, Korean Academy of Biological Psychiatry 2014
• Korea University Seog-Top Research Award 2017

Bibliography

International journal

• 1. LeeJ, Choi S, Kang J, Won E, Tae WS, Lee MS, Ham BJ. Structural characteristics ofthe brain reward circuit regions in patients with bipolar I disorder: Avoxel-based morphometric study. Psychiatry Res. 2017 Nov 30;269:82-89
• 2. HanKM, Won E, Kang J, Choi S, Kim A, Lee MS, Tae WS, Ham BJ. TESC gene-regulatinggenetic variant (rs7294919) affects hippocampal subfield volumes andparahippocampal cingulum white matter integrity in major depressve disorder. JPsychiatr Res. 2017 Oct;93:20-29.
• 3. HanKM, Chang J, Won E, Lee MS, Ham BJ. Precarious employment associated withdepressive symptoms and suicidal ideation in adult wage workers. J AffectDisord. 2017 Aug 15;218:201-209.
• 4. WonE, Kang J, Choi S, Kim A, Han KM, Yoon HK, Cho SH, Tae WS, Lee MS, Joe SH, KimYK, Ham BJ. The association between substance P and white matter integrity inmedication-naive patients with major depressive disorder. Sci Rep. 2017 Aug29;7(1):9707.
• 5. HanS, Yang SH, Kim JY, Mo S, Yang E, Song KM, Ham BJ, Mechawar N, Turecki G, LeeHW, Kim H. Down-regulation of cholinergic signaling in the habenula induces anhedonia-likebehavior. Sci Rep. 2017 Apr 18;7(1):900.
• 6. WonE, Han KM, Kang J, Kim A, Yoon HK, Chang HS, Park JY, Lee MS, Greenberg T, TaeWS, Ham BJ. Vesicular monoamine transporter 1 gene polymorphism and whitematter integrity in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry.2017 Apr 10;77:138-145.
• 7. HanKM, Won E, Kang J, Kim A, Yoon HK, Chang HS, Son KR, Lee MS, Tae WS, Ham BJ.Local gyrification index in patients with major depressive disorder and itsassociation with tryptophan hydroxylase-2 (TPH2) polymorphism. Hum Brain Mapp.2017 Mar;38(3):1299-1310.
• 8. HanKM, Won E, Sim Y, Kang J, Han C, Kim YK, Kim SH, Joe SH, Lee MS, Tae WS, HamBJ. Influence of FKBP5 polymorphism and DNA methylation on structural changesof the brain in major depressive disorder. Sci Rep. 2017 Feb 15;7:42621.
• 9. WonE, Choi S, Kang J, Lee MS, Ham BJ. Regional cortical thinning of theorbitofrontal cortex in medication-naïve female patients with major depressivedisorder is not associated with MAOA-uVNTR polymorphism. Ann Gen Psychiatry.2016 Oct 12;15:26.
• 10. HanKM, Kim D, Sim Y, Kang J, Kim A, Won E, Tae WS, Ham BJ. Alterations in thebrainstem volume of patients with major depressive disorder and theirrelationship with antidepressant treatment. J Affect Disord. 2017 Jan15;208:68-75
• 11. KangJ, Ham BJ, Wallraven C. Cannot avert the eyes: reduced attentional blink  toward others' emotional expressions in empathicpeople. Psychon Bull Rev. 2016 Oct 11.
• 12. ChoiS, Han KM, Kang J, Won E, Chang HS, Tae WS, Son KR, Kim SJ, Lee MS, Ham BJ.Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Geneon Structural Integrity of White Matter Tracts in Major Depressive Disorder.PLoS One. 2016 Oct 10;11(10):e0164301.
• 13. WonE, Choi S, Kang J, Kim A, Han KM, Chang HS, Tae WS, Son KR, Joe SH, Lee MS, HamBJ. Association between reduced white matter integrity in the corpus callosumand serotonin transporter gene DNA methylation in medication-naïve patientswith major depressive disorder. Transl Psychiatry. 2016 Aug 9;6(8):e866.
• 14. WonE, Kang J, Kim A, Choi S, Han KM, Tae WS, Chang HS, Son KR, Greenberg T, JoeSH, Lee MS, Ham BJ. Influence of BclI C/G (rs41423247) on hippocampal shape andwhite matter integrity of the parahippocampal cingulum in major depressivedisorder. Psychoneuroendocrinology. 2016 Oct;72:147-55.
• 15. ChangHJ, Kang J, Ham BJ, Lee YM. A functional neuroimaging study of the clinicalreasoning of medical students. Adv Health Sci Educ Theory Pract. 2016Dec;21(5):969-982.
• 16. WiseT, Radua J, Via E, Cardoner N, Abe O, Adams TM, Amico F, Cheng Y, Cole JH, deAzevedo Marques Périco C, Dickstein DP, Farrow TF, Frodl T, Wagner G, GotlibIH, Gruber O, Ham BJ, Job DE, Kempton MJ, Kim MJ, Koolschijn PC, Malhi GS,Mataix-Cols D, McIntosh AM, Nugent AC, O'Brien JT, Pezzoli S, Phillips ML,Sachdev PS, Salvadore G, Selvaraj S, Stanfield AC, Thomas AJ, van Tol MJ, vander Wee NJ, Veltman DJ, Young AH, Fu CH, Cleare AJ, Arnone D. Common anddistinct patterns of grey-matter volume alteration in major depression andbipolar disorder: evidence from voxel-based meta-analysis. Mol Psychiatry. 2016May 24.
• 17. NaKS, Won E, Kang J, Chang HS, Yoon HK, Tae WS, Kim YK, Lee MS, Joe SH, Kim H,Ham BJ. Brain-derived neurotrophic factor promoter methylation and corticalthickness in recurrent major depressive disorder. Sci Rep. 2016 Feb 15;6:21089.
