Professor Heon-Jeong Lee graduated from Korea University College of Medicine and received his master's and doctoral degrees from Korea University College of Medicine. He also received psychiatric training at Korea University Hospital and acquired the Psychiatric Board in 2000. In 2005, he was appointed as a professor at Korea University Medical College and has been working at Korea University Anam Hospital. His major research areas are bipolar disorder, sleep disorder, circadianrRhythm, and genomics. He is the principal investigator responsible for the early mood disorder cohort (Mood Disorders Cohort Research Consortium: MDCRC) project of the Ministry of Health and Welfare since 2014. We are also performing research on new methods for predicting depression, mania and mood instability using digital phenotype using wearable device and smartphone sensors.

ACADEMIC PREPARATION

PROFESSIONAL EXPERIENCE

RESEARCH INTERESTS

• Behavioral Genetics
• Bipolar Affective Disorders
• Chronobiology and Sleep Medicine

EDITORS

PROFESSIONAL MEMBERSHIPS

• Korean Neuropsychiatric Association
• Korean Academy of Sleep Medicine
• International Society of Bipolar Disorder
• American Academy of Sleep Medicine
• Society for Neuroscience
• International College of Neuropsychopharmacology
• World Federation of Societies of Biological Psychiatry
• International Society of Psychiatric Genetics
• Schizophrenia International Research Society

HONORS AND AWARDS

• ML PI Award, Korean Neuropsychiatric Association, 2015
• Dr. Paul Janssen Schizophrenia Research Award, Korean Neuropsychiatric Association, 2012
• KASMED Academic Award, Korean Academy of Sleep Medicine, 2011
• Psychiatry Investigation Award, Korean Neuropsychiatric Association, 2010
• Sanofi Young Investigator Award, Korean Academy of Sleep Medicine, 2007
• Chung-Ang Outstanding Paper Award, Korean Neuropsychiatric Association, 2007
• GSK Young Investigator Award, Korean Neuropsychiatric Association, 2006
• Lilly Young Investigator Award, Korean College of Neuropsychopharmacology, 2005
• Outstanding Paper Award, Korean Society of Biological Psychiatry, 2004
• Outstanding Paper Award, Korea University Medical Alumni, 2004
• Hana Medical Award, Korea Neuropsychiatric Association, 1999
• Association of Korean American Psychiatrists (AKAP) Scholarship Award, Toronto, Canada, 1998
• Korea University Special Scholarship, 1989-1995

PUBLICATION (International Journals only)

( *corresponding author)

• 1. Kang SG, Yoon HK, Cho CH, Kwon S, Kang J, Park YM, Lee E, Kim L, Lee HJ*. Decrease in fMRI brain activation during working memory performed after sleeping under 10 lux light. Sci Rep. 2016 Nov 9;6:36731. doi: 10.1038/srep36731.


• 2. Kang JM, Kang SG, Cho SJ, Lee YJ, Lee HJ, Kim JE, Shin SH, Park KH, Kim ST. The quality of life of suspected obstructive sleep apnea patients is related to their subjective sleep quality rather than the apnea-hypopnea index. Sleep Breath. 2016 Nov 4. [Epub ahead of print]


• 3. Song HM, Cho CH, Lee HJ*, Moon JH, Kang SG, Yoon HK, Park YM, Kim L. Association of CLOCK, ARNTL, PER2, and GNB3 polymorphisms with diurnal preference in a Korean population. Chronobiol Int. 2016;33(10):1455-1463.


• 4. Moon JH, Cho CH, Son GH, Geum D, Chung S, Kim H, Kang SG, Park YM, Yoon HK, Kim L, Jee HJ, An H, Kripke DF, Lee HJ*. Advanced Circadian Phase in Mania and Delayed Circadian Phase in Mixed Mania and Depression Returned to Normal after Treatment of Bipolar Disorder. EBioMedicine. 2016 Sep;11:285-295. doi: 10.1016/j.ebiom.2016.08.019.


• 5. Cho CH, Moon JH, Yoon HK, Kang SG, Geum D, Son GH, Lim JM, Kim L, Lee EI, Lee HJ*. Molecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity. Sci Rep. 2016 Aug 22;6:31846. doi: 10.1038/srep31846.


• 6. Kim S, Cho CH, Geum D, Lee HJ*. Association of CACNA1C Variants with Bipolar Disorder in the Korean Population. Psychiatry Investig. 2016;13(4):453-7.


• 7. Jeon HJ, Baek JH, Ahn YM, Kim SJ, Ha TH, Cha B, Moon E, Kang HJ, Ryu V, Cho CH, Heo JY, Kim K, Lee HJ*; Mood Disorders Cohort Research Consortium (MDCRC) Group. Review of Cohort Studies for Mood Disorders. Psychiatry Investig. 2016;13(3):265-76.