• 18. ArnoneD, Job D, Selvaraj S, Abe O, Amico F, Cheng Y, Colloby SJ, O'Brien JT, Frodl T,Gotlib IH, Ham BJ, Kim MJ, Koolschijn PC, Périco CA, Salvadore G, Thomas AJ,Van Tol MJ, van der Wee NJ, Veltman DJ, Wagner G, McIntosh AM.Computational meta-analysis ofstatistical parametric maps in major depression. Hum Brain Mapp. 2016Apr;37(4):1393-404.
• 19. HanKM, Won E, Paik JW, Lee MS, Lee HW, Ham BJ. Mental health service use in  adults with suicidal ideation within anationally representative sample of the Korean population. J Affect Disord.2016 Mar 15;193:339-47.
• 20. YoonHK, Kang J, Kwon DY, Ham BJ. Frontoparietal Cortical Thinning inRespiratory-Type Panic Disorder: A Preliminary Report. Psychiatry Investig.2016 Jan;13(1):146-51.
• 21. MyungW, Na KS, Ham BJ, Oh SJ, Ahn HW, Jung HY. Decreased medial frontal gyrus inpatients with adjustment disorder. J Affect Disord. 2016 Feb;191:36-40.
• 22. HamBJ, Greenberg T, Chase HW, Phillips ML. Impact of the glucocorticoid receptorBclI polymorphism on reward expectancy and prediction error related ventralstriatal reactivity in depressed and healthy individuals. J Psychopharmacol.2016 Jan;30(1):48-55
• 23. ChangHS, Won E, Lee HY, Ham BJ, Lee MS. Association analysis for corticotropinreleasing hormone polymorphisms with the risk of major depressive disorder andthe response to antidepressants. Behav Brain Res. 2015 Oct 1;292:116-24.
• 24. LeeBH, Hong JP, Hwang JA, Ham BJ, Na KS, Kim WJ, Trigo J, Kim YK. Alterations inplasma vascular endothelial growth factor levels in patients with  schizophrenia before and after treatment.Psychiatry Res. 2015 Jul 30;228(1):95-9.
• 25. WonE, Ham BJ. Imaging genetics studies on monoaminergic genes in major depressivedisorder. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 4;64:311-9.
• 26. ChoiS, Han KM, Won E, Yoon BJ, Lee MS, Ham BJ. Association of brain-derived  neurotrophic factor DNA methylation andreduced white matter integrity in the anterior corona radiata in majordepression. J Affect Disord. 2015 Feb 1;172:74-80.
• 27. ChangHS, Won ES, Lee HY, Ham BJ, Kim YG, Lee MS. The association ofproopiomelanocortin polymorphisms with the risk of major depressive disorderand  the response to antidepressants viainteractions with stressful life events. J Neural Transm (Vienna). 2015Jan;122(1):59-68.
• 28. PaeCU, Seo HJ, Lee BC, Seok JH, Jeon HJ, Paik JW, Kwak KP, Ham BJ, Han C, Lee SJ.A Meta-Analysis Comparing Open-Label versus Placebo-Controlled Clinical Trialsfor Aripiprazole Augmentation in the Treatment of Major Depressive Disorder:Lessons and Promises. Psychiatry Investig. 2014 Oct;11(4):371-9.
• 29. ChangHS, Won ES, Lee HY, Ham BJ, Kim YG, Lee MS. Association of ARRB1 polymorphismswith the risk of major depressive disorder and with treatment response tomirtazapine. J Psychopharmacol. 2015 May;29(5):615-22
• 30. .JungJ, Kang J, Won E, Nam K, Lee MS, Tae WS, Ham BJ. Impact of lingual gyrus volumeon antidepressant response and neurocognitive functions in Major DepressiveDisorder: A voxel-based morphometry study. J Affect Disord. 2014 Dec 1;169:179-87.
• 31. KiM, Paik JW, Choi KS, Ryu SH, Han C, Lee K, Ham BJ, Chang HS, Won ES, Jun TY,Lee MS. Delays in depression treatment among Korean population. Asia Pac Psychiatry.2014 Aug 8. doi: 10.1111/appy.12140.
• 32. BousmanCA, Sarris J, Won ES, Chang HS, Singh A, Lee HY, Ham BJ, Tan CH, Lee MS, Ng CH.Escitalopram efficacy in depression: a cross-ethnicity examination of theserotonin transporter promoter polymorphism. J Clin Psychopharmacol. 2014 Oct;34(5):645-8.
• 33. ChangHS, Lee HY, Cha JH, Won ES, Ham BJ, Kim B, Lee MS. Interaction of 5-HTT andHTR1A gene polymorphisms in treatment responses to mirtazapine in patients withmajor depressive disorder. J Clin Psychopharmacol. 2014 Aug;34(4):446-54.
• 34. KimYG, Chang HS, Won ES, Ham BJ, Lee MS. Serotonin-related polymorphisms in TPH1and HTR5A genes are not associated with escitalopram treatment response in Koreanpatients with major depression. Neuropsychobiology. 2014;69(4):210-9.
• 35. WonE, Park SC, Han KM, Sung SH, Lee HY, Paik JW, Jeon HJ, Lee MS, Shim SH, Ko YH,Lee KJ, Han C, Ham BJ, Choi J, Hwang TY, Oh KS, Hahn SW, Park YC, Lee MS. Evidence-based,pharmacological treatment guideline for depression in Korea, revised edition. JKorean Med Sci. 2014 Apr;29(4):468-84.
• 36. HanKM, Choi S, Jung J, Na KS, Yoon HK, Lee MS, Ham BJ. Cortical thickness,cortical and subcortical volume, and white matter integrity in patients withtheir first episode of major depression. J Affect Disord. 2014 Feb;155:42-8