• 8. Lee DH, Cho CH, Han C, Bok KN, Moon JH, Lee E, Lee HJ*, Kim L. Sleep Irregularity in the Previous Week Influences the First-Night Effect in Polysomnographic Studies. Psychiatry Investig. 2016 Mar;13(2):203-9.


• 9. Park J, Choi N, Kim SJ, Kim S, An H, Lee HJ, Lee YJ. The Impact of Celebrity Suicide on Subsequent Suicide Rates in the General Population of Korea from 1990 to 2010. J Korean Med Sci. 2016 Apr;31(4):598-603.


• 10. Koo YS, Song JY, Joo EY, Lee HJ, Lee E, Lee SK, Jung KY. Outdoor artificial light at night, obesity, and sleep health: Cross-sectional analysis in the KoGES study. Chronobiol Int. 2016;33(3):301-14.


• 11. Cho CH, Lee HJ*, Yoon HK, Kang SG, Bok KN, Jung KY, Kim L, Lee EI. Exposure to dim artificial light at night increases REM sleep and awakenings in humans. Chronobiol Int. 2016;33(1):117-23


• 12. Choo M, Hwang JA, Jeon SW, Oh SY, Yoon HK, Lee HJ, Kim YK*. Association Study between Norepinephrine Transporter Gene Polymorphism and Schizophrenia in a Korean Population. Psychiatry Investig. 2015 Oct;12(4):551-8.


• 13. Cho CH, Lee HJ*, Woo HG, Choi JH, Greenwood TA, Kelsoe JR. CDH13 and HCRTR2 May Be Associated with Hypersomnia Symptom of Bipolar Depression: A Genome-Wide Functional Enrichment Pathway Analysis. Psychiatry Investig. 2015 Jul;12(3):402-7.


• 14. Kwon JS*, Kim SN, Han J, Lee SI, Chang JS, Choi JS, Lee HJ, Cho SJ, Jun TY, Lee SH, Han C, Lee KU, Lee KK, Lee E. Satisfaction of immediate or delayed switch to paliperidone palmitate in patients unsatisfied with current oral atypical antipsychotics. Int Clin Psychopharmacol. 2015 Nov;30(6):320-8.


• 15. Kim HI, Lee HJ*, Cho CH, Kang SG, Yoon HK, Park YM, Lee SH, Moon JH, Song HM, Lee E, Kim L. Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior. Chronobiol Int. 2015;32(6):785-91.


• 16. Kang SG, Lee HJ*, Lee SH, Kim L. MEIS1, a Promising Candidate Gene, Is Not Associated with the Core Symptoms of Antipsychotic-Induced Restless Legs Syndrome in Korean Schizophrenia Patients. Psychiatry Investig. 2015 Apr;12(2):263-7.


• 17. So SJ, Lee HJ*, Kang SG, Cho CH, Yoon HK, Kim L. A Comparison of Personality Characteristics and Psychiatric Symptomatology between Upper Airway Resistance Syndrome and Obstructive Sleep Apnea Syndrome. Psychiatry Investig. 2015 Apr;12(2):183-9.


• 18. Kang SG, Na KS, Lee HJ, Chee IS, Lee K, Lee J*. DRD2 Genotypic and Haplotype Variation Is Associated With Improvements in Negative Symptoms After 6 Weeks' Amisulpride Treatment. J Clin Psychopharmacol. 2015;35(2):158-62.


• 19. Lee HY, Hong JP, Hwang JA, Lee HJ, Yoon HK, Lee BH, Kim YK*. Possible Association between Serotonin Transporter Gene Polymorphism and Suicide Behavior in Major Depressive Disorder. Psychiatry Investig. 2015;12(1):136-41.


• 20. Han EJ, Kim YK*, Hwang JA, Kim SH, Lee HJ, Yoon HK, Na KS. Evidence for Association between the Brain-Derived Neurotrophic Factor Gene and Panic Disorder: A Novel Haplotype Analysis. Psychiatry Investig. 2015;12(1):112-7.


• 21. Kim J, Choi N, Lee YJ, An H, Kim N, Yoon HK, Lee HJ*. High altitude remains associated with elevated suicide rates after adjusting for socioeconomic status: a study from South Korea. Psychiatry Investig. 2014;11(4):492-4.