• 37. NaKS, Chang HS, Won E, Han KM, Choi S, Tae WS, Yoon HK, Kim YK, Joe SH, Jung IK,Lee MS, Ham BJ, Association between glucocorticoid receptor methylation andhippocampal subfields in major depressive disorder. PLOS One. 2014Jan;9(1):e85425
• 38. KimJW, Kim YK, Hwang JA, Yoon HK, Ko YH, Han C, Lee HJ, Ham BJ, Lee HS. PlasmaLevels of IL-23 and IL-17 before and after Antidepressant Treatment in Patientswith Major Depressive Disorder. Psychiatry Investig. 2013 Sep;10(3):294-9.
• 39. HanKM, Chang HS, Choi IK, Ham BJ, Lee MS. CYP2D6 P34S Polymorphism and Outcomes ofEscitalopram Treatment in Koreans with Major Depression. Psychiatry Investig.2013 Sep;10(3):286-93.
• 40. NaKS, Ham BJ, Lee MS, Kim L, Kim YK, Lee HJ, Yoon HK. Decreased gray matter volumeof the medial orbitofrontal cortex in panic disorder with agoraphobia: a preliminarystudy. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug;45:195-200
• 41. LeeHY, Ham BJ. Stress and mental illness. J Korean Med Assoc. 2013Jun;56(6):471-477.
• 42. LeeHY, Oh CK, Ham BJ, Chang HS, Paik JW, Won ES, Hahn SW, Shim SH, Kwon YJ, JungHY, Lee MS. No Association between Serotonin Receptor 2C-759C/T Polymorphism andWeight Change or Treatment Response to Mirtazapine in Korean Depressive Patients.Psychiatry Investig. 2013 Jun;10(2):190-5.
• 43. SeokJH, Choi S, Lim HK, Lee SH, Kim I, Ham BJ. Effect of the COMT val158met polymorphismon white matter connectivity in patients with major depressive disorder.Neurosci Lett. 2013 Jun 17;545:35-9.
• 44. WonES, Chang HS, Lee HY, Ham BJ, Lee MS. Association between serotonin transporter-linkedpolymorphic region and escitalopram antidepressant treatment response in Koreanpatients with major depressive disorder. Neuropsychobiology. 2012;66(4):221-9.
• 45. SeokJH, Lee KU, Kim W, Lee SH, Kang EH, Ham BJ, Yang JC, Chae JH. Impact of early-lifestress and resilience on patients with major depressive disorder. Yonsei Med J.2012 Nov 1;53(6):1093-8.
• 46. YoonHK, Lee HJ, Kim L, Lee MS, Ham BJ. Impact of tryptophan hydroxylase 2 G-703Tpolymorphism on anger-related personality traits and orbitofrontal cortex. BehavBrain Res. 2012 May 16;231(1):105-10.
• 47. HwangSH, Rhee MK, Kang RH, Lee HY, Ham BJ, Lee YS, Lee MS. Development and validationof a screening scale for depression in Korea: the Lee and Rhee DepressionScale. Psychiatry Investig. 2012 Mar;9(1):36-44.
• 48. JeongHG, Ham BJ, Yeo HB, Jung IK, Joe SH. Gray matter abnormalities in patients withpremenstrual dysphoric disorder: an optimized voxel-based morphometry. J AffectDisord. 2012 Nov;140(3):260-7.
• 49. ChangHS., Lee HY, Ham BJ, Park YC, Hahn SW, Jeong YJ, Kim B, Lee MS. Association between brain-derivedneurotrophic factor V66M and treatment responses to escitalopram in patientswith major depressive disorder. Asia-Pacific Psychiatry.2012;4(4);241-249.
• 50. ShinC, Park MH. Han C, Patkar AA, Ham BJ, Kim SH, Joe SH, Pae CU, Jung IK.Attitudes on clinical research participation of community living elders inKorea Asia-Pacific Psychiatry. 2012;4(3):168-173.
• 51. WooJM, Kim W, Hwang TY, Frick KD, Choi BH, Seo YJ, Kang EH, Kim SJ, Ham BJ, LeeJS, Park YL. Impact of depression on work productivity and its improvement afteroutpatient treatment with antidepressants. Value Health. 2011 Jun;14(4):475-82.
• 52. LeeHY, Tae WS, Yoon HK, Lee BT, Paik JW, Son KR, Oh YW, Lee MS, Ham BJ. Demonstrationof decreased gray matter concentration in the midbrain encompassing the dorsalraphe nucleus and the limbic subcortical regions in major depressive disorder:an optimized voxel-based morphometry study. J Affect Disord. 2011 Sep;133(1-2):128-36.
• 53. LeeBT, Lee HY, Han C, Pae CU, Tae WS, Lee MS, Joe SH, Jung IK, Ham BJ. DRD2/ANKK1TaqI A polymorphism affects corticostriatal activity in response to negativeaffective facial stimuli. Behav Brain Res. 2011 Sep 30;223(1):36-41.
• 54. LeeBT, Lee HY, Park SA, Lim JY, Tae WS, Lee MS, Joe SH, Jung IK, Ham BJ. Neuralsubstrates of affective face recognition in alexithymia: a functional magneticresonance imaging study. Neuropsychobiology. 2011;63(2):119-24.
• 55. YangJ, Lee MS, Lee SH, Lee BC, Kim SH, Joe SH, Jung IK, Choi IG, Ham BJ. Associationbetween tryptophan hydroxylase 2 polymorphism and anger-related personalitytraits among young Korean women. Neuropsychobiology. 2010 Aug;62(3):158-63.
• 56. LeeHY, Ham BJ, Kang RH, Paik JW, Hahn SW, Lee MS, Lee MS. Trial of aripiprazole inthe treatment of first-episode schizophrenia. Psychiatry Clin Neurosci. 2010Feb;64(1):38-43.
• 57. PaeCU, Misra A, Ham BJ, Han C, Patkar AA, Masand PS. Paroxetine mesylate: comparableto paroxetine hydrochloride? Expert Opin Pharmacother. 2010 Feb;11(2):185-93.