• 22. Kripke DF*, Klimecki WT, Nievergelt CM, Rex KM, Murray SS, Shekhtman T, Tranah GJ, Loving RT, Lee HJ, Rhee MK, Shadan FF, Poceta JS, Jamil SM, Kline LE, Kelsoe JR. Circadian polymorphisms in night owls, in bipolars, and in non-24-hour sleep cycles. Psychiatry Investig. 2014;11(4):345-62.


• 23. Park YM*, Ko YH, Lee MS, Lee HJ, Kim L. Type-d personality can predict suicidality in patients with major depressive disorder. Psychiatry Investig. 2014;11(3):232-6.


• 24. Park YM*, Park HK, Kim L, Lee HJ, Kang SG. Acute-withdrawal restless legs syndrome following abrupt cessation of short-term tramadol. Psychiatry Investig. 2014;11(2):204-6.


• 25. Chung HA, Lee SY, Lee HJ, Kim JH, Sung IK, Shim CS, Jin CJ, Park HS. G protein β3 subunit polymorphism and long-term prognosis of functional dyspepsia. Gut Liver. 2014;8(3):271-6.


• 26. Jung JS, Lee HJ*, Cho CH, Kang SG, Yoon HK, Park YM, Moon JH, Yang HJ, Song HM, Kim L. Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia. Chronobiol Int. 2014;31(7):838-44.


• 27. Kang SG, Lee BH, Lee JS, Chai YG, Ko KP, Lee HJ, Han DM, Ji H, Jang GH, Shin HE. DRD3 gene rs6280 polymorphism may be associated with alcohol dependence overall and with Lesch type I alcohol dependence in Koreans. Neuropsychobiology. 2014;69(3):140-6.


• 28. Kim YK, Hwang JA, Lee HJ, Yoon HK, Ko YH, Lee BH, Jung HY, Hahn SW, Na KS. Association between norepinephrine transporter gene (SLC6A2) polymorphisms and suicide in patients with major depressive disorder. J Affect Disord. 2014;158:127-32.


• 29. Yoon HK, Kang SG, Lee HJ, Yoo Y, Choung JT, Seo WH, Kim L*. Apnea-related sleep fragmentation and poor vigilance in children with well-controlled asthma. J Sleep Res. 2013 Nov 4. doi: 10.1111/jsr.12103. [Epub ahead of print]


• 30. Kim YK, Hwang JA, Lee HJ, Lee BH, Na KS*. There is no association between the serotonin receptor gene and bipolar I disorder in the Korean population. Nord J Psychiatry. 2014;68(7):488-93.


• 31. Kim JW, Kim YK*, Hwang JA, Yoon HK, Ko YH, Han C, Lee HJ, Ham BJ, Lee HS. Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder. Psychiatry Investig. 2013;10(3):294-9.


• 32. Kang SG, Lee YJ, Kim SJ, Lim W, Lee HJ, Park YM, Cho IH, Cho SJ, Hong JP*. Weekend catch-up sleep is independently associated with suicide attempts and self-injury in Korean adolescents. Compr Psychiatry. 2014;55(2):319-25.


• 33. Kim YK, Na KS*, Hwang JA, Yoon HK, Lee HJ, Hahn SW, Lee BH, Jung HY. High insulin-like growth factor-1 in patients with bipolar I disorder: a trait marker? J Affect Disord. 2013;151(2):738-43.


• 34. Yeo HB, Yoon HK, Lee HJ, Kang SG, Jung KY, Kim L*. Effects of Korean Red Ginseng on Cognitive and Motor Function: A Double-blind, Randomized, Placebo-controlled Trial. J Ginseng Res. 2012 Apr;36(2):190-7.


• 35. Na KS, Ham BJ, Lee MS, Kim L, Kim YK, Lee HJ, Yoon HK. Decreased gray matter volume of the medial orbitofrontal cortex in panic disorder with agoraphobia: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:195-200.


• 36. Kim YK, Hong JP, Hwang JA, Lee HJ, Yoon HK, Lee BH, Jung HY, Hahn SW, Na KS*. TNF-alpha -308G>A polymorphism is associated with suicide attempts in major depressive disorder. J Affect Disord. 2013;150(2):668-72.


• 37. Park YM, Lee SH*, Lee HJ, Kang SG, Min JA, Chae JH. Association between BDNF gene polymorphisms and serotonergic activity using loudness dependence of auditory evoked potentials in healthy subjects. PLoS One. 2013;8(4):e60340.


• 38. Kripke DF*, Nievergelt CM, Tranah GJ, Murray SS, Rex KM, Grizas AP, Hahn EK, Lee HJ, Kelsoe JR, Kline LE. FMR1, circadian genes and depression: suggestive associations or false discovery? J Circadian Rhythms. 2013;11(1):3.