• 58. KimYK, Lee BC, Ham BJ, Yang BH, Roh S, Choi J, Kang TC, Chai YG, Choi IG. Increasedtransforming growth factor-beta1 in alcohol dependence. J Korean Med Sci. 2009Oct;24(5):941-4.
• 59. PaeCU, Marks DM, Shah M, Han C, Ham BJ, Patkar AA, Masand PS. Milnacipran: beyonda role of antidepressant. Clin Neuropharmacol. 2009 Nov-Dec;32(6):355-63.
• 60. PaeCU, Mandelli L, Han C, Ham BJ, Masand PS, Patkar AA, Steffens DC, De Ronchi D,Serretti A. Thyroid hormones affect recovery from depression during antidepressanttreatment. Psychiatry Clin Neurosci. 2009 Jun;63(3):305-13.
• 61. LeeBC, Choi IG, Kim YK, Ham BJ, Yang BH, Roh S, Choi J, Lee JS, Oh DY, Chai YG.Relation between plasma brain-derived neurotrophic factor and nerve growth factorin the male patients with alcohol dependence. Alcohol. 2009 Jun;43(4):265-9.
• 62. HamBJ, Jung IK. Current Pharmacotherapy of Depression. J Korean Med Assoc. 2009May;52(5):518-524.
• 63. LeeBT, Lee HY, Lee BC, Pae CU, Yoon BJ, Ryu SG, Choi IG, Lee MS, Ham BJ. Impact ofthe tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity inresponse to affective facial stimuli in patients with major depressivedisorder. Genes Brain Behav. 2009 Jul;8(5):512-8.
• 64. KangRH, Chang HS, Wong ML, Choi MJ, Park JY, Lee HY, Jung IK, Joe SH, Kim L, KimSH, Kim YK, Han CS, Ham BJ, Lee HJ, Ko YH, Lee MS, Lee MS. Brain-derived neurotrophicfactor gene polymorphisms and mirtazapine responses in Koreans with majordepression. J Psychopharmacol. 2010 Dec;24(12):1755-63.
• 65. JungSI, Seo CH, Jang K, Ham BJ, Choi IG, Kim JH, Lee BC. Efficacy of naltrexone inthe treatment of chronic refractory itching in burn patients: preliminaryreport of an open trial. J Burn Care Res. 2009 Mar-Apr;30(2):257-60
• 66. JeonSO, Chang HS, Lee HY, Ham BJ, Kang RH, Jeong YJ, Lee MS, CYP2D6 P34SPolymorphism and Mirtazapine Responses in Koreans with Major Depression,Mol.Cell. Toxicol, 5(4), 346-353, 2009
• 67. MarksDM, Park MH, Ham BJ, Han C, Patkar AA, Masand PS, Pae CU. Paroxetine: safetyand tolerability issues. Expert Opin Drug Saf. 2008 Nov;7(6):783-94.
• 68. LeeS, Kim W, Ham BJ, Chen W, Bear MF, Yoon BJ. Activity-dependent NR2B expressionis mediated by MeCP2-dependent epigenetic regulation. Biochem Biophys ResCommun. 2008 Dec 19;377(3):930-4.
• 69. KimLS, Hwang HS, Jon DI, Ham BJ, Seok JH. Dysfunction of the neural networkassociated with sustained attention in cancer patients with clinically significantdepressive symptoms. Neurosci Lett. 2008 Dec 5;447(1):1-6.
• 70. LeeBT, Ham BJ. Serotonergic genes and amygdala activity in response to negativeaffective facial stimuli in Korean women. Genes Brain Behav. 2008 Nov;7(8):899-905.
• 71. PaeCU, Mandelli L, Han C, Ham BJ, Masand PS, Patkar AA, Steffens DC, De Ronchi D,Serretti A. Do estradiol levels influence on the cognitive function duringantidepressant treatments in post-menopausal women with major depressive disorder?A comparison with pre-menopausal women. Neuro Endocrinol Lett. 2008 Aug;29(4):500-6.
• 72. LeeBT, Paik JW, Kang RH, Chung SY, Kwon HI, Khang HS, Lyoo IK, Chae JH, Kwon JH,Kim JW, Lee MS, Ham BJ. The neural substrates of affective face recognition inpatients with Hwa-Byung and healthy individuals in Korea. World J Biol Psychiatry.2009;10(4 Pt 2):552-9.
• 73. LeeBT, Ham BJ. Monoamine oxidase A-uVNTR genotype affects limbic brain activity inresponse to affective facial stimuli. Neuroreport. 2008 Mar 26;19(5):515-9.
• 74. KimMJ, Chey J, Chung A, Bae S, Khang H, Ham B, Yoon SJ, Jeong DU, Lyoo IK. Diminishedrostral anterior cingulate activity in response to threat-related events inposttraumatic stress disorder. J Psychiatr Res. 2008 Mar;42(4):268-77
• 75. HamBJ, Jhun HJ. Psychological job characteristics and alexithymic traits in Koreanwhite-collar workers. J Occup Health. 2008;50(1):63-5.
• 76. LeeSH, Ham BJ, Cho YH, Lee SM, Shim SH. Association study of dopamine receptor D2TaqI A polymorphism and reward-related personality traits in healthy Koreanyoung females. Neuropsychobiology. 2007;56(2-3):146-51.
• 77. LeeBT, Seok JH, Lee BC, Cho SW, Yoon BJ, Lee KU, Chae JH, Choi IG, Ham BJ. Neuralcorrelates of affective processing in response to sad and angry facial stimuliin patients with major depressive disorder. Prog Neuropsychopharmacol BiolPsychiatry. 2008 Apr 1;32(3):778-85.
• 78. KimDJ, Choi IG, Park BL, Lee BC, Ham BJ, Yoon S, Bae JS, Cheong HS, Shin HD. Majorgenetic components underlying alcoholism in Korean population. Hum Mol Genet.2008 Mar 15;17(6):854-8.
• 79. YangJW, Lee SH, Ryu SH, Lee BC, Kim SH, Joe SH, Jung IK, Choi IG, Ham BJ. Associationbetween monoamine oxidase A polymorphisms and anger-related personality traitsin Korean women. Neuropsychobiology. 2007;56(1):19-23.
• 80. LeeBC, Yang JW, Lee SH, Kim SH, Joe SH, Jung IK, Choi IG, Ham BJ. An interactionbetween the norepinephrine transporter and monoamine oxidase A polymorphisms,and novelty-seeking personality traits in Korean females. Prog NeuropsychopharmacolBiol Psychiatry. 2008 Jan 1;32(1):238-42.
• 81. LeeBT, Seong Whi Cho, Hyung Soo Khang, Lee BC, Choi IG, Lyoo IK, Ham BJ. The neuralsubstrates of affective processing toward positive and negative affectivepictures in patients with major depressive disorder. Prog Neuropsychopharmacol BiolPsychiatry. 2007 Oct 1;31(7):1487-92.
• 82. HamBJ, Chey J, Yoon SJ, Sung Y, Jeong DU, Ju Kim S, Sim ME, Choi N, Choi IG, RenshawPF, Lyoo IK. Decreased N-acetyl-aspartate levels in anterior cingulate andhippocampus in subjects with post-traumatic stress disorder: a proton magneticresonance spectroscopy study. Eur J Neurosci. 2007 Jan;25(1):324-9.
• 83. HamBJ, Sung Y, Kim N, Kim SJ, Kim JE, Kim DJ, Lee JY, Kim JH, Yoon SJ, Lyoo IK.Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjectswith panic disorder: a proton magnetic resonance spectroscopy (1H-MRS) study.Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):403-11
• 85. HamBJ, Lee YM, Kim MK, Lee J, Ahn DS, Choi MJ, Lyoo IK, Choi IG, Lee MS. Personality,dopamine receptor D4 exon III polymorphisms, and academic achievement inmedical students. Neuropsychobiology. 2006;53(4):203-9.
• 86. HamBJ, Lee MS, Lee HJ, Kang RH, Han CS, Choi MJ, Lee SH, Ryu SH. No associationbetween the tryptophan hydroxylase gene polymorphism and major depressivedisorders and antidepressant response in a Korean population. Psychiatr Genet.2005 Dec;15(4):299-301.
• 87. LeeMS, Ham BJ, Kee BS, Kim JB, Yeon BK, Oh KS, Oh BH, Lee C, Jung HY, Chee IS,Choe BM, Paik IH. Comparison of efficacy and safety of milnacipran and fluoxetinein Korean patients with major depression. Curr Med Res Opin. 2005 Sep;21(9):1369-75.
• 88. HanC, Lee BH, Kim YK, Lee HJ, Kim SH, Kim L, Lee MS, Joe SH, Ham BJ, Jung IK,Satisfaction of patients and caregivers with long-acting injectable risperidoneand oral atypical antipsychotics, Primary care and community psychiatry, 2005Sep, 10(3); 119-124
• 89. ChoiMJ, Kang RH, Ham BJ, Jeong HY, Lee MS. Serotonin receptor 2A gene polymorphism(-1438A/G) and short-term treatment response to citalopram. Neuropsychobiology.2005;52(3):155-62.
• 90. HamBJ, Lee MS, Lee YM, Kim MK, Choi MJ, Oh KS, Jung HY, Lyoo IK, Choi IG. Associationbetween the catechol O-methyltransferase Val108/158Met polymorphism andalexithymia. Neuropsychobiology. 2005;52(3):151-4.
• 91. ChoiIG, Kee BS, Son HG, Ham BJ, Yang BH, Kim SH, Lee JS, Son BK, Lee BY, Lee SY,Chai YG, Shin HD. Genetic polymorphisms of alcohol and aldehyde dehydrogenase,dopamine and serotonin transporters in familial and non-familial alcoholism.Eur Neuropsychopharmacol. 2006 Feb;16(2):123-8.
• 92. HamBJ, Choi MJ, Lee HJ, Kang RH, Lee MS. Reward dependence is related to norepinephrinetransporter T-182C gene polymorphism in a Korean population. Psychiatr Genet.2005 Jun;15(2):145-7.
• 93. JinSH, Ham BJ, Kim SY. Functional clustering in EEG photic and auditory driving inschizophrenia. Int J Psychophysiol. 2005 Jun;56(3):249-59.
• 94. LeeSH, Lee KJ, Lee HJ, Ham BJ, Ryu SH, Lee MS. Association between the 5-HT6 receptorC267T polymorphism and response to antidepressant treatment in major depressivedisorder. Psychiatry Clin Neurosci. 2005 Apr;59(2):140-5.
• 95. RyuSH, Lee SH, Lee HJ, Cha JH, Ham BJ, Han CS, Choi MJ, Lee MS. Associationbetween norepinephrine transporter gene polymorphism and major depression. Neuropsychobiology.2004;49(4):174-7.
• 96. ChoiMJ, Lee HJ, Lee HJ, Ham BJ, Cha JH, Ryu SH, Lee MS. Association between majordepressive disorder and the -1438A/G polymorphism of the serotonin 2A receptorgene. Neuropsychobiology. 2004;49(1):38-41.
• 97. HamBJ, Kim YH, Choi MJ, Cha JH, Choi YK, Lee MS. Serotonergic genes and personalitytraits in the Korean population. Neurosci Lett. 2004 Jan 2;354(1):2-5.
• 98. LeeHJ, Cha JH, Ham BJ, Han CS, Kim YK, Lee SH, Ryu SH, Kang RH, Choi MJ, Lee MS.Association between a G-protein beta 3 subunit gene polymorphism and the symptomatologyand treatment responses of major depressive disorders. Pharmacogenomics J.2004;4(1):29-33.
• 99. JinSH, Na SH, Kim SY, Ham BJ, Lee DH, Lee JH, Lee H. Hemispheric laterality anddimensional complexity in schizophrenia under sound and light stimulation. IntJ Psychophysiol. 2003 Jul;49(1):1-15.
• 100. NaSH, Jin SH, Kim SY, Ham BJ. EEG in schizophrenic patients: mutual informationanalysis. Clin Neurophysiol. 2002 Dec;113(12):1954-60.