• 39. Son WY, Lee HJ*, Yoon HK, Kang SG, Park YM, Yang HJ, Choi JE, An H, Seo HK, Kim L. GABA transporter SLC6A11 gene polymorphism associated with tardive dyskinesia. Nord J Psychiatry. 2014 Feb;68(2):123-8.


• 40. Lee HJ*, Son GH, Geum D. Circadian Rhythm Hypotheses of Mixed Features, Antidepressant Treatment Resistance, and Manic Switching in Bipolar Disorder. Psychiatry Investig. 2013 Sep;10(3):225-232.


• 41. Kang SG, Lee YJ, Kim SJ, Lim W, Lee HJ, Park YM, Cho IH, Cho SJ, Hong JP. Weekend catch-up sleep is independently associated with suicide attempts and self-injury in Korean adolescents. Compr Psychiatry. 2014 Feb;55(2):319-25.


• 42. Kim YK, Na KS, Hwang JA, Yoon HK, Lee HJ, Hahn SW, Lee BH, Jung HY. High insulin-like growth factor-1 in patients with bipolar I disorder: a trait marker? J Affect Disord. 2013 Nov;151(2):738-43.


• 43. Yeo HB, Yoon HK, Lee HJ, Kang SG, Jung KY, Kim L. Effects of Korean Red Ginseng on Cognitive and Motor Function: A Double-blind, Randomized, Placebo-controlled Trial. J Ginseng Res. 2012 Apr;36(2):190-7.


• 44. Kim YK, Hong JP, Hwang JA, Lee HJ, Yoon HK, Lee BH, Jung HY, Hahn SW, Na KS*. TNF-alpha -308G>A polymorphism is associated with suicide attempts in major depressive disorder. J Affect Disord. 2013 Sep 5;150(2):668-72.


• 45. Kang SG, Lee HJ*, Park YM, Yang HJ, Song HM, Lee YJ, Cho SJ, Cho SN, Kim L. The BTBD9 gene may be associated with antipsychotic-induced restless legs syndrome in schizophrenia. Hum Psychopharmacol. 2013;28(2):117-23.


• 46. Cho CH, Lee HJ*. Oxidative stress and tardive dyskinesia: Pharmacogenetic evidence. Prog Neuropsychopharmacol Biol Psychiatry. 2013 in press


• 47. Kang SG, Lee HJ*, Yoon HK, Cho SN, Park YM, Kim L. There is no evidence for an association between the serotonin receptor 3A gene C178T polymorphism and tardive dyskinesia in Korean schizophrenia patients. Nord J Psychiatry. 2013 in press


• 48. Lee HJ, Woo HG, Greenwood TA, Kripke DF, Kelsoe JR*. A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. J Affect Disord. 2013;145(2):200-7.


• 49. Min JA, Lee HJ, Lee SH, Park YM, Kang SG, Chae JH*. Gender-specific effects of brain-derived neurotrophic factor Val66Met polymorphism and childhood maltreatment on anxiety. Neuropsychobiology. 2013;67(1):6-13.


• 50. Yoon HK, Lee HJ, Kim L, Lee MS, Ham BJ*. Impact of tryptophan hydroxylase 2 G-703T polymorphism on anger-related personality traits and orbitofrontal cortex. Behav Brain Res. 2012;231(1):105-10.


• 51. Kang SG, Park YM*, Lee HJ, Yoon B. Duloxetine-induced liver injury in patients with major depressive disorder. Psychiatry Investig. 2011;8(3):269-71.


• 52. Yoon HK, Kim YK*, Lee HJ, Kwon DY, Kim L. Role of cytokines in atypical depression. Nord J Psychiatry 2012;66(3):183-8.


• 53. Lee HJ*, Kang SG. Genetics of tardive dyskinesia. Int Rev Neurobiol. 2011;98:231-64.


• 54. Lee HJ*, Rex KM, Nievergelt CM, Kelsoe JR, Kripke DF*. Delayed sleep phase syndrome is related to seasonal affective disorder. J Affect Disord. 2011 Oct;133(3):573-9.


• 55. Park YM, Choi JE, Kang SG, Koo SH, Kim L, Geum D, Lee HJ*. Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain. Hum Psychopharmacol. 2011; 26: 332-337.


• 56. Park YM, Kang SG, Choi JE, Kim YK, Kim SH, Park JY, Kim L, Lee HJ*. No Evidence for an Association between Dopamine D2 Receptor Polymorphisms and Tardive Dyskinesia in Korean Schizophrenia Patients. Psychiatry Investig. 2011;8: 49-54.