Korean Journal

• 101.NamYM, Joe SH, Kwon EJ, Ham BJ, Han CS, Ko YH. Associations between VasomotorSymptoms and Depression, Stress and Quality of Life in Midlife Women. Korean JPsychosom Med. 2016 Dec;24(2):146-156.
• 102.KimD, Chang HS, Won E, Ham BJ, Lee MS. Association between the AluInsertion/Deletion Polymorphism in the Tissue-Type Plasminogen Activator Geneand Mirtazapine Response in Koreans with Major Depression. Korean J BiolPsychiatry. 2016 Nov;23(4):140-147.
• 103.Oh J,Ko YH, Paik JW, Lee MS, Han C, Jeong HG, Ham BJ, Kim YK, Kim SH. VariablesInfluencing Subjective Well-Being in Patients with Schizophrenia. Korean JSchizophr Res. 2014 Oct;17(2):93-99.
• 104.ParkS, Joe SH, Kim SH, Han CS, Ham BJ, Ko YH. Fatigue and Its Association withSocio-Demographic and Clinical Variables in a Working Population. Korean JPsychosom Med. 2014 Jun;22(1):3-12. Han KM, Park SC, Won ES, Sung SH, Lee H,Koo JW, Lee K, Lee HY, Paik JW, Jeon HJ, Lee MS, Shim SH, Ko YH, Lee KJ, Han C,Ham BJ, Choi J, Hwang TY, Oh KS, Hahn SW, Park YC, Lee MS. Evidence-BasedKorean Pharmacological Treatment Guideline for Depression, Revised Edition(III) : Dose Increment, Switching, Combination, and Augmentation Strategy inAntidepressant Therapy. J Korean Neuropsychiatr Assoc. 2013 Sep;52(5):386-401.
• 105.SungSH, Park SC, Han KM, Won ES, Lee HY, Koo JW, Paik JW, Lee KM, Jeon HJ, Lee MS,Shim SH, Ko YH, Lee KJ, Han C, Ham BJ, Choi J, Hwang TY, Oh KS, Park YC, LeeMS, Hahn SW. Evidence-Based Korean Pharmacological Treatment Guideline forDepression, Revised Edition (II) : Antidepressant Efficacy Compared withPlacebo, Difference in Efficacy of Antidepressants, and Appropriate Time ofEfficacy Judgment in Antidepressant Therapy. J Korean Neuropsychiatr Assoc.2013 Sep;52(5):372-385.
• 106.ParkSC, Sung SH, Han KM, Won ES, Lee HY, Paik JW, Jeon HJ, Lee MS, Shim SH, Ko YH,Lee KJ, Han C, Ham BJ, Choi J, Lee H, Hwang TY, Oh KS, Park YC, Lee MS, HahnSW. Evidence-Based Korean Pharmacological Treatment Guideline for Depression,Revised Edition (I) : Initial Choice of Antidepressant Treatment. J KoreanNeuropsychiatr Assoc. 2013 Jul;52(4):253-262.
• 107.ShimIB, Joe SH, Ham BJ, Han C, Jeong HG, Ko YH. The Stress Perception, DepressiveSymptoms and Medical Comorbidity in Healthcare Center. Korean J Psychosom Med.2013 Jun;21(1):27-43.
• 108.MoonYS, Na KS, Kim CE, Kim YS, Yoon JS, Ahn YM, Jung HY, Yu BH, Jeon YW, Lee SK,Seok JH, Ham BJ, Park DB, Kim H, Lee BW, Hong CH, Kim JW, Han JH. Efficacy andSafety of Paliperidone Extended Release in Schizophrenia Patients Requiring aSwitch in Antipsychotic Medication by Switching Previous Antipsychotics toPaliperidone Extended Release. Korean J Psychopharmacol. 2012 Jul;23(3):97-106.
• 109.LeeJB, Ham BJ, Lee HY, Lee MS. Association between the Weight Gain and TreatmentResponse to Atypical Antipsychotics in Korean Patients with Schizophrenia.Korean J Biol Psychiatry. 2011 Nov;18(4):225-231.
• 110.HamBJ. Current Understanding in Neurobiology of Depressive Disorders: ImagingGenetic Studies on Serotonin Transporter. Korean J Biol Psychiatry. 2011Nov;18(4):176-180.
• 111.ParkKH, Lee HY, Ham BJ, Lee MS. Comparison of Clinical Symptoms between Early andLate Onset Depression in Elderly Depressive Patients in Korea. Korean J BiolPsychiatry. 2010 Aug;17(3):145-152.
• 112.LeeBT, Ryu J, Lee DH, Sohn MH, Kang NH, Ham BJ, Choi NH. Neural Substrates ofPosttraumatic Stress Disorder: Functional Magnetic Resonance Imaging StudyUsing Negative Priming Task. Korean J Biol Psychiatry. 2008 May;15(2):110-117.
• 113.HamBJ, Han CH. Optimising Antidepressant Use in Clinical Practice: ConsideringExternal Factors. J Korean Neuropsychiatr Assoc. 2008 Jan;47(1):22-27.
• 114.KimW, Hwang TY, Ham BJ, Lee JS, Choi BH, Kim SJ, Seo YJ, Kang EH, Woo JM. The Impactof Major Depressive Disorder on Productivity in Workers: A Preliminary StudyUsing WHO-HPQ(Health and Work Performance Questionnaire). J KoreanNeuropsychiatr Assoc. 2007 Nov;46(6):587-595.
• 115.LeeSM, Choi JH, Ham BJ, Lee SH. Serotonin Transporter-Linked Promoter RegionPolymorphism and Personality Traits in a Korean Female Population. Korean JBiol Psychiatry. 2007 Nov;14(4):268-273.