• 57. Oh KJ, Park J, Lee SY, Hwang I, Kim JB, Park TS, Lee HJ, Koo SH*. Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism. Am J Physiol Endocrinol Metab. 2011;300:E624-32.


• 58. Lee HJ, Kim L*, Kang SG, Yoon HK, Choi JE, Park YM, Kim SJ, Kripke DF. PER2 Variation is Associated with Diurnal Preference in a Korean Young Population. Behav Genet 2011;41(2):273-7


• 59. Park YM*, Kang SG, Lee BH, Lee HJ. Decreased thyroid function in Korean women with bipolar disorder receiving valproic acid. Gen Hosp Psychiatry. 2011 Mar-Apr;33(2):200.e13-5.


• 60. Park YM*, Lee BH, Lee HJ, Kang SG. Cholestatic jaundice induced by duloxetine in a patient with major depressive disorder. Psychiatry Investig. 2010;7(3):228-30.


• 61. Lee HJ, SY Lee*, Kim JH, Sung IK, Park HS, Jin CJ, Kang SG, Yoon HJ, Chun HJ. Depressive mood and quality of life in functional gastrointestinal disorders: differences between functional dyspepsia, irritable bowel syndrome and overlap syndrome. Gen Hosp Psychiatry 2010; 32(5):499-502.


• 62. Kang SG, Park YM, Choi JE, Lim SW, Lee HJ*, Lee SH, Kim YK, Kim SH, Cho SN, Kim L. Association study between antipsychotic-induced restless legs syndrome and polymorphisms of monoamine oxidase genes in schizophrenia. Hum Psychopharmacol. 2010;25(5):397-403.


• 63. Lee HJ, Lee SY, Choi JE, Kim JH, Sung IK*, Park HS, Jin CJ. G protein beta3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome. Neurogastroenterol Motil. 2010 Jul;22(7):758-63


• 64. Park YM, Lee HJ*, Kang SG, Choi JE, Cho JH, Kim L. Lack of Association between Glutathione S-Transferase-M1, -T1, and -P1 Polymorphisms and Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients. Psychiatry Investig. 2010;7(2):147-52.


• 65. Park YM, Lee HJ, Kang SG, Choi HS, Choi JE, Cho JH, Kim L*. Prevalence of idiopathic and secondary restless legs syndrome in Korean Women. Gen Hosp Psychiatry 2010;32(2):164-8.


• 66. Kim SJ, Cho SJ, Jang HM, Shin J, Park PW, Lee YJ, Cho IH, Choi JE, Lee HJ*. Interaction between brain-derived neurotrophic factor Val66Met polymorphism and recent negative stressor in harm avoidance. Neuropsychobiology. 2010;61(1):19-26.


• 67. Cho CH, Kang SG, Choi JE, Park YM, Lee HJ*, Kim L. Association between Antipsychotics-Induced Restless Legs Syndrome and Tyrosine Hydroxylase Gene Polymorphism. Psychiatry Investig. 2009 Sep;6(3):211-5.


• 68. Kang R, Chang H, Wong M, Choi M, Park J, Lee H, Jung I, Joe S, Kim L, Kim S, Kim Y, Han C, Ham B, Lee HJ, Ko Y, Lee M, Lee M*. Brain-derived neurotrophic factor gene polymorphisms and mirtazapine responses in Koreans with major depression. J Psychopharmacol. . 2010 Dec;24(12):1755-63


• 69. Kim YK, Lee HJ, Yang JC, Hwang JA, Yoon HK. A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder. Behav Genet. 2009 Mar;39(2):170-5.


• 70. Lee HJ, Kang SG, Choi JE, Park YM, Lim SW, Rhee MK, Kim SH, Kim L*. No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia. Psychiatry Invest 2009; 6: 108-111


• 71. Park YM, Chung YC, Lee SH, Lee KJ, Kim H, Choi JE, Kang SG, Lee MS, Lee HJ*. G-protein β3 Subunit Gene 825C/T Polymorphism Is Not Associated with Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients. Psychiatry Invest 2009; 6: 39-43.


• 72. Lee HY, Kim DJ, Lee HJ, Choi JE, Kim YK*. No association of serotonin transporter polymorphism (5-HTTVNTR and 5-HTTLPR) with characteristics and treatment response to atypical antipsychotic agents in schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33(2): 276-280.


• 73. Kang SG, Lee HJ*, Choi JE, An H, Rhee M, Kim L. Association study between glutathione S-transferase GST-M1, GST-T1, and GST-P1 polymorphisms and tardive dyskinesia. Hum Psychopharmacol. 2009;24(1):55-60.


• 74. Lim MH*, Kim JW, Song EY, Kim TH, Park TW, Lee HJ, Paik KC, Kim HW. COMT gene polymorphism association and drug response in Tourette syndrome.Psychiatr Genet. 2009;19(3):158.


• 75. Kang SG, Choi JE, An H, Park YM, Lee HJ*, Han C, Kim YK, Kim SH, Cho SN, Joe SH, Jung IK, Kim L, Lee MS. Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry 2008 ;32(8):1844-1847.


• 76. Shim SH, Hwangbo Y, Kwon YJ, Jeong HY, Lee BH, Lee HJ, Kim YK*. Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficit-hyperactivity disorder (ADHD). Prog Neuropsychopharmacol Biol Psychiatry 2008 ;32(8):1824-1828.


• 77. Kang SG, Choi JE, An H, Lim SW, Lee HJ*, Han C, Kim YK, Kim SH, Cho SN, Lee MS, Joe SH, Jung IK, Kim L. No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry. 2008 ;32(6):1545-1548


• 78. Kang SG, Lee HJ*, Kim L. Restless legs syndrome and periodic limb movements during sleep probably associated with olanzapine. J Psychopharmacol. 2009;23(5):597-601.


• 79. Lee HJ*. Comments on "Novelty seeking and the dopamine D4 receptor gene (DRD4) revisited in Asians: Haplotype characterization and relevance of the 2-repeat allele" by C. Reist et al. Am J Med Genet B Neuropsychiatr Genet 2007;144(4):453-457.Am J Med Genet B Neuropsychiatr Genet. 2009; 150B(1):151-2.


• 80. Kang SG, Lee HJ*, Choi JE, Park YM, Park JH, Han C, Kim YK, Kim SH, Lee MS, Joe SH, Jung IK, Kim L*. Association study between antipsychotics- induced restless legs syndrome and polymorphisms of dopamine D1, D2, D3, and D4 receptor genes in schizophrenia. Neuropsychobiology. 2008;57(1-2):49-54.


• 81. Yoon HK, Yang JC, Lee HJ, Kim YK*. The association between serotonin-related gene polymorphisms and panic disorder. J Anxiety Disord. 2008; 22(8):1529-1534.


• 82. Kang SG, Choi JE, Park YM, Lee HJ*, Han C, Kim YK, Kim SH, Lee MS, Joe SH, Jung IK, Kim L. Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene is not associated with tardive dyskinesia in schizophrenia. Neuropsychobiology. 2008;57(1-2):22-5.


• 83. Lee HJ, Kang SG, Choi JE, Park YM, Lim SW, Kim L*. No association between dopamine D3 receptor gene Ser9Gly polymorphism and tardive dyskinesia in schizophrenia. Clin Psychopharmacol Neurosci 2008:6(2):71-74


• 84. Kang SG, Lee HJ*, Park YM, Choi JE, Han C, Kim YK, Kim SH, Lee MS, Joe SH, Jung IK, Kim L. Possible association between the -2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(1):160-3.


• 85. Lim SW, Oh KS, Shin YC, Kang SG, Kim L, Park YM, Kim W, Lee HJ*.Clinical and temperamental differences between early- and late-onset alcoholism in Korean men. Compr Psychiatry. 2008; 49(1):94-7.


• 86. Park YM, Cho JH, Kang SG, Choi JE, Lee SH, Lee HJ*. Lack of association between the –759C/T polymorphism of the 5-HT2C receptor gene and olanzapine-induced weight gain among Korean schizophrenic patients. J Clin Pharm Thera 2008; 32 (1):160-163.


• 87. Kang SG, Lee HJ*, Choi JE, Park JH, Lee SS, Han C, Kim YK, Kim SH, Lee MS, Joe SH, Jung IK, Kim L. Possible association between G-protein beta 3 subunit C825T polymorphism and antipsychotic-induced restless legs syndrome in schizophrenia. Acta Neuropsychiatrica 2007 19 (6): 351-356


• 88. Lee HJ, Kang SG, Paik JW, Lee MS, Cho BH, Park YM, Kim W, Choi JE, Jung IK, Kim L, Lee MS*. No evidence for an association between G protein beta3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia. Hum Psychopharmacol. 2007 22(8):501-4


• 89. Lee HJ, Paik JW, Kang SG, Lim SW, Kim L*. Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference. Chronobiol Int. 2007;24(4):589-97.


• 90. Lee HJ, Kang SG, Choi JE, Paik JW, Kim YK, Kim SH, Lee MS, Joe SH, Jung IK, Kim L*. No association between dopamine D4 receptor gene -521 C/T polymorphism and tardive dyskinesia in schizophrenia. Neuropsychobiology. 2007;55(1):47-51.