• 116.JeonCM, Park BY, Byun JH, Lee BC, Ham BJ, Hur M, Choi IG. The Alteration ofCarbohydrate-Deficient Transferrin and Nerve Growth Factor in the Patients withAlcohol Dependence. Korean J Biol Psychiatry. 2007 Aug;14(3):161-166.
• 117.LeeYM, Ham BJ, Lee KA, Ahn DS, Kim MK. The Relation of Self-Efficacy withEnvironmental Factors, Personality and Academic Achievement in Medical Students.Korean J Med Educ. 2006 Dec;18(3):249-257.
• 118.ByunJH, Lee BC, Ham BJ, Chung CS, Hur M, Lee JJ, Choi IG. Comparing BiologicalMarkers of Alcohol Dependence in the Patients of an Alcohol Counseling Center.Korean J Biol Psychiatry. 2006 Nov;13(4):273-278.
• 119.LeeBC, Ham BJ. Antidepressant and Suicide. Korean J Biol Psychiatry. 2006Nov;13(4):244-251.
• 120.ChoiYR, Lee SI, Shin CJ, Son JW, Kim SK, Han BJ, Youn SJ, Park SM, Ham BJ. TheProperties of Temperament, Character and Stress Response in Patients withIrritable Bowel Syndrome. J Korean Neuropsychiatr Assoc. 2006Mar;45(2):136-144.
• 121.HamBJ, An HB, Cho SM, Ryu SG, Choi MJ, Lee MS, Choi IG. An Association Study ofthe Brain-Derived Neurotrophic Factor Genes Polymorphisms and PersonalityTraits. Korean J Biol Psychiatry. 2005 Nov;12(2):216-220.
• 122.YoonSC, Ham BJ, Byun JH, Eun HJ, Son HG, Suh KH, Choi IG. Temperament and CharcaterDimensions of Posttraumatic Stress Disorder in Burn Patients. Korean J BiolPsychiatry. 2005 Nov;12(2):159-164.
• 123.HaJH, Ham BJ, Ryu SG, Hwang TY, Lee JG, Lee YS, Lee JS, Kang DY, Choi IG, Lee MS.An Association Study of the 5-HTTLPR and COMT Genes Polymorphisms andPersonality Traits. Korean J Biol Psychiatry. 2004 Nov;11(2):88-93.
• 124.LeeMS, Ham BJ, Kee BS, Kim JB, Yeon BK, Oh KS, Oh BH, Lee C, Jung HY, Chee IS,Choe BM, Paik IH. The Efficacy and Safety of Milnacipran in Patients with MajorDepression: A comparison with Fluoxetine. J Korean Neuropsychiatr Assoc. 2004Jul;43(4):415-424.
• 125.YoonHK, Kang SG, Ham BJ, Lee HJ, Kwon HI, Suh KY, Kim L. Effects of Stress andPersonality Characteristics on Sleep. Sleep Med Psychophysiol. 2003Jun;10(1):32-38.
• 126.HamBJ. Diagnosis and Treatment of Restless Leg Syndrome and Periodic Limb Movementof Sleep. Sleep Med Psychophysiol. 2003 Jun;10(1):26-31.
• 127.KimYH, Ham BJ, Lee MS, Lee HY. Temperament and Character Inventory and RemissionState of Depression. J Korean Neuropsychiatr Assoc. 2003 May;42(3):335-339.
• 128.KangRH, Ham BJ, Cha JH, Lee MS. The Comparison of the Neurocognitive Functionsbetween Dysthymic Disorder and Major Depressive Disorder. J Korean Soc BiolPsychiatry. 2002 Dec;9(2):103-111.
• 129.LeeHJ, Yang JW, Lee BH, Ham BJ, Suh KY, Kim L. Effects of Total Sleep Deprivationon Visual Discrimination. Sleep Med Psychophysiol. 2002 Dec;9(2):122-126.
• 130.HamBJ, Kim L. Insomnia and Personality Trait. Sleep Med Psychophysiol. 2002Dec;9(2):100-105. Korean.
• 131.LeeHY, Ham BJ, Lee MS. 5-HTTLPR and Long-term effect of Antidepressant Treatementin Korean Depressive Patients. J Korean Soc Biol Psychiatry. 2002 Jul;9(1):34-41.
• 132.ShinDI, Ham BJ, Kwon HI, Park KW, Kim L, Suh KY. Alexithymia in Patients withTension-Type Headache. Sleep Med Psychophysiol. 2002 Jun;9(1):56-60.
• 132.ShinDI, Ham BJ, Kwon HI, Park KW, Kim L, Suh KY. Alexithymia in Patients withTension-Type Headache. Sleep Med Psychophysiol. 2002 Jun;9(1):56-60.
• 133.KangSG, Yoon HK, Ham BJ, Choi YK, Kim SH, Joe SH, Suh KY, Kim L. Effects of MinorStressful Events on Sleep in College Students. Sleep Med Psychophysiol. 2002Jun;9(1):48-55.
• 134.HamBJ, Kim L. Alexithymia: Concept and Implications for Treatment. Sleep MedPsychophysiol. 2002 Jun;9(1):18-23.
• 135.HamBJ, Seo YJ, Kim L. Acute Respiratory Distress due to Rapid Transquilization ina Bipolar Patient with Sleep Apnea. Sleep Med Psychophysiol. 2001Dec;8(2):144-147.
• 136.LeeHJ, Song HS, Ham BJ, Suh KY, Kim L. Effects of Total Sleep Deprivation on FineMotor Performance. Sleep Med Psychophysiol. 2001 Dec;8(2):129-137.
• 137.HamBJ, Lee MS. Pharmacogenomics of Depressive Disorders. J Korean Soc Biol Psychiatry.2001 Nov;8(2):226-232.
• 138.HamBJ, Kim L, Suh KY. Personality Characteristics of Chronic Insomniacs. J KoreanNeuropsychiatr Assoc. 1998 Mar;37(2):234-242.
• 139.HamBJ, Lee MS. Antidepressant and the Quality of Life of Depressive Patient. JKorean Soc Biol Psychiatry. 1997 Jun;4(1):116-120.