• 91. Kang SG, Lee HJ*, Jung SW, Cho SN, Han C, Kim YK, Kim SH, Lee MS, Joe SH, Jung IK, Kim L. Characteristics and clinical correlates of restless legs syndrome in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(5):1078-83.


• 92. Paik JW, Lee HJ, Kang SG, Lim SW, Lee MS, Kim L*. CLOCK gene 3111C/T polymorphism is not associated with seasonal variations in mood and behavior in Korean college students. Psychiatry Clin Neurosci. 2007;61(1):124-6.


• 93. Park YM, Chung YC, Lee SH, Lee KJ, Kim H, Byun YC, Lim SW, Paik JW, Lee HJ*. Weight gain associated with the alpha2a-adrenergic receptor -1,291 C/G polymorphism and olanzapine treatment. Am J Med Genet B Neuropsychiatr Genet. 2006 ;141(4):394-397.


• 94. Lee HJ, Sung SM, Lim SW, Paik JW, Kim L* (2006): Seasonality associated with the serotonin 2A receptor -1438 A/G polymorphism. J Affect Disord 95(3):145-148.


• 95. Kang SG, Lee HJ*, Lee MS, Kim L, Park JS. Atypical Neuroleptic Malignant Syndrome Associated With Aripiprazole. J Clin Psychopharmacol 2006;26(5):534.


• 96. Lee HJ, Kang RH, Lim SW, Paik JW, Choi MJ, Lee MS* (2006): No association between the brain-derived neurotrophic factor gene polymorphism and post-traumatic stress disorder. Stress & Health 22 (2): 115-119


• 97. Lee BH, Lee SW, Yoon D, Lee HJ, Yang JC, Shim SH, Kim DH, Ryu SH, Han C, Kim YK* (2006): Increased plasma nitric oxide metabolites in suicide attempters. Neuropsychobiology. 2006;53(3):127-132.


• 98. Lim MH*, Kim HW, Paik KC, Cho SC, Yoon do Y, Lee HJ. (2006): Association of the DAT1 polymorphism with attention deficit hyperactivity disorder (ADHD): a family-based approach. Am J Med Genet B Neuropsychiatr Genet. 141(3):309-311.


• 99. Lee HJ, Sung SM, Han CS, Kim YK, Kim SH, Lee MS, Joe SH, Jung IK, Kim L.* (2005): G-protein beta3 subunit C825T polymorphism tends to be associated with seasonal variation in young male college students. Neuropsychobiology 52(3):135-139.


• 100. Lee HJ, Kim L*, Han CS, Kim YK, Kim SH, Lee MS, Joe SH, Jung IK. (2005): Latency of auditory P300 correlates with self-control as measured by the Sixteen Personality Factor Questionnaire. Psychiatry Clin Neurosci. 59(4):418-424.


• 101. Lee HJ, Lee MS*, Kang RH, Kim H, Kim SD, Kee BS, Kim YH, Kim YK, Kim JB, Yeon BK, Oh KS, Oh BH, Yoon JS, Lee C, Jung HY, Chee IS, Paik IH. (2005): Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress & Anxiety 21(3):135-139.


• 102. Kim JY, Jung IK, Han C*, Cho SH, Kim L, Kim SH, Lee BH, Lee HJ, Kim YK. (2005) Antipsychotics and dopamine transporter gene polymorphisms in delirium patients. Psychiatry Clin Neurosci. 59(2):183-188.


• 103. Lee SH, Lee HJ, Ham BJ, Ryu SH, Han CS, Lee MS* (2005): Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder. Psychiatr Clin Neurosci 59(2): 140-145.


• 104. Ham BJ, Lee MS*, Lee HJ, Ryu SH, Lee SH, Choi MJ (2005): No association between the tryptophan hydroxylase gene polymorphism and antidepressant response in a Korean population. Psychiatr Genetics 15(4):299-301.


• 105. Ham BJ, Choi MJ, Lee HJ, Kang RH, Lee MS (2005): Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population. Psychiatr Genet. 15(2):145-147.


• 106. Lee HJ, Ji-Hyun Cha, Ham BJ, Han CS, Lee SH, Ryu SH, Kang RH, Choi MJ, Lee MS* (2004): Association between a G-protein 3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. Pharmacogenomics J. 4 (1):29-33


• 107. Choi MJ,† Lee HJ,† Lee HJ, Ham BJ, Cha JH, Ryu SH, Lee MS* (2004): Association between Major Depressive Disorder and the 1438A/G Polymorphism of the Serotonin 2A Receptor Gene. Neuropsychobiology 49 (1):38-41 (†equal contributors)


• 108. Lee SY, Lee HJ*, Kim YK, Kim SH, Kim L, Lee MS, Joe SH, Jung IK, Suh KY, Kim HK (2004): Neurocognitive function and quality of life in relation to hematocrit levels in chronic hemodialysis patients. J Psychosomatic Res 57 (1): 5-10.


• 109. Lee MS*, Lee HY, Lee HJ, Ryu SH (2004): Serotonin transporter promoter gene polymorphism and long-term outcome of antidepressant treatment. Psychiatr Genet 14: 111-115.


• 110. Lee HJ, Kim L,* Kim YK, Suh KY, Han J, Park MK, Park KW, Lee DH (2004): Auditory Event-Related Potentials and Psychological Changes during Sleep Deprivation. Neuropsychobiology 50 (1):1-5.


• 111. Ryu SH, Lee SH, Lee HJ, Cha JH, Ham BJ, Han CS, Choi MJ, Lee MS (2004): Association between norepinephrine transporter gene polymorphism and major depression. Neuropsychobiology 49 (2) : 114-117.


• 112. Jung IK, Lee HJ,* Cho BH (2004): Persistent psychotic disorder in an adolescent with a past history of butane gas dependence. Eur Psychiatry 19 (8) : 519-520.


• 113. Kim YK,* Myint AM, Lee BH, Han CS, Lee HJ, Kim DJ, Leonard BE(2004): Th1, Th2 and Th3 cytokine alteration in schizophrenia, Prog Neuropsychopharmacol Biol Psychiatry. 28(7):1129-1134.


• 114. Lee HJ*, Lee HS, Kim YK, Kim SH, Kim L, Lee MS, Joe SH, Jung IK, Suh KY, Kim S(2003): Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population. Am J Med Genet (Neuropsychiar Genet) 118B: 76-80.


• 115. Lee HJ*, Lee HS, Kim YK, Kim L, Lee MS, Jung IK, Suh KY, Kim S(2003): D2 and D4 dopamine receptor gene polymorphisms and personality traits in a young Korean population. Am J Med Genet (Neuropsychiar Genet) 121B:44-49


• 116. Lee HJ, Kim YK* (2003): Serum lipid levels and suicide attempts. Acta Psychiatr Scand 108 (3) : 215-221


• 117. Lee HJ, Kim L*, Suh KY(2003): Cognitive deterioration and changes of P300 during total sleep deprivation. Psychiatr Clin Neurosci 57(5): 490-496.


• 118. Kim YK*, Noh KB, Han CS, Lee HJ, Kim HS, Yoon SC, Kim DJ, Song KJ, Maes M, Song JW (2003): Borna disease virus and deficit schizophrenia. Acta Neuropsychiatrica 15 (3):262-265


• 119. Lee HJ, Kim L*, Joe SH, Suh KY (2002): The effects of season and climate on the first manic episode of bipolar affective disorder in Korea. Psychiatr Res 113(2): 151-159.


• 120. Lee HS*, Kim SH, Lee HJ, Kim L, Lee SK, Jang DW, Lee MS, Son BG, Suh KY, Kim S. Gender-Specific Molecular Heterosis of Dopamine D2 Receptor Gene(DRD2) for Smoking in Schizophrenia. Am J Med Genet (Neuropsychiar Genet) 2002; 114 (5): 593-597.


• 121. Kim YK*, Lee HJ, Kim JY, Yoon DK, Choi SH, Lee MS (2002): Lower serum cholesterol is correlated to suicidality in a Korean sample. Acta Psychiatr Scand 105(2): 141-148


• 122. Lee HJ*, Lee HS, Kim L, Lee MS, Suh KY, Kwak DI (2001): A case of risperidone-induced stuttering. J Clin Psychopharmacol 21(1): 115-116.


• 123. Lee MS*, Lee HJ, Kim L (2000): A case of delayed NMS induced by risperidone. Psychiatric Services 51(2): 254-255

Research Topic

His major research areas are bipolar disorder, sleep disorder, circadianrRhythm, and genomics. He is the principal investigator responsible for the early mood disorder cohort (Mood Disorders Cohort Research Consortium: MDCRC) project of the Ministry of Health and Welfare since 2014. We are also performing research on new methods for predicting depression, mania and mood instability using digital phenotype using wearable device and smartphone sensors.

• Psychiatry and Behavioral Science Education in KU
• Psychiatry Board Education in KU
• Polysomnography Training in KU

• 조철현
• 서주연
• 정승화
• 이병욱
• 이정빈
• 조아름
• 김수철
• 염지원
• 정재권