Books

• 1. Treatmentof depression (co-author),Karim Publishing Co. 2005.7,
• 2. DesigningClinical Research (co-author), Gunja Publishing Co. 2012.2
• 3. Textbookof Depressive Disorders (co-author), The Koran Academy of Depression andBipolar Disorders, 2012.9
• 4. Psychiatrictales (commentary), Isup Publishing Co.2013.48]

Main Academic and Clinical Interests

• ● Mood disorders
• ● Imaging genetics
• ● Affectiveneuroscience

We are interested in finding out the pathogenesis of the main mood disorders  : Major Depressive Disorder(MDD), Bipolar disorder(I, II), and Postpartum depression.

We examine both the structural and functional abnormalities in the brain of the patients diagnosed with mood disorders by employing cutting-edge neuroimaging techniques such as voxel-based morphometry, surface analysis and connectivity analysis.

We integrate interdisciplinary research approaches, mainly including structural/functional MRI and genetics analysis. Together with individualized result of each patient, this multidisciplinary information is being coded for Big Data driven decision making system development, which will enable not only more precise diagnosis but also the individually tailored treatment of mood disorders.

Furthermore, we carry out experimental researches on the affect-related tasks in association with functional neuroimaging techniques for more cognitive psychological comprehension of human affective processes.

 Research techniques include MRI, fMRI, EEG, genetic studies(blood analysis), Big Data

• Byung-Joo Ham
• MD, PhD
• byungjoo.ham@gmail.com


• Woo-Suk Tae
• PhD
• wstae@korea.ac.kr


• Mi-Ryung Han
• PhD
• genetic0309@korea.ac.kr


• Eunsoo Won
• MD, PhD
• eunsooowon@gmail.com


• Kyu-Man Han
• MD, PhD
• drkyumanhan@gmail.com


• Ji Won Kang
• Dr
• jwiris@gmail.com


• Hyun Jae Lee
• Dr
• lucy316@naver.com


• Seong Hyun Lee
• RN
• lee0420sh@gmail.com


• Jisoo Kang
• RN
• zzzysooo@gmail.com


• June Kang
• PhD
• cnsla@korea.ac.kr


• Aram Kim
• RN
• chloe_ark@korea.ac.kr


• Gongju Shim
• rhdwn0107@naver.com


• Wooyoung Kang
• wykang@korea.ac.kr


• Youbin Kang
• youbin_kang@hanmail.net

Joon-Kyung Seong

• PhD, Department of Bio-convergence Engineering, Korea University College of Health Science 
• http://brein.korea.ac.kr/

Jaewoo Kang

• PhD, Data Mining &Information Systems Laboratory, College of Information and Communications, Korea University
• http://infos.korea.ac.kr/

Heung-Il Suk

• PhD, Department of Brain &Cognitive Engineering, Korea University 
• www.ku-milab.org

Sung Won Han

• PhD, Department of Industrial Management Engineering, Korea University
• http://fda.korea.ac.kr/

Mary L. Phillips

• MD, Department of Psychiatry, University of Pittsburgh School of Medicine
• http://phillips.pitt.edu/

Macrogen Inc

• http://www.macrogen.co.kr/

Syntekabio Inc

• http://www.syntekabio.com/